BGC0000156: TAN-1612 biosynthetic gene cluster from Aspergillus niger
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Location: 1 - 13,275 nt. (total: 13,275 nt).
This entry is originally from NCBI GenBank JN257714.1.

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core biosynthetic genes
additional biosynthetic genes
transport-related genes
regulatory genes
other genes
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Gene details
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General
Compounds
Genes
Polyketide
History
NRPS/PKS domains
KnownClusterBlast
General information about the BGC
MIBiG accession BGC0000156
Short description TAN-1612 biosynthetic gene cluster from Aspergillus niger
Status Minimal annotation: no
A minimal annotation only contains information on the BGC loci and one or more linked chemical product(s)

Completeness: complete
Whether the loci encodes everything needed for the pathway producing the compound(s)
Biosynthetic class(es)
  • Polyketide (Tetracycline)
Loci NCBI GenBank: JN257714.1
Compounds
  • TAN-1612
  • 1-(2,3,5,10-tetrahydroxy-7-methoxy-4-oxo-1,2,3,4-tetrahydroanthracen-2-yl)pentane-2,4-dione
  • desmethyl TAN-1612
Species Aspergillus niger [taxonomy]
References
Chemical products information
TAN-1612
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C21H18O9
Chemical database entries
PubCHEM
ChemSpider
1-(2,3,5,10-tetrahydroxy-7-methoxy-4-oxo-1,2,3,4-tetrahydroanthracen-2-yl)pentane-2,4-dione
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C20H20O8
desmethyl TAN-1612
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C20H16O9
List of genes involved in compound(s) production
Identifiers Position Product Functions Evidence Extra
  • AEN83885.1
  • adaR
 501 - 3004 (+) AdaR
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  • AEN83886.1
  • adaD
 3412 - 4161 (-) O-methyltransferase
  • Tailoring (Methylation)
Heterologous expression
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  • AEN83887.1
  • adaC
 4637 - 5881 (+) AdaC
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  • AEN83888.1
  • adaB
 6256 - 7260 (-) metallo-beta-lactamase-like thioesterase/Claisen cyclase
  • Scaffold biosynthesis
Activity assay
Heterologous expression
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  • AEN83889.1
  • adaA
 7894 - 13275 (+) AdaA
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Polyketide-specific information
Subclass Tetracycline
Starter unit Acetyl-CoA
Cyclic? yes
Release type
  • Claisen condensation
Polyketide-synthases
Genes Properties Modules
adaA
+
adaB 		Synthase subclass: Iterative type I
Thioesterases:
  • adaB (Unknown)
Iterative PKS type: Non-reducing, C6-C11 first
Iteration counts: 9
Annotation changelog
MIBiG version Submitter Notes
1.0
  • Hidden contributor (ID: BMUFDHMMOLZWQLUNJMQED2GP, no GDPR consent given).
  • Submitted
2.0
  • Hidden contributor (ID: AAAAAAAAAAAAAAAAAAAAAAAA, no GDPR consent given).
  • Migrated from v1.4
3.0
  • Hidden contributor (ID: AAAAAAAAAAAAAAAAAAAAAAAA, no GDPR consent given).
  • Corrected gene identifiers
3.1
  • Hidden contributor (ID: AAAAAAAAAAAAAAAAAAAAAAAA, no GDPR consent given).
  • Update chemical activity to schema version 2.11
Detailed domain annotation
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