BGC0000241: lomaiviticin A biosynthetic gene cluster from Salinispora tropica CNB-440
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Location: 2,460,444 - 2,522,674 nt. (total: 62,231 nt).
This entry is originally from NCBI GenBank CP000667.1.

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core biosynthetic genes
additional biosynthetic genes
transport-related genes
regulatory genes
other genes
resistance
TTA codons
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Gene details
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General
Compounds
Genes
Polyketide
Saccharide
History
NRPS/PKS domains
KnownClusterBlast
General information about the BGC
MIBiG accession BGC0000241
Short description lomaiviticin A biosynthetic gene cluster from Salinispora tropica CNB-440
Status Minimal annotation: no
A minimal annotation only contains information on the BGC loci and one or more linked chemical product(s)

Completeness: complete
Whether the loci encodes everything needed for the pathway producing the compound(s)
Biosynthetic class(es)
  • Polyketide (Other)
  • Saccharide (hybrid/tailoring)
Loci NCBI GenBank: CP000667.1
Compounds
  • lomaiviticin A
  • lomaiviticin C
  • lomaiviticin D
  • lomaiviticin E
Species Salinispora tropica CNB-440 [taxonomy]
References
Chemical products information
lomaiviticin A
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C68H80N6O24
Chemical database entries
NPAtlas
PubCHEM
ChemSpider
lomaiviticin C
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C68H84N4O24
lomaiviticin D
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C69H86N4O24
lomaiviticin E
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C70H86N4O24
Chemical database entries
NPAtlas
List of genes involved in compound(s) production
Identifiers Position Product Functions Evidence Extra
  • Strop_2172
  • ABP54623.1
 2460444 - 2462018 (+) drug resistance transporter, EmrB/QacA subfamily
  • Resistance/immunity
Sequence-based prediction
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  • Strop_2173
  • ABP54624.1
 2462246 - 2462731 (+) hypothetical protein
  • Unknown
Sequence-based prediction
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  • Strop_2174
  • ABP54625.1
 2462891 - 2463721 (-) hypothetical protein
  • Unknown
Sequence-based prediction
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  • Strop_2175
  • ABP54626.1
 2463718 - 2464668 (-) ABC transporter related
  • Transport
Sequence-based prediction
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  • Strop_2176
  • ABP54627.1
 2464643 - 2465158 (-) Glyoxalase/bleomycin resistance protein/dioxygenase
  • Resistance/immunity
Sequence-based prediction
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  • Strop_2177
  • ABP54628.1
 2465303 - 2466079 (-) hypothetical protein
  • Unknown
Sequence-based prediction
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  • Strop_2178
  • ABP54629.1
 2466328 - 2467164 (-) transcriptional activator domain
  • Regulation
Sequence-based prediction
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  • Strop_2179
  • ABP54630.1
 2467536 - 2467877 (-) hypothetical protein
  • Unknown
Sequence-based prediction
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  • Strop_2180
  • ABP54631.1
 2467910 - 2468755 (+) transcriptional regulator, AraC family
  • Regulation
Sequence-based prediction
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  • Strop_2181
  • ABP54632.1
 2469003 - 2470436 (+) NDP-hexose 2,3-dehydratase
  • Precursor biosynthesis
Sequence-based prediction
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  • Strop_2182
  • ABP54633.1
 2470489 - 2471154 (-) hypothetical protein
  • Unknown
Sequence-based prediction
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  • Strop_2183
  • ABP54634.1
 2471199 - 2471645 (-) Carboxymuconolactone decarboxylase
  • Unknown
Sequence-based prediction
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  • Strop_2184
  • ABP54635.1
 2471575 - 2472402 (-) peptidase C26
  • Unknown
Sequence-based prediction
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  • Strop_2185
  • ABP54636.1
 2472868 - 2474640 (+) monooxygenase, FAD-binding
  • Tailoring (Hydroxylation)
Sequence-based prediction
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  • Strop_2186
