LOCUS       BGC0000194             21283 bp    DNA     linear   CON 06-FEB-2015
DEFINITION  Streptomyces coelicolor A3(2) complete genome.
ACCESSION   BGC0000194
VERSION     BGC0000194
KEYWORDS    .
SOURCE      Streptomyces coelicolor A3(2)
  ORGANISM  Streptomyces coelicolor A3(2)
            Bacteria; Actinobacteria; Streptomycetales; Streptomycetaceae;
            Streptomyces; Streptomyces albidoflavus group.
COMMENT     ##antiSMASH-Data-START##
            Version      :: 6.2.0-924c3663(changed)
            Run date     :: 2022-11-07 17:39:54
            NOTE: This is a single region extracted from a larger record!
            Orig. start  :: 0
            Orig. end    :: 21283
            ##antiSMASH-Data-END##
FEATURES             Location/Qualifiers
     gene            complement(1..441)
                     /gene="SCO5071"
                     /gene_synonym="SCBAC20F6.14c"
     CDS             complement(1..441)
                     /codon_start=1
                     /db_xref="UniProtKB/TrEMBL:Q7AKI2"
                     /gene="SCO5071"
                     /gene_synonym="SCBAC20F6.14c"
                     /note="SCBAC20F6.14c, ORFA hydroxylacyl-CoA dehydrogenase,
                     len: 146 aa; identical to previously sequenced TR:Q53925
                     (EMBL:X62373) Streptomyces coelicolor hydroxylacyl-CoA
                     dehydrogenase ORFA, 146 aa"
                     /product="hydroxylacyl-CoA dehydrogenase"
                     /protein_id="CAC37459.1"
                     /transl_table=11
                     /translation="MTITALPTGLYAEVLSFYGHQMQKLDGRDFAGYAATFTEDGEFRH
                     SPSLPAAHTRAGITAVLEDFHRKFDARKIQRRHWFDHTALSQASDGSITATSYCLVLTV
                     HADVKAPEFGPSCLVHDVLVRGADGELLLRSRHVTHDHVFPA"
     protocluster    1..21283
                     /aStool="rule-based-clusters"
                     /category="PKS"
                     /contig_edge="True"
                     /core_location="[15992:18616]"
                     /cutoff="20000"
                     /detection_rule="(t2ks and t2clf)"
                     /neighbourhood="35000"
                     /product="T2PKS"
                     /protocluster_number="1"
                     /t2pks_malonyl_elongations="7 (Score: 743.5; E-value:
                     1.2e-226)"
                     /t2pks_molecular_weights="acetyl-CoA_7 (Da): 325.334"
                     /t2pks_product_classes="benzoisochromanequinone"
                     /t2pks_starter_units="acetyl-CoA (Score: 0.0; E-value: 0)"
                     /tool="antismash"
     proto_core      15993..18616
                     /aStool="rule-based-clusters"
                     /tool="antismash"
                     /cutoff="20000"
                     /detection_rule="(t2ks and t2clf)"
                     /neighbourhood="35000"
                     /product="T2PKS"
                     /protocluster_number="1"
                     /t2pks_malonyl_elongations="7 (Score: 743.5; E-value:
                     1.2e-226)"
                     /t2pks_molecular_weights="acetyl-CoA_7 (Da): 325.334"
                     /t2pks_product_classes="benzoisochromanequinone"
                     /t2pks_starter_units="acetyl-CoA (Score: 0.0; E-value: 0)"
     cand_cluster    1..21283
                     /SMILES=""
                     /candidate_cluster_number="1"
                     /contig_edge="True"
                     /detection_rules="(t2ks and t2clf)"
                     /kind="single"
                     /product="T2PKS"
                     /protoclusters="1"
                     /tool="antismash"
     subregion       1..21283
                     /aStool="externally annotated by: MIBiG"
                     /contig_edge="True"
                     /label="BGC0000194"
                     /subregion_number="1"
                     /tool="antismash"
     region          1..21283
                     /candidate_cluster_numbers="1"
                     /contig_edge="True"
                     /product="T2PKS"
                     /region_number="1"
                     /rules="(t2ks and t2clf)"
                     /subregion_numbers="1"
                     /tool="antismash"
     misc_feature    515..1033
                     /gene="SCO5072"
                     /gene_synonym="SCBAC20F6.15"
                     /note="Pfam match to entry PF02737 3HCDH_N,
                     3-hydroxyacyl-CoA dehydrogenase, NAD binding domain, score
                     78.20, E-value 1.7e-19"
     gene            515..1438
                     /gene="SCO5072"
                     /gene_synonym="SCBAC20F6.15"
     CDS             515..1438
                     /codon_start=1
                     /db_xref="GOA:Q7AKI1"
                     /db_xref="InterPro:IPR006108"
                     /db_xref="InterPro:IPR006176"
                     /db_xref="InterPro:IPR008927"
                     /db_xref="InterPro:IPR013328"
                     /db_xref="InterPro:IPR016040"
                     /db_xref="InterPro:IPR022694"
                     /db_xref="UniProtKB/TrEMBL:Q7AKI1"
                     /gene="SCO5072"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1095:3-hydroxybutyryl-CoA dehydrogenase (Score: 202.3;
                     E-value: 1.5e-61)"
                     /gene_functions="biosynthetic-additional (t2pks) KR (Score:
                     159.4; E-value: 3.1e-49)"
                     /gene_kind="biosynthetic-additional"
                     /gene_synonym="SCBAC20F6.15"
                     /note="SCBAC20F6.15, ORF1 hydroxylacyl-CoA dehydrogenase,
                     len: 307 aa; identical to previously sequenced TR:Q53926
                     (EMBL:X62373) Streptomyces coelicolor hydroxylacyl-CoA
                     dehydrogenase ORF1, 307 aa. Contains Pfam matches to
                     entries PF02737 3HCDH_N, 3-hydroxyacyl-CoA dehydrogenase,
                     NAD binding domain and PF00725 3HCDH, 3-hydroxyacyl-CoA
                     dehydrogenase, C-terminal domain. Contains possible
                     hydrophobic membrane spanning region"
                     /product="hydroxylacyl-CoA dehydrogenase"
                     /protein_id="CAC37460.1"
                     /transl_table=11
                     /translation="MSTVTVIGAGTIGLGWINLFSARGLTVRVNSRRPDVRRVVHEALE
                     LFSPGRVDELAARIEYEPDVGRAVAGADVVSENAPDDLPLKQRLFAEIGAAAPDHALVL
                     SSTSKLLPDELSRDMPGPGRLVVAHPFNPPHIVPLVEVVRGERTDPEAVERTLAFLASV
                     GRTPVVVRRALPGFAANRLQSALLRESIHLVLEGVVTVEELDRIVTDSIGLRWSTIGPF
                     HAFHLGGGPGGLRKWLEHLGSGLEQGWRGLGQPALTPQAVEALVAQTEAAYGHRPYAEL
                     VRDRDDRHLAVLAALERTEQPQEETK"
     misc_feature    1040..1348
                     /gene="SCO5072"
                     /gene_synonym="SCBAC20F6.15"
                     /note="Pfam match to entry PF00725 3HCDH, 3-hydroxyacyl-CoA
                     dehydrogenase, C-terminal domain, score -8.40, E-value
                     0.048"
     regulatory      1425..1429
                     /gene="SCO5072"
                     /gene_synonym="SCBAC20F6.15"
                     /regulatory_class="ribosome_binding_site"
     gene            1435..2424
                     /gene="SCO5073"
                     /gene_synonym="SCBAC20F6.16"
     CDS             1435..2424
                     /NRPS_PKS="Domain: PKS_ER (15-327). E-value: 2.9e-54.
                     Score: 176.1. Matches aSDomain:
                     nrpspksdomains_SCO5073_PKS_ER.1"
                     /codon_start=1
                     /db_xref="GOA:Q7AKI0"
                     /db_xref="InterPro:IPR002085"
                     /db_xref="InterPro:IPR002364"
                     /db_xref="InterPro:IPR011032"
                     /db_xref="InterPro:IPR013149"
                     /db_xref="InterPro:IPR013154"
                     /db_xref="InterPro:IPR016040"
                     /db_xref="UniProtKB/TrEMBL:Q7AKI0"
                     /gene="SCO5073"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) ADH_N"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) ADH_zinc_N"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1028:crotonyl-CoA reductase / alcohol dehydrogenase
                     (Score: 285.6; E-value: 7.9e-87)"
                     /gene_kind="biosynthetic-additional"
                     /gene_synonym="SCBAC20F6.16"
                     /note="SCBAC20F6.16, ORF2, possible oxidoreductase, len:
                     329 aa; identical to previously sequenced TR:Q53927
                     (EMBL:X62373) Streptomyces coelicolor genes for
                     hydroxylacyl-CoA dehydrogenase ORF2, 329 aa. Contains Pfam
                     match to entry PF00107 adh_zinc, Zinc-binding
                     dehydrogenases and match to Prosite entry PS01162 Quinone
                     oxidoreductase / zeta-crystallin signature"
                     /product="putative oxidoreductase"
                     /protein_id="CAC37461.1"
                     /sec_met_domain="ADH_N (E-value: 2.3e-09, bitscore: 27.7,
                     seeds: 66, tool: rule-based-clusters)"
                     /sec_met_domain="ADH_zinc_N (E-value: 2.3e-29, bitscore:
                     92.6, seeds: 86, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MMRAVQFDRYGDPDVLYVAERPVPEPGPGQVRIAVDAVSVGHAQT
                     QMRREAFPAPMWRPVFPVVLGGDVVGRITAVGPGVTALRPGDRVGAFTLYGAYAEQVVV
                     DAVTVVPVPEELDAAEAAVLPGTGLIALGILRTGRLRKGETVLIHAAAGGVGHIAVQLA
                     RAAGAGLIIGTAGAAAKREFARATGADAVVDHRSAHWADEVRELTGGRGPDLILDGIGA
                     EVLEQGVGLLAPGGRLVFYGSSGGELAIPKVSVMDLIGIKYVTGFALSAWRGGRPQEYE
                     AGVAELTRLLAEGQVTSAVHARLPLERAAEAHAVVEARAQLGRVVLVP"
     misc_feature    1477..2421
                     /gene="SCO5073"
                     /gene_synonym="SCBAC20F6.16"
                     /note="Pfam match to entry PF00107 adh_zinc, Zinc-binding
                     dehydrogenases, score 276.60, E-value 3.3e-79"
     aSDomain        1480..2415
                     /aSDomain="PKS_ER"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_SCO5073_PKS_ER.1"
                     /evalue="2.90E-54"
                     /label="SCO5073_PKS_ER.1"
                     /locus_tag="SCO5073"
                     /protein_end="327"
                     /protein_start="15"
                     /score="176.1"
                     /tool="antismash"
                     /translation="LYVAERPVPEPGPGQVRIAVDAVSVGHAQTQMRREAFPAPMWRPV
                     FPVVLGGDVVGRITAVGPGVTALRPGDRVGAFTLYGAYAEQVVVDAVTVVPVPEELDAA
                     EAAVLPGTGLIALGILRTGRLRKGETVLIHAAAGGVGHIAVQLARAAGAGLIIGTAGAA
                     AKREFARATGADAVVDHRSAHWADEVRELTGGRGPDLILDGIGAEVLEQGVGLLAPGGR
                     LVFYGSSGGELAIPKVSVMDLIGIKYVTGFALSAWRGGRPQEYEAGVAELTRLLAEGQV
                     TSAVHARLPLERAAEAHAVVEARAQLGRVVL"
     CDS_motif       1861..1923
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_SCO5073_0001"
                     /evalue="7.50E-09"
                     /label="PKSI-ER_m5"
                     /locus_tag="SCO5073"
                     /protein_end="163"
                     /protein_start="142"
                     /score="27.9"
                     /tool="antismash"
                     /translation="GETVLIHAAAGGVGHIAVQLA"
     misc_feature    1861..1926
                     /gene="SCO5073"
                     /gene_synonym="SCBAC20F6.16"
                     /note="PS01162 Quinone oxidoreductase / zeta-crystallin
                     signature"
     regulatory      2477..2482
                     /regulatory_class="ribosome_binding_site"
     gene            2491..3135
                     /gene="SCO5074"
                     /gene_synonym="SCBAC20F6.17"
     CDS             2491..3135
                     /codon_start=1
                     /db_xref="UniProtKB/TrEMBL:Q9ADD7"
                     /gene="SCO5074"
                     /gene_synonym="SCBAC20F6.17"
                     /note="SCBAC20F6.17, possible dehydratase, len: 214 aa;
                     identical to previously sequenced TR:Q53928 (EMBL:X62373)
                     Streptomyces coelicolor ORF 3, 214 aa. Similar to TR:Q56172
                     (EMBL:L37334) putative dehydratase from granaticin
                     biosynthesis cluster of Streptomyces violaceoruber Tu22
                     (221 aa) fasta scores; opt: 349, Z-score: 400.9, E():
                     1.1e-14, 35.465% identity (37.195% ungapped) in 172 aa
                     overlap."
                     /product="putative dehydratase"
                     /protein_id="CAC37462.1"
                     /transl_table=11
                     /translation="MTSSLHHAIRLTTASAIALGGLVTLGTSAHAASVAVPYECRTWVQ
                     GNTHPVYDYARGFDVSVPASVRAGKKFKATYDPDPITAFAEYNQIVNDVRIAYRIPDGA
                     KVHKVRLTGGSGLGDSDVRVQVKGRDIVVSASGPFQGGVEFDLPTLKVTYKAPKTTGPL
                     NFVSGGSGYEDPGFYWYRYQPILDEWGPFECFPDPAKPEAVLASTQVKKHK"
     regulatory      3160..3163
                     /regulatory_class="ribosome_binding_site"
     gene            3169..4089
                     /gene="SCO5075"
                     /gene_synonym="ORF4"
                     /gene_synonym="SCBAC20F6.18"
                     /gene_synonym="SCBAC28G1.01"
     CDS             3169..4089
                     /NRPS_PKS="Domain: PKS_ER (19-251). E-value: 1.1e-34.
