LOCUS       BGC0000189              8123 bp    DNA     linear   BCT 27-FEB-2015
DEFINITION  Xenorhabdus bovienii SS-2004 chromosome, complete genome.
ACCESSION   BGC0000189
VERSION     BGC0000189
KEYWORDS    .
SOURCE      Xenorhabdus bovienii SS-2004
  ORGANISM  Xenorhabdus bovienii SS-2004
            Bacteria; Proteobacteria; Gammaproteobacteria; Enterobacterales;
            Morganellaceae; Xenorhabdus.
COMMENT     Annotation results relative to BLAST similarities, COG
            assignations, enzymatic function prediction (PRIAM software), TMHMM
            and SignalP predictions, and synteny conservation (Syntonizer
            software) are available in the MaGe annotation system
            http://www.genoscope.cns.fr/agc/mage.
            ##antiSMASH-Data-START##
            Version      :: 6.2.0-924c3663(changed)
            Run date     :: 2022-11-07 17:38:32
            ##antiSMASH-Data-END##
FEATURES             Location/Qualifiers
     CDS             1..1677
                     /EC_number="2.3.1.41"
                     /NRPS_PKS="Domain: PKS_KS(Iterative-KS) (183-470). E-value:
                     4.3e-28. Score: 90.1. Matches aSDomain:
                     nrpspksdomains_XBJ1_3894_PKS_KS.1"
                     /codon_start=1
                     /db_xref="EnsemblGenomes-Gn:XBJ1_3894"
                     /db_xref="EnsemblGenomes-Tr:CBJ83012"
                     /db_xref="GOA:D3V5T3"
                     /db_xref="InterPro:IPR014030"
                     /db_xref="InterPro:IPR014031"
                     /db_xref="InterPro:IPR016038"
                     /db_xref="InterPro:IPR016039"
                     /db_xref="UniProtKB/TrEMBL:D3V5T3"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1022:Beta-ketoacyl synthase (Score: 209.4; E-value:
                     1.6e-63)"
                     /gene_kind="biosynthetic-additional"
                     /inference="ab initio prediction:AMIGene:2.0"
                     /locus_tag="XBJ1_3894"
                     /product="putative 3-oxoacyl-[acyl-carrier-protein]
                     synthase"
                     /protein_id="CBJ83012.1"
                     /transl_table=11
                     /translation="MSNLPVIVGLGGINAAGRSSGFHSYKRIVSDSLSDEIMQDTWLDL
                     CHRMGIVKNTVSVTDAHIESAKNGTLIRKITHFDTQKVSSVTSAGQLPEGFEVGDLYNA
                     NHHPRGLRLTVYGASDLLSSIGISWPDIAKLVEPDQISVYASSALGQIDRFSLAGLIGN
                     PQNGTRISSKMLALSLADMPANFINSYIINSIGNTSANLGACASFLYNLKQGVNDIKQG
                     KAKISLVGCSEAAIVPEIIEGFRVMGALAEDHQLCKLDGTDIVNNRRATRPFSTNVGFT
                     IAESAQFVLLMSDDLALQCGANILGAVPDVFVNADANKKSISSPGIGNYITMMKAASLA
                     DHLLDGKLQYSYVQAHGTGTPQNRVTESHIINEVAKVFGLKCWDVTAIKSYVGHSIAAS
                     AGDQLACTLGVWQYGWIPGIKTIDHIAEDVHATNLNILMQNKFAGEHGEEMRATIINTK
                     GFGGNNASAVILSPQQTMQMLNKKHGSSAVYTYHQRNQIVKRISEDQDRAICRGEESVV
                     YNFGNAVMQSSDIKLSRQEVKLSGYNHTIKLPNAEEFSAFL"
     subregion       1..8123
                     /aStool="externally annotated by: MIBiG"
                     /contig_edge="True"
                     /label="BGC0000189"
                     /subregion_number="1"
                     /tool="antismash"
     region          1..8123
                     /contig_edge="True"
                     /product="unknown"
                     /region_number="1"
                     /subregion_numbers="1"
                     /tool="antismash"
