BGC0000291: A54145 biosynthetic gene cluster from Streptomyces fradiae
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Location: 1 - 126,933 nt. (total: 126,933 nt).
This entry is originally from NCBI GenBank DQ118863.1.

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core biosynthetic genes
additional biosynthetic genes
transport-related genes
regulatory genes
other genes
resistance
TTA codons
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Gene details
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General
Compounds
Genes
NRP
History
NRPS/PKS domains
KnownClusterBlast
General information about the BGC
MIBiG accession BGC0000291
Short description A54145 biosynthetic gene cluster from Streptomyces fradiae
Status Minimal annotation: no
A minimal annotation only contains information on the BGC loci and one or more linked chemical product(s)

Completeness: Unknown
Whether the loci encodes everything needed for the pathway producing the compound(s)
Biosynthetic class(es)
  • NRP
Loci NCBI GenBank: DQ118863.1
Compounds
  • A54145
Species Streptomyces fradiae [taxonomy]
References
Chemical products information
A54145
(no structure information available)
List of genes involved in compound(s) production
Identifiers Position Product Functions Evidence Extra
  • AAZ23044.1
 3 - 851 (+) hypothetical protein
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  • AAZ23045.1
 848 - 2473 (+) probable p-aminobenzoyl-glutamate transporter
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  • AAZ23046.1
 3365 - 4900 (-) probable histidine ammonia-lyase
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  • AAZ23047.1
 5048 - 5815 (+) transcriptional regulator
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  • AAZ23048.1
 6739 - 7635 (+) probable hydrolase
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  • AAZ23049.1
 8966 - 10024 (+) possible oxidoreductase
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  • AAZ23050.1
 10027 - 10467 (+) hypothetical protein
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  • AAZ23051.1
 11363 - 12862 (-) probable sugar kinase
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  • AAZ23052.1
 13059 - 15098 (-) probable dehydrogenase
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  • AAZ23053.1
 15190 - 16359 (-) probable sugar isomerase
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  • AAZ23054.1
 18507 - 19304 (+) hypothetical protein
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  • AAZ23055.1
 19323 - 20366 (-) hypothetical protein
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  • AAZ23056.1
 20753 - 21838 (-) hypothetical protein
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  • AAZ23057.1
 21918 - 23210 (-) probable integral membrane protein
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  • AAZ23058.1
 23207 - 24364 (-) probable secreted protein
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  • AAZ23059.1
 24542 - 25225 (-) probable putative response regulator
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  • AAZ23060.1
 25222 - 26619 (-) probable sensor kinase
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  • AAZ23061.1
 26669 - 28321 (-) probable D-aminoacylase
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  • AAZ23062.1
 28359 - 29798 (-) possible permease
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  • AAZ23063.1
 29795 - 31207 (-) probable decarboxylase
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  • AAZ23064.1
 31333 - 33018 (-) possible DNA-binding protein
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  • AAZ23065.1
 33118 - 34419 (-) hypothetical protein
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  • AAZ23066.1
 34423 - 35001 (+) hypothetical protein
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  • AAZ23067.1
 34950 - 35426 (+) hypothetical protein
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  • AAZ23068.1
 35510 - 36931 (-) hypothetical protein
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  • AAZ23069.1
 37360 - 38181 (+) hypothetical protein
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  • AAZ23070.1
 38233 - 38958 (-) possible response regulator
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  • AAZ23071.1
 38955 - 39803 (-) possible sensor kinase
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  • AAZ23072.1
 39941 - 40651 (+) hypothetical protein
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  • AAZ23073.1
 40648 - 42957 (+) hypothetical protein
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  • AAZ23074.1
  • lptEF
 43616 - 45814 (+) acyl-CoA ligase
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  • AAZ23075.1
  • lptA
 45924 - 64802 (+) peptide synthetase
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  • AAZ23076.1
  • lptB
 64799 - 71230 (+) peptide synthetase
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  • AAZ23077.1
  • lptC
 71227 - 86967 (+) peptide synthetase
