BGC0000020: maytansine biosynthetic gene cluster from Actinosynnema pretiosum subsp. auranticum
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Location: 1 - 82,746 nt. (total: 82,746 nt).
This entry is originally from NCBI GenBank AF453501.1.

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core biosynthetic genes
additional biosynthetic genes
transport-related genes
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Gene details
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General
Compounds
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NRPS/PKS domains
KnownClusterBlast
General information about the BGC
MIBiG accession BGC0000020
Short description maytansine biosynthetic gene cluster from Actinosynnema pretiosum subsp. auranticum
Status Minimal annotation: yes
A minimal annotation only contains information on the BGC loci and one or more linked chemical product(s)

Completeness: Unknown
Whether the loci encodes everything needed for the pathway producing the compound(s)
Biosynthetic class(es)
  • Polyketide
Loci NCBI GenBank: AF453501.1
Compounds
  • maytansine
  • ansamitocin P-3
Species Actinosynnema pretiosum subsp. auranticum [taxonomy]
References
Chemical products information
maytansine
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C34H46Cl1N3O10
Chemical database entries
PubCHEM
ansamitocin P-3
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C32H43Cl1N2O9
List of genes involved in compound(s) production
Identifiers Position Product Functions Evidence Extra
  • AAM54115.1
  • asm37
 2 - 1678 (+) unknown
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  • AAM54114.1
  • asm36
 1825 - 2142 (+) unknown
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  • AAM54113.1
  • asm35
 2129 - 3307 (-) bicyclomycin resistant protein
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  • AAM54112.1
  • asm34
 3450 - 4064 (-) transcriptional regulator
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  • AAM54111.1
  • asm33
 4151 - 4723 (+) dihydrofolate reductase
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  • AAM54110.1
  • asm32
 4854 - 5057 (-) unknown
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  • AAM54109.1
  • asm31
 5415 - 6461 (+) RNA polymerase sigma factor
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  • AAM54108.1
  • asm30
 6501 - 9518 (-) cytochrome P450
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  • AAM54107.1
  • asm29
 9664 - 10245 (+) transcriptional regulator
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  • AAM54106.1
  • asm28
 10393 - 10857 (+) unknown
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  • AAM54105.1
  • asm27
 10912 - 11937 (-) glucose 1-dehydrogenase
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  • AAM54104.1
  • asm26
 12117 - 12359 (+) acyl carrier protein
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  • AAM54103.1
  • asm25
 12455 - 13663 (-) glycosyltransferase
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  • AAM54076.1
  • asmB
 13741 - 22962 (-) polyketide synthase
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  • AAM54075.1
  • asmA
 22987 - 37041 (-) polyketide synthase
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  • AAM54102.1
  • asm24
 37440 - 38606 (-) 3-amino-5-hydroxybenzoate synthase
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  • AAM54101.1
  • asm23
 38826 - 39260 (+) 5-deoxy-5-amino-3-dehydroquinate dehydratase
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  • AAM54100.1
  • asm22
 39525 - 40280 (-) kinase
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  • AAM54099.1
  • asm21
 41063 - 43069 (-) O-carbamoyltransferase
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  • AAM54098.1
  • asm20
 43291 - 43638 (+) unknown
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  • AAM54097.1
  • asm19
 43652 - 44788 (-) 3-O-acyltransferase
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  • AAM54096.1
  • asm18
 44814 - 47555 (-) transcriptional activator
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  • AAM54095.1
  • asm17
 47733 - 48236 (-) O-methyltransferase
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  • AAM54094.1
  • asm16
 48388 - 49701 (-) unknown
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  • AAM54093.1
  • asm15
 49782 - 50855 (-) acyl-CoA dehydrogenase
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  • AAM54092.1
  • asm14
 50890 - 51162 (-) acyl carrier protein
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  • AAM54091.1
  • asm13
 51159 - 52184 (-) 3-hydroxyacyl-CoA dehydrogenase
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  • AAM54090.1
  • asm12
 52441 - 53766 (+) halogenase
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  • AAM54089.1
  • asm11
 53871 - 55313 (+) oxygenase
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  • AAM54088.1
  • asm10
 55310 - 56194 (+) methyltransferase
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  • AAM54087.1
  • asm9
 56445 - 57224 (-) amide synthase
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  • AAM54078.1
  • asmD
 57226 - 67200 (-) polyketide synthase
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  • AAM54077.1
  • asmC
 67210 - 71979 (-) polyketide synthase
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  • AAM54086.1
  • asm8
 72035 - 75388 (-) transcriptional regulator
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  • AAM54085.1
  • asm7
 75589 - 76635 (+) methyltransferase
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  • AAM54084.1
  • asm6
 76761 - 77054 (-) unknown
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  • AAM54083.1
  • asm5
 77077 - 78327 (-) Na+/H+ antiporter
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  • AAM54082.1
  • asm4
 78336 - 80582 (-) ABC transporter
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  • AAM54081.1
  • asm3
 80623 - 80889 (-) unknown
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  • AAM54080.1
  • asm2
 81057 - 81701 (-) transcriptional repressor
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  • AAM54079.1
  • asm1
 81928 - 82653 (+) quinone oxidoreductase
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Annotation changelog
MIBiG version Submitter Notes
1.0
  • Hidden contributor (ID: AAAAAAAAAAAAAAAAAAAAAAAA, no GDPR consent given).
  • Submitted
2.0
  • Hidden contributor (ID: AAAAAAAAAAAAAAAAAAAAAAAA, no GDPR consent given).
  • Migrated from v1.4
  • Updated compound(s) information (NPAtlas curation)
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