                     Score: 111.8. Matches aSDomain:
                     nrpspksdomains_SCO5075_PKS_ER.1"
                     /codon_start=1
                     /db_xref="GOA:Q8CJS3"
                     /db_xref="InterPro:IPR002085"
                     /db_xref="InterPro:IPR002364"
                     /db_xref="InterPro:IPR011032"
                     /db_xref="InterPro:IPR013154"
                     /db_xref="InterPro:IPR016040"
                     /db_xref="UniProtKB/TrEMBL:Q8CJS3"
                     /gene="SCO5075"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) ADH_N"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) ADH_zinc_N"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1028:crotonyl-CoA reductase / alcohol dehydrogenase
                     (Score: 232.3; E-value: 1.3e-70)"
                     /gene_kind="biosynthetic-additional"
                     /gene_synonym="ORF4"
                     /gene_synonym="SCBAC20F6.18"
                     /gene_synonym="SCBAC28G1.01"
                     /note="SCBAC28G1.01, possible oxidoreductase, previously
                     sequenced as ORF4, len: 167 aa; identical to C-terminal
                     region of previously sequenced TR:Q53929 (EMBL:X62373)
                     Streptomyces coelicolor ORF4, 306 aa; fasta scores: opt:
                     1029 Z-score: 1146.7 bits: 219.4 E(): 2.9e-56; 95.808%
                     identity in 167 aa overlap. Contains match to Prosite entry
                     PS01162 Quinone oxidoreductase / zeta-crystallin signature;
                     SCBAC20F6.18, ORF4, possible oxidoreductase, len: 170 aa;
                     identical to N-terminal region of the previously sequenced
                     TR:Q53929 (EMBL:X62373) Streptomyces coelicolor ORF 4, 306
                     aa. Contains match to Prosite entry PS01162 Quinone
                     oxidoreductase / zeta-crystallin signature"
                     /product="putative oxidoreductase"
                     /protein_id="CAD55222.1"
                     /sec_met_domain="ADH_N (E-value: 2.2e-14, bitscore: 43.9,
                     seeds: 66, tool: rule-based-clusters)"
                     /sec_met_domain="ADH_zinc_N (E-value: 1.5e-13, bitscore:
                     41.5, seeds: 86, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MPKAVAIHQFGGPDVLGLVDVPEPVPGPGQVTVRVRAAGVNGFDC
                     RVRSGGMRGRYPVEFPQIIGNEFAGVVERTGPEATGFAPGDEVLGFAVLQSGTELLAVG
                     ADQITVKPPELSWEVAGSLSAVGQTADIALAELRVGPGDTVLVHAAAGGVGSLAVQLVR
                     ERGGTAIGSAGEHNHDYLRSLGALPVAYGPGFADRVRALAPNGVDAALDCHGGPEALAV
                     SLELVADRARIATVANFRAAAQEGIVMPRVVRSAERLAALAALCAEGRLRPHVEAVLPF
                     AKAAEAHHRLEQGHVRGKLVLVPDL"
     aSDomain        3226..3921
                     /aSDomain="PKS_ER"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_SCO5075_PKS_ER.1"
                     /evalue="1.10E-34"
                     /label="SCO5075_PKS_ER.1"
                     /locus_tag="SCO5075"
                     /protein_end="251"
                     /protein_start="19"
                     /score="111.8"
                     /tool="antismash"
                     /translation="DVPEPVPGPGQVTVRVRAAGVNGFDCRVRSGGMRGRYPVEFPQII
                     GNEFAGVVERTGPEATGFAPGDEVLGFAVLQSGTELLAVGADQITVKPPELSWEVAGSL
                     SAVGQTADIALAELRVGPGDTVLVHAAAGGVGSLAVQLVRERGGTAIGSAGEHNHDYLR
                     SLGALPVAYGPGFADRVRALAPNGVDAALDCHGGPEALAVSLELVADRARIATVANFRA
                     AAQEGIVMPR"
     CDS_motif       3358..3396
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_SCO5075_0001"
                     /evalue="3.80E-03"
                     /label="PKSI-ER_m2"
                     /locus_tag="SCO5075"
                     /protein_end="76"
                     /protein_start="63"
                     /score="10.3"
                     /tool="antismash"
                     /translation="IGNEFAGVVERTG"
     CDS_motif       3517..3549
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_SCO5075_0002"
                     /evalue="9.70E+00"
                     /label="PKSI-ER_m2"
                     /locus_tag="SCO5075"
                     /protein_end="127"
                     /protein_start="116"
                     /score="0.1"
                     /tool="antismash"
                     /translation="WEVAGSLSAVG"
     misc_feature    3586..4102
                     /note="previously sequenced DNA fragment. EMBL:X62373
                     S.coelicolor genes for hydroxyacyl-CoA dehydrogenase"
     CDS_motif       3592..3651
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_SCO5075_0003"
                     /evalue="4.80E-08"
                     /label="PKSI-ER_m5"
                     /locus_tag="SCO5075"
                     /protein_end="161"
                     /protein_start="141"
                     /score="25.4"
                     /tool="antismash"
                     /translation="GDTVLVHAAAGGVGSLAVQL"
     misc_feature    3592..3657
                     /gene="SCO5075"
                     /gene_synonym="ORF4"
                     /gene_synonym="SCBAC20F6.18"
                     /gene_synonym="SCBAC28G1.01"
                     /note="PS01162 Quinone oxidoreductase / zeta-crystallin
                     signature"
     misc_feature    4068..9467
                     /note="previously sequenced DNA fragment. EMBL:X58833.1
                     S.coelicolor 6 actVA region genes of the actinorhodin
                     biosynthetic gene cluster"
     gene            4086..5687
                     /gene="SCO5076"
                     /gene_synonym="actVA1"
                     /gene_synonym="SCBAC28G1.02"
     CDS             4086..5687
                     /codon_start=1
                     /db_xref="GOA:Q7AKH9"
                     /db_xref="InterPro:IPR001411"
                     /db_xref="InterPro:IPR011701"
                     /db_xref="InterPro:IPR016196"
                     /db_xref="InterPro:IPR020846"
                     /db_xref="UniProtKB/TrEMBL:Q7AKH9"
                     /gene="SCO5076"
                     /gene_functions="transport (smcogs) SMCOG1005:Drug
                     resistance transporter, EmrB/QacA (Score: 349.2; E-value:
                     4.5e-106)"
                     /gene_kind="transport"
                     /gene_synonym="actVA1"
                     /gene_synonym="SCBAC28G1.02"
                     /note="SCBAC28G1.02, actVA1, probable integral membrane
                     protein, len: 533 aa; identical to previously sequenced
                     TR:Q53903 (EMBL:X58833) Streptomyces coelicolor 6 ActVA
                     region genes of the actinorhodin biosynthetic gene cluster,
                     ActVA1, 533 aa. Contains possible hydrophobic membrane
                     spanning regions"
                     /product="integral membrane protein"
                     /protein_id="CAC44189.1"
                     /transl_table=11
                     /translation="MTANPGRPGGPADQGHPRRWAILGVLVLSLVGIILDNTVLNVTLR
                     TLTDPEQGLGASHSQVEWVLSAYTLAFAATLFTWGVLGDRLGRRRVLLLGLGLFGLSSL
                     AGAYAGSPEQLIAARACMGVSGAAVLPSTLATIAAVFPLRERPKALGIWAASVGFALGI
                     GPVTGGILLAHFWWGSVLLVNVPLMAGCLVAVVLVVPETRGTAGRRVDAAGLLLSIAGV
                     VPLVYAIIEAGRSGGVTRPAVWAAGLAGLGLLLVFLWHERRTPEPSLELGFFRMKAFST
                     AVAAVGFVSFAMMGFLFFSAFYLQSVRGYTPLQAGGCTVALAVANVVCGPLSTVLVRSI
                     GPRNVCAAGMLAVTASLCGVTFVTQHAPVWLILVLFAALGAGVACVMPTAAVSIMNAIP
                     REKAGVASAMNNTVRQLGGALGVAVLGSLMGAAYRRGIEDELAVLPPSARHQAGESLDA
                     TLLAATRLGESGLVGPARQAFLDAMHLAAGAAAAVALVGALAVLRWLPSSVTTPTPPAG
                     AVPGREHSDHLKVQGS"
     regulatory      5677..5681
                     /gene="SCO5076"
                     /gene_synonym="actVA1"
                     /gene_synonym="SCBAC28G1.02"
                     /regulatory_class="ribosome_binding_site"
     gene            5689..6084
                     /gene="SCO5077"
                     /gene_synonym="actVA2"
                     /gene_synonym="SCBAC28G1.03"
     CDS             5689..6084
                     /codon_start=1
                     /db_xref="GOA:Q93IZ3"
                     /db_xref="InterPro:IPR011576"
                     /db_xref="InterPro:IPR012349"
                     /db_xref="InterPro:IPR024031"
                     /db_xref="UniProtKB/TrEMBL:Q93IZ3"
                     /gene="SCO5077"
                     /gene_synonym="actVA2"
                     /gene_synonym="SCBAC28G1.03"
                     /note="SCBAC28G1.03, actVA2, hypothetical protein, len: 131
                     aa; identical to previously sequenced TR:Q53904
                     (EMBL:X58833) Streptomyces coelicolor 6 ActVA region genes
                     of the actinorhodin biosynthetic gene cluster, ActVA2, 131
                     aa"
                     /product="hypothetical protein"
                     /protein_id="CAC44190.1"
                     /transl_table=11
                     /translation="MPFTPDELEYYASQNLGRLATVAPDGQPQANPVSFRVNTETGTID
                     IGGHNLTASKKFRNVTKHDQVAFVVDDLISTQPWNVRGIEVRGRAEALTDAQPPHPYFG
                     TAMIRIHPKRIITWGLGGDAAQRGRDV"
     regulatory      6166..6170
                     /regulatory_class="ribosome_binding_site"
     gene            6179..7024
                     /gene="SCO5078"
                     /gene_synonym="actVA3"
                     /gene_synonym="SCBAC28G1.04"
     CDS             6179..7024
                     /codon_start=1
                     /db_xref="UniProtKB/TrEMBL:Q93IZ2"
                     /gene="SCO5078"
                     /gene_synonym="actVA3"
                     /gene_synonym="SCBAC28G1.04"
                     /note="SCBAC28G1.04, actVA3, hypothetical protein, len: 281
                     aa; identical to previously sequenced TR:Q53905
                     (EMBL:X58833) Streptomyces coelicolor 6 ActVA region genes
                     of the actinorhodin biosynthetic gene cluster, ActVA3, 281
                     aa"
                     /product="hypothetical protein"
                     /protein_id="CAC44191.1"
                     /transl_table=11
                     /translation="MSTEIFHEEFAGGLVTEGPGAPWRLRPVDGLEAGDGLVRGGPDGL
                     VVVPSAAHPGTRRPAFTEPKPGPDGTPLHLRWGAFTTGGTTGGTAGARAAFTAVPGERL
                     SVRAEMGLRGFGLRSHPYDDVTEPDADARLGAGGLISVDLESGIIFDFFLTHSRLYAVY
                     ERLALRPDAEFAAFTYCVPVADRTPGTLHRLEVGYDVAAGTAHWTADGQEVLSVDRIGF
                     RALDARWLRRDNGGREEAVRPRGLSFGLGLFLERHFGQGVRLSVRRLSVLTSPAGSRDS
                     "
     regulatory      7036..7041
                     /regulatory_class="ribosome_binding_site"
     gene            7049..7933
                     /gene="SCO5079"
                     /gene_synonym="actVA4"
                     /gene_synonym="SCBAC28G1.05"
     CDS             7049..7933
                     /codon_start=1
                     /db_xref="InterPro:IPR008030"
                     /db_xref="InterPro:IPR016040"
                     /db_xref="UniProtKB/TrEMBL:Q7AKH8"
                     /gene="SCO5079"
                     /gene_functions="other (smcogs) SMCOG1199:NmrA family
                     protein (Score: 161.2; E-value: 6.5e-49)"
                     /gene_functions="biosynthetic-additional (t2pks) DIMER
                     (Score: 426.8; E-value: 8.7e-131)"
                     /gene_kind="biosynthetic-additional"
                     /gene_synonym="actVA4"
                     /gene_synonym="SCBAC28G1.05"
                     /note="SCBAC28G1.05, actVA4, conserved hypothetical
                     protein, len: 294 aa; identical to previously sequenced
                     TR:Q53906 (EMBL:X58833) Streptomyces coelicolor 6 ActVA
                     region genes of the actinorhodin biosynthetic gene cluster,
                     ActVA4, 294 aa"
                     /product="conserved hypothetical protein"
                     /protein_id="CAC44192.1"
                     /transl_table=11
                     /translation="MPDENKPVLVLGATGKQGGSAARYLLERGWTVRAFVRDPGAPKAK
                     ELRELGASLHTGDLEDAGSVRAAMKGAYGVFSIQTPMTPAGVEGEERQGKICADAARDL
                     GVQHYVHSSVGGAERPEGVNWRLSKLAIEQRIQENALRFTFLRPSYFMENLNHDMSPLV
                     MEDGVLTFRRGLGPANTLQMISGPDIGYFAADAFDDPDTFGGAKIELAGDELTGEQIAA
                     AFGRHTGLPARFVSVPIPELHRTGFEWQAISYTWLNGIGYHADIPTLRARFPQLLTLDQ
                     WLARTGWTPRDPA"
     regulatory      7918..7921
                     /gene="SCO5079"
                     /gene_synonym="actVA4"
                     /gene_synonym="SCBAC28G1.05"
                     /regulatory_class="ribosome_binding_site"
     gene            7930..9075
                     /gene="SCO5080"
                     /gene_synonym="actVA5"
                     /gene_synonym="SCBAC28G1.06"
     CDS             7930..9075
                     /codon_start=1
                     /db_xref="GOA:Q7AKH7"
                     /db_xref="InterPro:IPR006091"
                     /db_xref="InterPro:IPR009075"
                     /db_xref="InterPro:IPR009100"
                     /db_xref="InterPro:IPR013107"
                     /db_xref="InterPro:IPR013786"
                     /db_xref="UniProtKB/TrEMBL:Q7AKH7"
                     /gene="SCO5080"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1191:acyl-CoA dehydrogenase type 2 (Score: 382.5;
                     E-value: 2.8e-116)"
                     /gene_functions="biosynthetic-additional (t2pks) OXY
                     (Score: 44.7; E-value: 2.1e-14)"
                     /gene_kind="biosynthetic-additional"
                     /gene_synonym="actVA5"
                     /gene_synonym="SCBAC28G1.06"
                     /note="SCBAC28G1.06, actVA5, possible hydrolase, len: 381
                     aa; identical to previously sequenced TR:Q53907
                     (EMBL:X58833) Streptomyces coelicolor 6 ActVA region genes
                     of the actinorhodin biosynthetic gene cluster, ActVA5, 381
