BGC0000315: CDA1b biosynthetic gene cluster from Streptomyces coelicolor A3(2)
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Location: 3,519,449 - 3,602,320 nt. (total: 82,872 nt).
This entry is originally from NCBI GenBank AL645882.2.

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core biosynthetic genes
additional biosynthetic genes
transport-related genes
regulatory genes
other genes
resistance
TTA codons
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Gene details
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General
Compounds
Genes
Biosynthesis
History
NRPS/PKS domains
KnownClusterBlast
General information about the BGC
MIBiG accession BGC0000315
Short description CDA1b biosynthetic gene cluster from Streptomyces coelicolor A3(2)
Status Quality: questionable
The quality level of this entry.

Status: active
The status of this entry.

Completeness: complete
Whether the entry covers everything needed for the pathway producing the compound(s)
Biosynthetic class(es)
  • NRPS (Type I)
Loci
AL645882.2
3519449 - 3602320
via Knock-out studies
Compounds
  • CDA1b
  • CDA2a
  • CDA2b
  • CDA3a
  • CDA3b
  • CDA4a
  • CDA4b
Species Streptomyces coelicolor A3(2) [taxonomy]
References
Chemical products information
CDA1b Evidence:
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C66H79N14O29P1
CDA2a Evidence:
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C66H77N14O29P1
CDA2b Evidence:
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C67H81N14O29P1
CDA3a Evidence:
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C66H76N14O26
CDA3b Evidence:
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C67H80N14O25
CDA4a Evidence:
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C67H78N14O26
CDA4b Evidence:
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C67H78N14O26
Chemical database entries
NPAtlas
List of genes involved in compound(s) production
Identifiers Position Product Functions Evidence Extra
  • CAB38581.1
  • SCO3210
 3519449 - 3520903 (-) putative 2-dehydro-3-deoxyheptonate aldolase
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    • CAB38582.1
    • SCO3211
    		 3520900 - 3521676 (-) putative indoleglycerol phosphate synthase (trpC2)
    • Precursor biosynthesis
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    • CAB38583.1
    • SCO3212
    		 3521673 - 3522680 (-) probable anthranilate phosphoribotransferase (trpD2)
    • Precursor biosynthesis
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    • CAB38584.1
    • SCO3213
    		 3522697 - 3523299 (-) probable anthranilate synthase component II (trpG)
    • Precursor biosynthesis
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    • CAB38585.1
    • SCO3214
    		 3523296 - 3524831 (-) probable anthranilate synthase component I (trpE2)
    • Precursor biosynthesis
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    • CAB38586.1
    • SCO3215
    		 3524828 - 3525844 (-) 2-oxogluterate-3-methyltransferase (glmT)
    • Precursor biosynthesis
    • Activity assay Knock-out
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    • CAB38587.1
    • SCO3216
    		 3526137 - 3528527 (+) putative integral membrane ATPase
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      • CAB38588.1
      • SCO3217
      		 3529272 - 3531188 (+) putative transcriptional regulator
      • Regulation
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      • CAB38589.1
      • SCO3218
      		 3531250 - 3531465 (-) putative small conserved hypothetical protein
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        • CAB38590.1
        • SCO3219
        		 3531588 - 3532763 (-) putative lipase (putative secreted protein)
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          • CAB38591.1
          • SCO3220
          		 3532971 - 3533399 (-) putative secreted protein
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            • CAB38592.1
            • SCO3221
            		 3533492 - 3534346 (-) putative oxidoreductase
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              • CAB38593.1
              • SCO3222
              		 3534444 - 3534899 (-) putative secreted protein
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                • CAB38594.1
                • SCO3223
                		 3535054 - 3535848 (-) putative ABC transporter integral membrane protein
                • Transport
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                • CAB38595.1
                • SCO3224
                		 3535855 - 3536808 (-) putative ABC transporter ATP-binding protein
                • Transport
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                • CAB38596.1
                • SCO3225
                		 3536945 - 3538660 (+) two component sensor kinase (absA1)
                • Regulation
                • Other in vivo study
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                • CAB38597.1
                • SCO3226
                		 3538679 - 3539347 (+) two component system response regulator (absA2)
                • Regulation
                • Other in vivo study
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                • CAD55497.1
                • SCO3227
                		 3539337 - 3540671 (-) 4-hydroxyphenylglycine aminotransferase (hpgT)
                • Precursor biosynthesis
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                • CAB38520.1
                • SCO3228
                		 3540668 - 3541801 (-) 4-hydroxymandelate oxidase (Hmo)
                • Precursor biosynthesis
                • Knock-out
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                • CAB38519.1
                • SCO3229
                		 3541951 - 3543066 (-) 4-hydroxymandelic acid synthase (HmaS)
                • Precursor biosynthesis
                • Knock-out
