BGC0000070: griseofulvin biosynthetic gene cluster from Penicillium aethiopicum
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Location: 1 - 55,000 nt. (total: 55,000 nt).
This entry is originally from NCBI GenBank GU574478.1.

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core biosynthetic genes
additional biosynthetic genes
transport-related genes
regulatory genes
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Gene details
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General
Compounds
Genes
Polyketide
History
NRPS/PKS domains
KnownClusterBlast
General information about the BGC
MIBiG accession BGC0000070
Short description griseofulvin biosynthetic gene cluster from Penicillium aethiopicum
Status Minimal annotation: no
A minimal annotation only contains information on the BGC loci and one or more linked chemical product(s)

Completeness: complete
Whether the loci encodes everything needed for the pathway producing the compound(s)
Biosynthetic class(es)
  • Polyketide (Polyphenol)
Loci NCBI GenBank: GU574478.1
Compounds
  • griseofulvin
  • epidechlorogriseofulvin
  • norlichexanthone
  • dehydrogriseofulvin
  • 4-desmethylgriseofulvin
  • griseoxanthone B
Species Penicillium aethiopicum [taxonomy]
References
Chemical products information
griseofulvin [synonyms: fulvicin, grisactin, grisovin, griseofulvinum, spirofulvin]
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C17H17Cl1O6
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NPAtlas
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epidechlorogriseofulvin
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C17H18O6
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NPAtlas
norlichexanthone
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C14H10O5
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PubCHEM
dehydrogriseofulvin [synonyms: amudene]
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C17H15Cl1O6
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PubCHEM
4-desmethylgriseofulvin
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C16H15Cl1O6
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PubCHEM
griseoxanthone B
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C16H14O5
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PubCHEM
List of genes involved in compound(s) production
Identifiers Position Product Functions Evidence Extra
  • ADI24961.1
 326 - 1571 (+) unknown
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  • ADI24962.1
 1937 - 3246 (-) unknown
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  • ADI24963.1
 3547 - 4311 (-) unknown
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  • ADI24964.1
 6360 - 8546 (+) unknown
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  • ADI24952.1
 9820 - 11067 (-) GsfR2
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  • ADI24951.1
 11558 - 12585 (+) GsfK
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  • ADI24950.1
 13037 - 15154 (-) GsfR1
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  • ADI24949.1
 16116 - 18146 (+) GsfJ
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  • ADI24948.1
 18939 - 20914 (+) GsfI
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  • ADI24953.1
 21525 - 27196 (+) GsfA
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  • ADI24954.1
 27654 - 29095 (-) GsfB
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  • ADI24955.1
 29983 - 31173 (-) GsfC
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  • ADI24956.1
 31596 - 32896 (+) GsfD
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  • ADI24957.1
 33259 - 34392 (-) GsfE
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  • ADI24958.2
 35027 - 36729 (+) GsfF
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  • ADI24959.1
 36846 - 37878 (-) GsfG
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  • ADI24960.1
 40829 - 41717 (+) GsfH
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  • ADI24965.1
 42603 - 44954 (-) unknown
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  • ADI24966.1
 48793 - 49599 (-) unknown
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  • ADI24967.1
 50369 - 51714 (+) unknown
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  • ADI24968.1
 52308 - 54575 (+) unknown
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Polyketide-specific information
Subclass Polyphenol
Starter unit Acetyl-CoA
Cyclic? yes
Release type
  • Claisen condensation
Polyketide-synthases
Genes Properties Modules
ADI24953.1 Synthase subclass: Iterative type I
Iterative PKS type: Non-reducing, Unknown
Iteration counts: 6
Annotation changelog
MIBiG version Submitter Notes
1.0
  • Hidden contributor (ID: BMUFDHMMOLZWQLUNJMQED2GP, no GDPR consent given).
  • Submitted
2.0
  • Hidden contributor (ID: AAAAAAAAAAAAAAAAAAAAAAAA, no GDPR consent given).
  • Migrated from v1.4
  • Updated compound(s) information (NPAtlas curation)
3.0
  • Hidden contributor (ID: AAAAAAAAAAAAAAAAAAAAAAAA, no GDPR consent given).
  • Corrected gene identifiers
3.1
  • Hidden contributor (ID: AAAAAAAAAAAAAAAAAAAAAAAA, no GDPR consent given).
  • Update chemical activity to schema version 2.11
Detailed domain annotation
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