                     aa and similar to TR:Q9F0J3 (EMBL:AF218066) Streptomyces
                     arenae hydrolase NcnH, 405 aa; fasta scores: opt: 1391
                     Z-score: 1521.5 bits: 290.3 E(): 3.9e-77; 56.522% identity
                     in 368 aa overlap"
                     /product="putative hydrolase"
                     /protein_id="CAC44193.1"
                     /transl_table=11
                     /translation="MSEDTMTQERPSLTAHARRIAELAGKRAADAEQQRRLSPDVVDAV
                     LRAGFAAHFVPVAHGGRAATFGELVEPVAVLGEACASTAWYASLTASLGRMAAYLPDEG
                     QAELWSDGPDALIVGALMPLGRAEKTPGGWHVSGTWPFVSVVDHSDWALICAKVGEEPW
                     FFAVPRQEYGIVDSWYPMGMRGTGSNTLVLDGVFVPDARACTRAAIAAGLGPDAEAICH
                     TVPMRAVNGLAFALPMLGAARGAAAVWTSWTAGRLAGPTGQNAVSSQDRVVYEHTLARA
                     TGEIDAAQLLLERVAAVADAGSATGVLVGRGARDCALAAELLTAATDRLFASAGTRAQA
                     QDSPMQRLWRDVHAAGSHIGLQFGPGAALYAGELLRRSNDG"
     regulatory      9055..9060
                     /gene="SCO5080"
                     /gene_synonym="actVA5"
                     /gene_synonym="SCBAC28G1.06"
                     /regulatory_class="ribosome_binding_site"
     gene            9068..9409
                     /gene="SCO5081"
                     /gene_synonym="actVA6"
                     /gene_synonym="SCBAC28G1.07"
     CDS             9068..9409
                     /codon_start=1
                     /db_xref="InterPro:IPR007138"
                     /db_xref="InterPro:IPR011008"
                     /db_xref="UniProtKB/TrEMBL:Q7AKH6"
                     /gene="SCO5081"
                     /gene_synonym="actVA6"
                     /gene_synonym="SCBAC28G1.07"
                     /note="SCBAC28G1.07, actVA6, hypothetical protein, len: 113
                     aa; identical to previously sequenced TR:Q53908
                     (EMBL:X58833) Streptomyces coelicolor 6 ActVA region genes
                     of the actinorhodin biosynthetic gene cluster, ActVA6, 113
                     aa and similar to SW:TCMH_STRGA (EMBL:M80674) Streptomyces
                     glaucescens tetracenomycin polyketide synthesis hydroxylase
                     TcmH, 112 aa; fasta scores: opt: 193 Z-score: 247.6 bits:
                     51.0 E(): 3.5e-06; 43.210% identity in 81 aa overlap"
                     /product="hypothetical protein"
                     /protein_id="CAC44194.1"
                     /transl_table=11
                     /translation="MAEVNDPRVGFVAVVTFPVDGPATQHKLVELATGGVQEWIREVPG
                     FLSATYHASTDGTAVVNYAQWESEQAYRVNFGADPRSAELREALSSLPGLMGPPKAVFM
                     TPRGAILPS"
     misc_feature    9183..15082
                     /note="previously sequenced DNA fragment. EMBL:M64683
                     Streptomyces coelicolor ORF1-4 (actII) gene, complete cds"
     gene            complement(9375..10154)
                     /gene="SCO5082"
                     /gene_synonym="actII-1"
                     /gene_synonym="SCBAC28G1.08c"
     CDS             complement(9375..10154)
                     /codon_start=1
                     /db_xref="GOA:Q7AKH5"
                     /db_xref="InterPro:IPR001647"
                     /db_xref="InterPro:IPR003012"
                     /db_xref="InterPro:IPR004111"
                     /db_xref="InterPro:IPR009057"
                     /db_xref="InterPro:IPR011075"
                     /db_xref="InterPro:IPR015893"
                     /db_xref="UniProtKB/TrEMBL:Q7AKH5"
                     /gene="SCO5082"
                     /gene_functions="regulatory (smcogs) SMCOG1239:TetR family
                     transcriptional regulator (Score: 204; E-value: 4.2e-62)"
                     /gene_kind="regulatory"
                     /gene_synonym="actII-1"
                     /gene_synonym="SCBAC28G1.08c"
                     /note="SCBAC28G1.08c, actII-1, probable transcriptional
                     regulatory protein, len: 259 aa; identical to previously
                     sequenced TR:Q53901 (EMBL:M64683) Streptomyces coelicolor
                     ORF1-4 (ActII), 259 aa. Contains Pfam matches to entries
                     PF00440 tetR, Bacterial regulatory proteins, tetR family
                     and PF02909 tetR_C, Tetracyclin repressor, C-terminal
                     all-alpha domain and possible helix-turn-helix motif at
                     residues 53..73 (+2.78 SD)"
                     /product="putative transcriptional regulatory protein"
                     /protein_id="CAC44195.1"
                     /transl_table=11
                     /translation="MSRSEEGRPMPEEIPVPPWRRPKKAPPRMPLTQDRIVVTALGILD
                     AEGLDALSMRRLAQELKTGHASLYAHVGNRDELLDLVFDIVLTEVEVPEPEPGRWAEQV
                     KEMCRSLRRMFLAHRDLARIAIDRVPLGPNGMVGMERTMNLLRSGGLHDELAAYGGDLL
                     STFVTAEALEQSSRNPGTEQGREQAGVFADQLHGYLKSLPATSFPNLVHLAGPITSLDS
                     DRRFELGLEIIIAGLLAGAGEAADDQVRTAGSPPAES"
     misc_feature    complement(9432..9875)
                     /gene="SCO5082"
                     /gene_synonym="actII-1"
                     /gene_synonym="SCBAC28G1.08c"
                     /note="Pfam match to entry PF02909 tetR_C, Tetracyclin
                     repressor, C-terminal all-alpha domain, score 217.30,
                     E-value 2.2e-61"
     misc_feature    complement(9909..10049)
                     /gene="SCO5082"
                     /gene_synonym="actII-1"
                     /gene_synonym="SCBAC28G1.08c"
                     /note="Pfam match to entry PF00440 tetR, Bacterial
                     regulatory proteins, tetR family, score 43.50, E-value
                     1.3e-09"
     regulatory      complement(10160..10163)
                     /regulatory_class="ribosome_binding_site"
     gene            10265..12001
                     /gene="SCO5083"
                     /gene_synonym="actII-2"
                     /gene_synonym="SCBAC28G1.09"
     CDS             10265..12001
                     /codon_start=1
                     /db_xref="GOA:P46105"
                     /db_xref="InterPro:IPR011701"
                     /db_xref="InterPro:IPR016196"
                     /db_xref="InterPro:IPR020846"
                     /gene="SCO5083"
                     /gene_functions="transport (smcogs) SMCOG1005:Drug
                     resistance transporter, EmrB/QacA (Score: 361.7; E-value:
                     7.4e-110)"
                     /gene_kind="transport"
                     /gene_synonym="actII-2"
                     /gene_synonym="SCBAC28G1.09"
                     /note="SCBAC28G1.09, actII-2, probable actinorhodin
                     transporter, len: 578 aa; identical to previously sequenced
                     SW:AC22_STRCO (EMBL:M64683) Streptomyces coelicolor
                     probable actinorhodin transporter ActII-2, 578 aa. Contains
                     possible hydrophobic membrane spanning regions and a
                     leucine TTA codon, possible target for bldA regulation"
                     /product="putative actinorhodin transporter"
                     /protein_id="CAC44196.1"
                     /transl_table=11
                     /translation="MSSVEADEPDRATAPPSALLPEDGPGPDGTAAGPPPYARRWAALG
                     VILGAEIMDLLDGTVMNVAAPAVRADLGGSLSVIQWITVGYTLAFAVLLVVGGRLGDIY
                     GRKRMFVVGAVGFTAASVLCSVAAGPEMLTAARFLQGGLGALMIPQGLGLIKQMFPPKE
                     TAAAFGAFGPAIGLGAVLGPIVAGFLVDADLFGTGWRSVFLINLPIGVAVIVGAVLLLP
                     EGKAPVRPKFDVVGMALVTSGLTLLIFPLVQGRERGWPAWAFVLMLAGAAVLVGFVAHE
                     LRQERRGGATLIELSLLRRSRYAAGLAVALVFFTGVSGMSLLLALHLQIGLGFSPTRAA
                     LTMTPWSVFLVVGAILTGAVLGSKFGRKALHGGLVVLALGVLIMLLTIGDQAGGLTSWE
                     LVPGIAVAGLGMGIMIGLLFDIALADVDKQEAGTASGVLTAVQQLGFTVGVAVLGTLFF
                     GLLGSQATASVDDGASRARTELAAAGASTTEQDRLLADLRVCLRESASQQDSERTPDSC
                     RNLQQARPAVAEATARAWRTAHTENFSTAMVRTLWVVIALLAVSFALAFRLPPKPREEE
                     GF"
     misc_feature    10319..10321
                     /gene="SCO5083"
                     /gene_synonym="actII-2"
                     /gene_synonym="SCBAC28G1.09"
                     /note="TTA leucine codon; possible target for bldA
                     regulation"
     misc_feature    10319..10321
                     /note="tta leucine codon, possible target for bldA
                     regulation"
                     /tool="antismash"
     gene            12001..14136
                     /gene="SCO5084"
                     /gene_synonym="actII-3"
                     /gene_synonym="SCBAC28G1.10"
     CDS             12001..14136
                     /codon_start=1
                     /db_xref="GOA:Q53902"
                     /db_xref="InterPro:IPR000731"
                     /db_xref="InterPro:IPR004869"
                     /gene="SCO5084"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1035:MMPL domain-containing transport protein (Score:
                     567.2; E-value: 8.1e-172)"
                     /gene_kind="biosynthetic-additional"
                     /gene_synonym="actII-3"
                     /gene_synonym="SCBAC28G1.10"
                     /note="SCBAC28G1.10, actII-3, putative membrane protein,
                     len: 711 aa; identical to previously sequenced
                     SW:MMLA_STRCO (EMBL:M64683) Streptomyces coelicolor
                     putative membrane protein ActII-3, 711 aa. Contains
                     possible hydrophobic membrane spanning regions"
                     /product="putative membrane protein"
                     /protein_id="CAC44197.1"
                     /transl_table=11
                     /translation="MTRTLLSWPGGRRLKWLVLAAWIGLLIVLQPLAGKLGDVESNDAA
                     AWLPGNAESTEVLELSEKFQPADTSPTVIVYDRPSGITAADEAKARADATHFADGTGVV
                     GEPYGPVRSDDGKALRTVVNVHLGKDGWEGLNAAAKDMRAIARPSAPDGLGVHVTGPTG
                     YAADSAESFSSADFKLTLVTLLIVVTILVVTYRSPLLWLLPMISAGMSLVISQAIVYLL
                     AKNAGLTVNAQTAMILTVLVLGAATDYALLLVARYREELRRHEDRHEAMAVALRRAGPA
                     IVASAATVAVSMLVLLLAALNSTKGLGPVCAVGVLVGLLSMMTLLPALLVIFGRWVFWP
                     ARPKHGTEPDVTRGLWSRIARLVSGRPRAVWVTTSLLLGAVATLAVTLNADGLQQKDGF
                     KTKPESVVGEEILTRHFPAGSGEPMVVIAKGASADQVHAALETVPGVIEVAPPQVKDGL
                     AYVEATLGAGADSPAAMRSVTAARETLARLDGAQARVGGSSAVVHDMREASSRDRGLII
                     PVILAVVFCILALLLRALVAPLLLIASVVLSFFTALGLAALFFNHVFDFAGADSAFPLW
                     VFVFLVALGVDYNIFLVTRIKEESDRLGTRQGALKGLTSTGGVITAAGLVLAGTFAALA
                     TLPLVFIAELGFTVAVGVLLDTMIVRSVLVTALTLDVGRWMWWPHPLARREDPSEDPAV
                     SGMPDSIDSEASTTASR"
     stem_loop       14143..14185
                     /note="possible stem loop. Score 60: 20/20 (100%) matches,
                     0 gaps"
     misc_feature    14149..14154
                     /note="AseI site matched ATTAAT. Divides the AseI-K and the
                     AseI-N genomic restriction fragments; Cleavage site for
                     AseI restriction endonuclease AT*TAAT."
     misc_feature    complement(14149..14154)
                     /note="Cleavage site for AseI restriction endonuclease
                     AT*TAAT."
     misc_feature    14175..14180
                     /note="AseI site matched ATTAAT. Divides the AseI-K and the
                     AseI-N genomic restriction fragments; Cleavage site for
                     AseI restriction endonuclease AT*TAAT."
     misc_feature    complement(14175..14180)
                     /note="Cleavage site for AseI restriction endonuclease
                     AT*TAAT."
     gene            14286..15053
                     /gene="SCO5085"
                     /gene_synonym="actII-4"
                     /gene_synonym="SCBAC28G1.11"
     CDS             14286..15053
                     /codon_start=1
                     /db_xref="GOA:P46106"
                     /db_xref="InterPro:IPR001867"
                     /db_xref="InterPro:IPR005158"
                     /db_xref="InterPro:IPR011991"
                     /db_xref="InterPro:IPR016032"
                     /gene="SCO5085"
                     /gene_functions="regulatory (smcogs)
                     SMCOG1041:transcriptional regulator, SARP family (Score:
                     269.4; E-value: 1.2e-81)"
                     /gene_kind="regulatory"
                     /gene_synonym="actII-4"
                     /gene_synonym="SCBAC28G1.11"
                     /note="SCBAC28G1.11, actII-4, actinorhodin cluster
                     activator protein, len: 255 aa; identical to previously
                     sequenced SW:AC24_STRCO (EMBL:M64683) Streptomyces
                     coelicolor actinorhodin operon activator protein ActII-4,
                     255 aa. Contains a leucine TTA codon, possible target for
                     bldA regulation"
                     /product="actinorhodin cluster activator protein"
                     /protein_id="CAC44198.1"
                     /transl_table=11
                     /translation="MRFNLLGRVHVITDAGCVIPLKSSKATQLLVLLLLRRHEVVGSGV
                     LIEELWADHPPRSAMTTLQTYVYHTRRLLGEHRVTSDDRELVLTQPPGYFALIDEDELD
                     VAVAERLIRTGGRLLEENRLEEALASLDAGLDLWRGPALSTVPCGRVLESNIAHLEELR
                     LFGMQLRIDANWRLGRIGPMIPELRSLVISHPLNETLHAKLMGALCQMGRRAEALESYR
                     NLRRILSDELGVDPTPEIQRMHMEILNGEKVLV"
     misc_feature    14298..14300
                     /gene="SCO5085"
                     /gene_synonym="actII-4"
                     /gene_synonym="SCBAC28G1.11"
                     /note="TTA leucine codon; possible target for bldA
                     regulation"
     misc_feature    14298..14300
                     /note="tta leucine codon, possible target for bldA
                     regulation"
                     /tool="antismash"
     misc_feature    complement(14987..16021)
                     /note="previously sequenced DNA fragment. EMBL:M19536
                     S.coelicolor actIII gene, complete cds."
