BGC0000038: coelimycin P1 biosynthetic gene cluster from Streptomyces coelicolor A3(2)
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Location: 6,890,528 - 6,948,414 nt. (total: 57,887 nt).
This entry is originally from NCBI GenBank AL645882.2.

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General
Compounds
Genes
Polyketide
History
NRPS/PKS domains
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General information about the BGC
MIBiG accession BGC0000038
Short description coelimycin P1 biosynthetic gene cluster from Streptomyces coelicolor A3(2)
Status Minimal annotation: no
A minimal annotation only contains information on the BGC loci and one or more linked chemical product(s)

Completeness: complete
Whether the loci encodes everything needed for the pathway producing the compound(s)
Biosynthetic class(es)
  • Polyketide (Other)
Loci NCBI GenBank: AL645882.2
Compounds
  • coelimycin P1
Species Streptomyces coelicolor A3(2) [taxonomy]
References
Chemical products information
coelimycin P1
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C17H20N2O4S1
Chemical database entries
ChemSpider
List of genes involved in compound(s) production
Identifiers Position Product Functions Evidence Extra
  • CAB60184.1
  • SCO6265
 6890528 - 6891175 (-) ScbR; Butyrolactone-responsive repressor protein
  • Regulation
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  • CAB60185.1
  • SCO6266
 6891293 - 6892237 (+) ScbA; Butenolide synthase involved in SCB1 biosynthesis
  • Other enzymatic
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  • CAB60186.1
  • SCO6267
 6892353 - 6893207 (+) ScbB; Reductase involved in SCB1 biosynthesis
  • Other enzymatic
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  • CAB60187.1
  • SCO6268
 6893258 - 6894022 (-) CpkM; Two-component system histidine kinase
  • Regulation
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  • CAB60188.1
  • SCO6269
 6894148 - 6895200 (-) CpkP-beta; beta-Ketoacid-dependent ferredoxin reductase beta-subunit
  • Precursor biosynthesis
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  • CAB60189.1
  • SCO6270
 6895193 - 6897085 (-) CpkP-alpha; alpha-Ketoacid-dependent ferredoxin reductase alpha-subunit
  • Precursor biosynthesis
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  • CAD55505.1
  • SCO6271
 6897089 - 6898861 (-) AccA1; Acyl-CoA carboxylase alpha-subunit (biotinylated)
  • Precursor biosynthesis
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  • CAC22143.1
  • SCO6272
 6899170 - 6900822 (+) ScF; Secreted flavin-dependent epoxidase/dehydrogenase
  • Tailoring (Monooxygenation)
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  • CAC22144.1
  • SCO6273
 6900898 - 6907356 (-) CpkC; Polyketide synthase module 5
  • Scaffold biosynthesis
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  • CAC22145.1
  • SCO6274
 6907413 - 6918143 (-) CpkB; Polyketide synthase modules 3 and 4
  • Scaffold biosynthesis
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  • CAD55506.1
  • SCO6275
 6918286 - 6931959 (-) CpkA; Polyketide synthase loading module, and modules 1 and 2
  • Scaffold biosynthesis
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  • CAC37877.1
  • SCO6276
 6932285 - 6933607 (+) CpkD; Secreted flavin-dependent epoxidase/dehydrogenase
  • Tailoring (Monooxygenation)
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  • CAC37878.1
  • SCO6277
 6933604 - 6934464 (+) CpkE; Putative isomerase (alpha, beta-hydrolase fold)
  • Tailoring (Unknown)
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  • CAC37879.1
  • SCO6278
 6934507 - 6936138 (+) CpkF; Transmembrane efflux protein
  • Transport
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  • CAC37880.1
  • SCO6279
 6936149 - 6937705 (+) CpkG; Pyridoxal-dependent aminotransferase
  • Tailoring (Amination)