     gene            1..1677
                     /locus_tag="XBJ1_3894"
     aSDomain        550..1410
                     /aSDomain="PKS_KS"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_XBJ1_3894_PKS_KS.1"
                     /domain_subtype="Iterative-KS"
                     /evalue="4.30E-28"
                     /label="XBJ1_3894_PKS_KS.1"
                     /locus_tag="XBJ1_3894"
                     /protein_end="470"
                     /protein_start="183"
                     /score="90.1"
                     /tool="antismash"
                     /translation="ANFINSYIINSIGNTSANLGACASFLYNLKQGVNDIKQGKAKISL
                     VGCSEAAIVPEIIEGFRVMGALAEDHQLCKLDGTDIVNNRRATRPFSTNVGFTIAESAQ
                     FVLLMSDDLALQCGANILGAVPDVFVNADANKKSISSPGIGNYITMMKAASLADHLLDG
                     KLQYSYVQAHGTGTPQNRVTESHIINEVAKVFGLKCWDVTAIKSYVGHSIAASAGDQLA
                     CTLGVWQYGWIPGIKTIDHIAEDVHATNLNILMQNKFAGEHGEEMRATIINTKGFGGNN
                     ASAVIL"
     regulatory      1686..1745
                     /regulatory_class="promoter"
     gene            1789..1953
                     /locus_tag="XBJ1_3895"
                     /operon="XBJ1_operon0700"
     CDS             1789..1953
                     /codon_start=1
                     /db_xref="EnsemblGenomes-Gn:XBJ1_3895"
                     /db_xref="EnsemblGenomes-Tr:CBJ83013"
                     /db_xref="InterPro:IPR003735"
                     /db_xref="UniProtKB/TrEMBL:D3V5T4"
                     /inference="ab initio prediction:AMIGene:2.0"
                     /locus_tag="XBJ1_3895"
                     /operon="XBJ1_operon0700"
                     /product="conserved hypothetical protein"
                     /protein_id="CBJ83013.1"
                     /transl_table=11
                     /translation="MLQQIAAIRGAVNGLMAGVLESHLREELTNTEQTPEAQKASIEDA
                     VSLIRTYLR"
     operon          1789..4045
                     /operon="XBJ1_operon0700"
     gene            2021..3130
                     /gene="adhC"
                     /locus_tag="XBJ1_3896"
                     /operon="XBJ1_operon0700"
     CDS             2021..3130
                     /EC_number="1.1.1.284"
                     /EC_number="1.1.1.1"
                     /NRPS_PKS="Domain: PKS_ER (17-364). E-value: 1.1e-13.
                     Score: 42.9. Matches aSDomain:
                     nrpspksdomains_XBJ1_3896_PKS_ER.1"
                     /codon_start=1
                     /db_xref="EnsemblGenomes-Gn:XBJ1_3896"
                     /db_xref="EnsemblGenomes-Tr:CBJ83014"
                     /db_xref="GOA:D3V5T5"
                     /db_xref="InterPro:IPR002085"
                     /db_xref="InterPro:IPR002328"
                     /db_xref="InterPro:IPR011032"
                     /db_xref="InterPro:IPR013149"
                     /db_xref="InterPro:IPR013154"
                     /db_xref="InterPro:IPR014183"
                     /db_xref="InterPro:IPR016040"
                     /db_xref="UniProtKB/TrEMBL:D3V5T5"
                     /gene="adhC"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1040:alcohol dehydrogenase (Score: 265.3; E-value:
                     1.1e-80)"
                     /gene_kind="biosynthetic-additional"
                     /inference="ab initio prediction:AMIGene:2.0"
                     /locus_tag="XBJ1_3896"
                     /operon="XBJ1_operon0700"
                     /product="alcohol dehydrogenase class III"