     stem_loop       15056..15120
                     /note="possible stem loop. Score 96: 32/32 (100%) matches,
                     0 gaps"
     gene            complement(15127..15912)
                     /gene="SCO5086"
                     /gene_synonym="actIII"
                     /gene_synonym="SCBAC28G1.12c"
     CDS             complement(15127..15912)
                     /NRPS_PKS="Domain: PKS_KR (7-126). E-value: 3.2e-12. Score:
                     38.5. Matches aSDomain: nrpspksdomains_SCO5086_PKS_KR.1"
                     /codon_start=1
                     /db_xref="GOA:P16544"
                     /db_xref="InterPro:IPR002198"
                     /db_xref="InterPro:IPR002347"
                     /db_xref="InterPro:IPR016040"
                     /db_xref="InterPro:IPR020904"
                     /db_xref="PDB:1W4Z"
                     /db_xref="PDB:1X7G"
                     /db_xref="PDB:1X7H"
                     /db_xref="PDB:1XR3"
                     /db_xref="PDB:2RH4"
                     /db_xref="PDB:2RHC"
                     /db_xref="PDB:2RHR"
                     /db_xref="PDB:3CSD"
                     /db_xref="PDB:3QRW"
                     /db_xref="PDB:3RI3"
                     /db_xref="PDB:4DBZ"
                     /db_xref="PDB:4DC0"
                     /db_xref="PDB:4DC1"
                     /gene="SCO5086"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) adh_short"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1001:short-chain dehydrogenase/reductase SDR (Score:
                     263.4; E-value: 3.2e-80)"
                     /gene_functions="biosynthetic-additional (t2pks) KR C9
                     (Score: 438.4; E-value: 1.9e-134)"
                     /gene_kind="biosynthetic-additional"
                     /gene_synonym="actIII"
                     /gene_synonym="SCBAC28G1.12c"
                     /note="SCBAC28G1.12c, actIII, ketoacyl reductase, len: 261
                     aa; identical to previously sequenced SW:ACT3_STRCO
                     (EMBL:M19536) Streptomyces coelicolor putative ketoacyl
                     reductase ActIII, 261 aa. Contains Pfam matches to entries
                     PF00106 adh_short, short chain dehydrogenase and PF00678
                     adh_short_C2, Short chain dehydrogenase/reductase
                     C-terminus and match to Prosite entry PS00061 Short-chain
                     dehydrogenases/reductases family signature"
                     /product="ketoacyl reductase"
                     /protein_id="CAC44199.1"
                     /sec_met_domain="adh_short (E-value: 9.1e-41, bitscore:
                     130.3, seeds: 230, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MATQDSEVALVTGATSGIGLEIARRLGKEGLRVFVCARGEEGLRT
                     TLKELREAGVEADGRTCDVRSVPEIEALVAAVVERYGPVDVLVNNAGRPGGGATAELAD
                     ELWLDVVETNLTGVFRVTKQVLKAGGMLERGTGRIVNIASTGGKQGVVHAAPYSASKHG
                     VVGFTKALGLELARTGITVNAVCPGFVETPMAASVREHYSDIWEVSTEEAFDRITARVP
                     IGRYVQPSEVAEMVAYLIGPGAAAVTAQALNVCGGLGNY"
     misc_feature    complement(15151..15243)
                     /gene="SCO5086"
                     /gene_synonym="actIII"
                     /gene_synonym="SCBAC28G1.12c"
                     /note="Pfam match to entry PF00678 adh_short_C2, Short
                     chain dehydrogenase/reductase C-terminus, score 25.80,
                     E-value 1.4e-05"
     misc_feature    complement(15334..15894)
                     /gene="SCO5086"
                     /gene_synonym="actIII"
                     /gene_synonym="SCBAC28G1.12c"
                     /note="Pfam match to entry PF00106 adh_short, short chain
                     dehydrogenase, score 302.10, E-value 6.8e-87"
     CDS_motif       complement(15382..15522)
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_SCO5086_0002"
                     /evalue="5.50E-02"
                     /label="PKSI-KR_m1"
                     /locus_tag="SCO5086"
                     /protein_end="177"
                     /protein_start="130"
                     /score="6.2"
                     /tool="antismash"
                     /translation="MLERGTGRIVNIASTGGKQGVVHAAPYSASKHGVVGFTKALGLEL
                     AR"
     misc_feature    complement(15397..15483)
                     /gene="SCO5086"
                     /gene_synonym="actIII"
                     /gene_synonym="SCBAC28G1.12c"
                     /note="PS00061 Short-chain dehydrogenases/reductases family
                     signature"
     aSDomain        complement(15535..15891)
                     /aSDomain="PKS_KR"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_SCO5086_PKS_KR.1"
                     /evalue="3.20E-12"
                     /label="SCO5086_PKS_KR.1"
                     /locus_tag="SCO5086"
                     /protein_end="126"
                     /protein_start="7"
                     /score="38.5"
                     /specificity="KR activity: inactive"
                     /specificity="KR stereochemistry: C1"
                     /tool="antismash"
                     /translation="VALVTGATSGIGLEIARRLGKEGLRVFVCARGEEGLRTTLKELRE
                     AGVEADGRTCDVRSVPEIEALVAAVVERYGPVDVLVNNAGRPGGGATAELADELWLDVV
                     ETNLTGVFRVTKQVL"
     CDS_motif       complement(15817..15885)
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_SCO5086_0001"
                     /evalue="7.40E-06"
                     /label="PKSI-KR_m1"
                     /locus_tag="SCO5086"
                     /protein_end="32"
                     /protein_start="9"
                     /score="18.6"
                     /tool="antismash"
                     /translation="LVTGATSGIGLEIARRLGKEGLR"
     regulatory      15984..15987
                     /regulatory_class="ribosome_binding_site"
     gene            15993..17396
                     /gene="SCO5087"
                     /gene_synonym="actIORF1"
                     /gene_synonym="SCBAC28G1.13"
     CDS             15993..17396
                     /NRPS_PKS="Domain: PKS_KS(Iterative-KS) (47-437). E-value:
                     5.7e-57. Score: 185.3. Matches aSDomain:
                     nrpspksdomains_SCO5087_PKS_KS.1"
                     /codon_start=1
                     /db_xref="GOA:Q02059"
                     /db_xref="InterPro:IPR014030"
                     /db_xref="InterPro:IPR014031"
                     /db_xref="InterPro:IPR016038"
                     /db_xref="InterPro:IPR016039"
                     /db_xref="InterPro:IPR018201"
                     /db_xref="PDB:1QXG"
                     /db_xref="PDB:1TQY"
                     /gene="SCO5087"
                     /gene_functions="biosynthetic (rule-based-clusters) T2PKS:
                     t2ks"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1022:Beta-ketoacyl synthase (Score: 482.4; E-value:
                     2e-146)"
                     /gene_functions="biosynthetic-additional (t2pks) KS (Score:
                     768.6; E-value: 3.5e-234)"
                     /gene_kind="biosynthetic"
                     /gene_synonym="actIORF1"
                     /gene_synonym="SCBAC28G1.13"
                     /note="SCBAC28G1.13, actIORF1, actinorhodin polyketide
                     beta-ketoacyl synthase alpha subunit, len: 467 aa;
                     identical to C-terminal region of SW:KASA_STRCO
                     (EMBL:X63449) Streptomyces coelicolor actinorhodin
                     polyketide putative beta-ketoacyl synthase 1 ActI ORF1, 424
                     aa. Previously sequenced start codon at residue 44 of this
                     sequence. Also similar to TR:CAB45606 (EMBL:AL079356)
                     Streptomyces coelicolor polyketide beta-ketoacyl synthase
                     alpha (WhiE locus) SC6G9.15, 424 aa; fasta scores: opt:
                     1706 Z-score: 1660.2 bits: 316.4 E(): 9.5e-87; 61.871%
                     identity in 417 aa overlap. Contains Pfam matches to
                     entries PF00109 ketoacyl-synt, Beta-ketoacyl synthase,
                     N-terminal domain and PF02801 ketoacyl-synt_C,
                     Beta-ketoacyl synthase, C-terminal domain and match to
                     Prosite entry PS00606 Beta-ketoacyl synthases active site"
                     /product="actinorhodin polyketide beta-ketoacyl synthase
                     alpha subunit"
                     /protein_id="CAC44200.1"
                     /sec_met_domain="t2ks (E-value: 5.5e-239, bitscore: 783.6,
                     seeds: 25, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MPLDAAPVDPASRGPVSAFEPPSSHGADDDDDHRTNASKELFGLK
                     RRVVITGVGVRAPGGNGTRQFWELLTSGRTATRRISFFDPSPYRSQVAAEADFDPVAEG
                     FGPRELDRMDRASQFAVACAREAFAASGLDPDTLDPARVGVSLGSAVAAATSLEREYLL
                     LSDSGRDWEVDAAWLSRHMFDYLVPSVMPAEVAWAVGAEGPVTMVSTGCTSGLDSVGNA
                     VRAIEEGSADVMFAGAADTPITPIVVACFDAIRATTARNDDPEHASRPFDGTRDGFVLA
                     EGAAMFVLEDYDSALARGARIHAEISGYATRCNAYHMTGLKADGREMAETIRVALDESR
                     TDATDIDYINAHGSGTRQNDRHETAAYKRALGEHARRTPVSSIKSMVGHSLGAIGSLEI
                     AACVLALEHGVVPPTANLRTSDPECDLDYVPLEARERKLRSVLTVGSGFGGFQSAMVLR
                     DAETAGAAA"
     misc_feature    16125..16874
                     /gene="SCO5087"
                     /gene_synonym="actIORF1"
                     /gene_synonym="SCBAC28G1.13"
                     /note="Pfam match to entry PF00109 ketoacyl-synt,
                     Beta-ketoacyl synthase, N-terminal domain, score 310.40,
                     E-value 2.2e-89"
     aSDomain        16134..17303
                     /aSDomain="PKS_KS"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_SCO5087_PKS_KS.1"
                     /domain_subtype="Iterative-KS"
                     /evalue="5.70E-57"
                     /label="SCO5087_PKS_KS.1"
                     /locus_tag="SCO5087"
                     /protein_end="437"
                     /protein_start="47"
                     /score="185.3"
                     /tool="antismash"
                     /translation="VVITGVGVRAPGGNGTRQFWELLTSGRTATRRISFFDPSPYRSQV
                     AAEADFDPVAEGFGPRELDRMDRASQFAVACAREAFAASGLDPDTLDPARVGVSLGSAV
                     AAATSLEREYLLLSDSGRDWEVDAAWLSRHMFDYLVPSVMPAEVAWAVGAEGPVTMVST
                     GCTSGLDSVGNAVRAIEEGSADVMFAGAADTPITPIVVACFDAIRATTARNDDPEHASR
                     PFDGTRDGFVLAEGAAMFVLEDYDSALARGARIHAEISGYATRCNAYHMTGLKADGREM
                     AETIRVALDESRTDATDIDYINAHGSGTRQNDRHETAAYKRALGEHARRTPVSSIKSMV
                     GHSLGAIGSLEIAACVLALEHGVVPPTANLRTSDPECDLDYVPLEARERK"
     misc_feature    16599..16649
                     /gene="SCO5087"
                     /gene_synonym="actIORF1"
                     /gene_synonym="SCBAC28G1.13"
                     /note="PS00606 Beta-ketoacyl synthases active site"
     misc_feature    16899..17375
                     /gene="SCO5087"
                     /gene_synonym="actIORF1"
                     /gene_synonym="SCBAC28G1.13"
                     /note="Pfam match to entry PF02801 ketoacyl-synt_C,
                     Beta-ketoacyl synthase, C-terminal domain, score 248.10,
                     E-value 1.2e-70"
     misc_feature    17393..18115
                     /gene="SCO5088"
                     /gene_synonym="actIORF2"
                     /gene_synonym="SCBAC28G1.14"
                     /note="Pfam match to entry PF00109 ketoacyl-synt,
                     Beta-ketoacyl synthase, N-terminal domain, score 279.40,
                     E-value 4.5e-80"
     gene            17393..18616
                     /gene="SCO5088"
                     /gene_synonym="actIORF2"
                     /gene_synonym="SCBAC28G1.14"
     CDS             17393..18616
                     /NRPS_PKS="Domain: PKS_KS(Modular-KS) (59-364). E-value:
                     9.5e-30. Score: 95.6. Matches aSDomain:
                     nrpspksdomains_SCO5088_PKS_KS.1"
                     /codon_start=1