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  • AAZ23078.1
  • lptD
 86967 - 94121 (+) peptide synthetase
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  • AAZ23079.1
  • lptG
 94118 - 94360 (+) hypothetical protein
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  • AAZ23080.1
  • lptH
 94443 - 95237 (+) possible thioesterase
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  • AAZ23081.1
  • lptJ
 95249 - 96244 (+) hypothetical protein
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  • AAZ23082.1
  • lptK
 96241 - 97029 (+) possible O-methyltransferase
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  • AAZ23083.1
  • lptL
 97099 - 98058 (+) possible hydrolase
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  • AAZ23084.1
  • lptM
 98058 - 99119 (+) possible ABC transporter
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  • AAZ23085.1
  • lptN
 99116 - 99964 (+) possible ABC transporter permease
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  • AAZ23086.1
  • lptP
 100029 - 100649 (-) hypothetical protein
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  • AAZ23087.1
  • lptI
 101479 - 102537 (+) possible methyltransferase
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  • AAZ23088.1
 104185 - 105123 (+) possible regulator
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  • AAZ23089.1
 105287 - 105697 (+) hypothetical protein
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  • AAZ23090.1
 105694 - 105879 (-) hypothetical protein
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  • AAZ23091.1
 106395 - 107252 (-) possible transposase
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  • AAZ23092.1
 110701 - 112812 (-) possible protein kinase
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  • AAZ23093.1
 112824 - 113243 (-) hypothetical protein
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  • AAZ23094.1
 113931 - 114662 (-) possible transposase
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  • AAZ23095.1
 118101 - 119465 (+) possible DNA helicase
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  • AAZ23096.1
 118989 - 120017 (-) hypothetical protein
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  • AAZ23097.1
 120066 - 120731 (-) hypothetical protein
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  • AAZ23098.1
 121573 - 121971 (+) hypothetical protein
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  • AAZ23099.1
 122339 - 123214 (-) probable transposase
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  • AAZ23100.1
 123359 - 123673 (+) hypothetical protein
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  • AAZ23101.1
 123917 - 124387 (+) possible transposase
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  • AAZ23102.1
 124378 - 124752 (+) possible transposase
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  • AAZ23103.1
 125782 - 126729 (+) hypothetical protein
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NRP-specific information
Subclass N/A
Cyclic? no
NRP-synthases
Gene Modules
lptA
Module ?
Specificity: tryptophan
Evidence for specificity:
  • Structure-based inference
Module ?
Specificity: glutamic acid
Evidence for specificity:
  • Structure-based inference
Module ?
Specificity: asparagine / 3-hydroxyasparagine
Evidence for specificity:
  • Structure-based inference
  • Knock-out studies
Module ?
Specificity: threonine
Evidence for specificity:
  • Structure-based inference
Module ?
Specificity: glycine
Evidence for specificity:
  • Structure-based inference
lptB
Module ?
Specificity: alanine
Evidence for specificity:
  • Structure-based inference
Module ?
Specificity: aspartic acid
Evidence for specificity:
  • Structure-based inference
lptC
Module ?
Specificity: lysine
Evidence for specificity:
  • Structure-based inference
Module ?
Specificity: aspartic acid / 3-hydroxyaspartic acid / 3-methoxyaspartic acid
Evidence for specificity:
  • Structure-based inference
  • Knock-out studies
Module ?
Specificity: glycine
Evidence for specificity:
  • Structure-based inference
Module ?
Specificity: asparagine
Evidence for specificity:
  • Structure-based inference
lptD
Module ?
Specificity: 3R-methylglutamic acid / glutamic acid
Evidence for specificity:
  • Structure-based inference
  • Knock-out studies
Module ?
Specificity: isoleucine / valine
Evidence for specificity:
  • Structure-based inference
Annotation changelog
MIBiG version Submitter Notes
1.0
  • Hidden contributor (ID: AAAAAAAAAAAAAAAAAAAAAAAA, no GDPR consent given).
  • Submitted
2.0
  • Hidden contributor (ID: AAAAAAAAAAAAAAAAAAAAAAAA, no GDPR consent given).
  • Migrated from v1.4
3.0
  • Hidden contributor (ID: AAAAAAAAAAAAAAAAAAAAAAAA, no GDPR consent given).
  • Updated bioactivity data
  • Added NRP substrate specificities
3.1
  • Hidden contributor (ID: AAAAAAAAAAAAAAAAAAAAAAAA, no GDPR consent given).
  • Update chemical activity to schema version 2.11
Detailed domain annotation
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