                     /protein_id="CBJ83014.1"
                     /transl_table=11
                     /translation="MKSRAAVAFGPGQPLEIVEIDVAPPQAGEVLVKISHTGVCHTDAF
                     TLSGDDPEGVFPVILGHEGAGVVVEVGAGVTSVKPGDHVIPLYTAECGECLFCKSGKTN
                     LCVAVRATQGKGVMPDGTTRFSYNGQPIYHYMGCSTFSEYTVVAEVSLAKINPEANHEE
                     ICLLGCGVTTGIGAVHNTAKVQSGDSVAVFGLGGIGLAVIQGARQAKAGRIFAIDTNPA
                     KFELAKQFGATDCLNPNDYDKPIQQVIIEMTEWGVDHTFECIGNVNVMRAALESAHRGW
                     GQSVIIGVAGAGQEISTRPFQLVTGRSWRGTAFGGVKGRSQLPKMVEEAMKGEIELKPF
                     VTHTLPLERINEAFNLMHEGKSIRTVIHY"
     aSDomain        2072..3112
                     /aSDomain="PKS_ER"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_XBJ1_3896_PKS_ER.1"
                     /evalue="1.10E-13"
                     /label="XBJ1_3896_PKS_ER.1"
                     /locus_tag="XBJ1_3896"
                     /protein_end="364"
                     /protein_start="17"
                     /score="42.9"
                     /tool="antismash"
                     /translation="VEIDVAPPQAGEVLVKISHTGVCHTDAFTLSGDDPEGVFPVILGH
                     EGAGVVVEVGAGVTSVKPGDHVIPLYTAECGECLFCKSGKTNLCVAVRATQGKGVMPDG
                     TTRFSYNGQPIYHYMGCSTFSEYTVVAEVSLAKINPEANHEEICLLGCGVTTGIGAVHN
                     TAKVQSGDSVAVFGLGGIGLAVIQGARQAKAGRIFAIDTNPAKFELAKQFGATDCLNPN
                     DYDKPIQQVIIEMTEWGVDHTFECIGNVNVMRAALESAHRGWGQSVIIGVAGAGQEIST
                     RPFQLVTGRSWRGTAFGGVKGRSQLPKMVEEAMKGEIELKPFVTHTLPLERINEAFNLM
                     HEGKSIR"
     CDS_motif       2198..2236
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_XBJ1_3896_0001"
                     /evalue="2.90E-03"
                     /label="PKSI-ER_m2"
                     /locus_tag="XBJ1_3896"
                     /protein_end="72"
                     /protein_start="59"
                     /score="10.6"
                     /tool="antismash"
                     /translation="LGHEGAGVVVEVG"
     CDS_motif       2801..2821
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_XBJ1_3896_0002"
                     /evalue="4.70E+01"
                     /label="PKSI-ER_m2"
                     /locus_tag="XBJ1_3896"
                     /protein_end="267"
                     /protein_start="260"
                     /score="-2.0"
                     /tool="antismash"
                     /translation="FECIGNV"
     gene            3200..4045
                     /gene="yaiM"
                     /locus_tag="XBJ1_3897"
                     /operon="XBJ1_operon0700"
     CDS             3200..4045
                     /EC_number="3.1.1.1"
                     /codon_start=1
                     /db_xref="EnsemblGenomes-Gn:XBJ1_3897"
                     /db_xref="EnsemblGenomes-Tr:CBJ83015"
                     /db_xref="GOA:D3V5T6"
                     /db_xref="InterPro:IPR000801"
                     /db_xref="InterPro:IPR014186"
                     /db_xref="InterPro:IPR029058"
                     /db_xref="UniProtKB/TrEMBL:D3V5T6"
                     /gene="yaiM"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1104:putative esterase (Score: 97.3; E-value:
                     1.7e-29)"
                     /gene_kind="biosynthetic-additional"
                     /inference="ab initio prediction:AMIGene:2.0"
                     /locus_tag="XBJ1_3897"
                     /operon="XBJ1_operon0700"