                     /db_xref="GOA:Q02062"
                     /db_xref="InterPro:IPR014030"
                     /db_xref="InterPro:IPR014031"
                     /db_xref="InterPro:IPR016038"
                     /db_xref="InterPro:IPR016039"
                     /db_xref="PDB:1QXG"
                     /db_xref="PDB:1TQY"
                     /gene="SCO5088"
                     /gene_functions="biosynthetic (rule-based-clusters) T2PKS:
                     t2clf"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1093:Beta-ketoacyl synthase (Score: 652.6; E-value:
                     3.1e-198)"
                     /gene_functions="biosynthetic-additional (t2pks) CLF 7
                     (Score: 743.5; E-value: 1.2e-226)"
                     /gene_kind="biosynthetic"
                     /gene_synonym="actIORF2"
                     /gene_synonym="SCBAC28G1.14"
                     /note="SCBAC28G1.14, actIORF2, actinorhodin polyketide
                     beta-ketoacyl synthase beta subunit (also known as chain
                     length factor), len: 407 aa; identical to previously
                     sequenced SW:KASB_STRCO (EMBL:X63449) Streptomyces
                     coelicolor actinorhodin polyketide putative beta-ketoacyl
                     synthase 2 ActI ORF2, 407 aa. Contains Pfam matches to
                     entries PF00109 ketoacyl-synt, Beta-ketoacyl synthase,
                     N-terminal domain and PF02801 ketoacyl-synt_C,
                     Beta-ketoacyl synthase, C-terminal domain"
                     /product="actinorhodin polyketide beta-ketoacyl synthase
                     beta subunit"
                     /protein_id="CAC44201.1"
                     /sec_met_domain="t2clf (E-value: 1.4e-208, bitscore: 682.9,
                     seeds: 26, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MSVLITGVGVVAPNGLGLAPYWSAVLDGRHGLGPVTRFDVSRYPA
                     TLAGQIDDFHAPDHIPGRLLPQTDPSTRLALTAADWALQDAKADPESLTDYDMGVVTAN
                     ACGGFDFTHREFRKLWSEGPKSVSVYESFAWFYAVNTGQISIRHGMRGPSSALVAEQAG
                     GLDALGHARRTIRRGTPLVVSGGVDSALDPWGWVSQIASGRISTATDPDRAYLPFDERA
                     AGYVPGEGGAILVLEDSAAAEARGRHDAYGELAGCASTFDPAPGSGRPAGLERAIRLAL
                     NDAGTGPEDVDVVFADGAGVPELDAAEARAIGRVFGREGVPVTVPKTTTGRLYSGGGPL
                     DVVTALMSLREGVIAPTAGVTSVPREYGIDLVLGEPRSTAPRTALVLARGRWGFNSAAV
                     LRRFAPTP"
     aSDomain        17570..18484
                     /aSDomain="PKS_KS"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_SCO5088_PKS_KS.1"
                     /domain_subtype="Modular-KS"
                     /evalue="9.50E-30"
                     /label="SCO5088_PKS_KS.1"
                     /locus_tag="SCO5088"
                     /protein_end="364"
                     /protein_start="59"
                     /score="95.6"
                     /tool="antismash"
                     /translation="IPGRLLPQTDPSTRLALTAADWALQDAKADPESLTDYDMGVVTAN
                     ACGGFDFTHREFRKLWSEGPKSVSVYESFAWFYAVNTGQISIRHGMRGPSSALVAEQAG
                     GLDALGHARRTIRRGTPLVVSGGVDSALDPWGWVSQIASGRISTATDPDRAYLPFDERA
                     AGYVPGEGGAILVLEDSAAAEARGRHDAYGELAGCASTFDPAPGSGRPAGLERAIRLAL
                     NDAGTGPEDVDVVFADGAGVPELDAAEARAIGRVFGREGVPVTVPKTTTGRLYSGGGPL
                     DVVTALMSLREGVIAPTAGVTSVP"
     CDS_motif       18044..18082
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_SCO5088_0001"
                     /evalue="5.10E-04"
                     /label="PKSI-KS_m4"
                     /locus_tag="SCO5088"
                     /protein_end="230"
                     /protein_start="217"
                     /score="13.2"
                     /tool="antismash"
                     /translation="FDERAAGYVPGEG"
     misc_feature    18143..18604
                     /gene="SCO5088"
                     /gene_synonym="actIORF2"
                     /gene_synonym="SCBAC28G1.14"
                     /note="Pfam match to entry PF02801 ketoacyl-synt_C,
                     Beta-ketoacyl synthase, C-terminal domain, score 188.60,
                     E-value 1e-52"
     regulatory      18631..18634
                     /regulatory_class="ribosome_binding_site"
     gene            18641..18901
                     /gene="SCO5089"
                     /gene_synonym="actIORF3"
                     /gene_synonym="SCBAC28G1.15"
     CDS             18641..18901
                     /NRPS_PKS="Domain: ACP (13-81). E-value: 8.9e-14. Score:
                     43.4. Matches aSDomain: nrpspksdomains_SCO5089_ACP.1"
                     /codon_start=1
                     /db_xref="GOA:Q02054"
                     /db_xref="InterPro:IPR006162"
                     /db_xref="InterPro:IPR009081"
                     /db_xref="PDB:1AF8"
                     /db_xref="PDB:1NNZ"
                     /db_xref="PDB:2AF8"
                     /db_xref="PDB:2K0X"
                     /db_xref="PDB:2K0Y"
                     /db_xref="PDB:2KG6"
                     /db_xref="PDB:2KG8"
                     /db_xref="PDB:2KG9"
                     /db_xref="PDB:2KGA"
                     /db_xref="PDB:2KGC"
                     /db_xref="PDB:2KGD"
                     /db_xref="PDB:2KGE"
                     /gene="SCO5089"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) PP-binding"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1129:acyl carrier protein (Score: 111.2; E-value:
                     3.1e-34)"
                     /gene_functions="biosynthetic-additional (t2pks) ACP
                     (Score: 114.2; E-value: 5e-36)"
                     /gene_kind="biosynthetic-additional"
                     /gene_synonym="actIORF3"
                     /gene_synonym="SCBAC28G1.15"
                     /note="SCBAC28G1.15, actIORF3, actinorhodin polyketide
                     synthase acyl carrier protein, len: 86 aa; identical to
                     previously sequenced SW:ACPA_STRCO (EMBL:X63449)
                     Streptomyces coelicolor actinorhodin polyketide synthase
                     acyl carrier protein ActI ORF3, 86 aa. Contains Pfam match
                     to entry PF00550 pp-binding, Phosphopantetheine attachment
                     site and match to Prosite entry PS00012 Phosphopantetheine
                     attachment site"
                     /product="actinorhodin polyketide synthase acyl carrier
                     protein"
                     /protein_id="CAC44202.1"
                     /sec_met_domain="PP-binding (E-value: 3.6e-11, bitscore:
                     34.1, seeds: 164, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MATLLTTDDLRRALVECAGETDGTDLSGDFLDLRFEDIGYDSLAL
                     METAARLESRYGVSIPDDVAGRVDTPRELLDLINGALAEAA"
     misc_feature    18674..18874
                     /gene="SCO5089"
                     /gene_synonym="actIORF3"
                     /gene_synonym="SCBAC28G1.15"
                     /note="Pfam match to entry PF00550 pp-binding,
                     Phosphopantetheine attachment site, score 68.00, E-value
                     3.4e-17"
     aSDomain        18680..18883
                     /aSDomain="ACP"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_SCO5089_ACP.1"
                     /evalue="8.90E-14"
                     /label="SCO5089_ACP.1"
                     /locus_tag="SCO5089"
                     /protein_end="81"
                     /protein_start="13"
                     /score="43.4"
                     /tool="antismash"
                     /translation="LVECAGETDGTDLSGDFLDLRFEDIGYDSLALMETAARLESRYGV
                     SIPDDVAGRVDTPRELLDLINGA"
     misc_feature    18749..18796
                     /gene="SCO5089"
                     /gene_synonym="actIORF3"
                     /gene_synonym="SCBAC28G1.15"
                     /note="PS00012 Phosphopantetheine attachment site"
     regulatory      18890..18893
                     /gene="SCO5089"
                     /gene_synonym="actIORF3"
                     /gene_synonym="SCBAC28G1.15"
                     /regulatory_class="ribosome_binding_site"
     gene            18898..19848
                     /gene="SCO5090"
                     /gene_synonym="actVII"
                     /gene_synonym="SCBAC28G1.16"
     CDS             18898..19848
                     /NRPS_PKS="Domain: Polyketide_cyc (15-125). E-value:
                     1.9e-13. Score: 42.6. Matches aSDomain:
                     nrpspksdomains_SCO5090_Polyketide_cyc.1"
                     /codon_start=1
                     /db_xref="GOA:Q02055"
                     /db_xref="InterPro:IPR005031"
                     /db_xref="InterPro:IPR023393"
                     /gene="SCO5090"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1128:cyclase/dehydrase (Score: 398.5; E-value:
                     3.4e-121)"
                     /gene_functions="biosynthetic-additional (t2pks) CYC C7-C12
                     (Score: 404.0; E-value: 7.8e-124)"
                     /gene_kind="biosynthetic-additional"
                     /gene_synonym="actVII"
                     /gene_synonym="SCBAC28G1.16"
                     /note="SCBAC28G1.16, actVII, actinorhodin polyketide
                     synthase bifunctional cyclase/dehydratase, len: 316 aa;
                     identical to previously sequenced SW:CYPK_STRCO
                     (EMBL:X63449) Streptomyces coelicolor actinorhodin
                     polyketide synthase bifunctional cyclase/dehydratase ActI
                     ORF4, 316 aa"
                     /product="actinorhodin polyketide synthase bifunctional
                     cyclase/dehydratase"
                     /protein_id="CAC44203.1"
                     /transl_table=11
                     /translation="MSRPGEHRVVHTLRTQAPARRLYELVARVEDWPAVFEPTVHVQVL
                     ERGPGTERFRIWARVGGRVKTWTSRRTLDPDTLRVTFRQELTQPPIASMGGSWEFRGDG
                     DGTEVVLTHDFAAVDEAALPGLREALDANSGKELAALVALAERRQPPEELVFTFEDTLR
                     VPSGDDAYAFIERSDLWQERLPHVRKVTLTEEAAGTGPAETRDMTVQDMTMETVTTDGG
                     THTTRSIRLCVPARSIVYKQLVPPALLSGHCGAWTFGEDTVTARHTVAIDPARVEEVLG
                     KGATVADARTHLREVLGANSRATLRHAAAAAGPAS"
     aSDomain        18943..19272
                     /aSDomain="Polyketide_cyc"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_SCO5090_Polyketide_cyc.1"
                     /domain_subtype="Polyketide_cyc"
                     /evalue="1.90E-13"
                     /label="SCO5090_Polyketide_cyc.1"
                     /locus_tag="SCO5090"
                     /protein_end="125"
                     /protein_start="15"
                     /score="42.6"
                     /tool="antismash"
                     /translation="QAPARRLYELVARVEDWPAVFEPTVHVQVLERGPGTERFRIWARV
                     GGRVKTWTSRRTLDPDTLRVTFRQELTQPPIASMGGSWEFRGDGDGTEVVLTHDFAAVD
                     EAALPG"
     gene            19845..20738
                     /gene="SCO5091"
                     /gene_synonym="actIV"
                     /gene_synonym="SCBAC28G1.17"
     CDS             19845..20738
                     /codon_start=1
                     /db_xref="InterPro:IPR001279"
                     /db_xref="UniProtKB/TrEMBL:Q93IZ0"
                     /gene="SCO5091"
                     /gene_functions="resistance (resist) ClassB (Score: 89.3;
                     E-value: 1.6e-27)"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1170:metallo-beta-lactamase family protein (Score: 55;
                     E-value: 1.3e-16)"
                     /gene_functions="biosynthetic-additional (t2pks) CYC C5-C14
                     (Score: 467.3; E-value: 4.4e-143)"
                     /gene_kind="biosynthetic-additional"
                     /gene_synonym="actIV"
                     /gene_synonym="SCBAC28G1.17"
                     /note="SCBAC28G1.17, actIV, cyclase, len: 297 aa; identical
                     to previously sequenced TR:Q02057 (EMBL:X63449)
                     Streptomyces coelicolor dehydrogenase ActI ORF5, 297 aa.
