BGC0000110: spectinabilin biosynthetic gene cluster from Streptomyces orinoci
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Location: 1 - 38,365 nt. (total: 38,365 nt).
This entry is originally from NCBI GenBank AM778535.1.

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core biosynthetic genes
additional biosynthetic genes
transport-related genes
regulatory genes
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resistance
TTA codons
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Gene details
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General
Compounds
Genes
Polyketide
History
NRPS/PKS domains
KnownClusterBlast
General information about the BGC
MIBiG accession BGC0000110
Short description spectinabilin biosynthetic gene cluster from Streptomyces orinoci
Status Minimal annotation: no
A minimal annotation only contains information on the BGC loci and one or more linked chemical product(s)

Completeness: complete
Whether the loci encodes everything needed for the pathway producing the compound(s)
Remarks "The AT domain within module 6 is inactive and thus module 6 uses the AT domain from module 5."
Biosynthetic class(es)
  • Polyketide (Polyene)
Loci NCBI GenBank: AM778535.1
Compounds
  • spectinabilin
  • orinocin
  • SNF4435C
  • SNF4435D
Species Streptomyces orinoci [taxonomy]
References
Chemical products information
spectinabilin
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C28H31N1O6
Chemical database entries
NPAtlas
orinocin
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C19H19N1O6
Chemical database entries
NPAtlas
SNF4435C
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C28H31N1O6
Chemical database entries
NPAtlas
ChemSpider
SNF4435D
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C28H31N1O6
Chemical database entries
NPAtlas
ChemSpider
List of genes involved in compound(s) production
Identifiers Position Product Functions Evidence Extra
  • CAO85889.1
  • norD
1 - 390 (+) regulator protein NorD
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  • CAO85890.1
  • norE
387 - 2237 (-) aryl-coA ligase
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  • CAO85891.1
  • norF
2170 - 3186 (+) N-oxygenase
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  • CAO85892.1
  • norJ
3223 - 4287 (+) NorJ protein
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  • CAO85893.1
  • norA
4343 - 10036 (+) modular polyketide synthase NorA
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  • CAO85894.1
  • norG
10047 - 12158 (+) PABA synthase
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  • CAO85895.1
  • norH
12208 - 13428 (+) cytochrome P-450 monooxygenase
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  • CAO85896.1
  • norA_
13478 - 24355 (+) protein modular polyketide synthase NorA'
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  • CAO85897.1
  • norB
24342 - 30866 (+) modular polyketide synthase NorB
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  • CAO85898.1
  • norC
30873 - 37673 (+) modular polyketide synthase NorC
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  • CAO85899.1
  • norI
37673 - 38365 (+) methyltransferase NorI
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Polyketide-specific information
Subclass Polyene
Starter unit p-Nitrobenzoate
Cyclic? no
Release type
  • Macrolactonization
Polyketide-synthases
Genes Properties Modules
norA
+
norC
+
norB
+
norA_
Synthase subclass: Modular type I
Module 1
Specificity: Methylmalonyl-CoA
Evidence for specificity: Sequence-based prediction
Genes: norA
Core domains: Ketosynthase, Acyltransferase, Ketoreductase, Dehydratase, Thiolation (ACP/PCP)
KR-domain stereochemistry: L-OH
Non-canonical activity:
  • Iterated
Evidence for non-canonical activity:
  • Sequence-based prediction
Module 2
Specificity: Methylmalonyl-CoA
Evidence for specificity: Sequence-based prediction
Genes: norA_
Core domains: Ketosynthase, Acyltransferase, Ketoreductase, Dehydratase, Thiolation (ACP/PCP)
KR-domain stereochemistry: L-OH
Module 3
Specificity: Methylmalonyl-CoA
Evidence for specificity: Sequence-based prediction
Genes: norA_
Core domains: Ketosynthase, Acyltransferase, Ketoreductase, Dehydratase, Thiolation (ACP/PCP)
KR-domain stereochemistry: L-OH
Module 4
Specificity: Malonyl-CoA
Evidence for specificity: Sequence-based prediction
Genes: norB
Core domains: Ketosynthase, Acyltransferase, Ketoreductase, Dehydratase, Enoylreductase, Thiolation (ACP/PCP)
KR-domain stereochemistry: L-OH
Module 5
Specificity: Methylmalonyl-CoA
Genes: norC
Core domains: Ketosynthase, Acyltransferase, Thiolation (ACP/PCP)
Module 6
Genes: norC
Core domains: Ketosynthase, Thiolation (ACP/PCP)
Annotation changelog
MIBiG version Submitter Notes
1.0
  • Hidden contributor (ID: F65XGYSSLMUEJC2Q4T3BLCPS, no GDPR consent given).
  • Submitted
2.0
  • Hidden contributor (ID: AAAAAAAAAAAAAAAAAAAAAAAA, no GDPR consent given).
  • Migrated from v1.4
  • Updated compound(s) information (NPAtlas curation)
3.0
  • Hidden contributor (ID: AAAAAAAAAAAAAAAAAAAAAAAA, no GDPR consent given).
  • Removed ketoreductase stereochemistry annotation from modules without ketoreductases
  • Updated bioactivity data
3.1
  • Hidden contributor (ID: AAAAAAAAAAAAAAAAAAAAAAAA, no GDPR consent given).
  • Update chemical activity to schema version 2.11
Detailed domain annotation
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