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  • CAC37881.1
  • SCO6280
 6938012 - 6939643 (+) CpkO; KasO; SARP-family transcriptional activator
  • Regulation
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  • CAC37882.1
  • SCO6281
 6939907 - 6941544 (+) CpkH; Secreted flavin-dependent epoxidase/dehydrogenase
  • Tailoring (Monooxygenation)
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  • CAC37883.1
  • SCO6282
 6941746 - 6942543 (-) CpkI; Nicotinamide-dependent dehydrogenase
  • Other enzymatic
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  • CAC37884.1
  • SCO6283
 6942661 - 6943506 (+) CpkJ; NmrA-family protein (unknown function)
  • Unknown
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  • CAC37885.1
  • SCO6284
 6943673 - 6945265 (+) CpkK; Acyl-CoA carboxylase beta-subunit
  • Precursor biosynthesis
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  • CAC37886.1
  • SCO6285
 6945280 - 6945543 (+) CpkL; Hypothetical protein (unknown function)
  • Unknown
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  • CAC37887.1
  • SCO6286
 6945705 - 6946379 (-) ScbR2; Butyrolactone-responsive repressor protein
  • Regulation
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  • CAC37888.1
  • SCO6287
 6946617 - 6947423 (+) ScoT; Type II thioesterase
  • Scaffold biosynthesis
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  • CAC37890.1
  • SCO6288
 6947584 - 6948414 (+) CpkN; SARP-family transcriptional activator
  • Regulation
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Polyketide-specific information
Subclass Other
Starter unit Malonyl-CoA
Cyclic? no
Release type
  • Reductive release
Polyketide-synthases
Genes Properties Modules
SCO6273
+
SCO6274
+
SCO6275
+
SCO6273 		Synthase subclass: Modular type I
Thioesterases:
  • SCO6273 (Unknown)
Module 1
Specificity: Malonyl-CoA
Evidence for specificity: Structure-based inference
Genes: SCO6275
Core domains: Ketosynthase, Acyltransferase, Thiolation (ACP/PCP)
Module 2
Specificity: Malonyl-CoA
Evidence for specificity: Structure-based inference
Genes: SCO6275
Core domains: Ketosynthase, Acyltransferase, Dehydratase, Ketoreductase, Thiolation (ACP/PCP)
KR-domain stereochemistry: Unknown
Module 3
Specificity: Malonyl-CoA
Evidence for specificity: Structure-based inference
Genes: SCO6275
Core domains: Ketosynthase, Acyltransferase, Dehydratase, Ketoreductase, Thiolation (ACP/PCP)
KR-domain stereochemistry: Unknown
Module 4
Specificity: Malonyl-CoA
Evidence for specificity: Structure-based inference
Genes: SCO6274
Core domains: Ketosynthase, Acyltransferase, Dehydratase, Ketoreductase, Thiolation (ACP/PCP)
KR-domain stereochemistry: Unknown
Module 5
Specificity: Malonyl-CoA
Evidence for specificity: Structure-based inference
Genes: SCO6274
Core domains: Ketosynthase, Acyltransferase, Ketoreductase, Thiolation (ACP/PCP)
KR-domain stereochemistry: Unknown
Module 6
Specificity: Malonyl-CoA
Evidence for specificity: Structure-based inference
Genes: SCO6273
Core domains: Ketosynthase, Acyltransferase, Dehydratase, Ketoreductase, Thiolation (ACP/PCP)
KR-domain stereochemistry: Unknown
Annotation changelog
MIBiG version Submitter Notes
1.0
  • Hidden contributor (ID: RJXZFYIPTBJ27AV3IUUT4BRL, no GDPR consent given).
  • Submitted
2.0
  • Hidden contributor (ID: AAAAAAAAAAAAAAAAAAAAAAAA, no GDPR consent given).
  • Migrated from v1.4
3.0
  • Hidden contributor (ID: AAAAAAAAAAAAAAAAAAAAAAAA, no GDPR consent given).
  • Removed ketoreductase stereochemistry annotation from modules without ketoreductases
  • Removed duplications from gene synonyms
  • Updated bioactivity data
3.1
  • Hidden contributor (ID: AAAAAAAAAAAAAAAAAAAAAAAA, no GDPR consent given).
  • Update chemical activity to schema version 2.11
Detailed domain annotation
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