BGC0000117 - 1 region(s) - antiSMASH results

Identified secondary metabolite regions using strictness 'relaxed'

BGC0000117 (Streptomyces avermitilis)

Region	Type	From	To	Most similar known cluster		Similarity
Region 1	T1PKS	1	104,326	concanamycin A	Polyketide	39%

BGC0000117 - Region 1 - T1PKS

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Location: 1 - 104,326 nt. (total: 104,326 nt) Show pHMM detection rules used

Region on contig edge.

T1PKS: cds(PKS_AT and (PKS_KS or ene_KS or mod_KS or hyb_KS or itr_KS or tra_KS))

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core biosynthetic genes

additional biosynthetic genes

transport-related genes

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TTA codons

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Gene details

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MIBiG

NRPS/PKS domains

MIBiG comparison

KnownClusterBlast

NRPS/PKS modules

External annotation

Name		MIBiG
Version		3.0

Type		Subregion
Location		1 - 104,327
Label		BGC0000117

Detailed domain annotation

Selected features only

Show module domains

Similar gene clusters

Analysis type:

Reference	Similarity score	Type	Compound(s)	Organism
BGC0000117.1	0.84	Polyketide	oligomycin	Streptomyces avermitilis
BGC0000041.1	0.42	Polyketide	oronofacic acid	Pseudomonas syringae
BGC0000018.1	0.32	Polyketide	angolamycin	Streptomyces eurythermus
BGC0001164.1	0.31	Polyketide	1-heptadecene	Cyanothece sp. PCC 7822
BGC0001276.1	0.29	Polyketide	6-methylsalicyclic acid	Aspergillus terreus
BGC0001266.1	0.29	Polyketide	grayanic acid	Cladonia grayi
BGC0001273.1	0.29	Polyketide	asperlactone	Aspergillus ochraceus
BGC0001275.1	0.29	Polyketide	6-methylsalicyclic acid	Glarea lozoyensis
BGC0001304.1	0.29	Polyketide	aflavarin	Aspergillus flavus NRRL3357
BGC0000067.1	0.29	Polyketide	geldanamycin	Streptomyces hygroscopicus subsp. duamyceticus

Reference	Similarity score	Type	Compound(s)	Organism
BGC0000117.1	0.94	Polyketide	oligomycin	Streptomyces avermitilis
BGC0000041.1	0.74	Polyketide	oronofacic acid	Pseudomonas syringae
BGC0000018.1	0.65	Polyketide	angolamycin	Streptomyces eurythermus
BGC0001164.1	0.65	Polyketide	1-heptadecene	Cyanothece sp. PCC 7822
BGC0001276.1	0.63	Polyketide	6-methylsalicyclic acid	Aspergillus terreus
BGC0001266.1	0.63	Polyketide	grayanic acid	Cladonia grayi
BGC0001273.1	0.63	Polyketide	asperlactone	Aspergillus ochraceus
BGC0001275.1	0.63	Polyketide	6-methylsalicyclic acid	Glarea lozoyensis
BGC0001304.1	0.63	Polyketide	aflavarin	Aspergillus flavus NRRL3357
BGC0000067.1	0.62	Polyketide	geldanamycin	Streptomyces hygroscopicus subsp. duamyceticus

Similar known gene clusters

Module view

Legend

NRPS/PKS products

NRPS/PKS monomers

Predicted core structure(s)

For candidate cluster 1, location 0 - 104326:

Rough prediction of core scaffold based on assumed PKS linker matching; tailoring reactions not taken into account

Polymer prediction:: (mal - ohmal - Me-ohmal - redmal) + (redemal - ccmal) + (ohmal - Me-ohmal - ccmal) + (pk) + (pk - Me-ohmal - pk) + (ccmal - Me-redmal) + (pk - ccmal)
Non-colinear ordering:: olmA1 + olmA3 + olmA2 + olmA5 + olmA6 + olmA4 + olmA7

Direct lookup in NORINE database: strict or relaxed

Link to NORINE database query form

NRPS/PKS monomer predictions

olmA1

PKS_AT (512..806): mal

ATSignature: Malonyl-CoA

Top 3 matches:: Malonyl-CoA: 100.0%; inactive: 83.3%; 2-Rhyd-Malonyl-CoA: 62.5%

minowa: Malonyl-CoA

Prediction, score:

Malonyl-CoA: 218.3
inactive: 108.5
Methoxymalonyl-CoA: 64.5
Methylmalonyl-CoA: 52.4
Propionyl-CoA: 32.1
Isobutyryl-CoA: 26.1
2-Methylbutyryl-CoA: 24.1
Ethylmalonyl-CoA: 21.4
Benzoyl-CoA: 20.3
CHC-CoA: 11.9
fatty_acid: 11.3
Acetyl-CoA: 11.1
trans-1,2-CPDA: 0.0
3-Methylbutyryl-CoA: 0.0

