BGC0000182: pseudomonic acid A biosynthetic gene cluster from Pseudomonas fluorescens
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Location: 1 - 75,137 nt. (total: 75,137 nt).
This entry is originally from NCBI GenBank AF318063.3.

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Gene details
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General
Compounds
Genes
Polyketide
History
NRPS/PKS domains
KnownClusterBlast
General information about the BGC
MIBiG accession BGC0000182
Short description pseudomonic acid A biosynthetic gene cluster from Pseudomonas fluorescens
Status Minimal annotation: no
A minimal annotation only contains information on the BGC loci and one or more linked chemical product(s)

Completeness: complete
Whether the loci encodes everything needed for the pathway producing the compound(s)
Biosynthetic class(es)
  • Polyketide (Other)
Loci NCBI GenBank: AF318063.3
Compounds
  • pseudomonic acid A
Species Pseudomonas fluorescens [taxonomy]
References
Chemical products information
pseudomonic acid A [synonyms: mupirocin]
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C26H44O9
Chemical database entries
NPAtlas
ChemSpider
List of genes involved in compound(s) production
Identifiers Position Product Functions Evidence Extra
  • AFD33556.1
  • mupZ
201 - 569 (+) MupZ
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  • AAK28503.1
  • mupA
600 - 1709 (+) MupA
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  • AAM12909.2
  • mmpA
1706 - 10243 (+) MmpA
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  • AAM12910.1
  • mupB
10278 - 11183 (+) MupB
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  • AAM12911.1
  • mmpB
11325 - 17555 (+) MmpB
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  • AAM12912.1
  • mmpC
17629 - 20961 (+) MmpC
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  • AAM12913.2
  • mmpD
20958 - 40526 (+) MmpD
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  • AAM12914.1
  • mupC
40523 - 41818 (+) MupC
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  • AAM12915.1
  • macpA
41870 - 42175 (+) MacpA
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  • AAM12916.1
  • mupD
42216 - 42959 (+) MupD
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  • AAM12917.1
  • mupE
42983 - 44005 (+) MupE
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  • AAM12918.1
  • macpB
44062 - 44313 (+) MacpB
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  • AAM12919.1
  • mupF
44334 - 45344 (-) MupF
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  • AAM12920.1
  • macpC
45506 - 45742 (+) MacpC
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  • AAM12921.1
  • mupG
45729 - 46967 (+) MupG
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  • AAM12922.1
  • mupH
46964 - 48229 (+) MupH
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  • AAM12923.1
  • mupJ
48226 - 48993 (+) MupJ
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  • AAM12924.1
  • mupK
49047 - 49790 (+) MupK
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  • AAM12925.2
  • mmpE
49802 - 53377 (+) MmpE
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  • AAM12926.1
  • mupL
53423 - 54361 (+) MupL
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  • AAM12927.2
  • mupM
54444 - 57536 (+) MupM
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  • AAM12928.2
  • mupN
57597 - 58448 (+) MupN
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  • AAM12929.2
  • mupO
58574 - 59938 (+) MupO
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  • AAM12930.2
  • mupP
59935 - 60864 (+) MupP
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  • AAM12931.1
  • mupQ
60912 - 62267 (+) MupQ
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  • AAM12932.1
  • mupS
62264 - 63037 (+) MupS
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  • AAM12933.1
  • macpD
63031 - 63351 (+) MacpD
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  • AAM12934.1
  • mmpF
63348 - 65585 (+) MmpF
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  • AAM12935.1
  • macpE
65730 - 65972 (+) MacpE
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  • AAM12936.1
  • mupT
65995 - 66345 (+) MupT
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  • AAM12937.1
  • mupU
66415 - 67992 (+) MupU
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  • AAM12938.1
  • mupV
68027 - 70015 (+) MupV
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  • AAM12939.1
  • mupW
70055 - 71446 (+) MupW
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  • AAK28504.1
  • mupR
71638 - 72342 (+) MupR
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  • AAM12940.1
  • mupX
72380 - 73918 (+) MupX
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  • AAK28505.1
  • mupI
73911 - 74486 (-) MupI
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Polyketide-specific information
Subclass Other
Starter unit Acetyl-CoA
Cyclic? no
Release type
  • Hydrolysis
Polyketide-synthases
Genes Properties Modules
mmpB
+
mmpA
+
mmpD
Synthase subclass: Iterative type I/Trans-AT type I
Trans-acyltansferases: mmpC
Iterative PKS type: Highly reducing, Unknown
Iteration counts: 3
Module 1
Genes: mmpD
Core domains: Ketosynthase, Dehydratase, Dehydratase, Ketoreductase, Thiolation (ACP/PCP)
Scaffold-modifying domains: Methylation
KR-domain stereochemistry: Unknown
Module 2
Genes: mmpD
Core domains: Ketosynthase, Dehydratase, Ketoreductase, Thiolation (ACP/PCP)
KR-domain stereochemistry: Unknown
Module 3
Genes: mmpD
Core domains: Ketosynthase, Dehydratase, Ketoreductase, Thiolation (ACP/PCP)
Scaffold-modifying domains: Methylation
KR-domain stereochemistry: Unknown
Module 4
Genes: mmpD
Core domains: Ketosynthase, Ketoreductase, Thiolation (ACP/PCP)
KR-domain stereochemistry: Unknown
Module 5
Genes: mmpA
Core domains: Ketosynthase, Thiolation (ACP/PCP)
Module 6
Genes: mmpA
Core domains: Ketosynthase, Ketoreductase, Thiolation (ACP/PCP)
KR-domain stereochemistry: Unknown
Module 7
Genes: mmpA
Core domains: Ketosynthase, Thiolation (ACP/PCP), Thiolation (ACP/PCP)
Scaffold-modifying domains: Beta-branching
Module 8
Genes: mmpB
Core domains: Ketosynthase, Dehydratase, Ketoreductase, Thiolation (ACP/PCP), Thiolation (ACP/PCP), Thiolation (ACP/PCP)
KR-domain stereochemistry: Unknown
Non-canonical activity:
  • Iterated
Evidence for non-canonical activity:
  • Structure-based inference
Annotation changelog
MIBiG version Submitter Notes
1.0
  • Hidden contributor (ID: E74IDV7HCE4GDGQ2TWFM7I3H, no GDPR consent given).
  • Submitted
2.0
  • Hidden contributor (ID: AAAAAAAAAAAAAAAAAAAAAAAA, no GDPR consent given).
  • Migrated from v1.4
  • Updated compound(s) information (NPAtlas curation)
3.0
  • Hidden contributor (ID: AAAAAAAAAAAAAAAAAAAAAAAA, no GDPR consent given).
  • Removed entry error in polyketide synthase gene list
  • Removed ketoreductase stereochemistry annotation from modules without ketoreductases
  • Sorted modules by module number
  • Fix trans_at gene ID
3.1
  • Hidden contributor (ID: AAAAAAAAAAAAAAAAAAAAAAAA, no GDPR consent given).
  • Update chemical activity to schema version 2.11
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