BGC0000114: nigericin biosynthetic gene cluster from Streptomyces violaceusniger
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Location: 1 - 95,700 nt. (total: 95,700 nt).
This entry is originally from NCBI GenBank DQ354110.1.

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core biosynthetic genes
additional biosynthetic genes
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resistance
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Gene details
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General
Compounds
Genes
Polyketide
History
NRPS/PKS domains
KnownClusterBlast
General information about the BGC
MIBiG accession BGC0000114
Short description nigericin biosynthetic gene cluster from Streptomyces violaceusniger
Status Minimal annotation: no
A minimal annotation only contains information on the BGC loci and one or more linked chemical product(s)

Completeness: complete
Whether the loci encodes everything needed for the pathway producing the compound(s)
Biosynthetic class(es)
  • Polyketide (Polyether)
Loci NCBI GenBank: DQ354110.1
Compounds
  • nigericin
Species Streptomyces violaceusniger [taxonomy]
References
Chemical products information
nigericin [synonyms: azalomycin m, helexin c, polyetherin a]
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C40H68O11
Chemical database entries
NPAtlas
PubCHEM
List of genes involved in compound(s) production
Identifiers Position Product Functions Evidence Extra
  • ABC84455.1
 420 - 1232 (-) NigE
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  • ABC84456.1
 1475 - 8722 (+) NigAI
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  • ABC84457.1
 8764 - 15465 (+) NigAII
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  • ABC84458.1
 15507 - 27758 (+) NigAIII
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  • ABC84459.1
 27775 - 39942 (+) NigAIV
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  • ABC84460.1
 39985 - 52122 (+) NigAV
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  • ABC84461.1
 52139 - 57244 (+) NigAVI
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  • ABC84462.1
 57331 - 58197 (-) NigCII
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  • ABC84463.1
 58370 - 59629 (+) NigD
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  • ABC84464.1
 59705 - 60043 (-) NigAXI
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  • ABC84465.1
 60152 - 64051 (-) NigAX
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  • ABC84466.1
 64048 - 65478 (-) NigCI
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  • ABC84467.1
 65513 - 65980 (-) NigBIII
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  • ABC84468.1
 66016 - 66453 (-) NigBI
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  • ABC84469.1
 66450 - 72278 (-) NigAIX
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  • ABC84470.1
 72327 - 78947 (-) NIGAVIII
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  • ABC84471.1
 78995 - 93358 (-) NigAVII
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  • ABC84472.1
 93400 - 93948 (-) unknown
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Polyketide-specific information
Subclass Polyether
Starter unit Acetyl-CoA
Cyclic? no
Release type
  • Hydrolysis
Polyketide-synthases
Genes Properties Modules
ABC84462.1 Synthase subclass: Modular type I
Thioesterases:
  • ABC84462.1 (Unknown)
Annotation changelog
MIBiG version Submitter Notes
1.0
  • Hidden contributor (ID: CKAYQ42GR5EX6WJLHMEET7FX, no GDPR consent given).
  • Submitted
2.0
  • Hidden contributor (ID: AAAAAAAAAAAAAAAAAAAAAAAA, no GDPR consent given).
  • Migrated from v1.4
  • Updated compound(s) information (NPAtlas curation)
3.0
  • Hidden contributor (ID: AAAAAAAAAAAAAAAAAAAAAAAA, no GDPR consent given).
  • Cleaned up synonym list
  • Corrected gene identifiers
  • Updated bioactivity data
3.1
  • Hidden contributor (ID: AAAAAAAAAAAAAAAAAAAAAAAA, no GDPR consent given).
  • Update chemical activity to schema version 2.11
Detailed domain annotation
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