BGC0000300: amychelin biosynthetic gene cluster from Streptomyces sp. AA4
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Location: 2,722,391 - 2,757,628 nt. (total: 35,238 nt).
This entry is originally from NCBI GenBank GG657746.1.

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core biosynthetic genes
additional biosynthetic genes
transport-related genes
regulatory genes
other genes
resistance
TTA codons
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Gene details
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General
Compounds
Genes
NRP
History
NRPS/PKS domains
KnownClusterBlast
General information about the BGC
MIBiG accession BGC0000300
Short description amychelin biosynthetic gene cluster from Streptomyces sp. AA4
Status Minimal annotation: no
A minimal annotation only contains information on the BGC loci and one or more linked chemical product(s)

Completeness: Unknown
Whether the loci encodes everything needed for the pathway producing the compound(s)
Biosynthetic class(es)
  • NRP
Loci NCBI GenBank: GG657746.1
Compounds
  • amychelin
Species Streptomyces sp. AA4 [taxonomy]
References
Chemical products information
amychelin
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C30H42N8O14
Chemical database entries
NPAtlas
PubCHEM
List of genes involved in compound(s) production
Identifiers Position Product Functions Evidence Extra
  • SSMG_02531
  • EFL06860.1
2722391 - 2722987 (-) TetR family transcriptional regulator
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  • SSMG_02532
  • EFL06861.1
2723073 - 2724563 (+) predicted protein
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  • SSMG_02533
  • EFL06862.1
2724610 - 2725971 (+) amine oxidase
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  • SSMG_02534
  • EFL06863.1
2726287 - 2727519 (+) predicted protein
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  • SSMG_02535
  • EFL06864.1
2727576 - 2730929 (-) non-ribosomal peptide synthetase
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  • SSMG_02536
  • EFL06865.1
2730923 - 2738011 (-) hypothetical protein
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  • SSMG_02537
  • EFL06866.1
2738004 - 2742209 (-) predicted protein
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  • SSMG_02538
  • EFL06867.1
2742194 - 2749195 (-) predicted protein
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  • SSMG_02539
  • EFL06868.1
2749192 - 2749413 (-) mbtH protein
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  • SSMG_02540
  • EFL06869.1
2749462 - 2750268 (-) LipE protein
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  • SSMG_02541
  • EFL06870.1
2750241 - 2751416 (-) major facilitator superfamily transporter multidrug resistance protein
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  • SSMG_02542
  • EFL06871.1
2751559 - 2753106 (+) 2,3-dihydroxybenzoate-AMP ligase
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  • SSMG_02543
  • EFL06872.1
2753103 - 2754086 (+) predicted protein
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  • SSMG_02544
  • EFL06873.1
2754083 - 2755066 (+) predicted protein
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  • SSMG_02545
  • EFL06874.1
2755074 - 2756384 (-) salicylate synthase
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  • SSMG_02546
  • EFL06875.1
2756348 - 2757628 (-) peptide monooxygenase
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NRP-specific information
Subclass N/A
Cyclic? no
NRP-synthases
Gene Modules
SSMG_02535
Module ?
Specificity: serine
Evidence for specificity:
  • Structure-based inference
  • X-ray crystallography
SSMG_02536
Module ?
Specificity: serine
Evidence for specificity:
  • Structure-based inference
  • X-ray crystallography
Module ?
Specificity: serine
Evidence for specificity:
  • Structure-based inference
  • X-ray crystallography
SSMG_02537
Module ?
Specificity: N5-hydroxyornithine
Evidence for specificity:
  • Structure-based inference
  • X-ray crystallography
SSMG_02538
Module ?
Specificity: serine
Evidence for specificity:
  • Structure-based inference
  • X-ray crystallography
Module ?
Specificity: N5-formyl-N5-hydroxyornithine
Evidence for specificity:
  • Structure-based inference
  • X-ray crystallography
SSMG_02542
Module ?
Specificity: salicylic acid
Evidence for specificity:
  • Homology
  • X-ray crystallography
Annotation changelog
MIBiG version Submitter Notes
1.0
  • Hidden contributor (ID: AAAAAAAAAAAAAAAAAAAAAAAA, no GDPR consent given).
  • Submitted
2.0
  • Hidden contributor (ID: AAAAAAAAAAAAAAAAAAAAAAAA, no GDPR consent given).
  • Migrated from v1.4
  • Updated compound(s) information (NPAtlas curation)
3.0
  • Hidden contributor (ID: AAAAAAAAAAAAAAAAAAAAAAAA, no GDPR consent given).
  • Updated bioactivity data
  • Added NRP substrate specificities
3.1
  • Hidden contributor (ID: AAAAAAAAAAAAAAAAAAAAAAAA, no GDPR consent given).
  • Update chemical activity to schema version 2.11
Detailed domain annotation
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