BGC0000075: hygrocin A biosynthetic gene cluster from Streptomyces sp. LZ35
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Location: 1 - 76,600 nt. (total: 76,600 nt).
This entry is originally from NCBI GenBank JX504844.1.

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core biosynthetic genes
additional biosynthetic genes
transport-related genes
regulatory genes
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resistance
TTA codons
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Gene details
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General
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NRPS/PKS domains
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General information about the BGC
MIBiG accession BGC0000075
Short description hygrocin A biosynthetic gene cluster from Streptomyces sp. LZ35
Status Minimal annotation: yes
A minimal annotation only contains information on the BGC loci and one or more linked chemical product(s)

Completeness: Unknown
Whether the loci encodes everything needed for the pathway producing the compound(s)
Biosynthetic class(es)
  • Polyketide
Loci NCBI GenBank: JX504844.1
Compounds
  • hygrocin A
  • hygrocin B
Species Streptomyces sp. LZ35 [taxonomy]
References
Chemical products information
hygrocin A
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C28H31N1O8
Chemical database entries
NPAtlas
PubCHEM
hygrocin B
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C28H29N1O8
Chemical database entries
NPAtlas
PubCHEM
List of genes involved in compound(s) production
Identifiers Position Product Functions Evidence Extra
  • AFV30240.1
 1 - 582 (-) TetR family transcriptional regulator
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  • AFV30241.1
 762 - 2588 (+) fumarate reductase/succinate dehydrogenase flavoprotein domain protein
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  • AFV30242.1
 2612 - 4306 (+) NHL repeat containing protein
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  • AFV30243.1
 4327 - 5301 (-) alcohol dehydrogenas
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  • AFV30244.1
 5520 - 6149 (+) nitroreductase
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  • AFV30245.1
  • hgc1
 6685 - 9609 (+) LuxR family transcriptional regulator
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  • AFV30246.1
  • hgc2
 9642 - 11234 (-) FAD-binding monooxygenase
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  • AFV30247.1
  • hgcA
 11393 - 27940 (+) polyketide synthase
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  • AFV30248.1
  • hgcB
 27967 - 34623 (+) polyketide synthase
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  • AFV30249.1
  • hgcC
 34708 - 40260 (+) polyketide synthase
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  • AFV30250.1
  • hgcD
 40281 - 46865 (+) polyketide synthase
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  • AFV30251.1
  • hgcE
 46865 - 55399 (+) polyketide synthase
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  • AFV30252.1
  • hgcF
 55396 - 56280 (+) amide synthase
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  • AFV30253.1
  • hgc3
 56293 - 57519 (+) putative FMN-binding monoxygenase
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  • AFV30254.1
  • hgc4
 57570 - 58769 (+) cytochrome P450
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  • AFV30255.1
  • hgc5
 58770 - 59450 (-) 2OG-Fe(II) oxygenase
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  • AFV30256.1
  • hgc6
 59539 - 60267 (-) hypothetical protein
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  • AFV30257.1
  • hgc7
 60335 - 60841 (-) putative methylated-DNA-protein-cysteine S-methyltransferase
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  • AFV30258.1
  • hgc8
 60954 - 61580 (-) hypothetical protein
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  • AFV30259.1
  • hgc9
 61710 - 64433 (-) putative integral membrane sensor protein
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  • AFV30260.1
  • hgc10
 64613 - 65563 (+) putative protease B precursor
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  • AFV30261.1
  • hgc11
 65868 - 66923 (-) FAD-dependent pyridine nucleotide-disulfide oxidoreductase
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  • AFV30262.1
  • hgc12
 67301 - 68119 (+) putative integral-membrane protein
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  • AFV30263.1
  • hgc13
 68304 - 68936 (+) putative ECF-family sigma factor
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  • AFV30270.1
  • hgcM
 69067 - 69762 (-) phosphatase
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  • AFV30264.1
  • hgcL
 69958 - 71046 (-) oxidoreductase
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  • AFV30265.1
  • hgcK
 71088 - 72254 (-) AHBA synthase
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  • AFV30266.1
  • hgcJ
 72469 - 72915 (+) aDHQ dehydratase
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  • AFV30267.1
  • hgcN
 73021 - 73899 (+) kinase
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  • AFV30268.1
  • hgc14
 74058 - 74909 (+) MerR family transcriptional regulator
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  • AFV30269.1
  • hgcR1
 75063 - 76475 (-) hypothetical protein
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Annotation changelog
MIBiG version Submitter Notes
1.0
  • Hidden contributor (ID: AAAAAAAAAAAAAAAAAAAAAAAA, no GDPR consent given).
  • Submitted
2.0
  • Hidden contributor (ID: AAAAAAAAAAAAAAAAAAAAAAAA, no GDPR consent given).
  • Migrated from v1.4
  • Updated compound(s) information (NPAtlas curation)
3.0
  • Hidden contributor (ID: AAAAAAAAAAAAAAAAAAAAAAAA, no GDPR consent given).
  • Updated bioactivity data
3.1
  • Hidden contributor (ID: AAAAAAAAAAAAAAAAAAAAAAAA, no GDPR consent given).
  • Update chemical activity to schema version 2.11
Detailed domain annotation
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