LOCUS       BGC0000207             17540 bp    DNA     linear   BCT 22-JUN-2005
DEFINITION  Streptomyces chartreusis HKI-249 chartreusin biosynthesis gene
            cluster B.
ACCESSION   BGC0000207
VERSION     BGC0000207
KEYWORDS    .
SOURCE      Streptomyces chartreusis
  ORGANISM  Streptomyces chartreusis
            Bacteria; Actinobacteria; Streptomycetales; Streptomycetaceae;
            Streptomyces.
COMMENT     ##antiSMASH-Data-START##
            Version      :: 6.2.0-924c3663(changed)
            Run date     :: 2022-11-07 17:43:22
            NOTE: This is a single region extracted from a larger record!
            Orig. start  :: 0
            Orig. end    :: 17540
            ##antiSMASH-Data-END##
FEATURES             Location/Qualifiers
     source          1..17540
                     /db_xref="taxon:1969"
                     /mol_type="genomic DNA"
                     /organism="Streptomyces chartreusis"
                     /strain="HKI-249"
     subregion       1..17540
                     /aStool="externally annotated by: MIBiG"
                     /contig_edge="True"
                     /label="BGC0000207"
                     /subregion_number="1"
                     /tool="antismash"
     region          1..17540
                     /contig_edge="True"
                     /product="unknown"
                     /region_number="1"
                     /subregion_numbers="1"
                     /tool="antismash"
     gene            complement(822..1265)
                     /gene="chaK"
     CDS             complement(822..1265)
                     /codon_start=1
                     /db_xref="HSSP:O52646"
                     /db_xref="InterPro:IPR009959"
                     /db_xref="UniProtKB/TrEMBL:Q4R0L0"
                     /function="ester cyclase"
                     /gene="chaK"
                     /product="ChaK protein"
                     /protein_id="CAH10173.1"
                     /transl_table=11
                     /translation="MSSNVDVVRRMVRAYNTGDTSDVDQYIHPDYLNPASLEHMADKNW
                     RGPAVFAMAVKWLRATFSEEVRLEEIRYEERGDWVRAYLALYGRHVGELVGMPATGRRF
                     SGEQIHLIKLVDGRIRDHRDWPDYLGTYRQLDEPWPTAAGWRD"
     gene            complement(1318..2058)
                     /gene="chaL"
     CDS             complement(1318..2058)
                     /NRPS_PKS="Domain: PKS_KR (4-158). E-value: 4e-07. Score:
                     21.9. Matches aSDomain: nrpspksdomains_chaL_PKS_KR.1"
                     /codon_start=1
                     /db_xref="GOA:Q4R0K9"
                     /db_xref="HSSP:Q7Z4W1"
                     /db_xref="InterPro:IPR002198"
                     /db_xref="InterPro:IPR002347"
                     /db_xref="UniProtKB/TrEMBL:Q4R0K9"
                     /function="keto reductase"
                     /gene="chaL"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1001:short-chain dehydrogenase/reductase SDR (Score:
                     205.5; E-value: 1.5e-62)"
                     /gene_kind="biosynthetic-additional"
                     /product="ChaL protein"
                     /protein_id="CAH10174.1"
                     /transl_table=11
                     /translation="MRGIVITGGGTGIGRAAAHAFADAGDAVLIVGRSADTLAETAKGR
                     DGIHTLPLDLTEPDAAAVVVETARRQLGRLDVLVNNAGIASFAGLGSLEPASVEAQIRT
                     NLIAPILLTQQALDSLEETRGLVVNISSAGSIGLRTIPDNSVYCATKAGLDVLTRTWSV
                     ELAPRGIRVIGVAPGVTDTGVALRAGVSPAQYEAFMERMRAEIPLGRVGAPEDIAWWIV
                     TLASADGGYLNGAVIPVDGALSVT"
     aSDomain        complement(1585..2046)
                     /aSDomain="PKS_KR"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_chaL_PKS_KR.1"
                     /evalue="4.00E-07"
                     /label="chaL_PKS_KR.1"
                     /locus_tag="chaL"
                     /protein_end="158"
                     /protein_start="4"
                     /score="21.9"
                     /specificity="KR activity: inactive"
                     /specificity="KR stereochemistry: C2"
                     /tool="antismash"
                     /translation="VITGGGTGIGRAAAHAFADAGDAVLIVGRSADTLAETAKGRDGIH
                     TLPLDLTEPDAAAVVVETARRQLGRLDVLVNNAGIASFAGLGSLEPASVEAQIRTNLIA
                     PILLTQQALDSLEETRGLVVNISSAGSIGLRTIPDNSVYCATKAGLDVLT"
     CDS_motif       complement(1957..2046)
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_chaL_0001"
                     /evalue="9.70E-05"
                     /label="PKSI-KR_m1"
                     /locus_tag="chaL"
                     /protein_end="34"
                     /protein_start="4"
                     /score="15.0"
                     /tool="antismash"
                     /translation="VITGGGTGIGRAAAHAFADAGDAVLIVGRS"
     gene            2216..3001
                     /gene="chaZ"
     CDS             2216..3001
                     /NRPS_PKS="Domain: PKS_KR (7-162). E-value: 1.4e-11. Score:
                     36.4. Matches aSDomain: nrpspksdomains_chaZ_PKS_KR.1"
                     /codon_start=1
                     /db_xref="GOA:Q4R0K8"
                     /db_xref="HSSP:P16544"
                     /db_xref="InterPro:IPR002198"
                     /db_xref="InterPro:IPR002347"
                     /db_xref="UniProtKB/TrEMBL:Q4R0K8"
