BGC0000198: arenimycin A biosynthetic gene cluster from Salinispora arenicola CNB527
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Location: 3,084 - 41,108 nt. (total: 38,025 nt).
This entry is originally from NCBI GenBank NZ_AZXI01000002.1, but has been modified (see Modifications tab for details).

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core biosynthetic genes
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General
Compounds
Genes
Polyketide
Saccharide
History
NRPS/PKS domains
KnownClusterBlast
Modifications
General information about the BGC
MIBiG accession BGC0000198
Short description arenimycin A biosynthetic gene cluster from Salinispora arenicola CNB527
Status Minimal annotation: no
A minimal annotation only contains information on the BGC loci and one or more linked chemical product(s)

Completeness: complete
Whether the loci encodes everything needed for the pathway producing the compound(s)
Biosynthetic class(es)
  • Polyketide (Benzoisochromanequinone)
  • Saccharide (hybrid/tailoring)
Loci NCBI GenBank: NZ_AZXI01000002.1
Compounds
  • arenimycin A
Species Salinispora arenicola CNB527 [taxonomy]
References
Chemical products information
arenimycin A
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C33H33N1O14
List of genes involved in compound(s) production
Identifiers Position Product Functions Evidence Comment Extra
  • B033_RS0101505
  • WP_029025939.1
  • rfbA
 3084 - 3965 (+) glucose-1-phosphate thymidylyltransferase
  • Precursor biosynthesis
Sequence-based prediction
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  • B033_RS27985
  • WP_051422523.1
 3985 - 4641 (+) dTDP-4-dehydrorhamnose 3,5-epimerase family protein
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  • B033_RS0101515
  • WP_196237056.1
 4613 - 5113 (-) MarR family winged helix-turn-helix transcriptional regulator
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  • B033_RS0101520
  • WP_029025941.1
 5248 - 6198 (+) ABC transporter
  • Transport
Sequence-based prediction
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  • B033_RS0101525
  • WP_029025942.1
 6213 - 7037 (+) ABC transporter permease
  • Transport
Sequence-based prediction
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  • B033_RS0101530
  • WP_051422525.1
 7180 - 7923 (-) class I SAM-dependent methyltransferase
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  • B033_RS0101535
  • WP_029025944.1
 7920 - 9080 (-) DegT/DnrJ/EryC1/StrS family aminotransferase
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  • B033_RS27990
  • WP_051422526.1
  • rfbH
 9077 - 10429 (-) lipopolysaccharide biosynthesis protein RfbH
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  • B033_RS0101545
  • WP_155254773.1
 10426 - 11625 (-) hypothetical protein
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  • B033_RS27995
  • WP_042941991.1
 11703 - 12833 (-) hypothetical protein
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  • B033_RS0101555
  • WP_029025946.1
 13104 - 14339 (+) activator-dependent family glycosyltransferase
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  • B033_RS28000
  • WP_051422528.1
 14351 - 15823 (+) M20/M25/M40 family metallo-hydrolase
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  • B033_RS0101565
  • WP_029025947.1
 15744 - 16088 (-) DUF6176 family protein
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  • B033_RS28005
  • WP_051422530.1
 16173 - 17408 (-) cytochrome P450
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  • B033_RS0101575
  • WP_042941996.1
 17570 - 18301 (+) PIG-L family deacetylase
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  • B033_RS28010
  • WP_051422532.1
 18309 - 19460 (-) DUF1205 domain-containing protein
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  • B033_RS0101585
  • WP_029025949.1
 19488 - 20465 (-) aldo/keto reductase
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  • B033_RS32390
  • WP_196237057.1
 20731 - 21771 (+) methyltransferase
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  • B033_RS28015
  • WP_051422534.1
 21810 - 23432 (+) FAD-dependent monooxygenase
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  • B033_RS28020
  • WP_042941974.1
 23509 - 24339 (-) AfsR/SARP family transcriptional regulator
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  • B033_RS28025
  • WP_042941976.1
 24566 - 24919 (+) TcmI family type II polyketide cyclase
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  • B033_RS0101610
  • WP_029025951.1
 24916 - 25320 (+) hypothetical protein
  • Scaffold biosynthesis
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  • B033_RS0101615
  • WP_029025952.1
 25320 - 25805 (+) polyketide cyclase
  • Scaffold biosynthesis
Sequence-based prediction
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  • B033_RS28030
  • WP_155254779.1
 25877 - 26164 (+) antibiotic biosynthesis monooxygenase
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  • B033_RS32395
 26213 - 26499 (-) hypothetical protein
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  • B033_RS0101630
 26394 - 26765 (-) hypothetical protein
Derived by automated computational analysis using gene prediction method: GeneMarkS+.