                     /product="putative esterase"
                     /protein_id="CBJ83015.1"
                     /transl_table=11
                     /translation="MERIERRACFGGWQDVYQHDSTELGCTMSFAVYLPPQAEHQKLPV
                     LYWLSGLTCNEQNFITKAGAQRYAAEQGIILVAPDTSPRGENVADDDAYDLGQGAAFYL
                     NATQEPWAPHYRMYDYVVSELPALIEAHFPVTEDRAISGHSMGGHGALTIALRNPDRYH
                     SVSAFSPIVAPSQVPWGEKAFRAYLGDDRDTWKAYDTIRLIANSAKPLHLLIDIGNDDP
                     FLAEQLRPELLKEACEKAGQPYTLNLRTGYDHSYYFVASFIGEHIAYHAEVLKGCCADN
                     "
     gene            complement(4110..5090)
                     /locus_tag="XBJ1_3898"
     CDS             complement(4110..5090)
                     /EC_number="2.3.1.41"
                     /codon_start=1
                     /db_xref="EnsemblGenomes-Gn:XBJ1_3898"
                     /db_xref="EnsemblGenomes-Tr:CBJ83016"
                     /db_xref="GOA:D3V5T7"
                     /db_xref="InterPro:IPR013747"
                     /db_xref="InterPro:IPR013751"
                     /db_xref="InterPro:IPR016038"
                     /db_xref="InterPro:IPR016039"
                     /db_xref="UniProtKB/TrEMBL:D3V5T7"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1084:3-oxoacyl-(acyl carrier protein) synthase III
                     (Score: 178.3; E-value: 3.3e-54)"
                     /gene_kind="biosynthetic-additional"
                     /inference="ab initio prediction:AMIGene:2.0"
                     /locus_tag="XBJ1_3898"
                     /product="3-oxoacyl-[acyl-carrier-protein] synthase III"
                     /protein_id="CBJ83016.1"
                     /transl_table=11
                     /translation="MTRVAIASLGIWHPPTSVNNNWFIEHYAAQGIDMSGLLNALGHKN
                     RYLIRDSSDTTLTMSVAASNNAIQRLGCQAKDLDFIVFASQTPEYLIPSTALKIHHAIG
                     GGERALAFDMNANCAGLLVAVEMVSRAMMASPSCQLALVVGSDYLGAHSSNAPVYHSCF
                     AESAVAVILHKTEQGNGFIDSEFRIQTSVIDNSLFPACGLSNIHRHDVSAQVKFTPFDD
                     DICITAAFESIQLLLSRHNLVPADIKGFMFSQFSVSNIRRLCEELGVDQDKALFIGDEY
                     GYTATNSPFVALYETLERKKIVRGDFLIFWTIGAGWQSIAVLMQY"
     gene            complement(5244..5375)
                     /locus_tag="XBJ1_3899"
     CDS             complement(5244..5375)
                     /codon_start=1
                     /db_xref="EnsemblGenomes-Gn:XBJ1_3899"
                     /db_xref="EnsemblGenomes-Tr:CBJ83017"
                     /db_xref="UniProtKB/TrEMBL:D3V5T8"
                     /inference="ab initio prediction:AMIGene:2.0"
                     /locus_tag="XBJ1_3899"
                     /product="hypothetical protein"
                     /protein_id="CBJ83017.1"
                     /transl_table=11
                     /translation="MLIVEIGMSLMLDYRVLVCIKTWLYICIPINFKMQNLRFENYH"
     regulatory      complement(5268..5327)
                     /locus_tag="XBJ1_3899"
                     /regulatory_class="promoter"
     regulatory      complement(5326..5364)
                     /locus_tag="XBJ1_3899"
                     /regulatory_class="terminator"
     gene            complement(5405..6436)
                     /locus_tag="XBJ1_3900"
                     /operon="XBJ1_operon0701"
     CDS             complement(5405..6436)
                     /codon_start=1
                     /db_xref="EnsemblGenomes-Gn:XBJ1_3900"
                     /db_xref="EnsemblGenomes-Tr:CBJ83018"
                     /db_xref="GOA:D3V5T9"