                     Contains Pfam match to entry PF00753 lactamase_B,
                     Metallo-beta-lactamase superfamily"
                     /product="cyclase"
                     /protein_id="CAC44204.1"
                     /transl_table=11
                     /translation="MTVEVREVAEGVYAYEQAPGGWCVSNAGIVVGGDGALVVDTLSTI
                     PRARRLAEWVDKLAAGPGRTVVNTHFHGDHAFGNQVFAPGTRIIAHEDMRSAMVTTGLA
                     LTGLWPRVDWGEIELRPPNVTFRDRLTLHVGERQVELICVGPAHTDHDVVVWLPEERVL
                     FAGDVVMSGVTPFALFGSVAGTLAALDRLAELEPEVVVGGHGPVAGPEVIDANRDYLRW
                     VQRLAADAVDRRLTPLQAARRADLGAFAGLLDAERLVANLHRAHEELLGGHVRDAMAIF
                     AELVAYNGGQLPTCLA"
     misc_feature    19902..20456
                     /gene="SCO5091"
                     /gene_synonym="actIV"
                     /gene_synonym="SCBAC28G1.17"
                     /note="Pfam match to entry PF00753 lactamase_B,
                     Metallo-beta-lactamase superfamily, score 124.60, E-value
                     1.9e-33"
     regulatory      20739..20742
                     /regulatory_class="ribosome_binding_site"
     gene            20750..21283
                     /gene="SCO5092"
                     /gene_synonym="actVB"
                     /gene_synonym="SCBAC28G1.18"
     CDS             20750..21283
                     /codon_start=1
                     /db_xref="GOA:Q02058"
                     /db_xref="InterPro:IPR002563"
                     /db_xref="InterPro:IPR012349"
                     /gene="SCO5092"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1160:flavin reductase domain protein FMN-binding
                     (Score: 142.6; E-value: 1.4e-43)"
                     /gene_kind="biosynthetic-additional"
                     /gene_synonym="actVB"
                     /gene_synonym="SCBAC28G1.18"
                     /note="SCBAC28G1.18, actVB, actinorhodin polyketide
                     possible dimerase, len: 177 aa; identical to previously
                     sequenced SW:DIM6_STRCO (EMBL:X63449) Streptomyces
                     coelicolor actinorhodin polyketide dimerase ActI ORF6,
                     ActVB, 177 aa Contains Pfam match to entry PF01613
                     Flavin_Reduct, Flavin reductase like domain"
                     /product="actinorhodin polyketide putative dimerase"
                     /protein_id="CAC44205.1"
                     /transl_table=11
                     /translation="MAADQGMLRDAMARVPAGVALVTAHDRGGVPHGFTASSFVSVSME
                     PPLALVCLARTANSFPVFDSCGEFAVSVLREDHTDLAMRFARKSADKFAGGEFVRTARG
                     ATVLDGAVAVVECTVHERYPAGDHIILLGEVQSVHVEEKGVPAVYVDRRFAALCSAAGA
                     CPSATGRGVPAHAG"
     misc_feature    20783..21223
                     /gene="SCO5092"
                     /gene_synonym="actVB"
                     /gene_synonym="SCBAC28G1.18"
                     /note="Pfam match to entry PF01613 Flavin_Reduct, Flavin
                     reductase like domain, score 254.60, E-value 1.3e-72"
ORIGIN
        1 tcaggccggg aagacgtggt catgggtgac gtggcgggag cgcagcagca actcgccgtc
       61 cgccccccgg accaggacgt cgtgcacgag gcaactcggc ccgaactccg gcgccttgac
      121 gtcggcgtgg acggtgagca ccaggcagta gctggtcgcc gtgatcgagc cgtcggacgc
      181 ctggctcagc gccgtgtggt cgaaccagtg cctgcgctgg attttgcggg cgtcgaactt
      241 gcggtggaag tcctccagga cggcggtgat cccggcacgg gtgtgggcgg caggcagcga
      301 gggcgagtgc ctgaactcgc cgtcctcggt gaaggtcgcg gcgtagccgg cgaagtcacg
      361 gccgtccagc ttctgcatct ggtggccgta gaacgacagg acctcggcgt acaggccggt
      421 gggaagcgcg gtgatggtca tacggccacg gtcgcccggt ggcctcgaag ttccctcgag
      481 ccgggttcga gtgggcgctg ccaggctcgt cgccatgagc accgtgacag tgatcggggc
      541 gggcacgatc ggcctgggat ggatcaacct gttcagcgcc cgcgggctga ccgtacgcgt
      601 caacagccgt cggcccgacg tccggcgcgt cgtgcacgag gcgctcgagc tgttctcccc
      661 ggggcgggtg gacgagctgg cggcgcgcat cgagtacgag ccggacgtcg gccgggcggt
      721 ggccggggcg gacgtcgtct ccgagaacgc ccccgacgac ctgccgctca agcagcggtt
      781 gttcgcagag atcggagcgg ccgccccgga ccacgccctc gtgctgtcct cgacgtcgaa
      841 gctgcttccc gacgagctga gtcgggacat gccgggaccg ggccggctgg tcgtcgcgca
      901 tccgttcaac ccaccgcaca tcgttccgct ggtcgaggtg gtccgcggcg agcgcaccga
      961 cccggaggcc gtcgaacgga cactggcctt cctggcgtcg gtcgggcgga cccccgtcgt
     1021 ggtgcgcagg gcgctgcccg gcttcgcggc caaccggctg cagtcggcgc tgctgcgcga
     1081 gagcatccac ctcgtcctcg aaggcgtggt gaccgtcgag gagctcgacc ggatcgtcac
     1141 cgactcgatc ggcctgcgct ggtccaccat cgggccgttc cacgcgttcc acctgggcgg
     1201 cggtcccggc ggcctgcgca agtggctcga gcacctcggc agcggcctcg aacagggctg
     1261 gcgtgggctc ggacagcccg ccctcacccc gcaggccgtc gaggctctgg tcgcacagac
     1321 cgaagccgcc tacggacacc ggccctacgc cgaactggtc cgggaccgtg acgaccggca
     1381 cctcgccgta ctggccgccc tggagcggac cgagcagccc caggaggaga ccaagtgatg
     1441 cgtgccgtgc agttcgaccg gtacggggac cccgacgtgc tgtacgtcgc cgagcgtccc
     1501 gtccccgaac ccggccccgg ccaggtgaga atcgccgtcg acgccgtgag cgtcggccac
     1561 gcgcagaccc agatgcggcg cgaggccttc cccgcgccga tgtggcggcc cgtcttcccc
     1621 gtcgtcctcg gcggcgacgt ggtcggcagg atcaccgcgg tgggaccggg cgtcacggcc
     1681 ctgcggccgg gagaccgggt cggtgcgttc accctctacg gcgcctacgc cgagcaggtc
     1741 gtcgtcgacg ccgtcaccgt cgtacccgtg cccgaggagc tggacgccgc cgaggccgcg
     1801 gtcctcccgg gcaccggact gatcgccctc ggcatcctgc ggaccggacg actgcgcaag
     1861 ggcgagacgg tgctgatcca cgcggcggcc ggcggggtgg gccacatcgc ggtccagctc
     1921 gcccgggcgg ccggcgccgg cctgatcatc ggcaccgcgg gcgcggccgc caaacgcgag
     1981 ttcgcccgcg cgacgggcgc cgacgccgtc gtcgaccacc gctccgcaca ctgggccgac
     2041 gaggtccggg aactcaccgg ggggcgtggc cccgacctga tcctggacgg catcggcgcc
     2101 gaggtcctgg agcagggagt cggtctgctc gctccgggcg gccggctggt gttctacggc
     2161 tcgtccggcg gcgagctggc gatcccgaag gtgtcggtga tggacctcat cggcatcaag
     2221 tacgtcaccg gcttcgccct gtcggcctgg cgcggtggcc gcccgcagga gtacgaggcg
     2281 ggcgtcgccg aactcacccg actgctggcc gaaggacagg tcacgtccgc ggtgcacgcc
     2341 cggctgccgc tggagcgggc ggccgaggcg cacgccgtcg tcgaggccag ggcccagctg
     2401 ggccgggtcg tgctcgtccc ctgaaacgac caggcattcc tccgaagtgt ccaagcattc
     2461 ctgatccaag agcccgaagg agacctttcc atgacctcgt cgctgcacca cgcgatacgt
     2521 ctgaccaccg cgtccgccat cgccctgggc ggactcgtga ccctggggac cagcgcgcac
     2581 gccgcgagcg tcgccgtgcc gtacgagtgc cgcacctggg tgcagggcaa cacgcacccg
     2641 gtctacgact acgcgcgcgg cttcgacgtc agcgtgcccg cctcggtccg cgcgggcaag
     2701 aagttcaagg ccacctacga tcccgacccg atcaccgcct tcgccgagta caaccagatc
     2761 gtcaacgacg tgcggatcgc ctaccggatc ccggacggcg cgaaggtcca caaggtgcgg
     2821 ctcaccggcg gcagcggtct cggcgactcc gacgtccggg tccaggtcaa gggccgggac
     2881 atcgtcgtca gcgcctccgg ccccttccag ggcggtgtcg agttcgacct gccgacgctg
     2941 aaggtcacct acaaggcgcc gaagaccacc ggcccgctca acttcgtctc gggcggctcg
     3001 ggttacgagg accccggctt ctactggtac cgctaccagc cgatcctgga cgagtggggc
     3061 cccttcgagt gcttccccga cccggcgaag cccgaggccg tcctggccag cacccaggtc
     3121 aagaagcaca agtagacaca gcggggtcgg acgaacaatg gagaacgcat gcccaaggcc
     3181 gtagccatcc accagttcgg cgggccggac gtactgggcc tcgtcgatgt ccccgagccg
     3241 gtgccgggac cgggccaggt gaccgtccga gtgcgggccg ccggagtcaa cgggttcgac
     3301 tgccgggtgc gctccggcgg catgcgcggt cgctatccgg tcgagttccc gcagatcatc
     3361 ggcaacgagt tcgccggggt cgtcgagcgg accggaccgg aggcgaccgg gttcgcgccc
     3421 ggcgacgagg tgctcgggtt cgccgtgctt cagtccggca ccgagctgct cgccgtcggc
     3481 gcggaccaga tcaccgtgaa accgccggag ctgtcgtggg aggtcgcggg atccctctcg
     3541 gccgtcggac agaccgccga catcgccctg gccgaactgc gggtcggccc cggggacacc
     3601 gtgctcgtgc acgccgcggc cggcggcgtc ggcagcctcg ccgtccagct cgtccgggag
     3661 cggggcggca cggcgatcgg cagcgccggc gagcacaacc acgactacct gcggtcgttg
     3721 ggcgcactgc ccgtcgccta cggcccgggc ttcgccgacc gggtgcgggc cctggccccg
     3781 aacggcgtcg acgccgccct cgactgccac ggcggaccgg aagccctcgc cgtgtcgctc
     3841 gaactcgtcg cggaccgggc ccggatcgcc accgtcgcca acttccgcgc cgcggcccag
     3901 gagggcatcg tcatgccacg ggtggtgcgg tccgccgagc ggctcgccgc gctggccgca
     3961 ctctgcgccg agggccggct gcggccgcac gtcgaggccg tcctgccctt cgccaaggcg
     4021 gccgaggccc atcaccggct ggagcagggc catgtccggg gcaagctcgt cctggtgccg
     4081 gacctgtgac ggcgaacccc ggccgtccgg gcggcccggc ggaccagggc cacccgcgcc
     4141 gctgggccat cctcggggtg ctggtcctca gcctggtcgg catcatcctc gacaacaccg
     4201 tgctcaacgt gacgctgcgc accctcaccg accccgagca gggcctgggc gcctcgcaca
     4261 gccaggtgga atgggtgctc agcgcctaca ccctggcctt cgcggcgacg ctgttcacct
     4321 ggggagtgct gggcgaccga ctgggccgca ggcgggtact cctgctgggc ctcggcctgt
     4381 tcggactgtc gtccctggcc ggggcctacg ccgggtcgcc ggagcagctc atcgccgccc
     4441 gtgcctgcat gggggtgagc ggcgcggcgg tgctgccgag cacactcgcc accatcgccg
     4501 ccgtcttccc gctgcgcgag cggcccaagg ccctcgggat ctgggcggcc tcggtcggct
     4561 tcgccctcgg catcgggccc gtcaccggcg ggatactgct cgcgcacttc tggtggggct
     4621 cggtcctgct ggtcaacgtg cccctcatgg ccgggtgcct ggtcgcggtg gtgctggtgg
     4681 tgcccgagac ccggggcacg gcgggcaggc gcgtcgacgc ggccggactg ctgctctcga
     4741 tcgcgggtgt cgtgccgctc gtctacgcga tcatcgaggc cggccggagc ggcggggtca
     4801 cccggcccgc ggtctgggca gccggcctgg cgggcctcgg cctgctcctc gtgttcctgt
     4861 ggcacgagcg ccgtaccccg gaaccctcgc tggagctcgg cttcttccgg atgaaggcct
     4921 tctccaccgc cgtcgcggcc gtcggcttcg tcagcttcgc gatgatgggc ttcctcttct
     4981 tcagcgcctt ctacctgcag agcgtgcgcg gctacacacc cctgcaggcc gggggatgca
     5041 ccgtggcact ggccgtcgcg aacgtggtct gcggaccgct cagcacggtc ctggtgcgtt
     5101 cgatcggccc ccggaacgtg tgcgcggcgg gcatgctggc cgtcaccgca tcgctctgcg
     5161 gggtcacctt cgtgacccag cacgcacccg tatggctgat cctcgtcctg ttcgccgcgc
     5221 tgggggcggg cgtagcatgc gtcatgccga ccgcggccgt gtccatcatg aacgcgatcc
     5281 cacgcgagaa ggcgggcgtc gcctcggcga tgaacaacac cgtgcgccag ctgggcggcg
     5341 ccctgggcgt cgcggtgctc ggttccctca tgggcgccgc gtaccgccgc ggcatcgagg
     5401 acgagctcgc cgtactgccg ccctccgcgc ggcaccaggc cggcgagtcc ctggatgcca