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  • B033_RS32400
 26541 - 26914 (-) acetyl-CoA carboxylase carboxyl transferase subunit beta
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  • B033_RS33100
 26930 - 27148 (-) hypothetical protein
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  • B033_RS28035
  • WP_080678870.1
 27456 - 28559 (+) AfsR/SARP family transcriptional regulator
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  • B033_RS0101640
  • WP_029025954.1
 28590 - 29432 (+) class I SAM-dependent methyltransferase
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  • B033_RS0101645
  • WP_196237058.1
 29584 - 30003 (-) nuclear transport factor 2 family protein
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  • B033_RS0101650
  • WP_029025956.1
 30056 - 30511 (-) DUF1772 domain-containing protein
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  • B033_RS0101655
  • WP_051422536.1
 30734 - 31972 (+) cytochrome P450
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  • B033_RS0101660
  • WP_029025958.1
 32270 - 33538 (+) beta-ACP synthase
  • Scaffold biosynthesis
Sequence-based prediction
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  • B033_RS0101665
  • WP_029025959.1
 33535 - 34752 (+) beta-ketoacyl synthase
  • Scaffold biosynthesis
Sequence-based prediction
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  • B033_RS0101670
  • WP_029025960.1
 34845 - 35570 (+) SDR family oxidoreductase
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  • B033_RS28040
  • WP_080678872.1
 35639 - 37015 (+) NDP-hexose 2,3-dehydratase family protein
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  • B033_RS28045
  • WP_051422538.1
 37012 - 38010 (+) Gfo/Idh/MocA family oxidoreductase
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  • B033_RS0101685
  • WP_029025961.1
 38089 - 38343 (+) acyl carrier protein
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  • B033_RS0101690
  • WP_042941978.1
 38340 - 38666 (+) antibiotic biosynthesis monooxygenase
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  • B033_RS28050
  • WP_051422540.1
  • rfbB
 39238 - 40257 (+) dTDP-glucose 4,6-dehydratase
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  • B033_RS0101700
  • WP_196237059.1
  • rfbD
 40257 - 41108 (+) dTDP-4-dehydrorhamnose reductase
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Polyketide-specific information
Subclass Benzoisochromanequinone
Starter unit Acetyl-CoA
Ketide length 12
Cyclic? yes
Polyketide-synthases
Genes Properties Modules
B033_RS0101615
+
B033_RS0101660
+
B033_RS0101610
+
B033_RS0101665 		Synthase subclass: Type II
Saccharide-specific information
Subclass hybrid/tailoring
Annotation changelog
MIBiG version Submitter Notes
1.0
  • Hidden contributor (ID: N52IJH5LHPQ7BFWMKQOBW6U7, no GDPR consent given).
  • Submitted
2.0
  • Hidden contributor (ID: AAAAAAAAAAAAAAAAAAAAAAAA, no GDPR consent given).
  • Migrated from v1.4
3.0
  • Hidden contributor (ID: AAAAAAAAAAAAAAAAAAAAAAAA, no GDPR consent given).
  • Removed gene names of 'No gene ID'
  • Removed glycosyltransferase annotations on missing genes
3.1
  • Hidden contributor (ID: AAAAAAAAAAAAAAAAAAAAAAAA, no GDPR consent given).
  • Update chemical activity to schema version 2.11
Detailed domain annotation
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Modifications to original record
  • B033_RS0101630 was added