                     /function="putative FAD-dependent monooxygenase"
                     /gene="chaZ"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1001:short-chain dehydrogenase/reductase SDR (Score:
                     260.5; E-value: 2.5e-79)"
                     /gene_kind="biosynthetic-additional"
                     /product="ChaZ protein"
                     /protein_id="CAH10175.1"
                     /transl_table=11
                     /translation="MTDNIERTAIVTGASNGIGRAIAATLAAEGVRVHICGRDAETVEK
                     TVTELRADRGQVSGQACDVTKPDQVTALVADCVARYGPVDILVNNAGRPGGGITANIDN
                     ELWYATIDTNLNGVFLMSKSVLNEGRMTERQNGRIINIASVWGKQGTIGGAPYAAAKHG
                     VIGFSRCLALELAKTGITVNAVCPGYVETPMSVNVRACQAGIWQVDEEEALRRLASDIP
                     IGRYSEPEEVAWMVSYLASSKAASVTGQALNVCGGFGVH"
     aSDomain        2237..2701
                     /aSDomain="PKS_KR"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_chaZ_PKS_KR.1"
                     /evalue="1.40E-11"
                     /label="chaZ_PKS_KR.1"
                     /locus_tag="chaZ"
                     /protein_end="162"
                     /protein_start="7"
                     /score="36.4"
                     /specificity="KR activity: inactive"
                     /specificity="KR stereochemistry: C2"
                     /tool="antismash"
                     /translation="TAIVTGASNGIGRAIAATLAAEGVRVHICGRDAETVEKTVTELRA
                     DRGQVSGQACDVTKPDQVTALVADCVARYGPVDILVNNAGRPGGGITANIDNELWYATI
                     DTNLNGVFLMSKSVLNEGRMTERQNGRIINIASVWGKQGTIGGAPYAAAKH"
     CDS_motif       2243..2329
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_chaZ_0001"
                     /evalue="3.10E-04"
                     /label="PKSI-KR_m1"
                     /locus_tag="chaZ"
                     /protein_end="38"
                     /protein_start="9"
                     /score="13.4"
                     /tool="antismash"
                     /translation="IVTGASNGIGRAIAATLAAEGVRVHICGR"
     gene            complement(4406..5266)
                     /gene="chaI"
     CDS             complement(4406..5266)
                     /codon_start=1
                     /db_xref="GOA:Q4R0K7"
                     /db_xref="InterPro:IPR013216"
                     /db_xref="UniProtKB/TrEMBL:Q4R0K7"
                     /function="methyl transferase"
                     /gene="chaI"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1089:methyltransferase (Score: 109.2; E-value:
                     3.8e-33)"
                     /gene_kind="biosynthetic-additional"
                     /product="ChaI protein"
                     /protein_id="CAH10176.1"
                     /transl_table=11
                     /translation="MDSTAYKSGVTNAFKNAADSYDRGGVGFFTPMGRRLVELAAPQPG
                     ERVLDVGCGRGAALFPAARAVGPTGRAVGIDIADTMIEAARAEAARAGAENVELLVMDA
                     ERPSFARHSFELVLGSYSILFLPDAPAALARYPRIMTAGGRLAFTCPVFEADSFPFLPP
                     VFTPMIPASVPAALPADWQPSELRRRYNSWLSDVELLRATLGEAGFTDVTVRDEAVPMT
                     AESPAAWVDWSHTQGMRLLWERLPEPVAGELRDSLIAGLSELSGPDGSLVIETPVRFVT
                     ARVGS"
     gene            5465..5881
                     /gene="chaJ"
     CDS             5465..5881
                     /codon_start=1
                     /db_xref="HSSP:O52646"
                     /db_xref="InterPro:IPR009959"
                     /db_xref="UniProtKB/TrEMBL:Q4R0K6"
                     /function="ester cyclase"
                     /gene="chaJ"
                     /product="ChaJ protein"
                     /protein_id="CAH10177.1"
                     /transl_table=11
                     /translation="MSEAIDVVRRMVQAFATGKTDDASDYIHSEYLNPATLERSDKRGP
                     ESFTDSVDWVRNAFSELHLEEIEYREGGGYVTAYLVMSGRHTGDLVGLPPTGRRFAAEQ
                     LHLCEVVDGRIRHHREWRDDLGCLRQLGLPALPD"
     gene            6222..7850
                     /gene="chaT1"
     CDS             6222..7850
                     /codon_start=1
                     /db_xref="GOA:Q4R0K5"
                     /db_xref="InterPro:IPR001411"
                     /db_xref="InterPro:IPR001958"
                     /db_xref="InterPro:IPR004638"
                     /db_xref="InterPro:IPR007114"
                     /db_xref="InterPro:IPR011701"
                     /db_xref="UniProtKB/TrEMBL:Q4R0K5"
                     /function="putative efflux protein"
                     /gene="chaT1"
                     /gene_functions="transport (smcogs) SMCOG1005:Drug
                     resistance transporter, EmrB/QacA (Score: 450.4; E-value:
                     9.4e-137)"
                     /gene_kind="transport"
                     /product="ChaT1 protein"
                     /protein_id="CAH10178.1"
                     /transl_table=11
                     /translation="MTEVKTAEAPVTQRPWLVLAIMCVGFFMALLDGSIVNIAIPTLID
                     GLDASYDQVLWIIDGYMLVFSVLLITTGRLGDIYGYRRLFLIGITLFTVASALCGLSES
                     PDWLLAARVLQGLGGALLFPQVISSILTIFPPQLRGRAFGLFGAIVGFAPIVGPVVGGF
                     LLAHLSWRWIFFINVPIGIVTALLAVRYVPVMRPGRSNSLDLTGVALATAGLTGIVFGL
                     IEGERYDWGTITGPISIASVIIAGVVLLVLFVLWQHRRKTDSLMPLALFNARNFSVGNG
                     VGFIFQLGMIAIAFVLVLYLQTARGYSALETAAVMLPNAILTAVGSTYAGRLSDKFGGK
