BGC0000035: chalcomycin A biosynthetic gene cluster from Streptomyces bikiniensis
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Location: 1 - 85,915 nt. (total: 85,915 nt).
This entry is originally from NCBI GenBank AY509120.1.

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core biosynthetic genes
additional biosynthetic genes
transport-related genes
regulatory genes
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resistance
TTA codons
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Gene details
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General
Compounds
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History
NRPS/PKS domains
KnownClusterBlast
General information about the BGC
MIBiG accession BGC0000035
Short description chalcomycin A biosynthetic gene cluster from Streptomyces bikiniensis
Status Minimal annotation: yes
A minimal annotation only contains information on the BGC loci and one or more linked chemical product(s)

Completeness: Unknown
Whether the loci encodes everything needed for the pathway producing the compound(s)
Biosynthetic class(es)
  • Polyketide
Loci NCBI GenBank: AY509120.1
Compounds
  • chalcomycin A
Species Streptomyces bikiniensis [taxonomy]
References
Chemical products information
chalcomycin A
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C35H56O14
Chemical database entries
NPAtlas
List of genes involved in compound(s) production
Identifiers Position Product Functions Evidence Extra
  • AAS79439.1
  • ORF1
 1 - 1009 (-) conserved hypothetical protein
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  • AAS79440.1
  • ORF2
 1121 - 1963 (-) conserved hypothetical protein
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  • AAS79441.1
  • ORF3
 3008 - 3889 (-) conserved hypothetical protein
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  • AAS79442.1
  • chmCIV
 3991 - 5208 (-) putative D-chalcose pathway component
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  • AAS79443.1
  • chmCI
 5339 - 6118 (-) putative O-methyltransferase in D-chalcose pathway
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  • AAS79444.1
  • chmCV
 6239 - 7696 (-) putative D-chalcose pathway component
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  • AAS79445.1
  • chmR
 7761 - 10271 (-) putative beta-glucosidase
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  • AAS79446.1
  • chmPII
 10306 - 11511 (-) P450
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  • AAS79447.1
  • chmPI
 11549 - 12772 (-) P450
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  • AAS79448.1
  • chmI
 12762 - 13610 (-) putative thioesterase TEII family
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  • AAS79449.1
  • chmAII
 13631 - 14602 (-) putative TDP-glucose 4,6-dehydratase
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  • AAS79450.1
  • chmAI
 14645 - 15562 (-) putative TDP-glucose synthase
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  • AAS79451.1
  • chmJ
 15869 - 16459 (-) putative 3-epimerase in D-allose pathway
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  • AAS79452.1
  • chmMII
 16523 - 17290 (-) putative 3'OH-methyltransferase in D-mycinose pathway
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  • AAS79453.1
  • chmHI
 17551 - 18813 (+) P450
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  • AAS79454.1
  • chmHII
 18831 - 19052 (+) ferredoxin
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  • AAS79455.1
  • chmD
 19049 - 20029 (+) putative 4-ketoreductase in D-allose pathway
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  • AAS79456.1
  • chmMI
 20062 - 21273 (+) putative 2'OH-methyltransferase in D-mycinose pathway
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  • AAS79457.1
  • chmN
 21329 - 22585 (+) putative D-allose glycosyltransferase
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  • AAS79458.1
  • chrB
 22653 - 23495 (-) putative resistance determinant
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  • AAS79459.1
  • chmGI
 23622 - 36947 (+) polyketide synthase subunit
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  • AAS79460.1
  • chmGII
 37041 - 42965 (+) polyketide synthase subunit
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  • AAS79461.1
  • chmGIII
 43022 - 54388 (+) polyketide synthase subunit
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  • AAS79462.1
  • chmGIV
 54439 - 59277 (+) polyketide synthase subunit
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  • AAS79463.1
  • chmGV
 59387 - 63439 (+) polyketide synthase subunit
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  • AAS79464.1
  • chmCII
 63522 - 64760 (+) putative NDP-hexose 3,4-isomerase
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  • AAS79465.1
  • chmCIII
 64804 - 66081 (+) putative chalcose glycosyltransferase
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  • AAS79466.1
  • chmU
 66194 - 66940 (+) putative post-PKS ketoreductase
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  • AAS79467.1
  • ORF4
 67323 - 68471 (-) putative permease
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  • AAS79468.1
  • ORF5
 68733 - 70196 (-) conserved hypothetical protein
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  • AAS79469.1
  • ORF6
 70193 - 70888 (-) putative D-alanyl-D-alanine carboxypeptidase
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  • AAS79470.1
  • ORF7
 71382 - 72542 (-) sensory histidine kinase
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  • AAS79471.1
  • ORF8
 72638 - 73324 (-) putative two-component system response regulator
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  • AAS79472.1
  • ORF9
 73651 - 75081 (-) putative permease
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  • AAS79473.1
  • ORF10
 75401 - 76117 (-) conserved hypothetical protein
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  • AAS79474.1
  • ORF11
 76537 - 78375 (+) putative permease
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  • AAS79475.1
  • ORF12
 78521 - 79192 (+) putative merR-family transcriptional regulator
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  • AAS79476.1
  • ORF13
 79228 - 79983 (-) thioesterase TEII family
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  • AAS79477.1
  • ORF14
 80489 - 81439 (-) hypothetical protein
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  • AAS79478.1
  • ORF15
 81806 - 82528 (+) putative response regulator
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  • AAS79479.1
  • ORF16
 82712 - 85912 (+) hypothetical protein
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Annotation changelog
MIBiG version Submitter Notes
1.0
  • Hidden contributor (ID: AAAAAAAAAAAAAAAAAAAAAAAA, no GDPR consent given).
  • Submitted
2.0
  • Hidden contributor (ID: AAAAAAAAAAAAAAAAAAAAAAAA, no GDPR consent given).
  • Migrated from v1.4
  • Updated compound(s) information (NPAtlas curation)
3.0
  • Hidden contributor (ID: AAAAAAAAAAAAAAAAAAAAAAAA, no GDPR consent given).
  • Updated bioactivity data
3.1
  • Hidden contributor (ID: AAAAAAAAAAAAAAAAAAAAAAAA, no GDPR consent given).
  • Update chemical activity to schema version 2.11
Detailed domain annotation
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