BGC0000085: lankamycin biosynthetic gene cluster from Streptomyces rochei
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Location: 43,059 - 111,152 nt. (total: 68,094 nt).
This entry is originally from NCBI GenBank AB088224.2.

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core biosynthetic genes
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NRPS/PKS domains
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General information about the BGC
MIBiG accession BGC0000085
Short description lankamycin biosynthetic gene cluster from Streptomyces rochei
Status Minimal annotation: yes
A minimal annotation only contains information on the BGC loci and one or more linked chemical product(s)

Completeness: Unknown
Whether the loci encodes everything needed for the pathway producing the compound(s)
Biosynthetic class(es)
  • Polyketide
Loci NCBI GenBank: AB088224.2
Compounds
  • lankamycin
Species Streptomyces rochei [taxonomy]
References
Chemical products information
lankamycin
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C42H72O16
Chemical database entries
NPAtlas
PubCHEM
List of genes involved in compound(s) production
Identifiers Position Product Functions Evidence Extra
  • BAC76482.1
  • lkmD
 43059 - 44045 (-) putative NDP-hexose 4,6-dehydratase
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  • BAC76483.1
  • lkmE
 44059 - 44850 (-) putative thioesterase
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  • BAC76484.1
  • lkmF
 44847 - 46067 (-) P450 hydroxylase LkmF
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  • BAC76485.2
  • lkmBIII
 46101 - 47336 (-) putative NDP-4-keto-2,6-dideoxyhexose 3-C-methyltransferase
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  • BAC76486.1
  • lkmG
 47351 - 48163 (-) putative NDP-hexose 3-O-methyltransferase
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  • BAC76487.1
  • lkmBII
 48216 - 49223 (-) putative NDP-4-keto-2,6-dideoxyhexose 2,3-enoyl reductase
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  • BAC76488.1
  • lkmH
 49268 - 51709 (-) putative beta-glycosidase
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  • BAC76489.1
  • lkmI
 51875 - 53152 (-) glycosyltransferase LkmI
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  • BAC76490.1
  • lkmCII
 53164 - 54249 (-) putative NDP-4-keto-6-deoxyhexose 3,4-isomerase
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  • BAC76491.1
  • lkmAIII
 54246 - 64133 (-) lankamycin synthase LkmAIII
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  • BAC76492.1
  • lkmAII
 64130 - 75100 (-) lankamycin synthase LkmAII
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  • BAC76493.1
  • lkmAI
 75113 - 86068 (-) lankamycin synthase LkmAI
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  • BAC76494.2
  • lkmJ
 86505 - 87728 (+) putative O-acyltransferase
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  • BAC76495.1
  • lkmK
 87725 - 88939 (+) P450 hydroxylase LkmK
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  • BAC76496.1
  • lkmCIV
 88944 - 90143 (+) putative NDP-6-deoxyhexose 3,4-dehydratase
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  • BAC76497.1
  • lkmCV
 90186 - 91658 (+) putative NDP-4,6-dideoxyhexose 3,4-enoyl reductase
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  • BAC76498.1
  • lkmL
 91673 - 92950 (-) glycosyltransferase LkmL
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  • BAC76499.1
  • lkmBIV
 93108 - 94085 (+) putative NDP-3-methyl-4-keto-2,6-dideoxyhexose 4-ketoreductase
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  • BAC76500.2
  • lkmCVI
 94099 - 95019 (-) putative NDP-3-keto-6-deoxyhexose 3-ketoreductase
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  • BAC76501.1
  • lkmM
 95226 - 96395 (-) putative glycosyltransferase
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  • BAC76502.1
  • lkmN
 96823 - 98523 (+) putative ABC transporter protein
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  • BAC76503.1
  • lkmO
 98593 - 99489 (+) putative NDP-hexose 3-O-methyltransferase
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  • BAC76504.1
  • lkmBVII
 99510 - 100139 (+) putative NDP-4-keto-6-deoxyhexose 3,5-epimerase
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  • BAC76505.1
  • lkmP
 100212 - 101642 (-) probable adenosylhomocysteinase
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  • BAC76506.1
  • lkmQ
 101632 - 102492 (-) probable 5,10-methylenetetrahydrofolate reductase
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  • BAC76507.1
  • lkmR
 102489 - 105896 (-) probable 5-methyltetrahydrofolate-homocysteine S-methyltransferase
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  • BAC76508.1
  • lkmS
 105935 - 106945 (-) putative glucose kinase
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  • BAC76509.1
  • lkmT
 107035 - 108255 (-) probable S-adenosylmethionine synthetase
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  • BAC76510.1
  • lkmU
 108557 - 109621 (-) putative NDP-glucose synthase
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  • BAC76511.1
  • lkmBVI
 109701 - 111152 (+) putative NDP-4-keto-6-deoxyhexose 2,3-dehydratase
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Annotation changelog
MIBiG version Submitter Notes
1.0
  • Hidden contributor (ID: AAAAAAAAAAAAAAAAAAAAAAAA, no GDPR consent given).
  • Submitted
2.0
  • Hidden contributor (ID: AAAAAAAAAAAAAAAAAAAAAAAA, no GDPR consent given).
  • Migrated from v1.4
  • Updated compound(s) information (NPAtlas curation)
3.0
  • Hidden contributor (ID: AAAAAAAAAAAAAAAAAAAAAAAA, no GDPR consent given).
  • Updated bioactivity data
3.1
  • Hidden contributor (ID: AAAAAAAAAAAAAAAAAAAAAAAA, no GDPR consent given).
  • Update chemical activity to schema version 2.11
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