                     YVLMAGLAMLTVGLLVLVASTDAHSDAWSLLPGLIIIGIASGATFAPLQQATMDGVNPQ
                     LAGAASGVSNTTRQVGGVLGTAVLGALLSARINADLPEEAQEQAAQLPSELRDQFLAAA
                     DSAGNFSPPSVPSGLSVSEADLFRRLGDDAFATSFTHAMHVTFLVAAAVLIAATVLCGL
                     FTTPPRAEPAQETAGEEDTRSTSED"
     gene            8041..9207
                     /gene="chaO"
     CDS             8041..9207
                     /codon_start=1
                     /db_xref="GOA:Q4R0K4"
                     /db_xref="HSSP:Q5SGZ2"
                     /db_xref="InterPro:IPR006089"
                     /db_xref="InterPro:IPR006090"
                     /db_xref="InterPro:IPR006091"
                     /db_xref="InterPro:IPR006092"
                     /db_xref="InterPro:IPR009075"
                     /db_xref="InterPro:IPR009100"
                     /db_xref="InterPro:IPR013764"
                     /db_xref="UniProtKB/TrEMBL:Q4R0K4"
                     /function="putative dehydrogenase"
                     /gene="chaO"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1006:acyl-CoA dehydrogenase (Score: 375.1; E-value:
                     6.3e-114)"
                     /gene_kind="biosynthetic-additional"
                     /product="ChaO protein"
                     /protein_id="CAH10179.1"
                     /transl_table=11
                     /translation="MSSLDLLSEDERFVVRTVRDFVDRDVKPVVRELERTDTYPEALIE
                     RMKELGVFGLAVPQEYGGTPVSMPCYVLVTEELARGWMSLAGAMGGHTVVAKLLLHFGT
                     EEQRQRHLPLMATGETRATMALTETGGGSDLQAMRTVARREGDGYVVNGAKTWITNSRR
                     SRLIALLCKTDPDAEPAHSGMSVLLVEHGPGLTVSRDLPKLGYKGVESCELSFENHRAR
                     ADALLGGVEGHGFAQMMRGLETGRLQVAARALGVGRAALEDALAYAQERESFGKPIWQH
                     QSIGNYLADMATSLTAARQLTLYAARRAEAGHRVDMEAGMAKLFASETAMQIALNAVRI
                     HGGYGYSTEFDVERYFRDAPLMIVGEGTNEIQRNIIADRLVKRGGLDV"
     gene            9395..10141
                     /gene="chaQ"
     CDS             9395..10141
                     /codon_start=1
                     /db_xref="InterPro:IPR003738"
                     /db_xref="UniProtKB/TrEMBL:Q4R0K3"
                     /gene="chaQ"
                     /product="hypothetical protein"
                     /protein_id="CAH10180.1"
                     /transl_table=11
                     /translation="MCGRYASTRSPQDLAQLFEVTEWHPEETLAPSWNVAPTDDVWAVL
                     ERAPRGSDDDAPAVRRLRPLRWGLVPSWAKDVKIGARMINARVETVHEKPAFRRAFVKR
                     RCLLPADGFYEWDQVKDAKSGKVRKQPYFIHPEDGQVLALAGLYEFWRDPAVKDGDDPA
                     AWLLTCTIITTEATDAAGRIHPRMPLALTPEHYDAWLDPHHQSTDDLRALLTTPADGQL
                     DARPVSPAVNSVSNNGPQLLDEVPAP"
     gene            10283..11209
                     /gene="chaT2"
     CDS             10283..11209
                     /codon_start=1
                     /db_xref="GOA:Q4R0K2"
                     /db_xref="InterPro:IPR006127"
                     /db_xref="UniProtKB/TrEMBL:Q4R0K2"
                     /function="putative ABC transporter"
                     /gene="chaT2"
                     /gene_functions="transport (smcogs) SMCOG1252:cation ABC
                     transporter, periplasmic (Score: 225.2; E-value: 1.7e-68)"
                     /gene_kind="transport"
                     /product="ChaT2 protein"
                     /protein_id="CAH10181.1"
                     /transl_table=11
                     /translation="MPLSSPRVHAALLTGTCLTLLVGCAGSSDTAGVHGPAAASVIPVV
                     ASTNVYGDLARRIGGAKVQVTSIISDPDQDPHSYEASTRNQLALSKAEIVIENGGGYDD
                     FVDRMLKSAGSSPGVINAVEVSGKTAPKGGELNEHVWYDFPTVAELADRIAIALGKADP
                     ADAATFTENAKDFVSLLQPLERKEARIKAEHGGEAVAITEPVPLYMIEASGLRNATPEE
                     FSEAIEEGDDVSPRTLQSTLALFTGKKVEALVYNEQTSGPQTEKAERVAEAAGIPVVPV
                     TETLPKGKDYLAWMTANVDALASALAK"
     gene            11266..12075
                     /gene="chaT3"
     CDS             11266..12075
                     /codon_start=1
                     /db_xref="GOA:Q4R0K1"
                     /db_xref="InterPro:IPR003439"
                     /db_xref="InterPro:IPR003593"
                     /db_xref="UniProtKB/TrEMBL:Q4R0K1"
                     /function="putative transport system component"
                     /gene="chaT3"
                     /gene_functions="transport (smcogs) SMCOG1000:ABC
                     transporter ATP-binding protein (Score: 159.1; E-value:
                     2.5e-48)"
                     /gene_kind="transport"
                     /product="ChaT3 protein"
                     /protein_id="CAH10182.1"
                     /transl_table=11
                     /translation="MADALISLRRAALSYGERVVWRDLDLDVRPGEFLAVLGPNGAGKT
                     SFVRALLGQRRLSAGTLTVLGRPPGRGSRHIGYVPQQAALSAQAMLRARDLVRLGVDGH
                     RFGPRPRTGAVRRRADEILASVGATAYADVPVALLSGGERQRVRIGQALATDPRILLCD
                     EPLLSLDLHHQRAVTELVDARRRSHGTAVVFVTHEINPVLGLVDRVLYLARGGHRVGTP
                     DEVLTSEALSRLYGTQVDVVRVRDRVVVVGAPEEAAHHPQLPGGARP"
     gene            12072..12941
                     /gene="chaT4"
     CDS             12072..12941
                     /codon_start=1
                     /db_xref="GOA:Q4R0K0"
                     /db_xref="InterPro:IPR001626"
