BGC0000230: griseorhodin A biosynthetic gene cluster from Streptomyces sp. JP95
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Location: 1 - 36,905 nt. (total: 36,905 nt).
This entry is originally from NCBI GenBank AF509565.1.

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core biosynthetic genes
additional biosynthetic genes
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General
Compounds
Genes
Polyketide
History
NRPS/PKS domains
KnownClusterBlast
General information about the BGC
MIBiG accession BGC0000230
Short description griseorhodin A biosynthetic gene cluster from Streptomyces sp. JP95
Status Minimal annotation: no
A minimal annotation only contains information on the BGC loci and one or more linked chemical product(s)

Completeness: complete
Whether the loci encodes everything needed for the pathway producing the compound(s)
Biosynthetic class(es)
  • Polyketide (Polyphenol)
Loci NCBI GenBank: AF509565.1
Compounds
  • griseorhodin A
Species Streptomyces sp. JP95 [taxonomy]
References
Chemical products information
griseorhodin A
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C25H16O10
Chemical database entries
PubCHEM
List of genes involved in compound(s) production
Identifiers Position Product Functions Evidence Extra
  • AAM33679.1
  • grhR1
 1245 - 2066 (+) putative transcriptional activator
  • Regulation
Sequence-based prediction
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  • AAM33680.1
  • grhR2
 2296 - 3117 (+) putative transcriptional activator
  • Regulation
Sequence-based prediction
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  • AAM33656.1
  • grhD
 3315 - 4130 (+) putative thioesterase GrhD
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  • AAM33655.1
  • grhC
 4323 - 4583 (+) putative acyl carrier protein
  • Scaffold biosynthesis
Sequence-based prediction
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  • AAM33657.1
  • grhE
 4744 - 5715 (+) putative cyclase
  • Scaffold biosynthesis
Sequence-based prediction
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  • AAM33658.1
  • grhF
 5777 - 6580 (+) putative phosphopantetheinyl transferase
  • Scaffold biosynthesis
Sequence-based prediction
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  • AAM33659.1
  • grhG
 6920 - 8485 (+) putative transcarboxylase component of acyl-CoA carboxylase
  • Precursor biosynthesis
Sequence-based prediction
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  • AAM33660.1
  • grhH
 8502 - 8843 (+) GrhH
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  • AAM33661.1
  • grhI
 9055 - 9423 (+) GrhI
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  • AAM33667.1
  • grhO1
 9482 - 10885 (+) putative FAD-binding oxidoreductase
  • Tailoring (Monooxygenation)
Sequence-based prediction
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  • AAM33669.1
  • grhO2
 10944 - 11717 (+) putative 3-oxoacyl-ACP reductase GrhO2
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  • AAM33670.1
  • grhO3
 11774 - 13024 (+) putative cytochrome P450 GrhO3
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  • AAM33671.1
  • grhO4
 13031 - 13234 (+) putative ferredoxin
  • Other enzymatic
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  • AAM33662.1
  • grhJ
 13473 - 14360 (+) GrhJ
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  • AAM33672.1
  • grhO5
 14492 - 16105 (+) putative FAD-dependent monooxygenase GrhO5
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  • AAM33681.1
  • grhR3
 16161 - 16679 (-) putative transcriptional repressor
  • Regulation
Sequence-based prediction
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  • AAM33673.1
  • grhO6
 16851 - 18413 (+) putative FAD-dependent monooxygenase GrhO6
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  • AAM33674.1
  • grhO7
 18609 - 19586 (+) putative NADPH:quinone oxidoreductase GrhO7
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  • AAM33663.1
  • grhK
 19815 - 21404 (+) putative efflux protein
  • Transport
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  • AAM33664.1
  • grhL
 21607 - 22638 (+) putative methyltransferase
  • Tailoring (Methylation)
Sequence-based prediction
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  • AAM33675.1
  • grhO8
 22699 - 24288 (+) putative FAD-dependent monooxygenase GrhO8
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  • AAM33676.1
  • grhO9
 24529 - 26118 (-) putative FAD-dependent oxidoreductase GrhO9
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  • AAM33665.1
  • grhM
 26432 - 26884 (+) GrhM
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  • AAM33666.1
  • grhN
 27019 - 27462 (+) GrhN
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  • AAM33677.1
  • grhP
 27459 - 29336 (+) putative class II glutamine amidotransferase GrhP
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  • AAM33678.1
  • grhRQ
 29428 - 29799 (+) putative cyclase
  • Scaffold biosynthesis
Sequence-based prediction
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  • AAM33682.1
  • grhS
 29796 - 30230 (+) Unknown
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  • AAM33653.1
  • grhA
 30227 - 31507 (+) putative ketosynthase alpha
  • Scaffold biosynthesis
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  • AAM33654.1
  • grhB
 31504 - 32766 (+) putative ketosynthase beta
  • Scaffold biosynthesis
Sequence-based prediction
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  • AAM33685.1
  • grhT
 32829 - 34037 (+) putative bifunctional cyclase/3-oxoacyl-ACP reductase
  • Scaffold biosynthesis
Sequence-based prediction
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  • AAM33668.1
  • grhO10
 34070 - 34819 (+) putative 3-oxoacyl-ACP reductase
  • Scaffold biosynthesis
Sequence-based prediction
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  • AAM33683.1
  • grhU
 34821 - 35144 (+) Unknown
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  • AAM33684.1
  • grhV
 35141 - 35449 (+) Unknown
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Polyketide-specific information
Subclass Polyphenol
Ketide length 13
Cyclic? no
Polyketide-synthases
Genes Properties Modules
grhC
+
grhA
+
grhT
+
grhE
+
grhRQ 		Synthase subclass: Type II
Annotation changelog
MIBiG version Submitter Notes
1.0
  • Hidden contributor (ID: CUIZDUBUBVAF27VHF4OZXTI3, no GDPR consent given).
  • Submitted
2.0
  • Hidden contributor (ID: AAAAAAAAAAAAAAAAAAAAAAAA, no GDPR consent given).
  • Migrated from v1.4
3.0
  • Hidden contributor (ID: AAAAAAAAAAAAAAAAAAAAAAAA, no GDPR consent given).
  • Removed duplicate gene annotations
  • Removed undefined 'kr' gene from subcluster
3.1
  • Hidden contributor (ID: AAAAAAAAAAAAAAAAAAAAAAAA, no GDPR consent given).
  • Update chemical activity to schema version 2.11
Detailed domain annotation
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