  • ABP54637.1
 2474803 - 2476269 (-) protoporphyrinogen oxidase
  • Unknown
Sequence-based prediction
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  • Strop_2187
  • ABP54638.1
 2476390 - 2477496 (-) ParB domain protein nuclease
  • Unknown
Sequence-based prediction
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  • Strop_2188
  • ABP54639.1
 2477548 - 2479059 (-) monooxygenase, FAD-binding
  • Tailoring (Oxidation)
Sequence-based prediction
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  • Strop_2189
  • ABP54640.1
 2479056 - 2480528 (-) monooxygenase, FAD-binding
  • Tailoring (Oxidation)
Sequence-based prediction
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  • Strop_2190
  • ABP54641.1
 2480681 - 2481472 (+) short-chain dehydrogenase/reductase SDR
  • Scaffold biosynthesis
Sequence-based prediction
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  • Strop_2191
  • ABP54642.1
 2481527 - 2482399 (+) NmrA family protein
  • Tailoring (Unknown)
Sequence-based prediction
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  • Strop_2192
  • ABP54643.1
 2482473 - 2483090 (-) hypothetical protein
  • Unknown
Sequence-based prediction
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  • Strop_2193
  • ABP54644.1
 2483105 - 2483434 (-) Polyketide synthesis cyclase
  • Scaffold biosynthesis
Sequence-based prediction
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  • Strop_2194
  • ABP54645.1
 2483463 - 2484248 (-) short-chain dehydrogenase/reductase SDR
  • Scaffold biosynthesis
Sequence-based prediction
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  • Strop_2195
  • ABP54646.1
 2484439 - 2485476 (+) hydroxyneurosporene-O-methyltransferase
  • Unknown
Sequence-based prediction
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  • Strop_2196
  • ABP54647.1
 2485530 - 2487041 (+) monooxygenase, FAD-binding
  • Tailoring (Reduction)
Sequence-based prediction
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  • Strop_2197
  • ABP54648.1
 2487067 - 2488026 (+) cyclase/dehydrase
  • Scaffold biosynthesis
Sequence-based prediction
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  • Strop_2198
  • ABP54649.1
 2488023 - 2489462 (+) monooxygenase, FAD-binding
  • Unknown
Sequence-based prediction
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  • Strop_2199
  • ABP54650.1
 2489449 - 2490927 (+) monooxygenase, FAD-binding
  • Unknown
Sequence-based prediction
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  • Strop_2200
  • ABP54651.1
 2490997 - 2491740 (+) hypothetical protein
  • Unknown
Sequence-based prediction
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  • Strop_2201
  • ABP54652.1
 2491809 - 2493692 (-) hypothetical protein
  • Unknown
Sequence-based prediction
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  • Strop_2202
  • ABP54653.1
 2493667 - 2494023 (-) 4Fe-4S ferredoxin, iron-sulfur binding domain protein
  • Unknown
Sequence-based prediction
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  • Strop_2203
  • ABP54654.1
 2494093 - 2494887 (-) hypothetical protein
  • Unknown
Sequence-based prediction
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  • Strop_2204
  • ABP54655.1
 2494939 - 2496441 (-) L-glutamine synthetase
  • Unknown
Sequence-based prediction
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  • Strop_2205
  • ABP54656.1
 2496438 - 2497892 (-) Amidase
  • Unknown
Sequence-based prediction
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  • Strop_2206
  • ABP54657.1
 2498099 - 2499385 (+) Adenylosuccinate lyase
  • Unknown
Sequence-based prediction
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  • Strop_2207
  • ABP54658.1
 2499369 - 2499770 (+) GCN5-related N-acetyltransferase
  • Unknown
Sequence-based prediction
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  • Strop_2208
  • ABP54659.1
 2499843 - 2501612 (-) ABC transporter related
  • Transport
Sequence-based prediction
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  • Strop_2209
  • ABP54660.1
 2501752 - 2502072 (-) Rieske (2Fe-2S) domain protein
  • Unknown
Sequence-based prediction
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  • Strop_2210
  • ABP54661.1
 2502319 - 2502729 (+) Glyoxalase/bleomycin resistance protein/dioxygenase
  • Resistance/immunity