                     /db_xref="UniProtKB/TrEMBL:Q4R0K0"
                     /function="putative transport system component"
                     /gene="chaT4"
                     /gene_functions="other (smcogs) SMCOG1245:ABC transporter
                     protein, integral membrane (Score: 228.3; E-value:
                     1.9e-69)"
                     /gene_kind="other"
                     /product="ChaT4 protein"
                     /protein_id="CAH10183.1"
                     /transl_table=11
                     /translation="MTLAQGIWQQIFAFDHYGELLALVRNSLAAGAALGLVGGLVGVFV
                     IMRDLPFAVHGISELSFAGASAALLLGVNVVAGSIVGSLVAAGAIGLLGARARDRNSVI
                     GVIMPFGLGLGVLFLALYKGRAANKFGLLTGQIVAVDTPQMSWLLGTSAVVLVALAVMW
                     RPLVFASADAEVAEARGVPVRGMSFAFMIVLGLAVALSVQIVGALLVLTLVVTPAAAAA
                     RVTASPVLLPVLSAVFAVASIEGGILLALGSSIPISPYVTTISFGIYLVCRRFGGKRAR
                     TGGVGVQG"
     gene            12988..15051
                     /gene="chaT5"
     CDS             12988..15051
                     /codon_start=1
                     /db_xref="GOA:Q4R0J9"
                     /db_xref="InterPro:IPR000150"
                     /db_xref="InterPro:IPR001366"
                     /db_xref="InterPro:IPR001757"
                     /db_xref="InterPro:IPR005834"
                     /db_xref="InterPro:IPR006404"
                     /db_xref="InterPro:IPR006416"
                     /db_xref="InterPro:IPR008250"
                     /db_xref="UniProtKB/TrEMBL:Q4R0J9"
                     /function="putative ATPase"
                     /gene="chaT5"
                     /gene_functions="other (smcogs) SMCOG1037:heavy metal
                     translocating P-type ATPase (Score: 483.4; E-value:
                     2e-146)"
                     /gene_kind="other"
                     /product="ChaT5 protein"
                     /protein_id="CAH10184.1"
                     /transl_table=11
                     /translation="MPATLTPPAADPAASVRAGAVPRRRTRLLALPEVRRAAAATALFL
                     LALPLQLAGAPALIWGALYVLSYATGGWEPGWEGLKALKGRTLDVDLLMVVAALGAASI
                     GQVMDGALLIVIFATSGALEALATARTADSVRGLLDLAPATATRIAADGTEQTLPVDEL
                     AVGDTVLVRPGERVGADGRVLDGASEVDQTSITGEPLPALKEPGDEVFAGTLNGTGALR
                     VRVERDASDSVIARIVRMVEEASETKAPTQLFIEKVEQRYSLGMVAATLAVFGVPLAFG
                     EAFSEALLRGMTFMIVASPCAVVLATMPPLLSAIANAGRHGVLVKSAVAMERLGQIDAV
                     ALDKTGTLTEGTPRVVDVRPLRERGLDEVELLTFAAAAEHPSEHPLARAVVDAARERGL
                     DLPATEGFTSAPGIGVMAVVGGRTVQVGAPARLLAEAEAEVEVEVEAKCAADAGGDTDG
                     VVAALVRELEESGRSAVLVVVDGTPAGVLGIADRLRPDAAATVAALTVLTGTAPTLLTG
                     DNPRAAARLAAEAGVEDVRAGLLPQEKVGAVRELEGAGRRVMVVGDGVNDAPALAAAHI
                     GVAMGRAGSDLALETADAVIVRDELVAVPATVALSRRARELVVQNLVIAGVFIAGLVVW
                     DLAGTLPLPLGVAGHEGSTVLVGLNGLRLLRDSAWKRAAPEGTGTPAGAAKL"
     gene            complement(15146..16213)
                     /gene="chaR3"
     CDS             complement(15146..16213)
                     /codon_start=1
                     /db_xref="GOA:Q4R0J8"
                     /db_xref="HSSP:P03023"
                     /db_xref="InterPro:IPR000843"
                     /db_xref="InterPro:IPR001761"
                     /db_xref="InterPro:IPR010982"
                     /db_xref="UniProtKB/TrEMBL:Q4R0J8"
                     /function="putative LacI-family transcriptional regulator"
                     /gene="chaR3"
                     /gene_functions="regulatory (smcogs) SMCOG1078:LacI family
                     transcription regulator (Score: 299.5; E-value: 5.5e-91)"
                     /gene_kind="regulatory"
                     /product="ChaR3 protein"
                     /protein_id="CAH10185.1"
                     /transl_table=11
                     /translation="MTRGSADDSAPRGRSRRNFAGSRPVMDDVARLAGVSKQTVSRVLN
                     DHPSVRAETRETVLSAMRTLGYRPSRSARSLASGRTRMVGVISFDAARYGPASILTAIN
                     TAAQEAGYLLSSIALDTAEPDTVVEAVNRLSAEGADGVIAIAPQLWVGKALADTRLDTP
                     LVVLENGVDADTQQVTGDSRAGARKAVGYLLDLGHRTVWHVAGPTGWTSADHRLGSWQA
                     CLEAAGAAVPTPLIGDWSADSGYELGRRLARRTDVTAVFASNDQMALGLLHALHEAGRS
                     VPGDISVVGYDDIPEAAHFLPPLTTVRTDFAEIGTRSLRLLLDRLDGTEEPARTRSLVP
                     VDLVIRASSGPPPTR"
ORIGIN
        1 gatgagtctc ataccattaa ggttccctct ctttctactg cttttcgcca agaaccacaa
       61 tgcagcgcac ttatatcagt gagtttttgc cacgctgcca cctcaggcgt aagagggtgg
      121 gcgctcttgt gtccgcccca aatacgcaac cgacccgcca caattagcca catggactcc
      181 gaacgattca aatccaaatc attcgcgttc gcgcgatctc ctaatccgga aaccctcatc
      241 cgctacaccc atcccttttc tctttagtaa tccttttgga aagggaacct gaggcgttcc
      301 cgtaatcccc ggaatttgaa cgtaaaggag aaccccttcc acacactact cccggcaccc
      361 actttttttt tccctcatcg cacccccatt tatcctaacc cacgcctctc cctctggcaa
      421 aatcgccccc aaaatcctac cccgtacctg caacctcgcc ttccccgcga aattactcgc
      481 tcccgaactt cttccgacaa tgggatcctc tcaaacaaac ttaaccgggt tgcgcgtcgc
      541 ctgattcgcc tcctatatgg gcctcccccc cccccgcggc gactcaacga gtccagacct
      601 tcccgactcg gcgttgtgta atcgcctttg cctattcctc ctcaactggc tggtcgaccc
      661 ccacggcgcc cctgcgcccg aactggacgg gactccgcac cggaacgggg cgctcgctcg
      721 agccaacagt agcccgaccg caccgtccca acgggtcgga cgaccagaca tatgcgctgc