                     /db_xref="InterPro:IPR013747"
                     /db_xref="InterPro:IPR013751"
                     /db_xref="InterPro:IPR016038"
                     /db_xref="InterPro:IPR016039"
                     /db_xref="UniProtKB/TrEMBL:D3V5T9"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1084:3-oxoacyl-(acyl carrier protein) synthase III
                     (Score: 118.4; E-value: 5.8e-36)"
                     /gene_kind="biosynthetic-additional"
                     /inference="ab initio prediction:AMIGene:2.0"
                     /locus_tag="XBJ1_3900"
                     /operon="XBJ1_operon0701"
                     /product="acylating ketosynthases, acylation of the
                     XclA-derived xenolcyloins with acetyl-, propionyl- or
                     maleonyl-CoA"
                     /protein_id="CBJ83018.1"
                     /transl_table=11
                     /translation="MENNISIISAAGILPPGNIIIHPEDNIRNEFSAPGEVQLSRSRTL
                     WRLEHKKDLIELMKVSLLAAVKQVQMDISDIDYLILSQVWSDNILGDEAGRLARELKLS
                     CPVVSINVGTSGGATGLEIATAMFANSEFHNIAVIAGCNYSHWFSMSDPARTLLSDGAA
                     CLVLSRKQGMTVTGCHTLSTAHYDVLKFNEGPERYVYYKPKGGEYIFNNMKETIYQCCN
                     KVCQSNGMSLNEVSAFYVYDPSDWVASAAAEALGVGKDKIISIFHKYGSLGPAQSFFGF
                     MEMQDNKNLTDSDWVIVMGLGPSTTATAVLFRWQNIPCNVYYYDHKTQLSNPMLPSGVT
                     QNI"
     operon          complement(5405..8123)
                     /operon="XBJ1_operon0701"
     gene            complement(6426..8123)
                     /locus_tag="XBJ1_3901"
                     /operon="XBJ1_operon0701"
     CDS             complement(6426..8123)
                     /EC_number="2.2.1.6"
                     /codon_start=1
                     /db_xref="EnsemblGenomes-Gn:XBJ1_3901"
                     /db_xref="EnsemblGenomes-Tr:CBJ83019"
                     /db_xref="GOA:D3V5U0"
                     /db_xref="InterPro:IPR011766"
                     /db_xref="InterPro:IPR012000"
                     /db_xref="InterPro:IPR012001"
                     /db_xref="InterPro:IPR029035"
                     /db_xref="InterPro:IPR029061"
                     /db_xref="UniProtKB/TrEMBL:D3V5U0"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1055:pyruvate oxidase/decarboxylase (Score: 304.8;
                     E-value: 2e-92)"
                     /gene_kind="biosynthetic-additional"
                     /inference="ab initio prediction:AMIGene:2.0"
                     /locus_tag="XBJ1_3901"
                     /operon="XBJ1_operon0701"
                     /product="S-selective acyloin-like condensation enzyme"
                     /protein_id="CBJ83019.1"
                     /transl_table=11
                     /translation="MSVNIAKALVKLLEDCEVKAAFGVSGGFIAPIWQELTESEKIKLF
                     HCRHESGGAFSASEFSLCHQVPAVAFATAGPGISNALTGLRAAKLDGAKVIFISSITSV
                     ASSGKWSLQETTVQDIDGLCIPDGHGYFDEIIIINQKDDYAHVESKLRKGLNKKDGYVV
                     GIFLTTKVQQEIIDYENDEALSLSHDDLDENAKRHSREIADLLVNENAVFWAGFGARHA
                     SALLTQIAIKTNSRVISTPRGKGIFDEKHSLYAGTSGLGSDSESINKTLHCPLLSAVII
                     MGSRLGELSSSYAQNNLKKVKVYYIGLNAQEIKGNLPSHTVLIDSDIETFLTSIDTCLA
                     EKVIPSSHIKAISAPHDSHKCYSDAAKDVIHPLDVMSVVQEIAIDMFDCYVASEAGNSF
                     VWTNRYLKFSNPLRYRVSTAYGAMGHYACGLVGMAASKERCAVGIIGDGAMLMSNEVST
                     AVRFGLPAIWLVMNDSGYNMCRQGQELLGYPPLDCSIPQVDFAVFGQSIGATGYNVRNK