     5461 ccctgctggc cgcgactagg ctgggggaga gcggacttgt cggccccgcg cgccaggcat
     5521 tcctggacgc catgcacctg gccgccgggg ccgctgccgc ggtggcgctc gtgggggccc
     5581 ttgccgtgct ccgctggctg ccctcctccg tcacgactcc gacgcccccg gcaggggccg
     5641 tgcccggccg ggagcattcc gatcacctca aggtccaagg aagctgacat gcctttcact
     5701 cctgacgagc tcgagtacta cgcctcccag aacctcggcc ggctggccac cgtggcgccc
     5761 gacggccagc cccaggccaa cccggtctcg ttccgcgtca acaccgagac cggcacgatc
     5821 gacatcggcg ggcacaacct gaccgccagc aagaagttcc gcaacgtcac caagcacgac
     5881 caggtcgcct tcgtcgtcga cgacctgatc tccacgcagc cgtggaacgt acgcggtatc
     5941 gaagtgcgcg gccgggccga ggcgctgacc gacgcgcagc cgccgcaccc ctacttcggt
     6001 accgcgatga tccgtatcca ccccaagcgc atcatcacct ggggcctcgg cggcgacgcc
     6061 gcccagcgcg gccgcgacgt ctgacccagc acccttcgac tccgcttcga gcggacctcg
     6121 acgccctctt gccaaggtgg agcccgtagg acgggtacac cacggggagg gcggctggat
     6181 gagtacagag atcttccatg aggagttcgc cggggggctg gtgaccgagg ggccgggcgc
     6241 gccgtggcgg cttcgcccgg tcgacggtct cgaggcggga gacgggctgg tccgcggggg
     6301 accggacggc ctggtggtcg tgccgagcgc cgcccacccg gggacccggc ggccggcgtt
     6361 caccgagccc aagcccgggc cggacggcac cccgctgcat ctgcggtggg gtgccttcac
     6421 caccggcggc accaccggcg gcaccgccgg cgcgcgggcg gcgttcaccg ccgtgcccgg
     6481 cgaacggctc tcggtcaggg ccgagatggg gctgcgcggc ttcggtctgc gctcccatcc
     6541 gtacgacgac gtgaccgaac ccgacgcgga cgcccggctc ggcgcgggcg gtctgatctc
     6601 ggtcgatctc gagtccggga tcatcttcga cttcttcctc acacacagcc ggctctacgc
     6661 ggtctacgag cggctcgcgc tgcggccgga cgccgagttc gcggccttca cctactgcgt
     6721 cccggtcgcg gaccgcaccc ccggcacgct ccaccggctc gaggtcggat acgacgtcgc
     6781 ggccggcacc gcccactgga cggccgacgg gcaggaggtc ctgtccgtgg accggatcgg
     6841 cttccgcgca ctggacgcgc gctggctccg gcgggacaac ggcggccgcg aggaggccgt
     6901 acggccgcgc ggactcagct tcggcctcgg gctcttcctg gagcgccact tcggccaggg
     6961 ggtgcggctg tcggtgcgaa ggctgtcggt gctcacctcg cccgccggct cccgcgactc
     7021 gtgacgacga ccaacgaaag gcactgcgat gcccgatgag aacaagcccg tactggtcct
     7081 cggcgccacc ggaaagcaag gcggctccgc ggcccggtac ctgctggaac gcggctggac
     7141 agtccgggcc ttcgtccggg accccggcgc gcccaaggcc aaggagctgc gtgagctggg
     7201 ggcgagcctg cacaccggcg acctggagga cgccggctcg gtgcgcgccg cgatgaaggg
     7261 tgcgtacggc gtgttcagca tccaaacgcc gatgacaccg gccggcgtgg agggcgagga
     7321 gcggcagggc aagatatgcg ccgacgccgc ccgcgacctc ggcgtccagc actacgtcca
     7381 cagctcggtg ggcggcgcgg aacggccgga gggcgtgaac tggcggctgt ccaagctcgc
     7441 gatcgagcag cggatccagg agaacgcgct ccggttcacc ttcctgcggc cgtcgtactt
     7501 catggagaac ctgaaccacg acatgtcgcc cctcgtcatg gaggacggcg tgctgacctt
     7561 ccggaggggg ctcgggccgg ccaacaccct gcagatgatc agcggccccg acatcgggta
     7621 cttcgcggcc gacgccttcg acgaccccga caccttcggc ggcgccaaga tcgagctggc
     7681 cggggacgag ctgaccggcg agcagatcgc ggccgcgttc ggccggcaca ccgggctgcc
     7741 cgcccgcttc gtgtcggtgc cgataccgga gctgcaccgc acggggttcg agtggcaggc
     7801 gatctcgtac acctggctca acggcatcgg ctatcacgcc gacatcccca cgctgcgcgc
     7861 ccggttcccg cagctgctca ccctcgacca gtggctggcc aggaccggct ggaccccgag
     7921 ggacccggca tgagcgagga cacgatgacc caggagcggc cgtccctgac ggcacacgcc
     7981 cgccggatcg ccgaactcgc cgggaagcgg gcggccgacg ccgaacagca gcgccggctg
     8041 agccccgacg tcgtcgacgc ggtccttcga gccggtttcg ccgcccactt cgtaccggtg
     8101 gcgcacggcg gccgggccgc gacgttcggg gagctggtgg agcccgtcgc ggtgctcggc
     8161 gaggcctgtg cctcgaccgc ctggtacgcc tcgctcacgg cgagcctcgg ccggatggcc
     8221 gcctacctgc cggacgaggg ccaggccgag ctgtggtccg acggccccga cgccctgatc
     8281 gtcggtgccc tgatgccgct gggccgggcc gagaagaccc cgggcggctg gcacgtgtcg
     8341 ggcacctggc cgttcgtcag cgtcgtggat cactccgact gggcgctgat ctgcgccaag
     8401 gtcggcgagg agccgtggtt cttcgcggtg ccgcgacagg agtacgggat cgtcgacagc
     8461 tggtacccga tgggtatgcg cggaacgggc agcaacacgc tcgtcctcga cggggtgttc
     8521 gtgccggatg cgcgggcctg cacccgtgcg gccatcgcgg caggtctcgg tccggatgcc
     8581 gaggcgatct gtcacaccgt gcccatgagg gcggtcaacg ggctggcctt cgcactgccg
     8641 atgctcggcg cggcccgcgg ggccgcggcc gtgtggacct cgtggaccgc cggaagactg
     8701 gccgggccga ccgggcagaa cgccgtctcg tcccaggacc gcgtggtgta cgagcacacg
     8761 ctggcccggg ccacgggtga gatcgacgcg gcccagctgc tgttggagcg ggtcgcggcg
     8821 gtcgccgacg ccggctcggc gaccggcgta ctggtcggcc gcggggcgcg ggactgcgcc
     8881 ctggcggcgg agctgctgac cgccgcgacc gaccggctgt tcgcctcggc gggcacccgg
     8941 gcacaggccc aggacagccc gatgcagcgc ctgtggcgcg atgtgcacgc ggcgggcagc
     9001 catatcgggc tgcagttcgg gcccggggcg gcgctgtacg ccggagagct gttgaggagg
     9061 agcaacgatg gctgaagtga acgatccccg ggtgggcttc gtcgcggtcg tcaccttccc
     9121 ggtggacggc cccgccaccc agcacaagct ggtggagctg gccaccggcg gggtgcagga
     9181 gtggatccgc gaggtgcccg gcttcctgtc ggccacgtat cacgcgagca cggacgggac
     9241 cgcggtcgtc aactacgccc agtgggagag cgagcaggcc taccgggtga acttcggcgc
     9301 cgacccgcgc tcggcggagc tgcgggaggc gctgagctcg ctgcccgggc tcatggggcc
     9361 gccgaaggcc gtgttcatga ctccgcgggg ggcgatcctg ccgtcctgac ctggtcgtcc
     9421 gcggcctcgc cggccccggc cagcaggccg gcgatgatga tctcgaggcc gagctcgaac
     9481 cggcggtcgg agtcgagcga ggtgatcggg ccggccaggt ggaccaggtt cgggaaactg
     9541 gtggccggca gtgacttcag gtagccgtgg agctggtcgg cgaacacgcc ggcctgctcc
     9601 cggccctgtt ccgttccggg gttgcgggac gactgctcca gggcctccgc cgtgacgaag
     9661 gtcgacagca ggtcgccccc gtaggcggcg agttcgtcgt gcaggccccc ggagcgcagc
     9721 aggttcatgg tgcgctccat ccccaccatc ccgttgggtc ccagcggcac ccggtcgatc
     9781 gcgatccgtg ccaggtcccg gtgggccagg aacatcctcc gcagcgaccg gcacatctcc
     9841 ttgacctgct ccgcccagcg gccgggttcc ggttccggga cctccacctc ggtcagcacg
     9901 atgtcgaaga cgaggtcgag cagctcgtcc cggttcccca cgtgcgcgta cagcgaggcg
     9961 tgtccggtct tcagctcctg cgcgagccgc cgcatgctca gggcgtcgag tccctcggcg
    10021 tcgaggatgc cgagcgccgt gacgacgatc cggtcctggg tcaggggcat gcgcggcggc
    10081 gccttcttcg gccggcgcca cggaggcacg ggaatctcct cgggcatggg cctcccttcc
    10141 tcgcttcgcg acacgtgctc ctcatcgtat ggcatgaacg ggccaccgtt tcttgacgcg
    10201 accaccgttc cattgtagaa cggtggtcgt tcgtggacca atagtcgagg acccggggga
    10261 cgccatgagt tccgttgaag ccgacgagcc ggacagggcc acggccccgc cgtcggcgtt
    10321 actgcccgag gacggccccg gaccggacgg aaccgcggcc ggacccccgc cctacgcgcg
    10381 ccgttgggcc gcgctgggag tcatcctcgg cgccgagatc atggacctgc tcgacggcac
    10441 ggtcatgaac gtggccgcgc ccgccgtccg cgcggacctg ggcggcagcc tcagcgtcat
    10501 ccagtggatc accgtcgggt acacgctcgc gttcgccgtc ctgctcgtgg tgggcggccg
    10561 gctgggcgac atctacggcc gcaagcgcat gttcgtcgtc ggcgccgtcg gcttcaccgc
    10621 ggcctccgtg ctgtgctcgg tggcggccgg tcccgagatg ctcaccgcgg cacgcttcct
    10681 tcagggcggg ctcggcgcgc tgatgattcc gcaagggctc ggtctcatca agcaaatgtt
    10741 cccgcccaag gagacggcgg cggcgttcgg cgcgttcgga cccgccatcg ggctgggcgc
    10801 cgtgctcggc ccgatcgtcg ccgggttcct ggtcgacgcc gacctgttcg gcacgggctg
    10861 gcggtccgtc ttcctgatca atctgccgat cggcgtggcc gtgatcgtcg gcgcggtcct
    10921 gctgctgccc gagggcaagg cgcccgtgcg gccgaagttc gacgtcgtcg gcatggcgct
    10981 ggtgacgtcc gggctcaccc tgctcatctt cccgctcgtc caggggcgcg aacgcggctg
    11041 gcccgcctgg gcgttcgtgc tgatgctggc cggagcggcc gtgctcgtcg gcttcgtcgc
    11101 ccacgaactg cggcaggaga ggcgcggcgg cgccacgctc atcgagctca gcctgctgcg
    11161 caggtcccgc tacgccgcgg gactggcggt ggcactggtg ttcttcaccg gcgtctccgg
    11221 aatgtcgctg ctgctcgccc tgcacctgca gatcggcctg ggcttcagcc ccaccagggc
    11281 cgcgctgacc atgacgccct ggtcggtgtt cctcgtcgtc ggcgcgatcc tgaccggggc
    11341 ggtgctggga tcgaagttcg gccgcaaggc cctgcacggc gggctcgtgg tgctggcgct
    11401 gggcgtgctg atcatgctgt tgacgatcgg cgaccaggcc ggcgggctga ccagctggga
    11461 gctcgtcccc ggtatcgccg ttgccgggct cggcatgggc atcatgatcg gactgctctt
    11521 cgacatcgcc ctggccgacg tcgacaagca ggaggccggt accgcctccg gcgtcctcac
    11581 cgcggtccag cagctcggct tcaccgtggg cgtcgcggtg ctcgggaccc tgttcttcgg
    11641 gctgctcggc tcacaggcca cggcgagcgt cgacgacggc gcgagccggg cccgcaccga
    11701 actcgccgcc gccggggcga gcacgaccga gcaggaccgg ctcctggccg acctgcgggt
    11761 gtgcctgcgg gaatcggcga gtcagcagga ctccgaacgg acgccggaca gctgccgaaa
    11821 cctccagcag gcccggccgg cggtggccga ggccacggcg cgggcctggc ggacggccca
    11881 caccgagaac ttcagcaccg cgatggtccg cacgctctgg gtggtgatcg cactgctggc
    11941 ggtctccttc gcgctggcct tccggctgcc gcccaagccg cgtgaggaag agggcttctg
    12001 atgacacgca cactgctgtc ctggcccggc ggacgccggc tcaagtggct ggtgctcgcg
    12061 gcctggatcg gtctgctgat cgtgctccag ccgctggcag ggaagctcgg cgacgtcgag
    12121 tccaacgacg ccgccgcctg gctccccggc aatgcggagt cgaccgaagt gctcgagctg
    12181 tccgagaagt tccagccggc cgacaccagc ccgaccgtga tcgtctacga ccgcccgtcc
    12241 gggatcacgg ccgccgacga ggcgaaggcg cgggccgacg ccacgcactt cgcggacggc
    12301 accggtgtgg tgggcgagcc ctacggcccg gtgcgctcgg acgacggcaa ggccctgcgc
    12361 accgtcgtca acgtccacct cggcaaggac ggctgggagg ggctcaacgc ggccgcgaag
    12421 gacatgcggg cgatcgcccg gccgagcgcc ccggacggtc tcggcgtcca cgtcacgggt
    12481 ccgaccggtt acgccgccga ttccgcagag tccttcagca gcgccgactt caagctcacc
    12541 ctggtcaccc tcctcatcgt cgtgacgatc ctcgtcgtca cctatcgcag tcccttgctc
    12601 tggctgctgc cgatgatctc cgcgggcatg tccctggtca tctcgcaggc catcgtctac
    12661 ctgctggcca agaacgcggg actcacggtc aacgcccaga cggcgatgat cctcacggtc
    12721 ctggtgctcg gcgcggccac cgactacgcg ctgttgctcg tcgcccgcta ccgcgaggag
    12781 ctgcggcggc acgaggaccg gcacgaggcc atggccgtgg cgctgcgccg ggccggtccc
    12841 gccatcgtgg ccagcgccgc caccgtcgcc gtcagcatgc tcgtcctgct gctggccgct
    12901 ctgaactcca ccaagggtct cggcccggtc tgcgccgtcg gcgtgctggt cggcctgctg
    12961 tcgatgatga cgttgctgcc cgccctgctg gtgatcttcg gacgctgggt cttctggccg
    13021 gcccggccga agcacggtac ggagcccgac gtcacccggg gtctgtggtc gcggatcgcc
    13081 cggctggtgt ccggccgtcc gcgtgccgtc tgggtcacca ccagcctgct gctgggggcg
    13141 gtggccacgc tggccgtcac cctgaacgcc gacggcctcc agcagaagga cggtttcaag
    13201 accaagccgg agtcggtggt gggcgaggag atcctgaccc ggcacttccc ggccggctcc
    13261 ggtgaaccca tggtcgtcat cgccaagggc gcctcggcgg accaggtgca cgcagctctg
    13321 gagaccgtgc ccggcgtcat cgaggtcgca ccaccacagg tgaaggacgg cctcgcctat