      781 cccggggcct cgagccccgg ggccgcgcac cgctcccggc gtcagtcccg ccagcccgcc
      841 gcggtcggcc acggctcgtc gagctgccgg tacgtgccga gatagtccgg ccagtcacgg
      901 tggtcccgga tcctgccgtc gaccagcttg atcagatgga tctgctcccc ggagaaacga
      961 cggcccgtcg cgggcatccc caccagttcg ccgacatggc ggccgtacag ggccagatag
     1021 gcgcgcaccc agtcgccgcg ctcctcgtac cggatctcct ccaggcgcac ctcctcggag
     1081 aaggtcgccc gcagccactt caccgccatc gcgaagacgg ccggtccgcg ccagttcttg
     1141 tccgccatgt gctccaggga ggcggggttc agatagtcgg ggtgaatgta ctggtccaca
     1201 tcactggtgt cgccggtgtt gtaggcgcgc accatcctcc gtacgacatc gacgttgctg
     1261 ctcacggccg ttcctttcag aagggtgcct cggggcatgg acggaggcgg agggggctca
     1321 cgtgaccgac agcgcgccgt ccaccggtat caccgcgccg ttgaggtacc ccccgtccgc
     1381 cgaggccagc gtgacgatcc accaggcgat gtcctccgga gcaccgaccc ggccgagcgg
     1441 gatctccgcc cgcatccgct ccatgaacgc ctcgtactgg gccggggaca caccggcccg
     1501 cagcgccaca ccggtgtcgg tgacacccgg cgcgacgccg atgacccgga tgccgcgcgg
     1561 ggccagctcg acggaccagg tgcgggtgag cacgtccagg cccgccttcg tggcgcagta
     1621 caccgagttg tccgggatgg tgcgcagccc gatcgacccg gccgaactga tgttgacgac
     1681 gagaccgcgg gtctcctcca gcgagtccag ggcctgttgg gtgagcagga tcggcgcgat
     1741 cagattggtc ctgatctgcg cctcgaccga ggccggttcc agcgagccga ggccggcgaa
     1801 gctcgcgatc ccggcgttgt tgacgagcac gtcgagccgc ccgagctgac gtcgagcggt
     1861 ttcgacgacg acggccgccg cgtccggctc ggtcaggtcg agcgggaggg tgtggatgcc
     1921 gtcccggccc ttcgcggtct cggcgagcgt gtccgccgac cgcccgacga tcaggaccgc
     1981 gtcgccggcg tcggcgaaag cgtgcgcggc ggcacggccg atgcccgtgc cgccgccggt
     2041 gatgacgatt cctcgcatgc tgctgctgtc tcctctttct catggacggg gcatctcaag
     2101 gtgccgggag cgcctagaag acgacttgaa gcggcctcag cgcattggct gcggctcatt
     2161 ctgaattcca ttccgcctcg agtgcggtgc taggccgggc tgcgaacttt ggcccatgac
     2221 ggacaacatt gagcggacag ccatcgtcac cggcgcgagc aatgggatcg gccgggcgat
     2281 cgccgccaca ctggcggcgg aaggcgtacg cgtacatatc tgcggcaggg acgccgaaac
     2341 cgtcgagaag acggtgaccg aactgcgggc ggacagaggc caggtcagtg gccaggcgtg
     2401 cgacgtcacc aagcccgacc aggtgaccgc gttggtggcg gactgcgtcg cacggtacgg
     2461 accggtggac atcctggtga acaacgccgg ccggcccggc ggaggaatca ccgcgaacat
     2521 cgacaacgaa ttgtggtacg ccaccatcga caccaatctc aacggtgttt tcctgatgtc
     2581 caaatccgtg ctgaacgaag ggcgcatgac ggagcggcag aacggccgca tcatcaacat
     2641 cgcctcggtg tggggaaaac agggaacgat cggaggcgcg ccctacgcgg ccgccaaaca
     2701 cggcgtcatc ggattcagcc gctgcctcgc gctggaactc gcgaagaccg ggatcacggt
     2761 caatgctgtg tgccccggat atgtcgagac cccgatgtcg gtcaacgtac gcgcctgcca
     2821 ggcgggcatc tggcaggtgg acgaggagga ggccctgcgc cgcctggcct ccgacatccc
     2881 catcggccgg tacagcgagc cggaggaggt cgcctggatg gtctcctacc tcgcctcgtc
     2941 caaggccgcc tcggtcaccg gccaggcgct caacgtgtgc ggcggcttcg gtgtccactg
     3001 acccccgccc ctcccgcgca cgcgatcgcc gcgccgccga acagtgggga ggcgggggcc
     3061 gatggcgaac gtcgcggtga tcggcgcggg gacgggcgga ctctgcctgg cccaggcact
     3121 ccacgcggcc ggcatcgagg tgaccgtcca tgaacggcac cgcaccccga ccggcgcgct
     3181 gcacggctac cgggtccgca tcaatccgac cggagcccgt gccctgcgtc gttgcctgcc
     3241 cgcccaggtg tgggagacgt tcctgtcccg ggccgggcgg atcgggcagg aattcggatt
     3301 cctcaccgaa cgactgaggg aactcgccgt cctcgacggc ggaccggacg ccgaaccgca
     3361 ctactccgcc gagcgcggca tgctgcggga ggtcctgctg acggggctgg aggacgtggt
     3421 ccggttcggc gcctgcttcg agaggtacga gcgtacccag gacggccggt tcgagtgcca
     3481 cttcgccgat ggcaccagca ccacggccga cctcgtcgtc ggcgcggacg gcgccaactc
     3541 ccgtgtccgc gcccagtatc tgccgcacgc gcgccgcgtc gacatcggga tggtctcgat
     3601 cgtcggccgc ctcgccctgc ccgtcgccga acaactgcta cccgagcgtc tgagctcccg
     3661 ccccaactcg gtcgtcgcgc ccggaggcac ggggatgttc gtcgcacggc acgagcccgg
     3721 cacggacgag gggtacctca tgtgggctta cggcgccgga gcacaccgct atcccgcgga
     3781 cgtcgagacc ctgcccggcg atcaactggc cgaactggtc gacgggttga ccggatcctg
     3841 gcaccccgca ctgcgcgcga tggtccgcga gaccgacccg ggcacggtca acgcggtgcc
     3901 catccgcacc tcggttcccc cggacccctg gccggcgacc cgggtgaccc tcctcggcga
     3961 cgccatccac agcatgacgc cactgcgcgg cgtgggcgcg aacatggcac tcaacgacgc
     4021 cgcgctcctc gcccgcgaac tcaccggcag cgcggacacg cgcctggccg tgagccggta
     4081 cgaggacgcg atgcggcggg acggcttccg cgcggtctcc gagtcgctgc gcgccgcccg
     4141 gatgttcgtg tccgagagca cgacacagcg gctgctgttc aagacggtgc tccggaccgc
     4201 atccgccgta cccccgctcc gcaaggcatt gttcgccaag ctcgcttgac cggcacacgg
     4261 aacccactcg acagcggacg ccctcccggc gtccgctgtc gagcatgcgg cgaggccggg
     4321 cagaacaccg gccgtcgagc atgcggatgg ggaggcgagc ggacatcacg cccgccgcat
     4381 ccccaccatg cagatggacc ccctgtcagg agccgacgcg agcggtgacg aaccgcaccg
     4441 gagtctcgat caccaacgag ccgtcgggac cgctcagttc ggacagcccg gcgatcaggg
     4501 aatcacgcaa ctccccggcg accggctccg gaagccgctc ccacagcagc cgcatgccct
     4561 gcgtgtgcga ccagtcgacc cacgcggccg gtgactccgc ggtcatggga acggcctcgt
     4621 cccgtacggt cacgtcggtg aacccggcct cgccgagggt cgctcggagc agctcgacgt
     4681 ccgacagcca gctgttgtag cgacggcgca gctcgctcgg ctgccagtcg gcgggcaggg
     4741 ccgcgggcac cgacgccggg atcatcgggg tgaacaccgg cggcaggaac gggaagctgt
     4801 ccgcctcgaa cacggggcag gtgaaggcga gcctgccccc ggccgtcatg atgcgcgggt
     4861 aacgggccaa cgccgcaggc gcgtcgggca ggaacaggat gctgtagctg ccgagaacga
     4921 gttcgaacga gtgacgcgcg aagctcggac gctcggcgtc catgaccagc agctccacgt
