BGC0000104: mycophenolic acid biosynthetic gene cluster from Penicillium brevicompactum
Shows the layout of the region, marking coding sequences and areas of interest. Clicking a gene will select it and show any relevant details. Clicking an area feature (e.g. a candidate cluster) will select all coding sequences within that area. Double clicking an area feature will zoom to that area. Multiple genes and area features can be selected by clicking them while holding the Ctrl key.
Location: 7,000 - 32,485 nt. (total: 25,486 nt).
This entry is originally from NCBI GenBank HQ731031.1.

Legend:

core biosynthetic genes
additional biosynthetic genes
transport-related genes
regulatory genes
other genes
resistance
reset zoomreset view
zoomzoom to selection
Gene details
Shows details of the most recently selected gene, including names, products, location, and other annotations.
Select a gene to view the details available for it
General
Compounds
Genes
Polyketide
Terpene
History
NRPS/PKS domains
KnownClusterBlast
General information about the BGC
MIBiG accession BGC0000104
Short description mycophenolic acid biosynthetic gene cluster from Penicillium brevicompactum
Status Minimal annotation: no
A minimal annotation only contains information on the BGC loci and one or more linked chemical product(s)

Completeness: complete
Whether the loci encodes everything needed for the pathway producing the compound(s)
Biosynthetic class(es)
  • Polyketide (Other)
  • Terpene (Sesquiterpene/Dolichol)
Loci NCBI GenBank: HQ731031.1
Compounds
  • mycophenolic acid
Species Penicillium brevicompactum [taxonomy]
References
Chemical products information
mycophenolic acid
Copy SMILES
C17H20O6
Chemical database entries
NPAtlas
PubCHEM
ChEBI
ChEMBL
ChemSpider
List of genes involved in compound(s) production
Identifiers Position Product Functions Evidence Extra
  • ADY00128.1
  • mpaA
7000 - 8136 (-) putative prenyl transferase
copy AA seq
copy Nt seq
  • ADY00129.1
  • mpaB
9643 - 11119 (+) MpaB
copy AA seq
copy Nt seq
  • ADY00130.1
  • mpaC
11535 - 19279 (-) polyketide synthase
copy AA seq
copy Nt seq
  • ADY00131.1
  • mpaD
22778 - 24179 (+) putative P450 monooxygenase
copy AA seq
copy Nt seq
  • ADY00132.1
  • mpaE
24739 - 25524 (+) putative metallo-beta-lactamase superfamily II enzyme
copy AA seq
copy Nt seq
  • ADY00133.1
  • mpaF
25957 - 27656 (-) putative inosine monophosphate dehydrogenase
copy AA seq
copy Nt seq
  • ADY00134.1
  • mpaG
28274 - 29522 (-) putative O-methyltransferase
copy AA seq
copy Nt seq
  • ADY00135.1
  • mpaH
31005 - 32485 (-) putative hydrolase
copy AA seq
copy Nt seq
Polyketide-specific information
Subclass Other
Starter unit Acetyl-CoA
Cyclic? yes
Release type
  • Hydrolysis
Polyketide-synthases
Genes Properties Modules
mpaC Synthase subclass: Iterative type I
Iterative PKS type: Non-reducing, C2-C7 first
Iteration counts: 3
Terpene-specific information
Carbon count subclass Sesquiterpene
Structural subclass Dolichol
Prenyltransferases mpaA
Annotation changelog
MIBiG version Submitter Notes
1.0
  • Hidden contributor (ID: 4CPIGDAOCCI5BMKFFN3C7RIM, no GDPR consent given).
  • Submitted
2.0
  • Hidden contributor (ID: AAAAAAAAAAAAAAAAAAAAAAAA, no GDPR consent given).
  • Migrated from v1.4
  • Updated compound(s) information (NPAtlas curation)
3.1
  • Hidden contributor (ID: AAAAAAAAAAAAAAAAAAAAAAAA, no GDPR consent given).
  • Update chemical activity to schema version 2.11
Detailed domain annotation
Shows NRPS- and PKS-related domains for each feature that contains them. Click on each domain for more information about the domain's location, consensus monomer prediction, and other details.
A glossary is available here.
Selected features only
Show module domains
Similar known gene clusters
Shows clusters from the MiBIG database that are similar to the current region. Genes marked with the same colour are interrelated. White genes have no relationship.
Click on reference genes to show details of similarities to genes within the current region.
Click on an accession to open that entry in the MiBIG database.