PKS_AT (1524..1812): mal

ATSignature: Malonyl-CoA

Top 3 matches:: Malonyl-CoA: 91.7%; inactive: 75.0%; 2-Rhyd-Malonyl-CoA: 58.3%

minowa: Malonyl-CoA

Prediction, score:

Malonyl-CoA: 219.3
inactive: 102.5
Methoxymalonyl-CoA: 59.0
Methylmalonyl-CoA: 57.3
Propionyl-CoA: 37.7
fatty_acid: 24.5
Isobutyryl-CoA: 19.9
Ethylmalonyl-CoA: 19.6
Acetyl-CoA: 19.3
Benzoyl-CoA: 18.3
CHC-CoA: 16.1
2-Methylbutyryl-CoA: 12.4
trans-1,2-CPDA: 8.5
3-Methylbutyryl-CoA: 0.0

PKS_AT (2997..3295): mmal

ATSignature: Methylmalonyl-CoA

Top 3 matches:: Methylmalonyl-CoA: 95.8%; Methoxymalonyl-CoA: 91.7%; Malonyl-CoA: 87.5%

minowa: Methylmalonyl-CoA

Prediction, score:

Methylmalonyl-CoA: 195.4
Ethylmalonyl-CoA: 180.6
Methoxymalonyl-CoA: 158.3
2-Methylbutyryl-CoA: 119.9
CHC-CoA: 104.8
Propionyl-CoA: 101.3
trans-1,2-CPDA: 97.2
Malonyl-CoA: 89.1
Isobutyryl-CoA: 77.8
Benzoyl-CoA: 63.3
Acetyl-CoA: 50.2
fatty_acid: 34.7
3-Methylbutyryl-CoA: 30.8
inactive: 21.8

PKS_AT (4509..4798): mal

ATSignature: Malonyl-CoA

Top 3 matches:: Malonyl-CoA: 95.8%; inactive: 79.2%; 2-Rhyd-Malonyl-CoA: 58.3%

minowa: Malonyl-CoA

Prediction, score:

Malonyl-CoA: 212.9
inactive: 114.1
Methoxymalonyl-CoA: 56.2
Methylmalonyl-CoA: 53.8
Propionyl-CoA: 40.2
fatty_acid: 22.9
Isobutyryl-CoA: 22.9
Ethylmalonyl-CoA: 19.9
Acetyl-CoA: 18.3
Benzoyl-CoA: 17.0
2-Methylbutyryl-CoA: 10.8
CHC-CoA: 10.4
trans-1,2-CPDA: 10.0
3-Methylbutyryl-CoA: 0.0

olmA2

PKS_AT (561..861): mal

ATSignature: Malonyl-CoA

Top 3 matches:: Malonyl-CoA: 79.2%; inactive: 70.8%

minowa: Malonyl-CoA

Prediction, score:

Malonyl-CoA: 184.6
inactive: 74.4
Methoxymalonyl-CoA: 56.6
Methylmalonyl-CoA: 40.0
Benzoyl-CoA: 26.7
Propionyl-CoA: 25.4
Ethylmalonyl-CoA: 19.6
2-Methylbutyryl-CoA: 17.7
Isobutyryl-CoA: 15.6
Acetyl-CoA: 11.2
trans-1,2-CPDA: 0.0
fatty_acid: 0.0
CHC-CoA: 0.0
3-Methylbutyryl-CoA: 0.0

PKS_AT (2006..2300): mmal

ATSignature: Methylmalonyl-CoA

Top 3 matches:: Methylmalonyl-CoA: 100.0%; Methoxymalonyl-CoA: 95.8%; Ethylmalonyl-CoA: 91.7%

minowa: Methylmalonyl-CoA

Prediction, score:

Methylmalonyl-CoA: 211.1
Ethylmalonyl-CoA: 200.1
Methoxymalonyl-CoA: 166.0
2-Methylbutyryl-CoA: 148.9
trans-1,2-CPDA: 121.4
Propionyl-CoA: 100.3
Malonyl-CoA: 91.6
Isobutyryl-CoA: 80.9
CHC-CoA: 75.6
Benzoyl-CoA: 65.1
Acetyl-CoA: 51.3
3-Methylbutyryl-CoA: 37.0
inactive: 22.1
fatty_acid: 14.7

PKS_AT (3584..3874): mal

ATSignature: Malonyl-CoA

Top 3 matches:: Malonyl-CoA: 91.7%; inactive: 83.3%

minowa: Malonyl-CoA

Prediction, score:

Malonyl-CoA: 209.7
inactive: 103.5
Methoxymalonyl-CoA: 76.2
Methylmalonyl-CoA: 69.4
Propionyl-CoA: 49.1
Ethylmalonyl-CoA: 32.6
Isobutyryl-CoA: 30.6
2-Methylbutyryl-CoA: 28.0
Acetyl-CoA: 24.3
CHC-CoA: 23.9
Benzoyl-CoA: 23.7
fatty_acid: 19.3
trans-1,2-CPDA: 12.2
3-Methylbutyryl-CoA: 0.0

olmA3

PKS_AT (573..871): emal

ATSignature: Ethylmalonyl-CoA, Methoxymalonyl-CoA

Top 3 matches:: Ethylmalonyl-CoA: 79.2%; Methoxymalonyl-CoA: 79.2%; Methylmalonyl-CoA: 70.8%

minowa: Ethylmalonyl-CoA

Prediction, score:

Ethylmalonyl-CoA: 193.1
Methylmalonyl-CoA: 184.1
Methoxymalonyl-CoA: 150.5
2-Methylbutyryl-CoA: 122.5
trans-1,2-CPDA: 114.9
CHC-CoA: 91.9
Propionyl-CoA: 86.2
Malonyl-CoA: 80.3
Isobutyryl-CoA: 75.9
Benzoyl-CoA: 46.4
Acetyl-CoA: 46.1
fatty_acid: 30.6
3-Methylbutyryl-CoA: 25.1
inactive: 17.9

PKS_AT (2635..2935): mal

ATSignature: Malonyl-CoA

Top 3 matches:: Malonyl-CoA: 95.8%; inactive: 87.5%; 2-Rhyd-Malonyl-CoA: 54.2%

minowa: Malonyl-CoA

Prediction, score:

Malonyl-CoA: 193.2
inactive: 90.5
Methylmalonyl-CoA: 57.3
Methoxymalonyl-CoA: 52.1
Ethylmalonyl-CoA: 25.1
Propionyl-CoA: 23.4
Benzoyl-CoA: 18.2
Acetyl-CoA: 16.3
trans-1,2-CPDA: 15.7
Isobutyryl-CoA: 15.6
CHC-CoA: 15.0
2-Methylbutyryl-CoA: 13.1
fatty_acid: 6.2
3-Methylbutyryl-CoA: 0.0

olmA6

PKS_AT (569..867): pk

ATSignature: Methylmalonyl-CoA

Top 3 matches:: Methylmalonyl-CoA: 100.0%; Methoxymalonyl-CoA: 95.8%; Ethylmalonyl-CoA: 91.7%

minowa: Ethylmalonyl-CoA

Prediction, score:

Ethylmalonyl-CoA: 218.4
Methylmalonyl-CoA: 212.3
Methoxymalonyl-CoA: 177.6
2-Methylbutyryl-CoA: 141.3
trans-1,2-CPDA: 132.5
Propionyl-CoA: 112.5
Malonyl-CoA: 98.0
Isobutyryl-CoA: 97.9
CHC-CoA: 93.1
Benzoyl-CoA: 74.9
Acetyl-CoA: 61.7
3-Methylbutyryl-CoA: 54.3
inactive: 46.8
fatty_acid: 43.7

PKS_AT (2097..2395): mmal

ATSignature: Methylmalonyl-CoA

Top 3 matches:: Methylmalonyl-CoA: 100.0%; Methoxymalonyl-CoA: 95.8%; Ethylmalonyl-CoA: 91.7%

minowa: Methylmalonyl-CoA

Prediction, score:

Methylmalonyl-CoA: 209.4
Ethylmalonyl-CoA: 208.2
Methoxymalonyl-CoA: 178.3
2-Methylbutyryl-CoA: 129.2
trans-1,2-CPDA: 121.2
Propionyl-CoA: 106.7
Malonyl-CoA: 101.7
CHC-CoA: 100.1
Isobutyryl-CoA: 97.8
Benzoyl-CoA: 70.3
Acetyl-CoA: 58.3
3-Methylbutyryl-CoA: 50.7
fatty_acid: 43.1
inactive: 38.6

PKS_AT (3617..3915): pk

ATSignature: Methylmalonyl-CoA

Top 3 matches:: Methylmalonyl-CoA: 100.0%; Methoxymalonyl-CoA: 95.8%; Ethylmalonyl-CoA: 91.7%

minowa: Ethylmalonyl-CoA

Prediction, score:

Ethylmalonyl-CoA: 211.7
Methylmalonyl-CoA: 209.1
Methoxymalonyl-CoA: 177.8
2-Methylbutyryl-CoA: 136.0
trans-1,2-CPDA: 122.8
Propionyl-CoA: 109.4
Malonyl-CoA: 103.6
CHC-CoA: 96.2
Isobutyryl-CoA: 93.5
Benzoyl-CoA: 69.0
Acetyl-CoA: 56.9
3-Methylbutyryl-CoA: 54.3
inactive: 42.4
fatty_acid: 42.4

olmA7

PKS_AT (574..872): pk

ATSignature: Methylmalonyl-CoA

Top 3 matches:: Methylmalonyl-CoA: 100.0%; Methoxymalonyl-CoA: 95.8%; Ethylmalonyl-CoA: 91.7%

minowa: Ethylmalonyl-CoA

Prediction, score:

Ethylmalonyl-CoA: 213.7
Methylmalonyl-CoA: 212.2
Methoxymalonyl-CoA: 180.8
2-Methylbutyryl-CoA: 135.9
trans-1,2-CPDA: 122.9
Propionyl-CoA: 109.4
Malonyl-CoA: 106.3
Isobutyryl-CoA: 99.6
CHC-CoA: 98.0
Benzoyl-CoA: 71.9
3-Methylbutyryl-CoA: 59.5
Acetyl-CoA: 58.4
inactive: 42.8
fatty_acid: 42.4

PKS_AT (2091..2380): mal

ATSignature: Malonyl-CoA

Top 3 matches:: Malonyl-CoA: 95.8%; inactive: 79.2%; 2-Rhyd-Malonyl-CoA: 58.3%

minowa: Malonyl-CoA

Prediction, score:

Malonyl-CoA: 214.1
inactive: 113.5
Methoxymalonyl-CoA: 55.5
Methylmalonyl-CoA: 53.3
Propionyl-CoA: 40.0
Isobutyryl-CoA: 22.8
fatty_acid: 22.3
Ethylmalonyl-CoA: 19.9
Acetyl-CoA: 18.5
Benzoyl-CoA: 16.4
2-Methylbutyryl-CoA: 10.6
CHC-CoA: 10.1
trans-1,2-CPDA: 9.6
3-Methylbutyryl-CoA: 0.0

olmA5

PKS_AT (583..880): pk

ATSignature: Methylmalonyl-CoA

Top 3 matches:: Methylmalonyl-CoA: 100.0%; Methoxymalonyl-CoA: 95.8%; Ethylmalonyl-CoA: 91.7%

minowa: Ethylmalonyl-CoA

Prediction, score:

Ethylmalonyl-CoA: 206.3
Methylmalonyl-CoA: 206.2
Methoxymalonyl-CoA: 178.7
2-Methylbutyryl-CoA: 128.0
trans-1,2-CPDA: 124.6
Propionyl-CoA: 109.8
CHC-CoA: 92.2
Malonyl-CoA: 91.3
Isobutyryl-CoA: 85.0
Benzoyl-CoA: 74.6
Acetyl-CoA: 52.9
3-Methylbutyryl-CoA: 49.8
fatty_acid: 48.4
inactive: 27.3

olmA4

PKS_AT (590..899): mal

ATSignature: Malonyl-CoA

Top 3 matches:: Malonyl-CoA: 83.3%; inactive: 75.0%; 2-Methylbutyryl-CoA: 54.2%

minowa: Malonyl-CoA

Prediction, score:

Malonyl-CoA: 160.3
inactive: 70.6
Methoxymalonyl-CoA: 51.3
Methylmalonyl-CoA: 34.1
Propionyl-CoA: 15.9
Isobutyryl-CoA: 9.2
Benzoyl-CoA: 7.6
2-Methylbutyryl-CoA: 6.9
fatty_acid: 5.2
Ethylmalonyl-CoA: 4.0
Acetyl-CoA: 0.1
trans-1,2-CPDA: 0.0
3-Methylbutyryl-CoA: 0.0
CHC-CoA: -0.2

PKS_AT (2373..2671): mmal

ATSignature: Methylmalonyl-CoA

Top 3 matches:: Methylmalonyl-CoA: 100.0%; Methoxymalonyl-CoA: 95.8%; Ethylmalonyl-CoA: 91.7%

minowa: Methylmalonyl-CoA

Prediction, score:

Methylmalonyl-CoA: 223.9
Ethylmalonyl-CoA: 215.1
Methoxymalonyl-CoA: 184.5
2-Methylbutyryl-CoA: 153.5
trans-1,2-CPDA: 136.8
Propionyl-CoA: 122.4
Malonyl-CoA: 112.7
CHC-CoA: 94.2
Isobutyryl-CoA: 87.5
Benzoyl-CoA: 81.6
Acetyl-CoA: 64.6
inactive: 37.1
fatty_acid: 36.9
3-Methylbutyryl-CoA: 32.9