BGC0000069 - 1 region(s) - antiSMASH results

Identified secondary metabolite regions using strictness 'relaxed'

BGC0000069 (Archangium violaceum Cb vi76)

Region	Type	From	To	Most similar known cluster		Similarity
Region 1	T1PKS	1	63,402	ajudazol A	NRP + Polyketide:Modular type I	30%

BGC0000069 - Region 1 - T1PKS

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Location: 1 - 63,402 nt. (total: 63,402 nt) Show pHMM detection rules used

Region on contig edge.

T1PKS: cds(PKS_AT and (PKS_KS or ene_KS or mod_KS or hyb_KS or itr_KS or tra_KS))

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core biosynthetic genes

additional biosynthetic genes

transport-related genes

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TTA codons

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Gene details

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MIBiG

NRPS/PKS domains

MIBiG comparison

KnownClusterBlast

NRPS/PKS modules

External annotation

Name		MIBiG
Version		3.0

Type		Subregion
Location		1 - 63,403
Label		BGC0000069

Detailed domain annotation

Selected features only

Show module domains

Similar gene clusters

Analysis type:

Reference	Similarity score	Type	Compound(s)	Organism
BGC0000069.1	0.67	Polyketide	gephyronic acid	Archangium violaceum Cb vi76
BGC0001909.1	0.32	Polyketide	strobilurin	Strobilurus tenacellus
BGC0001858.1	0.29	Polyketide	alternapyrone B, alternapyrone C, alternapyrone D, alternapyrone E, alternapyrone F	Parastagonospora nodorum SN15
BGC0000041.1	0.27	Polyketide	oronofacic acid	Pseudomonas syringae
BGC0001068.1	0.25	Terpene, Polyketide	pyripyropene A	unidentified unclassified sequences.
BGC0000018.1	0.25	Polyketide	angolamycin	Streptomyces eurythermus
BGC0000056.1	0.24	Polyketide	esperamicin	Actinomadura verrucosospora
BGC0001911.1	0.24	Terpene	raimonol	Streptomyces anulatus
BGC0000067.1	0.23	Polyketide	geldanamycin	Streptomyces hygroscopicus subsp. duamyceticus
BGC0000003.1	0.23	Polyketide	AF-toxin	Alternaria alternata

Reference	Similarity score	Type	Compound(s)	Organism
BGC0000069.1	0.87	Polyketide	gephyronic acid	Archangium violaceum Cb vi76
BGC0001909.1	0.65	Polyketide	strobilurin	Strobilurus tenacellus
BGC0001858.1	0.62	Polyketide	alternapyrone B, alternapyrone C, alternapyrone D, alternapyrone E, alternapyrone F	Parastagonospora nodorum SN15
BGC0000041.1	0.60	Polyketide	oronofacic acid	Pseudomonas syringae
BGC0001068.1	0.58	Terpene, Polyketide	pyripyropene A	unidentified unclassified sequences.
BGC0000018.1	0.58	Polyketide	angolamycin	Streptomyces eurythermus
BGC0000056.1	0.57	Polyketide	esperamicin	Actinomadura verrucosospora
BGC0001911.1	0.57	Terpene	raimonol	Streptomyces anulatus
BGC0000067.1	0.57	Polyketide	geldanamycin	Streptomyces hygroscopicus subsp. duamyceticus
BGC0000003.1	0.56	Polyketide	AF-toxin	Alternaria alternata

Similar known gene clusters

Module view

Legend

NRPS/PKS products

NRPS/PKS monomers

Predicted core structure(s)

For candidate cluster 1, location 0 - 63402:

Rough prediction of core scaffold based on assumed PKS linker matching; tailoring reactions not taken into account

Polymer prediction:: (Me-mal) + (Me-ccmal) + (Me-ccmal) + (Me-ohmal) + (ccmal)
Non-colinear ordering:: gphH + gphI + gphF + gphG + gphJ

Direct lookup in NORINE database: strict or relaxed

Link to NORINE database query form

NRPS/PKS monomer predictions

gphF

PKS_AT (1341..1623): mal

ATSignature: Malonyl-CoA

Top 3 matches:: Malonyl-CoA: 87.5%; inactive: 75.0%; 2-Rhyd-Malonyl-CoA: 58.3%

minowa: Malonyl-CoA

Prediction, score:

Malonyl-CoA: 173.0
inactive: 102.8
Methoxymalonyl-CoA: 41.3
Methylmalonyl-CoA: 40.2
Propionyl-CoA: 34.6
2-Methylbutyryl-CoA: 18.8
Isobutyryl-CoA: 18.0
CHC-CoA: 17.6
fatty_acid: 17.0
Benzoyl-CoA: 16.1
Acetyl-CoA: 10.3
Ethylmalonyl-CoA: 9.8
trans-1,2-CPDA: 9.2
3-Methylbutyryl-CoA: 0.0

gphG

PKS_AT (451..730): mal

ATSignature: Malonyl-CoA

Top 3 matches:: Malonyl-CoA: 87.5%; inactive: 70.8%; Methylmalonyl-CoA: 54.2%

minowa: Malonyl-CoA

Prediction, score:

Malonyl-CoA: 133.5
inactive: 92.7
Methoxymalonyl-CoA: 62.0
Methylmalonyl-CoA: 55.9
Propionyl-CoA: 43.8
Isobutyryl-CoA: 30.4
Benzoyl-CoA: 27.3
trans-1,2-CPDA: 27.0
2-Methylbutyryl-CoA: 23.6
CHC-CoA: 21.7
Ethylmalonyl-CoA: 20.0
Acetyl-CoA: 16.6
fatty_acid: 9.2
3-Methylbutyryl-CoA: 0.0

gphH

PKS_AT (561..851): mal

ATSignature: Malonyl-CoA

Top 3 matches:: Malonyl-CoA: 75.0%; inactive: 66.7%; Methylmalonyl-CoA: 58.3%

minowa: Malonyl-CoA

Prediction, score:

Malonyl-CoA: 109.9
Methylmalonyl-CoA: 56.1
inactive: 49.5
Methoxymalonyl-CoA: 48.5
Ethylmalonyl-CoA: 30.0
Propionyl-CoA: 22.6
Benzoyl-CoA: 19.5
2-Methylbutyryl-CoA: 16.5
Acetyl-CoA: 14.2
CHC-CoA: 13.2
trans-1,2-CPDA: 11.7
fatty_acid: 9.6
Isobutyryl-CoA: 3.2
3-Methylbutyryl-CoA: 0.0

gphI

PKS_AT (528..804): mal

ATSignature: Malonyl-CoA

Top 3 matches:: Malonyl-CoA: 66.7%; Methylmalonyl-CoA: 62.5%; inactive: 58.3%

minowa: Malonyl-CoA

Prediction, score:

Malonyl-CoA: 104.4
Methylmalonyl-CoA: 55.5
inactive: 47.6
Methoxymalonyl-CoA: 44.6
Propionyl-CoA: 28.1
2-Methylbutyryl-CoA: 27.7
CHC-CoA: 25.5
Acetyl-CoA: 20.3
Ethylmalonyl-CoA: 18.9
trans-1,2-CPDA: 18.1
3-Methylbutyryl-CoA: 12.6
Benzoyl-CoA: 12.4
Isobutyryl-CoA: 10.3
fatty_acid: 8.4

gphJ

PKS_AT (570..859): mal

ATSignature: Malonyl-CoA

Top 3 matches:: Malonyl-CoA: 83.3%; inactive: 70.8%; Propionyl-CoA: 54.2%

minowa: Malonyl-CoA

Prediction, score:

Malonyl-CoA: 141.6
inactive: 101.9
Methoxymalonyl-CoA: 69.2
Methylmalonyl-CoA: 57.9
Propionyl-CoA: 33.9
Isobutyryl-CoA: 33.4
Benzoyl-CoA: 23.1
Acetyl-CoA: 23.0
Ethylmalonyl-CoA: 13.6
trans-1,2-CPDA: 13.3
2-Methylbutyryl-CoA: 12.6
3-Methylbutyryl-CoA: 12.3
CHC-CoA: 12.2
fatty_acid: 11.8