                     KELREALIHAIEEKKPAVINAFIDKYEIPPLGDRVETFRKLKEELDGK"
ORIGIN
        1 atgagtaatt tacccgtaat tgttggtttg ggtggtatca atgcggccgg aagaagttct
       61 ggattccaca gctataaacg cattgtgtca gacagtctca gcgacgagat catgcaagat
      121 acatggctcg atttatgtca tcgaatgggc attgttaaaa atacagtatc ggttacagat
      181 gcccatatcg agagtgccaa aaacggcaca ctgatcagaa aaataacgca cttcgatacg
      241 caaaaagtat cttctgtaac cagtgcgggt cagttgccgg aaggatttga agttggtgat
      301 ttatataacg caaaccatca tccgcgcggt ttacgtctga cagtctatgg agcctcggat
      361 ttactcagtt caattggcat ttcatggcca gatatcgcca aattggtgga acccgatcaa
      421 atttctgttt atgccagtag cgctctgggt cagatagacc gattttcatt ggcaggttta
      481 attggcaacc cacagaatgg cacacgtatt agttccaaaa tgctagcgct ttcccttgct
      541 gacatgccgg caaattttat taatagctat attatcaata gtatcggcaa cacatcagct
      601 aatctaggtg cctgtgcaag ctttctgtat aacctcaaac agggcgtcaa tgatatcaaa
      661 caaggtaagg caaagatcag tttagtcgga tgctctgaag cagctatcgt ccctgaaatt
      721 atcgaagggt ttcgagttat gggcgctctc gcagaagacc atcaactatg taaactggat
      781 ggaaccgata ttgttaacaa ccgccgtgct acccgaccat tttcaactaa tgttggattt
      841 accattgccg aatctgcgca attcgtatta ctcatgagtg acgatcttgc tttacagtgt
      901 ggtgccaaca tccttggcgc tgtgcctgat gttttcgtca atgcggatgc caataaaaaa
      961 tcaatatcct cacccggaat tggtaactac attaccatga tgaaagcagc ctccctagct
     1021 gaccatctac tggatggcaa attacagtat tcttacgttc aggcacatgg tactggaaca
     1081 ccacagaacc gagtcactga aagtcatatc attaatgaag ttgccaaagt ttttggactc
     1141 aaatgctggg atgtcaccgc cataaaatcg tatgtaggac attccatcgc cgcctctgcg
     1201 ggcgatcaat tagcctgtac attgggggtt tggcagtacg gatggatccc tggtattaaa
     1261 accatcgatc acattgccga ggatgtacat gcaacaaatc tgaatatttt gatgcagaat
     1321 aagtttgcag gcgagcacgg tgaggagatg cgtgccacaa tcatcaatac caaaggattc
     1381 ggtggcaata acgccagtgc agttatttta tctccacagc aaaccatgca gatgctgaac
     1441 aaaaaacacg gtagctccgc tgtctacaca tatcatcagc gtaatcaaat tgttaaacgt
     1501 ataagtgaag atcaggatcg agcaatttgt cgtggtgaag aatcggttgt ttacaatttc
     1561 ggcaacgcag tgatgcaatc atcagatata aaactttcac gtcaggaagt gaaattatca
     1621 ggatataatc acaccataaa gttgccgaat gcagaggaat tcagtgcatt cttgtgagaa
     1681 agccataggg aatagccaag tacagtgcag tattcaagcg ttattttatg gctttactgc
     1741 ctgccatata aaactacgcc tcaaatcata ataaattaac gatgccctgt gttacagcaa
     1801 attgccgcta ttcgtggtgc cgtcaatgga ctaatggcgg gtgtccttga aagccattta
     1861 cgtgaagaac tgacaaatac cgagcaaaca ccagaagcac agaaagcctc gatcgaagat
     1921 gccgtttctc tgatccgaac ttatcttcgc tgatacccca attagcttta ttaatccata
     1981 tccgcgaaca tataacactg cctattcaaa aggagagttt atgaaatcac gagccgctgt
     2041 tgcattcggg ccgggccagc cccttgaaat tgttgaaatt gatgttgcac cgcctcaggc
     2101 cggagaggtt ctggttaaaa tcagccatac cggtgtgtgt catacagatg ccttcaccct
     2161 gtcaggggat gatccggaag gcgtatttcc cgtcatactc gggcatgaag gcgcaggcgt
     2221 agtcgttgag gtgggcgcag gcgttaccag cgtcaaaccc ggtgatcatg ttatccctct
     2281 ttataccgca gaatgtggag agtgcctgtt ctgcaaatcc gggaaaacca acctgtgtgt
     2341 cgccgtgcgg gcaactcagg gaaaaggtgt catgccggat ggcacaactc gtttttccta
     2401 taatggacag cctatttatc attatatggg atgctccaca ttcagcgaat acaccgttgt
     2461 cgccgaagtc tcactggcaa aaatcaatcc ggaagccaac catgaagaaa tatgcctgct
     2521 gggttgtggt gtcactaccg gcattggcgc tgtgcacaat actgcgaaag tgcaatctgg
     2581 tgactctgtt gctgtctttg ggctcggcgg tattggcctt gccgtgatcc aaggtgctcg