     4981 tctcggcgcc ggcccgcgcc gcctcggccc gcgcggcctc gatcatggtg tcggcgatgt
     5041 cgatgccgac ggcgcgcccc gtgggcccga cggcccgcgc ggccgggaac agggcggccc
     5101 cccggccaca gccgacgtcg agcacccgct cacccggctg cggcgccgcg agttcgacca
     5161 gacggcggcc catgggggtg aagaaaccca ccccgcccct gtcgtaggaa tcggcggcgt
     5221 tcttgaaggc gttcgtcacc ccggacttgt aggcagtcga atccattctt cctccgcatc
     5281 atcggttctt ctgagagaca agcggtcgac gctggagcac cgcatgagtg cgggtcgaga
     5341 atttctcgag tcaccctctc ggaattgccg cgcacggttc ggggaggtct tgtggtccgt
     5401 gttctgtgcg acaaagatgg ccgcgatgaa cacatggccc gacgggacgg aaagggagag
     5461 ggagatgagc gaggcaatag atgtggtccg ccgtatggtc caggcattcg cgacgggaaa
     5521 gaccgacgac gcatccgact acatccactc ggaatatctc aacccggcga cactggaacg
     5581 ctccgacaag cgcggcccgg agagcttcac ggactccgtg gactgggtgc gcaacgcgtt
     5641 ctccgaattg cacttggagg agatcgagta ccgcgagggc ggcgggtacg tcacggcgta
     5701 cctggtcatg agcggtcggc acaccggcga cctcgtcgga ctgccgccca ccggccgccg
     5761 gttcgcggcc gaacagctgc acctgtgcga ggtggtcgac ggccgcatcc ggcaccaccg
     5821 cgaatggcgc gacgacctgg gctgtctccg gcaactcggg ctcccggcac tgcccgactg
     5881 acccctcccg cggcgagatc gacctcgttg cgaggccctc actgcccttg ctagagtccg
     5941 attcggcttc tcaccgttgg gctcatgcct cgccaaccag cttcttcggg tcccgatgac
     6001 cgtggagaag gtgggagtca catacaccaa gggatatctc tgttccggtg gtggctccca
     6061 acgtgcctcc gccgtgcggg atttcccttc ggccaacggt tttcgggctc agcgacgcat
     6121 gacatcggcg ttccgctcaa gctcgtcgag tgcgggcgca cggtattgcg ccacgtcccc
     6181 gaagccacgg ccggtgctcc gagttcatgg aggtcatcgg agtgacggaa gtcaaaacgg
     6241 cggaagcccc ggtcacgcag cggccatggt tggtcctcgc catcatgtgt gtcggcttct
     6301 tcatggcgct gctcgacgga agcatcgtca atatcgccat cccgacattg atcgacggcc
     6361 tggacgcgtc ctacgaccaa gtgctgtgga tcatcgacgg atacatgctg gtcttctcgg
     6421 tactgctgat caccaccggg cgcctcggcg acatctacgg gtatcggcgg cttttcctga
     6481 tcggtatcac cctcttcacc gtggcctcgg ccctgtgcgg gctgtccgag tcgcccgact
     6541 ggctgctcgc cgcgcgtgtg ctgcaagggc tgggcggggc gctgctgttc ccgcaggtga
     6601 tctcgtcgat cctgacgatc ttcccgcctc agctgcgcgg tcgggcgttc ggcctcttcg
     6661 gggccatcgt cggcttcgcg ccgatcgtcg gcccggtcgt cggcggtttc ctcctcgccc
     6721 acctcagctg gcgctggatc ttcttcatca acgtcccgat cggcatcgtc accgccctgc
     6781 tggccgtccg gtacgtcccg gtcatgcggc ccggccgcag caacagcctc gacctgaccg
     6841 gcgtcgccct ggccaccgcc ggcctcaccg gcatcgtctt cggcctcatc gagggcgagc
     6901 gctacgactg gggaaccatc accggcccga tcagcatcgc gtccgtcatc atcgccggcg
     6961 tcgtgctgct cgtcctgttc gtcctgtggc agcaccgccg caagaccgac tccctcatgc
     7021 cgctggccct cttcaacgcc cgtaacttct cggtcggcaa cggcgtcggc ttcatcttcc
     7081 agctcgggat gatcgccatc gccttcgtcc tggtgctcta tctccagacg gcccgcggtt
     7141 acagcgctct ggagaccgcc gcggtcatgc tgcccaacgc gatcctgacc gcggtcggct
     7201 ccacctacgc gggccggctg tccgacaagt tcggcggcaa gtacgtcctc atggccggcc
     7261 tcgccatgct caccgtcggt ctgctcgtcc tggtcgcctc caccgacgcg cacagcgacg
     7321 cctggagtct gctgcccggc ctgatcatca tcggcatcgc cagcggcgcc accttcgccc
     7381 cgctgcaaca ggccaccatg gacggcgtga acccccagtt ggcgggtgcg gcctcgggcg
     7441 tctccaacac gacccgccag gtgggcggcg tcctcggcac cgccgtactg ggcgccctgc
     7501 tgtccgcccg tatcaacgcc gatctccccg aggaggccca ggaacaggcc gcccagctgc
     7561 cgtcggaact gcgcgaccaa ttcctggccg ccgccgacag cgcggggaac ttcagtccgc
     7621 ccagcgttcc ttcgggcctc agtgtgagcg aggccgacct gttccggcgc ctgggtgacg
     7681 acgccttcgc gacgagcttc acccacgcca tgcacgtcac cttcctggtc gcggccgcag
     7741 tgctcatcgc ggcgaccgtc ttgtgcggcc tcttcacgac gccgccgagg gcggaacccg
     7801 cccaggagac cgcgggtgag gaggacaccc gcagcacatc cgaggactga ccccgccacc
     7861 actctcggct gagcagagcg ggcgcctcgc gcgcccgctc tcaccggtgc tcctgcgtgc
     7921 cccctccgac cggtgctgtc gcgtgcccgc tcccggccgg ccgtgtcggg gcgttctcgc
     7981 ggaccagttc atgcgtgacc atgaagggag atccggcggg cacaccgaag gagcggcacc
     8041 atgagcagtc tcgacctcct gtccgaggac gagcggttcg tcgtcaggac ggtgcgcgac
     8101 ttcgtggaca gggacgtcaa gcccgtcgtc cgggagctgg agcgcaccga cacatacccc
     8161 gaagccctca tcgagcggat gaaggaactc ggcgtcttcg gactcgccgt cccgcaggag
     8221 tacggcggca cacccgtctc catgccctgc tacgtcctcg tcaccgagga gctggcccgg
     8281 ggctggatga gcctggccgg cgcgatgggc gggcacaccg tcgtcgccaa gctgctgctg
     8341 cacttcggca ccgaggagca gcggcagcgc cacctgcccc tgatggccac cggcgagacc
     8401 cgcgcgacga tggcactgac cgagaccggc ggcggctccg acctccaggc gatgcgcacc
     8461 gtcgcccgaa gggagggcga cggctatgtg gtgaacggcg cgaagacgtg gatcaccaac
     8521 tcccgccgct cgcggctcat cgccctgctg tgcaagaccg acccggacgc cgagcccgcg
     8581 cacagcggca tgtccgtcct cctcgtcgag cacggaccgg gcctgaccgt ctcccgtgat
     8641 ctgcccaagc tcggctacaa gggcgtggag agctgcgagc tgtccttcga gaaccaccgc
     8701 gcacgtgccg acgcgctgct ggggggagtg gaggggcacg gcttcgccca gatgatgcgg
     8761 ggtctggaga ccggccgcct ccaagtcgcc gcccgcgccc tgggcgtggg ccgggccgcc
     8821 ctggaggacg cgctcgccta cgcgcaggaa cgcgagtcct tcggcaagcc gatctggcag
     8881 caccagtcga tcggcaacta ccttgccgac atggcgactt cgctcaccgc cgcacgccag
     8941 ctcaccctct atgccgcccg tcgggcggag gccggacacc gggtggacat ggaggccggc
     9001 atggcgaagc tcttcgcctc cgagacggcc atgcagatcg ctctcaacgc cgtccgcatc
     9061 catggcggct acggctactc gaccgagttc gacgtagagc gctacttccg ggacgcgccg
     9121 ctgatgatcg tcggagaggg caccaacgag atccagcgca acatcatcgc cgaccggctc
