BGC0000094: methymycin biosynthetic gene cluster from Streptomyces venezuelae
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Location: 1 - 37,948 nt. (total: 37,948 nt).
This entry is originally from NCBI GenBank AF079138.1.

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core biosynthetic genes
additional biosynthetic genes
transport-related genes
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Gene details
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General
Compounds
Genes
Polyketide
Saccharide
History
NRPS/PKS domains
KnownClusterBlast
General information about the BGC
MIBiG accession BGC0000094
Short description methymycin biosynthetic gene cluster from Streptomyces venezuelae
Status Minimal annotation: no
A minimal annotation only contains information on the BGC loci and one or more linked chemical product(s)

Completeness: incomplete
Whether the loci encodes everything needed for the pathway producing the compound(s)
Biosynthetic class(es)
  • Polyketide (Macrolide)
  • Saccharide (hybrid/tailoring)
Loci NCBI GenBank: AF079138.1
Compounds
  • methymycin
Species Streptomyces venezuelae [taxonomy]
References
Chemical products information
methymycin [synonyms: pikromycin]
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C25H43N1O7
Chemical database entries
NPAtlas
List of genes involved in compound(s) production
Identifiers Position Product Functions Evidence Extra
  • AAC69327.1
  • pikR2
 154 - 1122 (+) rRNA methyltransferase PikR2
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  • AAC69328.1
  • pikR1
 1283 - 2293 (-) rRNA methyltransferase PikR1
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  • AAC69329.1
  • pikAI
 2912 - 16753 (+) type I polyketide synthase PikAI
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  • AAC69330.1
  • pikAII
 16858 - 28077 (+) type I polyketide synthase PikAII
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  • AAC69331.1
  • pikAIII
 28161 - 32849 (+) type I polyketide synthase PikAIII
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  • AAC69332.1
  • pikAIV
 32952 - 36992 (+) type I polyketide synthase PikAIV
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  • AAC69333.1
  • pikAV
 36989 - 37834 (+) thioesterase II PikAV
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Polyketide-specific information
Subclass Macrolide
Starter unit Malonyl-CoA
Cyclic? yes
Release type
  • Macrolactamization
Polyketide-synthases
Genes Properties Modules
pikAIV
+
pikAI
+
pikAII
+
pikAIII 		Synthase subclass: Modular type I
Module 0
Specificity: Propionyl-CoA
Evidence for specificity: Structure-based inference
Genes: pikAI
Core domains: Ketosynthase, Acyltransferase, Thiolation (ACP/PCP)
Module 1
Specificity: Methylmalonyl-CoA
Evidence for specificity: Structure-based inference
Genes: pikAI
Core domains: Ketosynthase, Acyltransferase, Ketoreductase, Thiolation (ACP/PCP)
KR-domain stereochemistry: L-OH
Module 2
Specificity: Malonyl-CoA
Evidence for specificity: Structure-based inference
Genes: pikAI
Core domains: Ketosynthase, Acyltransferase, Dehydratase, Ketoreductase, Thiolation (ACP/PCP)
KR-domain stereochemistry: D-OH
Module 3
Specificity: Methylmalonyl-CoA
Evidence for specificity: Structure-based inference
Genes: pikAII
Core domains: Ketosynthase, Acyltransferase, Ketoreductase, Thiolation (ACP/PCP)
KR-domain stereochemistry: Inactive
Module 4
Specificity: Methylmalonyl-CoA
Evidence for specificity: Structure-based inference
Genes: pikAII
Core domains: Ketosynthase, Acyltransferase, Dehydratase, Enoylreductase, Ketoreductase, Thiolation (ACP/PCP)
KR-domain stereochemistry: D-OH
Module 5
Specificity: Methylmalonyl-CoA
Evidence for specificity: Structure-based inference
Genes: pikAIII
Core domains: Ketosynthase, Acyltransferase, Ketoreductase, Thiolation (ACP/PCP)
KR-domain stereochemistry: D-OH
Module 6
Specificity: Methylmalonyl-CoA
Evidence for specificity: Structure-based inference
Genes: pikAIV
Core domains: Ketosynthase, Acyltransferase, Thiolation (ACP/PCP)
Saccharide-specific information
Subclass hybrid/tailoring
Annotation changelog
MIBiG version Submitter Notes
1.0
  • Hidden contributor (ID: RIBLHRV4YSJAGJ5EVZV4GS2Z, no GDPR consent given).
  • Submitted
2.0
  • Hidden contributor (ID: AAAAAAAAAAAAAAAAAAAAAAAA, no GDPR consent given).
  • Migrated from v1.4
  • Updated compound(s) information (NPAtlas curation)
3.0
  • Hidden contributor (ID: AAAAAAAAAAAAAAAAAAAAAAAA, no GDPR consent given).
  • Removed ketoreductase stereochemistry annotation from modules without ketoreductases
3.1
  • Hidden contributor (ID: AAAAAAAAAAAAAAAAAAAAAAAA, no GDPR consent given).
  • Update chemical activity to schema version 2.11
Detailed domain annotation
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