     2641 tcaggcaaaa gcaggcagaa tatttgctat tgataccaat ccggcaaaat ttgaactggc
     2701 caaacagttc ggtgcaaccg actgcctgaa cccgaatgat tacgataaac ctattcagca
     2761 ggtcattatc gaaatgacag aatggggggt ggatcatacc ttcgagtgta ttggtaatgt
     2821 caatgtcatg cgtgccgcac tcgaaagtgc gcaccggggc tgggggcaat ctgtcattat
     2881 tggtgtagcg ggtgccggac aggaaatctc cacccggcca ttccaactgg tcaccggccg
     2941 ttcatggcgc ggaactgctt ttggcggagt caaaggccgc agtcagttgc ctaaaatggt
     3001 ggaagaggca atgaaaggtg aaattgagtt aaaacctttt gtgacccaca ccttaccact
     3061 tgagcgcatc aatgaagcat tcaacctgat gcatgaggga aaatccattc gtaccgtcat
     3121 tcattactaa gtcgtattgc ggaaattaaa aaccgcgctg tgaaaggagt gaacctgtat
     3181 gttttacaga gaggaaaaaa tggagaggat tgaacgccgc gcttgttttg ggggatggca
     3241 ggatgtttat cagcacgatt cgaccgagct tggctgtacc atgagttttg ctgtctatct
     3301 tcctcctcag gctgaacatc agaaattacc ggtgctgtac tggctctcgg ggctaacatg
     3361 caatgaacag aatttcatca ctaaagcggg cgctcaacgc tatgctgccg aacagggtat
     3421 tatccttgtc gctccagata ccagcccgcg tggtgagaac gttgcggatg atgatgctta
     3481 tgatttgggt cagggagccg ctttctatct caatgcaaca caagaacctt gggcaccgca
     3541 ctatcgcatg tacgattatg tggtgtcaga gttaccggca ttgatcgaag cacattttcc
     3601 agtaacagag gatcgcgcta ttagcggcca ctctatggga ggtcatggcg cactgacaat
     3661 cgcgctacgc aatccggatc gttatcacag tgtatcggca ttctcgccca ttgttgcccc
     3721 ctctcaagtt ccctggggag agaaagcttt tcgtgcttat ctgggtgatg atcgtgacac
     3781 atggaaagcc tatgatacca tcaggttgat cgccaatagt gctaaaccct tacatttgtt
     3841 gattgatatc ggtaatgatg atccgtttct tgcagaacag ttacgccctg aattgctgaa
     3901 agaggcatgc gaaaaggccg gacagcctta tacactgaat cttcgcacgg gttatgatca
     3961 tagctactac tttgtcgcca gttttatcgg tgagcatatc gcatatcatg ctgaggtatt
     4021 gaagggctgc tgtgctgata attgatggat tactgcaagt taagacaaaa cgcctcgcaa
     4081 tttagcgggg cgttagataa taacatcatt taatattgca ttaatacagc gatactttgc
     4141 cagccagcac caatcgtcca gaaaatcagg aaatcacccc ggacaatttt ttttctttcc
     4201 agcgtttcat aaagtgcaac aaatgggcta ttggttgcag tgtaaccata ctcatcacca
     4261 ataaataatg ccttatcctg atccacacca agttcttcac agagtcgtcg aatgttactt
     4321 acagaaaatt gtgaaaacat aaatccctta atatcagcag gaactaaatt atgtcgtgaa
     4381 agtaacaatt ggatagattc gaatgcggcg gtaatacaga tatcatcatc aaagggggtg
     4441 aatttgactt gtgcagaaac atcatgccgg tgaatatttg ataatccaca tgcagggaaa
     4501 agtgaattat cgattactga ggtttgtata cgaaattctg agtctataaa accattgccc
     4561 tgttcagttt tatgaaggat taccgctaca gccgactctg caaaacatga gtggtagacc
     4621 ggtgcattac tgctgtgagc cccaagatag tcgctgccta caaccagtgc aagctggcat
     4681 gacggacttg ccatcatcgc cctggaaacc atttctaccg caactaataa ccccgcacaa
     4741 ttggcattca tgtcaaatgc caaagccctt tctccgcctc caatagcatg atgtattttg
     4801 agcgccgttg aaggaatgag atattctggc gtttgagaag caaacacgat gaagtctaga
     4861 tccttagcct gacatcccag ccgctgaata gcattattag atgctgcaac tgacatcgtg
     4921 agtgttgtat cagatgaatc acggatcagg taacgatttt tatggccaag cgcattcagc
     4981 aaaccactca tatcaatgcc ttgggcggca tagtgttcta taaaccaatt attattaacc
     5041 gaagttggag gatgccaaat tcctaacgat gcaatcgcta ctcttgtcat aattgctcct
     5101 atttataatc gtagtcatta gaaatacctg atttatacta aatagtttca tcggcaggga
     5161 ttaaagttat aagaaactta cggacgttcc tcattttttt aatgtcactc tccgagaaaa
     5221 atcgaacaat tttgcttgcc gaattaatga taattttcaa atcgtaaatt ctgcatttta
     5281 aagttaatgg gtatacatat ataaagccat gttttaatac atactagcac cctataatca
     5341 agcatcaggc tcatcccaat ctcgactatt aacacataga catgatcagt tttgcctgaa