     9181 gtgaagcggg gaggactgga cgtctgaccc ggacgacccg acacgccccg gccgacgcac
     9241 ctcagctcga cacgcctcgg ccggacactc ctaggctcga cacgcctcgg ccggtcgctc
     9301 ctaggcccga cacaccccgg cccggcacac ccggccgtca cacccccgac caccccacca
     9361 ggacccaaac cccccaccgt ggcagagtgg ccctatgtgc ggccgctacg cctccacccg
     9421 cagcccccag gacctggccc agctgttcga ggtcaccgag tggcaccccg aggagaccct
     9481 cgcgccgagc tggaacgtgg ccccgaccga cgacgtctgg gcggtcctgg aacgcgctcc
     9541 gcggggctcc gacgacgacg ccccggccgt gcgccggctg cggccgctcc gctggggcct
     9601 cgtgccctcc tgggcgaagg acgtgaagat cggcgcgagg atgatcaacg cgcgtgtgga
     9661 gaccgtgcac gagaagcccg ccttccgccg cgcgttcgtc aaacgccgct gcctgctgcc
     9721 ggccgacggc ttctacgagt gggaccaggt caaggacgcc aagtccggca aggtccgcaa
     9781 gcagccctac ttcatccacc cggaggacgg gcaggtcctg gccctcgccg gtctgtacga
     9841 gttctggcgc gacccggccg tcaaggacgg cgacgatccc gccgcctggc tgctgacctg
     9901 caccatcatc accaccgagg ccaccgacgc ggccggccgc atccaccccc gtatgccgct
     9961 cgcgctcacc cccgagcact acgacgcctg gctcgacccg caccaccagt ccacggacga
    10021 cctgcgcgcc ctgctcacca cgccggccga cggtcagctc gacgcccgcc ccgtctcgcc
    10081 cgcggtgaac agcgtcagca acaacggccc ccagctcctg gacgaggttc ccgccccctg
    10141 accacggcga aggtgagctc tcggtaaggg ttggcccgag agggccccgc acagcagttt
    10201 tgacatccat tttcatttag cgtggagccg ctgccgggac ggatcgggct cggcggatca
    10261 ttcgccctgc tcggaggtat ccatgcccct gtcctcaccc cgcgtgcacg cggccctgct
    10321 gaccggcacc tgcctgactc tcctcgtcgg ctgtgccggc tcctcggaca ccgccggggt
    10381 gcacggtccc gccgcggcct ccgtcatccc cgtcgtggcc tcgacgaacg tctacgggga
    10441 cctggccagg cgaataggcg gcgccaaggt ccaggtcacc tcgatcatca gcgaccccga
    10501 ccaggacccg cactcctacg aggcgagcac ccgcaaccaa ctggcgctgt ccaaggccga
    10561 gatcgtcatc gagaacggcg gcggctacga cgacttcgtc gaccgcatgc tgaagagcgc
    10621 gggctcgtcc cccggcgtga tcaacgccgt cgaggtgtca gggaagaccg ccccgaaggg
    10681 cggcgagctc aacgagcatg tctggtacga cttcccgacg gtcgccgaac tcgccgaccg
    10741 catcgccatc gcactcggca aggccgaccc ggccgacgcc gcgaccttca ccgagaacgc
    10801 gaaggacttc gtaagcctcc ttcagccgct ggagcgcaaa gaggcccgga tcaaggccga
    10861 gcacggcggc gaggcggtgg ccatcaccga gcccgtcccg ctgtacatga tcgaggccag
    10921 tgggctgagg aacgccacac ccgaggagtt cagcgaggcg atcgaggaag gcgacgatgt
    10981 ctccccgagg accctccaga gcaccctggc gctgttcacc ggcaagaagg tcgaggcgct
    11041 ggtctacaac gagcagacct ccggcccgca gaccgagaag gcggagcgcg tggccgaggc
    11101 cgccggcatc ccggtcgtgc ccgtcaccga gaccctcccc aagggcaagg actacctcgc
    11161 ctggatgacc gccaacgtgg acgcgctcgc gagcgcgctg gccaagtgac aacccccggc
    11221 gtgtcccgcc ccggcacgga cgacgcactg accggctccc tcggcatggc cgacgcgctg
    11281 atcagtctgc ggcgagcggc cctgtcgtac ggcgagcgcg tggtgtggcg ggacctcgat
    11341 ctcgacgtgc ggccgggcga gttcctggcc gtgctcgggc ccaacggggc cgggaagacc
    11401 agcttcgtgc gcgcgctgct cgggcagcgc cggctgtccg ccggcacgct cacggtgctg
    11461 ggccgtccgc ccggccgcgg cagccggcac atcggctacg tcccccagca ggcggccctg
    11521 tccgcacagg ccatgctgcg tgcccgggac ctcgtccgtc tcggcgtcga cgggcaccgc
    11581 ttcgggcctc ggccgcgcac gggcgccgta cgccgccgcg cggacgagat cctcgcctcg
    11641 gtcggggcca cggcgtacgc cgacgtcccc gtcgccctgc tctccggcgg cgaacggcaa
    11701 cgcgtgcgca tcgggcaggc cctcgcgacc gacccccgca tcctgctctg cgacgaaccc
    11761 ctgctctccc tcgacctgca ccaccagcgg gccgtcacgg aactggtcga cgcacggcgc
    11821 cgctcccacg gcaccgcggt ggtcttcgtc acccacgaga tcaaccccgt gctgggcctc
    11881 gtggaccgcg tgctgtacct cgcccgcggc ggccaccgcg tcggcacgcc cgacgaggtc
    11941 ctcacctccg aggcgctgtc gcggctgtac ggcacacagg tcgacgtcgt ccgtgtccgc
    12001 gaccgcgtgg tggtcgtcgg cgcacccgaa gaggcggccc accatcccca actgcccggc
    12061 ggagcaaggc catgaccctc gcccagggaa tctggcagca gatcttcgcc ttcgaccact
    12121 acggcgaact gctcgccctc gtccggaact cgctcgccgc cggggccgcg ctcgggctgg
    12181 tcggcggcct ggtgggcgtg ttcgtgatca tgcgggacct gccgttcgcg gtgcacggga
    12241 tcagcgagct gtcgttcgcc ggggcctcgg ccgcgctgct gctgggcgtg aacgtcgtgg
    12301 ccgggtcgat cgtcggctcc ctcgtcgcgg cgggggccat cgggctgctc ggggcgcggg
    12361 cccgggaccg caactcggtg atcggcgtca tcatgccgtt cggcctcggg ctcggcgtgc
    12421 tgttcctcgc gctgtacaag ggccgcgcgg cgaacaagtt cggcctgttg accgggcaga
    12481 tcgtcgccgt cgacaccccg cagatgtcct ggctgctcgg cacgtcggcg gtggtgctgg
    12541 tcgcgctcgc ggtgatgtgg cgaccgctcg tcttcgccag tgccgacgcg gaggtggccg
    12601 aggcgcgggg cgtgccggtg cggggaatgt ccttcgcctt catgatcgtg ctgggcctcg
    12661 cggtcgcgct gtccgtccag atcgtcggcg cccttctggt cctgaccctc gtcgtcacac
    12721 ccgcggcggc cgcggctcgc gtcacggcct cgccggtgct gcttcccgtc ctgagcgcgg
    12781 tgttcgcggt ggcctccatc gagggcggca tcctgctggc cctcggcagc agcatcccca
    12841 tcagcccgta cgtcaccacg atctcgttcg gcatctacct cgtgtgcagg cgtttcggcg
    12901 gcaaacgggc ccggaccggt ggggtcggcg tgcagggctg acatgaaggc atgaacgagt
    12961 cttcatgtat tcctctattg tgggggcatg cctgccacgc tcaccccacc cgcggccgac
    13021 cccgccgcct ccgtgcgcgc cggagccgtc cccaggcggc gcacccggct gctcgcgctg
    13081 ccggaggtcc gccgggccgc cgcggccacc gcgctgttcc tgctcgcgct gccgctccag
    13141 ctcgccggag cgcccgcctt gatctggggt gcgctgtacg tgctgtcgta cgccaccggc
    13201 ggctgggagc cgggctggga agggctcaag gcgctcaagg gcaggaccct cgacgtcgat
    13261 ctgctgatgg tcgtcgccgc gctcggcgcc gcatcgatcg ggcaggtcat ggacggcgcc
    13321 ctgctgatcg tcatcttcgc gacctccggc gcgctggagg cgctcgccac cgcccgcacc
