BGC0000079 - 1 region(s) - antiSMASH results

Identified secondary metabolite regions using strictness 'relaxed'

BGC0000079 (Streptomyces antibioticus)

Region	Type	From	To	Most similar known cluster		Similarity
Region 1	T1PKS	1	79,604	lasalocid	Polyketide	50%

BGC0000079 - Region 1 - T1PKS

Download region GenBank file

Download region SVG

Location: 1 - 79,604 nt. (total: 79,604 nt) Show pHMM detection rules used

Region on contig edge.

T1PKS: cds(PKS_AT and (PKS_KS or ene_KS or mod_KS or hyb_KS or itr_KS or tra_KS))

Legend:

core biosynthetic genes

additional biosynthetic genes

transport-related genes

regulatory genes

other genes

resistance

TTA codons

reset view

zoom to selection

Gene details

Select a gene to view the details available for it

MIBiG

NRPS/PKS domains

MIBiG comparison

KnownClusterBlast

NRPS/PKS modules

External annotation

Name		MIBiG
Version		3.0

Type		Subregion
Location		1 - 79,605
Label		BGC0000079

Detailed domain annotation

Selected features only

Show module domains

Similar gene clusters

Analysis type:

Reference	Similarity score	Type	Compound(s)	Organism
BGC0000079.1	0.80	Polyketide	X-14547	Streptomyces antibioticus
BGC0000041.1	0.43	Polyketide	oronofacic acid	Pseudomonas syringae
BGC0001164.1	0.33	Polyketide	1-heptadecene	Cyanothece sp. PCC 7822
BGC0000018.1	0.33	Polyketide	angolamycin	Streptomyces eurythermus
BGC0000067.1	0.31	Polyketide	geldanamycin	Streptomyces hygroscopicus subsp. duamyceticus
BGC0000019.1	0.31	Polyketide	angolamycin	Streptomyces eurythermus
BGC0001273.1	0.30	Polyketide	asperlactone	Aspergillus ochraceus
BGC0001275.1	0.30	Polyketide	6-methylsalicyclic acid	Glarea lozoyensis
BGC0001988.1	0.30	Polyketide	neosartorin	Aspergillus novofumigatus IBT 16806
BGC0001276.1	0.29	Polyketide	6-methylsalicyclic acid	Aspergillus terreus

Reference	Similarity score	Type	Compound(s)	Organism
BGC0000079.1	0.93	Polyketide	X-14547	Streptomyces antibioticus
BGC0000041.1	0.74	Polyketide	oronofacic acid	Pseudomonas syringae
BGC0001164.1	0.66	Polyketide	1-heptadecene	Cyanothece sp. PCC 7822
BGC0000018.1	0.66	Polyketide	angolamycin	Streptomyces eurythermus
BGC0000067.1	0.65	Polyketide	geldanamycin	Streptomyces hygroscopicus subsp. duamyceticus
BGC0000019.1	0.64	Polyketide	angolamycin	Streptomyces eurythermus
BGC0001273.1	0.64	Polyketide	asperlactone	Aspergillus ochraceus
BGC0001275.1	0.63	Polyketide	6-methylsalicyclic acid	Glarea lozoyensis
BGC0001988.1	0.63	Polyketide	neosartorin	Aspergillus novofumigatus IBT 16806
BGC0001276.1	0.63	Polyketide	6-methylsalicyclic acid	Aspergillus terreus

Similar known gene clusters

Module view

Legend

NRPS/PKS products

NRPS/PKS monomers

Predicted core structure(s)

For candidate cluster 1, location 0 - 79604:

Rough prediction of core scaffold based on assumed PKS linker matching; tailoring reactions not taken into account

Polymer prediction:: (mal - ohmal - pk) + (ccmal - pk - Me-ohmal) + (redmal) + (ccmal - ccmal) + (Me-ohmal)
Non-colinear ordering:: idmL + idmN + idmO + idmM + idmP

Direct lookup in NORINE database: strict or relaxed

Link to NORINE database query form

NRPS/PKS monomer predictions

idmJ

Search NORINE for peptide: strict or relaxed

AMP-binding (9..394): X

NRPSPredictor2: hydrophobic-aliphatic

SVM prediction details:

Predicted physicochemical class:: hydrophobic-aliphatic
Large clusters prediction:: N/A
Small clusters prediction:: N/A
Single AA prediction:: N/A

Stachelhaus prediction details:

Stachelhaus sequence:: DLlYLAlVcK
Nearest Stachelhaus code:: iva
Stachelhaus code match:: 70% (weak)

idmL

PKS_AT (569..865): mal

ATSignature: Malonyl-CoA

Top 3 matches:: Malonyl-CoA: 75.0%; Methylmalonyl-CoA: 70.8%; CE-Malonyl-CoA: 62.5%

minowa: Malonyl-CoA

Prediction, score:

Malonyl-CoA: 140.2
Methylmalonyl-CoA: 124.6
Methoxymalonyl-CoA: 101.7
Ethylmalonyl-CoA: 82.0
2-Methylbutyryl-CoA: 75.7
Isobutyryl-CoA: 75.5
Propionyl-CoA: 65.4
Benzoyl-CoA: 58.0
trans-1,2-CPDA: 47.1
inactive: 45.7
Acetyl-CoA: 45.4
fatty_acid: 26.1
CHC-CoA: 24.1
3-Methylbutyryl-CoA: 19.8

PKS_AT (1617..1918): mal

ATSignature: Malonyl-CoA

Top 3 matches:: Malonyl-CoA: 95.8%; inactive: 83.3%; 2-Rhyd-Malonyl-CoA: 58.3%

minowa: Malonyl-CoA

Prediction, score:

Malonyl-CoA: 231.6
inactive: 124.4
Methoxymalonyl-CoA: 77.6
Methylmalonyl-CoA: 67.9
Propionyl-CoA: 46.4
Isobutyryl-CoA: 40.8
2-Methylbutyryl-CoA: 39.0
Ethylmalonyl-CoA: 34.6
CHC-CoA: 29.2
Benzoyl-CoA: 24.7
Acetyl-CoA: 19.5
fatty_acid: 16.4
trans-1,2-CPDA: 9.8
3-Methylbutyryl-CoA: 0.0

PKS_AT (3180..3478): pk

ATSignature: Ethylmalonyl-CoA

Top 3 matches:: Ethylmalonyl-CoA: 91.7%; Methoxymalonyl-CoA: 87.5%; Methylmalonyl-CoA: 83.3%

minowa: Methylmalonyl-CoA

Prediction, score:

Methylmalonyl-CoA: 179.3
Ethylmalonyl-CoA: 173.3
Methoxymalonyl-CoA: 141.6
2-Methylbutyryl-CoA: 107.7
trans-1,2-CPDA: 96.6
Propionyl-CoA: 93.0
Malonyl-CoA: 83.1
Isobutyryl-CoA: 80.4
CHC-CoA: 76.3
Benzoyl-CoA: 42.6
fatty_acid: 38.2
Acetyl-CoA: 37.1
3-Methylbutyryl-CoA: 36.5
inactive: 24.2

idmM

PKS_AT (563..848): mal

ATSignature: Malonyl-CoA

Top 3 matches:: Malonyl-CoA: 95.8%; inactive: 79.2%; 2-Rhyd-Malonyl-CoA: 58.3%

minowa: Malonyl-CoA

Prediction, score:

Malonyl-CoA: 198.2
inactive: 110.6
Methoxymalonyl-CoA: 74.5
Methylmalonyl-CoA: 69.5
Propionyl-CoA: 49.0
Isobutyryl-CoA: 43.7
Ethylmalonyl-CoA: 35.6
Benzoyl-CoA: 29.4
2-Methylbutyryl-CoA: 29.0
CHC-CoA: 23.5
trans-1,2-CPDA: 19.8
Acetyl-CoA: 17.2
fatty_acid: 14.7
3-Methylbutyryl-CoA: 0.0

PKS_AT (2296..2581): mal

ATSignature: Malonyl-CoA

Top 3 matches:: Malonyl-CoA: 95.8%; inactive: 79.2%; 2-Rhyd-Malonyl-CoA: 58.3%

minowa: Malonyl-CoA

Prediction, score:

Malonyl-CoA: 200.2
inactive: 109.0
Methoxymalonyl-CoA: 71.8
Methylmalonyl-CoA: 64.5
Propionyl-CoA: 38.4
Isobutyryl-CoA: 35.7
Ethylmalonyl-CoA: 27.9
Benzoyl-CoA: 24.8
CHC-CoA: 23.8
Acetyl-CoA: 18.1
trans-1,2-CPDA: 15.5
2-Methylbutyryl-CoA: 14.8
fatty_acid: 10.6
3-Methylbutyryl-CoA: 3.3

idmN

PKS_AT (570..855): mal

ATSignature: Malonyl-CoA

Top 3 matches:: Malonyl-CoA: 95.8%; inactive: 79.2%; 2-Rhyd-Malonyl-CoA: 58.3%

minowa: Malonyl-CoA

Prediction, score:

Malonyl-CoA: 208.2
inactive: 111.2
Methoxymalonyl-CoA: 76.8
Methylmalonyl-CoA: 71.5
Propionyl-CoA: 45.9
Isobutyryl-CoA: 44.3
Ethylmalonyl-CoA: 36.9
Benzoyl-CoA: 28.0
CHC-CoA: 27.6
2-Methylbutyryl-CoA: 24.2
trans-1,2-CPDA: 20.3
Acetyl-CoA: 18.8
fatty_acid: 16.8
3-Methylbutyryl-CoA: 0.0

PKS_AT (2397..2695): pk

ATSignature: Ethylmalonyl-CoA

Top 3 matches:: Ethylmalonyl-CoA: 91.7%; Methoxymalonyl-CoA: 87.5%; Methylmalonyl-CoA: 83.3%

minowa: Methylmalonyl-CoA

Prediction, score:

Methylmalonyl-CoA: 179.3
Ethylmalonyl-CoA: 173.3
Methoxymalonyl-CoA: 141.6
2-Methylbutyryl-CoA: 107.7
trans-1,2-CPDA: 96.6
Propionyl-CoA: 93.0
Malonyl-CoA: 83.1
Isobutyryl-CoA: 80.4
CHC-CoA: 76.3
Benzoyl-CoA: 42.6
fatty_acid: 38.2
Acetyl-CoA: 37.1
3-Methylbutyryl-CoA: 36.5
inactive: 24.2

PKS_AT (4129..4427): mmal

ATSignature: Methylmalonyl-CoA

Top 3 matches:: Methylmalonyl-CoA: 100.0%; Methoxymalonyl-CoA: 95.8%; Ethylmalonyl-CoA: 91.7%

minowa: Methylmalonyl-CoA

Prediction, score:

Methylmalonyl-CoA: 217.1
Ethylmalonyl-CoA: 208.2
Methoxymalonyl-CoA: 172.1
2-Methylbutyryl-CoA: 144.3
trans-1,2-CPDA: 132.6
Propionyl-CoA: 115.2
Malonyl-CoA: 103.6
CHC-CoA: 90.8
Isobutyryl-CoA: 73.4
Benzoyl-CoA: 72.6
Acetyl-CoA: 50.4
fatty_acid: 39.7
3-Methylbutyryl-CoA: 33.7
inactive: 32.2

idmO

PKS_AT (572..857): mal

ATSignature: Malonyl-CoA

Top 3 matches:: Malonyl-CoA: 95.8%; inactive: 79.2%; 2-Rhyd-Malonyl-CoA: 58.3%

minowa: Malonyl-CoA

Prediction, score:

Malonyl-CoA: 205.7
inactive: 111.7
Methoxymalonyl-CoA: 73.7
Methylmalonyl-CoA: 65.5
Propionyl-CoA: 43.3
Isobutyryl-CoA: 35.6
Benzoyl-CoA: 27.7
Ethylmalonyl-CoA: 26.9
2-Methylbutyryl-CoA: 20.2
CHC-CoA: 19.8
Acetyl-CoA: 16.8
trans-1,2-CPDA: 15.3
fatty_acid: 11.7
3-Methylbutyryl-CoA: 0.0

idmP

PKS_AT (582..880): mmal

ATSignature: Methylmalonyl-CoA

Top 3 matches:: Methylmalonyl-CoA: 100.0%; Methoxymalonyl-CoA: 95.8%; Ethylmalonyl-CoA: 91.7%

minowa: Methylmalonyl-CoA

Prediction, score:

Methylmalonyl-CoA: 217.1
Ethylmalonyl-CoA: 208.2
Methoxymalonyl-CoA: 172.1
2-Methylbutyryl-CoA: 144.3
trans-1,2-CPDA: 132.6
Propionyl-CoA: 115.2
Malonyl-CoA: 103.6
CHC-CoA: 90.8
Isobutyryl-CoA: 73.4
Benzoyl-CoA: 72.6
Acetyl-CoA: 50.4
fatty_acid: 39.7
3-Methylbutyryl-CoA: 33.7
inactive: 32.2