BGC0000303: anthramycin biosynthetic gene cluster from Streptomyces refuineus subsp. thermotolerans
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Location: 1 - 33,150 nt. (total: 33,150 nt).
This entry is originally from NCBI GenBank EU195114.1.

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core biosynthetic genes
additional biosynthetic genes
transport-related genes
regulatory genes
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resistance
TTA codons
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General
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NRPS/PKS domains
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General information about the BGC
MIBiG accession BGC0000303
Short description anthramycin biosynthetic gene cluster from Streptomyces refuineus subsp. thermotolerans
Status Minimal annotation: yes
A minimal annotation only contains information on the BGC loci and one or more linked chemical product(s)

Completeness: Unknown
Whether the loci encodes everything needed for the pathway producing the compound(s)
Biosynthetic class(es)
  • NRP
Loci NCBI GenBank: EU195114.1
Compounds
  • anthramycin
Species Streptomyces refuineus subsp. thermotolerans [taxonomy]
References
Chemical products information
anthramycin
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C16H17N3O4
Chemical database entries
NPAtlas
PubCHEM
List of genes involved in compound(s) production
Identifiers Position Product Functions Evidence Extra
  • ABW71832.1
 1 - 1860 (-) putative amidotransferase
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  • ABW71833.1
 1883 - 3385 (-) putative aldehyde dehydrogease
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  • ABW71834.1
 3382 - 4446 (-) putative alcohol dehydrogenase
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  • ABW71835.1
 4468 - 5700 (-) cytochrome P-450 hydroxylase
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  • ABW71836.1
 5697 - 6755 (-) methyltransferase
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  • ABW71837.1
 6789 - 8654 (-) hypothetical protein
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  • ABW71838.1
 8651 - 10114 (-) FAD oxidoreductase
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  • ABW71839.1
 10514 - 12808 (+) drug-resistance pump
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  • ABW71840.1
 12855 - 13625 (+) putative hydroxylase/glyoxylase
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  • ABW71841.1
 13654 - 14847 (+) transporter
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  • ABW71842.1
 14967 - 15236 (+) hypothetical protein
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  • ABW71843.1
 15320 - 15829 (+) putative L-DOPA 2,3-dioxygenase
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  • ABW71844.1
 15826 - 16734 (+) putative L-tyosine 3-hydroxylase
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  • ABW71845.1
 16731 - 17624 (+) hypothetical protein
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  • ABW71846.1
 17615 - 18445 (+) hypothetical protein
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  • ABW71847.1
 18442 - 19683 (+) putative kynureninase
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  • ABW71848.1
 19694 - 20479 (+) putative tryptophan 2,3-dioxygenase
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  • ABW71849.1
 20514 - 20690 (+) hypothetical protein
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  • ABW71850.1
 20687 - 21730 (+) putative aromatic C-methyltransferase
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  • ABW71851.1
 21723 - 22613 (+) putative aryl formamidase
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  • ABW71852.1
 22610 - 24412 (+) nonribosomal peptide synthetase
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  • ABW71853.1
 24414 - 28754 (+) nonribosomal peptide synthetase
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  • ABW71854.1
 28633 - 30135 (+) putative kynurenine 3-monooxygenase
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  • ABW71855.1
 30248 - 31684 (-) flavin-containing oxidoreductase
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  • ABW71856.1
 31715 - 32536 (-) putative regulator
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Annotation changelog
MIBiG version Submitter Notes
1.0
  • Hidden contributor (ID: AAAAAAAAAAAAAAAAAAAAAAAA, no GDPR consent given).
  • Submitted
2.0
  • Hidden contributor (ID: AAAAAAAAAAAAAAAAAAAAAAAA, no GDPR consent given).
  • Migrated from v1.4
  • Updated compound(s) information (NPAtlas curation)
3.0
  • Hidden contributor (ID: AAAAAAAAAAAAAAAAAAAAAAAA, no GDPR consent given).
  • Updated bioactivity data
3.1
  • Hidden contributor (ID: AAAAAAAAAAAAAAAAAAAAAAAA, no GDPR consent given).
  • Update chemical activity to schema version 2.11
Detailed domain annotation
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