    13381 gccgactcgg tgcgcggcct gctcgacctg gcgcccgcca cggccacccg catcgccgcc
    13441 gacggcaccg aacaaaccct ccccgtcgac gagttggcgg tcggcgacac cgtcctcgta
    13501 cggcccggcg agcgcgtcgg ggccgacggg cgggtgctcg acggagcgag cgaggtggat
    13561 cagacgagca tcaccggcga gccgctcccg gcgttgaagg agccgggcga cgaagtcttc
    13621 gcgggcacgc tcaacggcac cggcgcgctg cgcgtccggg tcgaacggga cgcctccgac
    13681 tccgtgatcg cccgcatcgt acggatggtg gaggaggcgt cggagaccaa ggcgcccacg
    13741 cagctgttca tcgagaaggt cgaacagcgt tactcgctgg gcatggtggc cgcgacgctc
    13801 gccgtgttcg gtgtgccgct cgcgttcggt gaggcgttct ccgaggcgct gctgcgtggg
    13861 atgaccttca tgatcgtggc ctcgccgtgc gcggtggtcc tggccaccat gccacccctg
    13921 ctgtcggcca tcgccaacgc cggccggcac ggcgtgctgg tgaagtcggc cgtggcgatg
    13981 gaacgcctcg gccagatcga cgccgtggcg ctggacaaga ccggcacgct cacggagggg
    14041 acgccacggg tcgtcgacgt acggccgctg cgtgaacgtg gcctggacga ggtcgagttg
    14101 ctgacgttcg ccgcggcggc cgagcacccc agcgagcacc cgctggcccg cgcggtggtg
    14161 gacgcggcac gcgagcgtgg cctcgacctg ccggccaccg agggcttcac atccgcgccc
    14221 gggatcggcg tcatggccgt cgtcgggggc cgtacggtcc aggtgggcgc cccggcgcgg
    14281 ctgctcgccg aagccgaagc cgaggtagag gttgaagtcg aggccaagtg cgcagccgat
    14341 gccggcggcg acaccgacgg cgtggtcgcg gcactggtcc gggaactgga ggagtccggc
    14401 cgtagcgccg tcctcgtggt cgtcgacgga accccggccg gtgtgctcgg catcgccgac
    14461 cggctgcgtc ccgacgcggc cgccacggtc gccgctctga ccgtcctcac cggcaccgcc
    14521 ccgaccctcc tcaccggcga caacccccgt gccgccgcgc gcctggcagc cgaggccggt
    14581 gtcgaggacg tgcgggccgg gctgctgccg caggaaaagg tgggcgcggt gcgggagttg
    14641 gagggtgcgg ggcgccgggt gatggtcgtc ggggacggcg tcaacgacgc gcccgcgctg
    14701 gccgccgcgc acatcggcgt cgccatgggc cgagccggct ccgacctcgc cctggagacc
    14761 gccgacgcgg tgatcgtgcg cgacgagctc gtcgccgtac ccgccaccgt cgccctgtcc
    14821 cgccgcgccc gcgagctggt cgtgcagaac ctcgtgatcg ccggggtgtt catcgccggc
    14881 ctggtcgtct gggacctggc cgggacgctg ccgctgcctc tcggggtcgc gggccacgag
    14941 ggctccacgg tcctcgtcgg cctgaacgga ctgcgcctgc tgcgggactc ggcctggaag
    15001 cgggcggcgc cggagggaac cgggaccccg gcgggtgccg caaagttgta gtgcctgcaa
    15061 atgcggctgc cggtcgttgc gatgcggccg atgcgcgagt cggccgaggg cgagcgccgg
    15121 catcgcgaac tccggaggag agctgtcaac gagtgggcgg ggggccgctg ctggcgcgaa
    15181 tcaccaggtc gaccgggacc agcgagcggg tccgggccgg ttcctcggtg ccgtcgagac
    15241 ggtccaggag cagccggagc gagcgcgtgc cgatctcggc gaagtccgtg cgcacggtgg
    15301 tcagcggggg aaggaagtgt gcggcctcgg ggatgtcgtc gtagcccacg acactgatgt
    15361 cgccggggac ggagcggccc gcttcgtgga gggcgtgcag cagaccgagg gccatctggt
    15421 cgttggaggc gaacacggcc gtgacgtccg tgcgccgggc cagccgccgt cccagctcgt
    15481 agcccgagtc ggcactccag tcgccgatca gcggggtcgg caccgccgcg ccggccgcct
    15541 ccagacaggc ctgccagctg cccagccggt gatcggccga ggtccagccg gtcgggccgg
    15601 cgacgtgcca caccgtacgg tgccccaggt ccagcagata cccgaccgcc ttgcgggcac
    15661 cggcccggga gtcgccggtg acctgctggg tgtcggcgtc gacgccgttc tccagcacga
    15721 ccagcggggt gtcgagacga gtgtccgcca gagccttgcc gacccacagc tgaggggcga
    15781 tggcgatcac cccgtccgcg ccctcggcgg acagccggtt caccgcctcg accaccgtgt
    15841 cgggttccgc ggtgtccagg gcgatcgagc tgagcaggta accggcttcc tgcgcagcgg
    15901 tgttgatcgc ggtcaggatc gaggcggggc cgtagcgggc ggcgtcgaag gagatcacgc
    15961 cgaccatccg ggtccgcccg ctggccagcg aacgggcact gcggctcggc cggtagccca
    16021 gcgtgcgcat ggcgctcagc actgtctcgc gggtctcggc ccgcaccgac ggatggtcgt
    16081 tgaggacgcg ggagacggtc tgcttggaga cgcccgccag ccgggccacg tcgtccatca
    16141 cggggcgcga gcccgcgaag ttccgtctgc tgcgcccccg tggagcggag tcgtcggcgg
    16201 agcctcgggt catgatcgct gtttcctcgc catcgtcacg gcggcggcat ccgccccggc
    16261 aggtctccca gcataggcag gtcggcgggg cggaacgccg tacggcgccg cctcagcccg
    16321 cccgcacggc ccggacacga ccgaggatcc actcggcacg cgtcaccacc gccgaccgcg
    16381 ccgcatccgc cgcctcccgc ggcacatgga ccctggcatc ggcatgcagc ggcagcaccc
    16441 ggacccgcag cgccgccccc gccgcaagcc ggccgatgtc ccagacccgc cccgagaaga
    16501 actggtcggc gaccaacctc tctcccacat gggcccgccc ggcgtccccg ctccagtgca
    16561 accgcagcac ggcgccctcc gggagatcgt ccggtacgtc gacgcggtac tcggcggcga
    16621 ccgtgtcgta gtacttgtcc gcgggcgcgc tcgcacgtcc cagcacacag gtcgcgggct
    16681 cgggcgcagg gcccgggggc cgcaccaggg tgagcgaagc ccggagcggc tcgtcgccgc
    16741 cgctcccgac gcggtaccgg gcgaggacgc cgtcggcctc ggcggtcacc gtctccccgt
    16801 ccaccaccag cgggctgtgc ggcgccggca agacggcgaa cgacgttcgc ccggcagcgc
    16861 cgtgcacccg tacctcgtca ccgtcgaaga cgatcccgtc ggcgctcagc accagccgct
    16921 cggcgcccca ggccacgccc cgatggacgg tacgggccgt cgcggcgtcc agcaccagca
    16981 gaccggcccg tccgccgtcc gccgcttcca cctcgaccag cgcgccggtg ccgggccgca
    17041 gcccggtcac caggatccgg cccccgactt cggcgatgtc cccggacggc gcaccgaccg
    17101 acgccaccgt gccggcgtcc agggcgagtt cgggcgcgat gccgtcggtg gccgcgagca
    17161 ccaggaccgt acgcccgtcc acgtcgaccg tgcagaccgg ctgcgccgtc gcccagtcca
    17221 gtcgggcgcc cgcgacgtcg agccgcagcg gccagcagaa gaacgcgccc gccggcacgg
    17281 tcaccggagt ggcgggcagc gtcaacgcct ctgcttcgcc cgggaattcg accgtgaagg
    17341 atgtgtccgg gcggtccggc agcggctcgt gcggctggtg gttgttacga agaggaaccc
    17401 ggagtcgccg tcggcgcgca cggcccaccg cagggtgtcc cggtccagct gtccctcggg
    17461 caggcgctcc ggcagcaccg actccatcgg ggcgatgaga tggccgtagt ccgccagcag
    17521 caggtgctgg aggcggagtt
//