    13381 gtcgaggcga cgctcggcgc cggggcggac tcgccggcgg ccatgcgttc ggtcaccgcg
    13441 gcccgcgaga cactcgcccg gctggacggt gcgcaggcac gggtgggcgg cagcagcgcc
    13501 gtcgtgcacg acatgcggga ggcgtccagc cgcgaccgcg gtctgatcat tccggtgatc
    13561 ctcgccgtgg tgttctgcat cctcgcgctg ctgctgcgag cactggtggc gccgctgctg
    13621 ctgatcgcga gcgtggtgct gtccttcttc accgcgctcg gcctcgccgc cctcttcttc
    13681 aaccacgtct tcgacttcgc gggagccgat tcggccttcc ccctgtgggt cttcgtcttc
    13741 ctggtcgccc tgggcgtcga ctacaacatc ttcctcgtca cccggatcaa ggaggagagc
    13801 gaccggctcg gcacccggca gggcgcgctc aagggcctca cctcgaccgg tggcgtgatc
    13861 accgcggccg ggctggtgct ggccgggacc ttcgccgcgc tggccacgct gccgctggtc
    13921 ttcatcgccg agctcggatt cacggtcgcg gtgggcgtcc tgctcgacac catgatcgtg
    13981 cgatcggtcc tggtcaccgc gctcactctc gatgtcggcc ggtggatgtg gtggccgcac
    14041 ccgctcgccc ggcgcgagga cccttccgag gacccagccg tatcaggaat gccagattct
    14101 attgattcgg aagcctcgac cactgcctct cggtaaaatc cagcaaaaat taatcagtgc
    14161 agctcgctgc actgattaat ttttgatcaa taggagatcg cttgtgacgg caagcacatt
    14221 gaaatctgtt gagtaggcct gttattgtcg cccccaggag acggagaatc tcgacggggg
    14281 cgcagatgag attcaactta ttgggacgtg tccatgtaat caccgatgcg ggatgtgtaa
    14341 ttccgcttaa atcctcgaag gcgacccagc tcctggtgct gctgctcctc aggcggcacg
    14401 aggtggtggg atcgggggtg ctcatcgagg agttgtgggc ggaccacccg ccccgcagcg
    14461 ccatgacgac gctgcagacg tacgtgtacc acacccgccg gctgctgggg gagcaccggg
    14521 tgacgagcga cgaccgggaa ttggtcctga cccagccgcc cggctacttc gccctgatcg
    14581 acgaggacga actcgacgtc gcggtcgccg agcgtctgat ccgcaccggc ggccggctgc
    14641 tcgaggagaa ccggctcgag gaggcgctcg cctcgttgga cgcgggactg gatctctggc
    14701 gaggcccggc gctgtccacc gtaccgtgcg gccgggtgct cgaaagcaat atcgcgcacc
    14761 tggaagagct gcggcttttt ggaatgcagc tccgtatcga cgcgaattgg cggctgggca
    14821 gaatagggcc gatgattccg gaactccggt ccctggtaat ttcgcatccg ctgaacgaga
    14881 ccctgcacgc caaactgatg ggcgcgctct gtcagatggg caggcgcgcc gaggcgctgg
    14941 aatcgtatcg gaatctccgg cggatactgt ccgacgaact gggggtggat ccgacgccgg
    15001 aaatccagcg tatgcacatg gaaattctca acggtgagaa ggtgctcgtg tagcaccggt
    15061 ccgtgaacgc ggtggagccc ctcgcagcct gcgaggggct ccaccgcgtt cacggaccgg
    15121 ccggcgtcag tagttcccca gcccgccgca gacgttcagc gcctgcgcgg tgaccgcggc
    15181 cgcaccgggc ccgatcaggt acgccaccat ctccgccacc tcggacggct gcacgtaccg
    15241 gccgatcggc acgcgcgcgg tgatccggtc gaaggcctcc tcggtcgaca cctcccagat
    15301 gtccgagtag tgctcgcgca cggacgcggc catcggcgtc tcgacgaatc cggggcagac
    15361 ggcgttcacc gtgatgccgg tcctcgccag ttcgagaccg agcgccttgg tgaagccgac
    15421 cacgccgtgc ttcgaggcgg agtagggcgc ggcgtgcacc acaccctgct ttccgccggt
    15481 cgaggcgatg ttgacgattc ggcccgtgcc ccgttcgagc atgccgcccg ccttgaggac
    15541 ctgtttggtc acccggaaca cgccggtgag gttggtctcc acgacatcga gccagagttc
    15601 gtcggcgagt tcggccgtgg cgccgccgcc gggccggccc gcgttgttca ccagcacgtc
    15661 gaccggaccg taacgctcga ccaccgccgc cacgagagcc tcgatctccg ggaccgagcg
    15721 gacgtcgcag gtccgcccgt ccgcctccac gcccgcctcc cgcaactcct tcagcgtcgt
    15781 ccgcagtcct tcttcgccgc gcgcgcagac gaacacgcgc aacccctcct taccgagcct
    15841 gcgggcgatc tccagcccga ttccgctggt cgcacccgtc accagtgcga cttcggagtc
    15901 ctgcgtggcc atgtgttccc ctccctgcct cgtggtccct cacgcgctca gctttgggcg
    15961 cccggctcga gcggcggtcg aagggagatg gggtgccgct ggacgcggcg ccggtggatc
    16021 cggcatcgag gggtcccgta tcggccttcg agcctccttc gagccacggg gccgacgatg
    16081 acgacgacca ccggacgaac gcatcgaagg agctgttcgg attgaagcgc agagtcgtca
    16141 tcacgggcgt cggcgtccgc gcccccggcg ggaacggcac ccggcagttc tgggaactgc
    16201 tcacctcggg gcggacggcg acgcgccgga tctcgttctt cgacccctcg ccctaccgtt
    16261 cacaggtcgc ggcggaggcc gacttcgacc cggtcgccga gggcttcggc ccgcgggagc
    16321 tcgaccggat ggaccgggcc tcgcagttcg ccgtggcctg tgcccgggag gcgttcgccg
    16381 ccagcgggct cgacccggac accctcgacc ccgcccgggt cggggtcagc ctcggcagcg
    16441 cggtggcagc ggcgaccagc ctggagcgcg agtatctgct gctgtcggac tccggccgtg
    16501 actgggaggt cgacgcggcc tggctgtccc ggcacatgtt cgactacctg gtgcccagcg
    16561 tcatgccggc cgaggtcgcc tgggcggtcg gcgccgaggg cccggtcacg atggtctcca
    16621 ccggctgcac ctcgggcctg gactccgtcg gcaacgcggt ccgggcgatc gaggagggca
    16681 gcgccgacgt gatgttcgcg ggagccgccg acaccccgat caccccgatc gtcgtcgcct
    16741 gcttcgacgc gatccgcgcc acgacggcgc gcaacgacga cccggagcac gcctcgcggc
    16801 cgttcgacgg tacgcgggac ggcttcgtgc tggccgaagg agccgcgatg ttcgtcctgg
    16861 aggactacga cagcgcgctg gcccgcggag cccgcatcca cgccgagatc tcggggtacg
    16921 cgacgcgctg caacgcgtac cacatgacgg gcctgaaggc cgacggccgc gagatggccg
    16981 agaccatccg ggtcgccctc gacgagtccc gcacggacgc gacggacatc gactacatca
    17041 acgcgcacgg ctccggcacc cggcagaacg accgccacga gacagcggcg tacaagcgcg
    17101 ccctcggcga acacgcccgg cgcactccgg tcagctcgat caagtcgatg gtcggccact
    17161 cgctgggcgc gatcggctcg ctggagatcg cggcctgcgt actcgccctc gaacacggcg
    17221 tggtgccccc gaccgccaac ctgcgcacca gcgaccccga gtgcgatctc gactacgttc
    17281 cgctggaggc cagggagcgg aagctgcggt ccgtactcac cgtgggcagc ggcttcggcg
    17341 gcttccagag cgcgatggtg ctgcgcgacg ccgagaccgc gggggcggcc gcatgagcgt
    17401 cctcatcacc ggagtcggcg tcgtcgcacc caacggcctc ggcctggcgc cgtactggtc
    17461 ggcggtgctg gacggccgcc acggcctcgg cccggtcacc cgcttcgacg tgagccggta
    17521 cccggcgacc ctcgccggcc agatcgacga cttccacgcg ccggaccaca tcccgggccg
    17581 gttgctgccg cagacggacc cctccacacg gctcgcgctg accgccgcgg actgggccct
    17641 ccaggacgcg aaggcggacc cggagtcgct gaccgactac gacatgggcg tggtgaccgc
    17701 caacgcctgc ggtgggttcg acttcaccca ccgggagttc cgcaagctgt ggtccgaggg
    17761 ccccaagtcg gtcagcgtgt acgagtcctt cgcctggttc tacgcggtga acaccggcca
    17821 gatctccatc cggcacggta tgcgcggtcc gagcagtgcc ctggtcgccg agcaggccgg
    17881 gggcctggac gccctgggcc acgcccgccg tacgatccgc cgcggcacgc cgctggtggt
    17941 ctccggcggg gtggactcgg cactcgaccc gtggggctgg gtctcgcaga tcgccagtgg
    18001 ccggatcagc acggccaccg atccggaccg ggcgtatctg cccttcgacg agcgggcggc
    18061 cggctacgtt ccgggcgagg gcggggccat cctcgtcctg gaggacagcg ccgcggccga
    18121 ggcccgcggc cggcacgacg cgtacggcga actcgccggc tgcgcctcca ccttcgaccc
    18181 cgcccccgga tccggacggc ccgcgggcct ggaacgcgcg atccggctgg cgctgaacga
    18241 cgccgggacc ggtcccgagg acgtcgacgt cgtgttcgcc gacggcgcgg gcgtgcccga
    18301 gctggacgcc gccgaggccc gggcgatcgg ccgggtgttc ggccgcgaag gggtgcccgt
    18361 caccgtcccc aagacgacga cgggccgcct ctactccggc ggcggcccgc tcgacgtggt
    18421 caccgccctg atgtccctgc gcgaaggggt gatcgcgccg accgcgggcg tgacgtccgt
    18481 accccgggag tacggcatcg acctggtgct cggcgaaccc cgcagcacgg ccccgcgcac
    18541 cgcactggtc ctggccaggg gccgctgggg cttcaactcg gcggcggtcc tgcgccgttt
    18601 cgcaccgacc ccgtaacgac cccgagaact ggagaaagcc atggcaaccc tgctgaccac
    18661 cgacgatctg cgccgcgccc tcgtggagtg cgccggtgag acggacggga cggacctgtc
    18721 cggcgacttc ctcgacctcc gcttcgagga catcgggtac gactcgctcg ccctgatgga
    18781 gaccgcggcg cgactcgaga gccggtacgg cgtgtccata cccgacgacg tcgccggccg
    18841 cgtcgacacg ccgcgagagc tgctcgacct gatcaacggc gcactggccg aggcggcatg
    18901 agccggccgg gagaacaccg ggtggtccac accctgagga cccaggcccc ggcgcggcgg
    18961 ctctacgagc tggtcgcacg cgtcgaagac tggccggccg tcttcgaacc caccgtgcac
    19021 gtacaggtcc tggagcgcgg cccgggcacc gaacgcttcc ggatctgggc gcgcgtgggc
    19081 ggccgggtga agacctggac gtcccgccgg acgctggatc ccgacaccct gagggtgacg
    19141 ttccgccagg agctcaccca gccgcccatc gcctcgatgg gcgggagctg ggagttccgg
    19201 ggcgacggcg acggcaccga agtcgtgctg acccacgact tcgccgcggt cgacgaagcc
    19261 gccctgccgg gactgcgcga ggcgctggac gcgaacagcg ggaaggagct ggccgcgctg
    19321 gtcgcgctgg cggagcgccg gcagccgccc gaggagctgg tcttcacgtt cgaggacacg
    19381 ctccgggtgc cgtccgggga cgacgcctac gccttcatcg agcgcagcga cctgtggcag
    19441 gaacggctgc cgcacgtgcg gaaggtgaca ctcaccgagg aggcggcggg taccggcccc
    19501 gccgagacgc gggacatgac cgtccaggac atgaccatgg agacggtgac caccgacggc
    19561 ggtacccaca ccacccgttc gatccggctc tgcgtccccg cgaggagcat cgtgtacaag
    19621 cagctcgtcc cgcccgccct gctctccggg cactgcggcg cctggacctt cggcgaggac
    19681 acggtcaccg cccgccacac cgtggcgatc gacccggccc gcgtggaaga ggtcctgggc
    19741 aaaggcgcga ccgtcgcgga cgcccgtacc catctgcgcg aggtgctcgg tgccaacagc
    19801 cgggccacgc tccgccacgc ggcggccgcc gccgggccgg cgtcatgacg gtcgaggtcc
    19861 gtgaggtcgc cgagggtgtc tacgcctacg agcaggcccc cggcggctgg tgcgtcagca
    19921 acgcgggcat cgtggtgggc ggcgacggcg cgctcgtcgt cgacacgctg tcgacgatcc
    19981 cgagggcgcg gcggctggcg gagtgggtcg acaagctcgc cgcgggcccc ggccgtaccg
    20041 tggtcaacac ccacttccac ggcgaccacg ccttcggcaa ccaggtcttc gcgccgggga
    20101 cgcggatcat cgcgcacgag gacatgcggt ccgccatggt gacgaccggc ctggccctca
    20161 ccgggctctg gccgcgggtc gactggggcg agatcgagct gaggccgccg aacgtgacct
    20221 tccgcgaccg gttgaccctg cacgtcggcg agcgacaggt cgaactgatc tgcgtcggcc
    20281 ccgcgcacac cgatcacgac gtggtggtct ggctgcccga ggagcgggtg ctgttcgcgg
    20341 gggacgtcgt catgtcgggc gtcactccgt tcgccctctt cggttcggtg gccggcacgc
    20401 tggccgcgct cgaccggctg gcggagctgg agcccgaggt ggtcgtcggc gggcacggcc
    20461 cggtggcggg acccgaggtg atcgacgcca accgggacta tctgcgctgg gtccagcgcc
    20521 tcgccgccga tgcggtcgac cgccggctga caccgttgca ggccgcgcgc cgggcggacc
    20581 tcggcgcctt cgccgggctg ctggacgcgg agcgcctcgt cgcgaacctg caccgggccc
    20641 acgaggagct gctgggcggg cacgtgcgtg acgccatggc gatcttcgcg gagctggtcg
    20701 cctacaacgg tgggcagctg cccacctgcc tcgcctaggg agttcgaaga tggcagccga
    20761 ccagggaatg ctccgggacg ccatggcccg ggtgccggcc ggggtggcgc tcgtcaccgc
    20821 ccatgaccgc gggggagtcc cgcacggttt caccgccagt tcgttcgtgt ccgtctcgat
    20881 ggagccgcca ctggcactgg tctgcctggc tcgtacggcc aactccttcc cggtgttcga
    20941 cagttgcggc gagttcgcgg tgagcgtgct gcgcgaggac cacacggacc tggccatgcg
    21001 cttcgcgcgc aagtccgcgg acaagttcgc gggcggggag ttcgtccgta ccgcgcgggg
    21061 agcgaccgtg ctcgacggag cggtcgcggt cgtcgagtgc acggtccacg agcgctaccc
    21121 ggcgggcgac cacatcatcc tgctcggcga ggtccagtcc gtgcacgtcg aggagaaggg
    21181 cgtaccggcg gtctacgtgg accgccggtt cgccgccctg tgctcggcgg cgggtgcctg
    21241 cccgtccgcc accgggcggg gcgtgcccgc gcatgccggc tga
//
