BGC0000147 - 1 region(s) - antiSMASH results

Identified secondary metabolite regions using strictness 'relaxed'

BGC0000147 (Sorangium cellulosum)

Region	Type	From	To	Most similar known cluster		Similarity
Region 1	T1PKS	1	67,523	ebelactone	Polyketide	5%

BGC0000147 - Region 1 - T1PKS

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Location: 1 - 67,523 nt. (total: 67,523 nt) Show pHMM detection rules used

Region on contig edge.

T1PKS: cds(PKS_AT and (PKS_KS or ene_KS or mod_KS or hyb_KS or itr_KS or tra_KS))

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core biosynthetic genes

additional biosynthetic genes

transport-related genes

regulatory genes

other genes

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TTA codons

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Gene details

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MIBiG

NRPS/PKS domains

MIBiG comparison

KnownClusterBlast

NRPS/PKS modules

External annotation

Name		MIBiG
Version		3.0

Type		Subregion
Location		1 - 67,524
Label		BGC0000147

Detailed domain annotation

Selected features only

Show module domains

Similar gene clusters

Analysis type:

Reference	Similarity score	Type	Compound(s)	Organism
BGC0000147.1	0.71	Polyketide	soraphen A	Sorangium cellulosum
BGC0000041.1	0.43	Polyketide	oronofacic acid	Pseudomonas syringae
BGC0001283.1	0.25	Polyketide	arsono-polyketide	Streptomyces lividans 1326
BGC0001504.1	0.24	Polyketide	amycomicin	Amycolatopsis sp. AA4
BGC0000067.1	0.22	Polyketide	geldanamycin	Streptomyces hygroscopicus subsp. duamyceticus
BGC0001062.1	0.22	Polyketide	TLN-05220	Micromonospora echinospora subsp. challisensis
BGC0001235.1	0.20	NRP, Polyketide	antalid	Polyangium spumosum
BGC0001892.1	0.20	Polyketide	botcinic acid	Botrytis cinerea B05.10
BGC0000076.1	0.19	Polyketide	hypothemycin	Hypomyces subiculosus
BGC0000077.1	0.19	Polyketide	hypothemycin	Hypomyces subiculosus

Reference	Similarity score	Type	Compound(s)	Organism
BGC0000147.1	0.89	Polyketide	soraphen A	Sorangium cellulosum
BGC0000041.1	0.74	Polyketide	oronofacic acid	Pseudomonas syringae
BGC0001283.1	0.59	Polyketide	arsono-polyketide	Streptomyces lividans 1326
BGC0001504.1	0.57	Polyketide	amycomicin	Amycolatopsis sp. AA4
BGC0000067.1	0.55	Polyketide	geldanamycin	Streptomyces hygroscopicus subsp. duamyceticus
BGC0001062.1	0.54	Polyketide	TLN-05220	Micromonospora echinospora subsp. challisensis
BGC0001235.1	0.52	NRP, Polyketide	antalid	Polyangium spumosum
BGC0001892.1	0.52	Polyketide	botcinic acid	Botrytis cinerea B05.10
BGC0000076.1	0.51	Polyketide	hypothemycin	Hypomyces subiculosus
BGC0000077.1	0.51	Polyketide	hypothemycin	Hypomyces subiculosus

Similar known gene clusters

Module view

Legend

NRPS/PKS products

NRPS/PKS monomers

Predicted core structure(s)

For candidate cluster 1, location 0 - 67523:

Rough prediction of core scaffold based on assumed PKS linker matching; tailoring reactions not taken into account

Polymer prediction:: (mal) + (redmal - pk) + (ohmal - Me-redmal - Me-ohmal - pk - Me-ccmal)
Non-colinear ordering:: sorC + sorA + sorB

Direct lookup in NORINE database: strict or relaxed

Link to NORINE database query form

NRPS/PKS monomer predictions

sorC

PKS_AT (100..404): mal

ATSignature: Malonyl-CoA

Top 3 matches:: Malonyl-CoA: 75.0%; inactive: 70.8%; 2-Rhyd-Malonyl-CoA: 58.3%

minowa: Malonyl-CoA

Prediction, score:

Malonyl-CoA: 136.4
inactive: 82.9
Methoxymalonyl-CoA: 65.7
Methylmalonyl-CoA: 52.2
Propionyl-CoA: 46.5
2-Methylbutyryl-CoA: 28.4
Ethylmalonyl-CoA: 23.4
CHC-CoA: 21.4
Isobutyryl-CoA: 16.2
Acetyl-CoA: 14.5
Benzoyl-CoA: 14.0
3-Methylbutyryl-CoA: 13.9
trans-1,2-CPDA: 11.7
fatty_acid: 0.0

sorA

PKS_AT (633..930): pk

ATSignature: Benzoyl-CoA

Top 3 matches:: Benzoyl-CoA: 100.0%; Methylmalonyl-CoA: 70.8%; Ethylmalonyl-CoA: 62.5%

minowa: Benzoyl-CoA

Prediction, score:

Benzoyl-CoA: 279.7
Isobutyryl-CoA: 131.3
Methylmalonyl-CoA: 121.7
Ethylmalonyl-CoA: 101.1
Methoxymalonyl-CoA: 100.1
Malonyl-CoA: 68.5
Acetyl-CoA: 55.6
trans-1,2-CPDA: 55.5
2-Methylbutyryl-CoA: 54.4
Propionyl-CoA: 52.6
3-Methylbutyryl-CoA: 49.5
CHC-CoA: 49.3
inactive: 33.4
fatty_acid: 23.4

PKS_AT (1065..1367): mal

ATSignature: Malonyl-CoA

Top 3 matches:: Malonyl-CoA: 100.0%; inactive: 87.5%; 2-Rhyd-Malonyl-CoA: 54.2%

minowa: Malonyl-CoA

Prediction, score:

Malonyl-CoA: 226.4
inactive: 133.5
Methoxymalonyl-CoA: 76.7
Methylmalonyl-CoA: 67.6
Isobutyryl-CoA: 45.3
Propionyl-CoA: 40.1
2-Methylbutyryl-CoA: 25.4
Ethylmalonyl-CoA: 25.3
Benzoyl-CoA: 21.5
Acetyl-CoA: 16.7
trans-1,2-CPDA: 9.6
CHC-CoA: 6.2
fatty_acid: 0.0
3-Methylbutyryl-CoA: 0.0

PKS_AT (2627..2929): mal

ATSignature: Malonyl-CoA

Top 3 matches:: Malonyl-CoA: 100.0%; inactive: 87.5%; 2-Rhyd-Malonyl-CoA: 54.2%

minowa: Malonyl-CoA

Prediction, score:

Malonyl-CoA: 225.3
inactive: 129.3
Methoxymalonyl-CoA: 67.9
Methylmalonyl-CoA: 57.0
Isobutyryl-CoA: 41.5
Propionyl-CoA: 26.8
2-Methylbutyryl-CoA: 23.1
Acetyl-CoA: 16.3
Benzoyl-CoA: 12.1
Ethylmalonyl-CoA: 11.9
CHC-CoA: 3.7
trans-1,2-CPDA: 0.0
fatty_acid: 0.0
3-Methylbutyryl-CoA: 0.0

PKS_AT (4708..4999): pk

ATSignature: Methoxymalonyl-CoA

Top 3 matches:: Methoxymalonyl-CoA: 100.0%; Ethylmalonyl-CoA: 91.7%; Methylmalonyl-CoA: 91.7%

minowa: Methylmalonyl-CoA

Prediction, score:

Methylmalonyl-CoA: 204.7
Ethylmalonyl-CoA: 204.0
Methoxymalonyl-CoA: 196.3
2-Methylbutyryl-CoA: 147.1
trans-1,2-CPDA: 138.5
Propionyl-CoA: 119.3
Malonyl-CoA: 117.3
CHC-CoA: 105.6
Isobutyryl-CoA: 102.4
Benzoyl-CoA: 76.6
Acetyl-CoA: 62.1
fatty_acid: 47.0
3-Methylbutyryl-CoA: 47.0
inactive: 38.6

sorB

PKS_AT (563..865): mal

ATSignature: Malonyl-CoA

Top 3 matches:: Malonyl-CoA: 100.0%; inactive: 87.5%; 2-Rhyd-Malonyl-CoA: 54.2%

minowa: Malonyl-CoA

Prediction, score:

Malonyl-CoA: 225.3
inactive: 129.3
Methoxymalonyl-CoA: 67.9
Methylmalonyl-CoA: 57.0
Isobutyryl-CoA: 41.5
Propionyl-CoA: 26.8
2-Methylbutyryl-CoA: 23.1
Acetyl-CoA: 16.3
Benzoyl-CoA: 12.1
Ethylmalonyl-CoA: 11.9
CHC-CoA: 3.7
trans-1,2-CPDA: 0.0
fatty_acid: 0.0
3-Methylbutyryl-CoA: 0.0

PKS_AT (2126..2422): mmal

ATSignature: Methylmalonyl-CoA

Top 3 matches:: Methylmalonyl-CoA: 100.0%; Methoxymalonyl-CoA: 95.8%; Ethylmalonyl-CoA: 91.7%

minowa: Methylmalonyl-CoA

Prediction, score:

Methylmalonyl-CoA: 218.9
Ethylmalonyl-CoA: 204.2
Methoxymalonyl-CoA: 180.5
2-Methylbutyryl-CoA: 154.9
trans-1,2-CPDA: 121.8
Propionyl-CoA: 118.5
CHC-CoA: 116.2
Malonyl-CoA: 101.4
Isobutyryl-CoA: 100.7
Benzoyl-CoA: 79.5
Acetyl-CoA: 63.0
fatty_acid: 50.5
3-Methylbutyryl-CoA: 29.2
inactive: 26.6

PKS_AT (4202..4497): mmal

ATSignature: Methylmalonyl-CoA

Top 3 matches:: Methylmalonyl-CoA: 100.0%; Methoxymalonyl-CoA: 95.8%; Ethylmalonyl-CoA: 91.7%

minowa: Methylmalonyl-CoA

Prediction, score:

Methylmalonyl-CoA: 209.9
Ethylmalonyl-CoA: 195.6
Methoxymalonyl-CoA: 173.8
2-Methylbutyryl-CoA: 147.6
trans-1,2-CPDA: 120.1
Propionyl-CoA: 112.9
CHC-CoA: 109.5
Malonyl-CoA: 98.0
Isobutyryl-CoA: 96.7
Benzoyl-CoA: 71.5
Acetyl-CoA: 64.9
fatty_acid: 41.1
inactive: 25.8
3-Methylbutyryl-CoA: 20.4

PKS_AT (5758..6052): pk

ATSignature: Methoxymalonyl-CoA

Top 3 matches:: Methoxymalonyl-CoA: 100.0%; Methylmalonyl-CoA: 95.8%; Ethylmalonyl-CoA: 91.7%

minowa: Ethylmalonyl-CoA

Prediction, score:

Ethylmalonyl-CoA: 215.1
Methylmalonyl-CoA: 213.5
Methoxymalonyl-CoA: 202.1
2-Methylbutyryl-CoA: 149.1
trans-1,2-CPDA: 142.7
Propionyl-CoA: 117.0
CHC-CoA: 111.6
Malonyl-CoA: 106.1
Isobutyryl-CoA: 97.1
Benzoyl-CoA: 74.7
Acetyl-CoA: 54.4
fatty_acid: 45.4
inactive: 45.2
3-Methylbutyryl-CoA: 44.7

PKS_AT (7312..7608): mmal

ATSignature: Methylmalonyl-CoA

Top 3 matches:: Methylmalonyl-CoA: 100.0%; Methoxymalonyl-CoA: 95.8%; Ethylmalonyl-CoA: 91.7%

minowa: Methylmalonyl-CoA

Prediction, score:

Methylmalonyl-CoA: 214.1
Ethylmalonyl-CoA: 201.6
Methoxymalonyl-CoA: 179.2
2-Methylbutyryl-CoA: 156.9
trans-1,2-CPDA: 122.3
Propionyl-CoA: 116.1
CHC-CoA: 111.7
Isobutyryl-CoA: 105.7
Malonyl-CoA: 103.8
Benzoyl-CoA: 73.6
Acetyl-CoA: 71.4
fatty_acid: 45.7
3-Methylbutyryl-CoA: 40.6
inactive: 28.4