     5401 tcaattaaat attttgagtc acaccactag gtaacattgg attacttagc tgtgtcttat
     5461 gatcataata atatacattg caaggaatat tctgccatcg aaatagaaca gcagtcgcag
     5521 tggtcgaagg gcccaatccc ataacaatga cccaatcaga gtcagtcaaa tttttattat
     5581 cctgcatttc cataaaaccg aaaaagctct gtgctggccc caaacttcca tatttgtgaa
     5641 aaatagagat aattttatct ttccctacgc ccaacgcttc tgcagctgca ctggcaaccc
     5701 aatcgctcgg gtcataaacg taaaaagcgc tgacctcatt tagactcatt ccgtttgatt
     5761 gacacacttt attacagcac tggtaaatcg tctccttcat attattaaat atatattcac
     5821 cccccttcgg tttatagtag acataacgtt caggtccttc attaaatttc aatacatcgt
     5881 aatgtgcagt actcaaagta tgacaacccg tcactgtcat accttgtttt cggctaagta
     5941 ctaagcatgc agcaccatca cttaacaaag tcctcgcggg atcgctcatt gagaaccaat
     6001 gcgaataatt acaccccgca ataacagcga tgttatgaaa ttcagagtta gcaaacatag
     6061 cagtggcgat ttccagtcca gttgcaccac cacttgttcc gacattaatt gacaccaccg
     6121 gacaggatag ctttagttct ctggccagtc gtccggcctc atcgcccaaa atgttatcag
     6181 accatacttg gctaagaatc agataatcaa tatctgaaat atccatctgt acctgtttta
     6241 ctgctgctaa caaactgact ttcattaatt caattaaatc ttttttatgc tctaaacgcc
     6301 ataaagtgcg tgatcgagat aactgcactt caccgggtgc gctgaattca ttacgtatgt
     6361 tatcttctgg gtgaataata atgtttcccg gtggcaggat acctgccgcc gaaataattg
     6421 agatgttatt ttccatccag ctcttccttt aatttcctga aagtttcaac tctatcaccg
     6481 agaggaggga tctcatattt atcaataaat gcattaatta cggcaggttt cttttcttca
     6541 attgcatgaa taagggcttc acgtaattct tttttattcc ttacgttata acctgtcgct
     6601 ccaatagact gtccaaatac agcaaagtca acttgaggta tactgcagtc aagtggcgga
     6661 taacctaata gctcctgccc ctgtctgcac atattgtaac cggaatcatt catcacaagc
     6721 cagatagcag gtaatccgaa tctgactgcc gtacttactt cattcgacat cagcattgcg
     6781 ccatcaccta tgatacctac tgcacagcgc tcttttgatg cagccattcc taccaatcca
     6841 caagcgtagt gccccatggc gccataagct gtacttacac gatatctcaa tggattcgaa
     6901 aacttcaggt agcgattagt ccagacaaag gaatttcccg cttctgaagc aacataacaa
     6961 tcgaacatat cgatagctat ttcctgaacc acactcatca catcaagcgg gtggatcaca
     7021 tcttttgctg catctgaata gcatttatga ctgtcatgtg gtgctgaaat ggccttaatg
     7081 tgactggaag gtattacttt ctcagccaag caggtatcaa tagaagtgag aaatgtttca
     7141 atatcgctgt caatgagaac agtatgcgag ggcagattcc ctttaatttc ctgtgcattt
     7201 agacctatat aataaacttt aaccttctta aggttatttt gggcatagga tgaactcagc
     7261 tcacccaatc tgcttcccat aatgataaca gctgacaata acggacaatg taatgtttta
     7321 ttaatacttt ctgaatccga tcctaaacca ctggttccgg cataaagact atgtttttca
     7381 tcaaagatcc ctttcccccg cggagtagat atgacccgtg aatttgtttt tatagcaatc
     7441 tgtgtcaaca atgcagaagc atgccgagca ccaaatcctg cccaaaaaac agcattttca
     7501 ttgacgagca aatcggctat ttcccgtgaa tgacgtttcg cattttcgtc taaatcatca
     7561 tgagataagg aaagcgcctc atcattttca taatcgatga tttcctgctg cacttttgtt
     7621 gtcaaaaata taccaaccac gtaaccgtct ttcttattta atcctttcct taatttgctc
     7681 tcgacgtgag cgtaatcatc cttttggttt atgatgatga tttcatcaaa ataaccgtgt
     7741 ccatcaggga tacacagtcc atctatatct tgtactgtag tttcctgtag gctccacttt
     7801 cctgaagagg caacagatgt gattgatgag ataaaaatga cctttgcacc atctaacttt
     7861 gctgctctta acccagttaa tgcattactt attcccggac ccgctgtagc aaaagcgacg
     7921 gctggaacct gatgacataa actgaattca gatgcagaaa aggctcctcc cgactcatgt
     7981 ctacagtgaa atagttttat tttttctgat tccgttaatt cctgccatat aggtgcaata
     8041 aaccccccgg aaaccccaaa tgccgcttta acctcacaat cctcaagcaa tttaactaaa
     8101 gctttcgcaa tattaactga cat
//