Sequence-based prediction
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  • Strop_2211
  • ABP54662.1
 2502798 - 2503595 (+) Glyoxalase/bleomycin resistance protein/dioxygenase
  • Resistance/immunity
Sequence-based prediction
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  • Strop_2212
  • ABP54663.1
 2503680 - 2505242 (-) TAP domain protein
  • Unknown
Sequence-based prediction
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  • Strop_2213
  • ABP54664.1
 2505434 - 2506576 (-) protein of unknown function DUF1205
  • Unknown
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  • Strop_2214
  • ABP54665.1
 2506573 - 2507688 (-) O-methyltransferase, family 2
  • Unknown
Sequence-based prediction
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  • Strop_2215
  • ABP54666.1
 2507870 - 2508811 (+) hypothetical protein
  • Unknown
Sequence-based prediction
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  • Strop_2216
  • ABP54667.1
 2508877 - 2509863 (+) NAD-dependent epimerase/dehydratase
  • Precursor biosynthesis
Sequence-based prediction
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  • Strop_2217
  • ABP54668.1
 2509873 - 2510484 (+) dTDP-4-dehydrorhamnose 3,5-epimerase
  • Precursor biosynthesis
Sequence-based prediction
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  • Strop_2218
  • ABP54669.1
 2510535 - 2511548 (+) oxidoreductase domain protein
  • Unknown
Sequence-based prediction
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  • Strop_2219
  • ABP54670.1
 2511568 - 2512302 (-) hypothetical protein
  • Unknown
Sequence-based prediction
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  • Strop_2220
  • ABP54671.1
 2512374 - 2513414 (-) protein of unknown function DUF1205
  • Unknown
Sequence-based prediction
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  • Strop_2221
  • ABP54672.1
 2513431 - 2514642 (-) DegT/DnrJ/EryC1/StrS aminotransferase
  • Precursor biosynthesis
Sequence-based prediction
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  • Strop_2222
  • ABP54673.1
 2514817 - 2515824 (+) dTDP-glucose 4,6-dehydratase
  • Precursor biosynthesis
Sequence-based prediction
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  • Strop_2223
  • ABP54674.1
 2515821 - 2517092 (+) beta-ketoacyl synthase
  • Scaffold biosynthesis
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  • Strop_2224
  • ABP54675.1
 2517089 - 2518375 (+) beta-ketoacyl synthase
  • Scaffold biosynthesis
Sequence-based prediction
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  • Strop_2225
  • ABP54676.1
 2518375 - 2518629 (+) phosphopantetheine-binding
  • Scaffold biosynthesis
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  • Strop_2226
  • ABP54677.1
 2518611 - 2519594 (+) acyl transferase domain protein
  • Precursor biosynthesis
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  • Strop_2227
  • ABP54678.1
 2519716 - 2520690 (+) hypothetical protein
  • Precursor biosynthesis
Sequence-based prediction
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  • Strop_2229
  • ABP54679.1
 2521135 - 2521617 (+) transcriptional regulator, AraC family
  • Unknown
Sequence-based prediction
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  • Strop_2230
  • ABP54680.1
 2521802 - 2522674 (+) Glucose-1-phosphate thymidylyltransferase
  • Precursor biosynthesis
Sequence-based prediction
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Polyketide-specific information
Subclass Other
Ketide length 10
Cyclic? yes
Polyketide-synthases
Genes Properties Modules
Strop_2197
+
Strop_2223
+
Strop_2193 		Synthase subclass: Type II
Saccharide-specific information
Subclass hybrid/tailoring
Annotation changelog
MIBiG version Submitter Notes
1.0
  • Hidden contributor (ID: UJYWT4SZRXDY2IOPYAIF6MII, no GDPR consent given).
  • Submitted
2.0
  • Hidden contributor (ID: AAAAAAAAAAAAAAAAAAAAAAAA, no GDPR consent given).
  • Migrated from v1.4
  • Updated compound(s) information (NPAtlas curation)
3.0
  • Hidden contributor (ID: AAAAAAAAAAAAAAAAAAAAAAAA, no GDPR consent given).
  • Removed gene names of 'No gene ID'
3.1
  • Hidden contributor (ID: AAAAAAAAAAAAAAAAAAAAAAAA, no GDPR consent given).
  • Update chemical activity to schema version 2.11
Detailed domain annotation
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