BGC0000306: arylomycin biosynthetic gene cluster from Streptomyces filamentosus NRRL 11379
Shows the layout of the region, marking coding sequences and areas of interest. Clicking a gene will select it and show any relevant details. Clicking an area feature (e.g. a candidate cluster) will select all coding sequences within that area. Double clicking an area feature will zoom to that area. Multiple genes and area features can be selected by clicking them while holding the Ctrl key.
View antiSMASH-generated output
Download Cluster GenBank file
Download region SVG
Location: 6,273,710 - 6,304,320 nt. (total: 30,611 nt).
This entry is originally from NCBI GenBank ABYX02000001.1.

Legend:

core biosynthetic genes
additional biosynthetic genes
transport-related genes
regulatory genes
other genes
resistance
TTA codons
reset zoomreset view
zoomzoom to selection
Gene details
Shows details of the most recently selected gene, including names, products, location, and other annotations.
Select a gene to view the details available for it
General
Compounds
Genes
NRP
History
NRPS/PKS domains
KnownClusterBlast
General information about the BGC
MIBiG accession BGC0000306
Short description arylomycin biosynthetic gene cluster from Streptomyces filamentosus NRRL 11379
Status Minimal annotation: no
A minimal annotation only contains information on the BGC loci and one or more linked chemical product(s)

Completeness: complete
Whether the loci encodes everything needed for the pathway producing the compound(s)
Biosynthetic class(es)
  • NRP (Other lipopeptide)
Loci NCBI GenBank: ABYX02000001.1
Compounds
  • arylomycin
Species Streptomyces filamentosus NRRL 11379 [taxonomy]
References
Chemical products information
arylomycin
Copy SMILES
C46H68N6O11
Chemical database entries
PubCHEM
List of genes involved in compound(s) production
Identifiers Position Product Functions Evidence Extra
  • SSIG_07966
  • EWS95122.1
 6273710 - 6284167 (-) hypothetical protein
copy AA seq
copy Nt seq
  • SSIG_05822
  • EWS95123.1
 6284796 - 6285965 (+) hypothetical protein
copy AA seq
copy Nt seq
  • SSIG_05823
  • EWS95124.1
 6286024 - 6298917 (+) hypothetical protein
copy AA seq
copy Nt seq
  • SSIG_05824
  • EWS95125.1
 6298943 - 6299164 (+) MbtH domain-containing protein
copy AA seq
copy Nt seq
  • SSIG_05825
  • EWS95126.1
 6299212 - 6300276 (+) 4-hydroxyphenylpyruvate dioxygenase
copy AA seq
copy Nt seq
  • SSIG_05826
  • EWS95127.1
 6300273 - 6301388 (+) L-lactate oxidase
copy AA seq
copy Nt seq
  • SSIG_05827
  • EWS95128.1
 6301381 - 6302730 (+) GntR family transcriptional regulator
copy AA seq
copy Nt seq
  • SSIG_05828
  • EWS95129.1
 6302792 - 6303664 (+) heme ABC exporter, ATP-binding protein CcmA
copy AA seq
copy Nt seq
  • SSIG_05829
  • EWS95130.1
 6303697 - 6304320 (+) hypothetical protein
copy AA seq
copy Nt seq
NRP-specific information
Subclass Other lipopeptide
Cyclic? no
Release type
  • Hydrolysis
Lipid moiety 10-methylundecanoic acid
Thioesterase genes
  • SSIG_05823 (Unknown)
NRP-synthases
Gene Modules
SSIG_07966
Module 1
Specificity: serine
Evidence for specificity:
  • Structure-based inference
Condensation domain type: Starter
Modification domains: Methylation
Module 2
Specificity: alanine
Evidence for specificity:
  • Structure-based inference
Condensation domain type: Unknown
SSIG_05823
Module 2
Specificity: glycine
Evidence for specificity:
  • Structure-based inference
Module 3
Specificity: 4-hydroxyphenylglycine
Evidence for specificity:
  • Structure-based inference
Condensation domain type: LCL
Modification domains: Methylation
Module 4
Specificity: alanine
Evidence for specificity:
  • Structure-based inference
Condensation domain type: LCL
Module 5
Specificity: tyrosine
Evidence for specificity:
  • Structure-based inference
Condensation domain type: LCL
Annotation changelog
MIBiG version Submitter Notes
1.0
  • Hidden contributor (ID: UK5BZZ5BLXFR5LGS2GITT5IB, no GDPR consent given).
  • Submitted
2.0
  • Hidden contributor (ID: AAAAAAAAAAAAAAAAAAAAAAAA, no GDPR consent given).
  • Migrated from v1.4
3.0
  • Hidden contributor (ID: AAAAAAAAAAAAAAAAAAAAAAAA, no GDPR consent given).
  • Corrected NRP module activity
  • Updated NRP substrate specificities
3.1
  • Hidden contributor (ID: AAAAAAAAAAAAAAAAAAAAAAAA, no GDPR consent given).
  • Update chemical activity to schema version 2.11
Detailed domain annotation
Shows NRPS- and PKS-related domains for each feature that contains them. Click on each domain for more information about the domain's location, consensus monomer prediction, and other details.
A glossary is available here.
Selected features only
Show module domains
Similar known gene clusters
Shows clusters from the MiBIG database that are similar to the current region. Genes marked with the same colour are interrelated. White genes have no relationship.
Click on reference genes to show details of similarities to genes within the current region.
Click on an accession to open that entry in the MiBIG database.