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                • CAB38518.1
                • SCO3230
                		 3543335 - 3565726 (+) CDA peptide synthetase I (CdaPs1)
                • Scaffold biosynthesis
                • Other in vivo study
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                • CAB38517.1
                • SCO3231
                		 3565723 - 3576735 (+) CDA peptide synthetase II (CdaPs2)
                • Scaffold biosynthesis
                • Other in vivo study
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                • CAD55498.1
                • SCO3232
                		 3576735 - 3583988 (+) CDA peptide synthetase III (CdaPs3)
                • Scaffold biosynthesis
                • Other in vivo study
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                • CAB38877.1
                • SCO3233
                		 3583992 - 3584810 (+) putative type II thioesterase
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                  • CAB38878.1
                  • SCO3234
                  		 3584822 - 3585724 (+) 3-hydroxyasparagine phosphotransferase (HasP)
                  • Tailoring
                  • Knock-out
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                  • CAB38879.1
                  • SCO3235
                  		 3585800 - 3587647 (-) putative ABC transporter
                  • Transport
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                  • CAB38880.1
                  • SCO3236
                  		 3587687 - 3588688 (-) Asparagine oxygenase (AsnO)
                  • Precursor biosynthesis
                  • Activity assay Knock-out
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                  • CAB38881.1
                  • SCO3237
                  		 3588746 - 3590134 (-) conserved hypothetical protein
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                    • CAB38882.1
                    • SCO3238
                    		 3590146 - 3591306 (-) hypothetical protein
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                      • CAB38883.1
                      • SCO3239
                      		 3591313 - 3592182 (-) conserved hypothetical protein
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                        • CAB38884.1
                        • SCO3240
                        		 3592179 - 3592889 (-) conserved hypothetical protein
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                          • CAB38885.1
                          • SCO3241
                          		 3592886 - 3593758 (-) putaive isomerase
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                            • CAB38886.1
                            • SCO3242
                            		 3593755 - 3594630 (-) puitative transferase
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                              • CAB38887.1
                              • SCO3243
                              		 3594627 - 3595793 (-) putative myo-inositol phosphate synthase
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                                • CAB38888.1
                                • SCO3244
                                		 3595843 - 3596640 (-) putative secreted protein
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                                  • CAB38889.1
                                  • SCO3245
                                  		 3596708 - 3597970 (-) Hexenoyl-S-ACP Monooxygenase (hcmO)
                                  • Precursor biosynthesis
                                  • Activity assay
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                                  • CAB38890.1
                                  • SCO3246
                                  		 3598017 - 3599009 (-) 3-Oxoacyl-[acyl carrier protein] synthase III (fabH4)
                                  • Precursor biosynthesis
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                                  • CAB38891.1
                                  • SCO3247
                                  		 3599006 - 3600808 (-) Hexanoyl-S-ACP oxidase/epoxidase (hxcO)
                                  • Precursor biosynthesis
                                  • Activity assay Knock-out
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                                  • CAB38892.1
                                  • SCO3248
                                  		 3600858 - 3602078 (-) 3-Oxoacyl-[acyl carrier protein] synthase II (fabF3)
                                  • Precursor biosynthesis
                                  • Other in vivo study
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                                  • CAB38893.1
                                  • SCO3249
                                  		 3602075 - 3602320 (-) acyl carrier protein
                                  • Precursor biosynthesis
                                  • Activity assay
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                                  Biosynthesis information

                                  Biosynthetic modules

                                  Name
                                  1
                                  Type
                                  nrps-type1
                                  Genes
                                  SCO3230
                                  Substrates
                                  serine (evidence: Sequence-based prediction)
                                  Integrated Monomers
                                  Domains
                                  condensation (Starter), adenylation
                                  Name
                                  2
                                  Type
                                  nrps-type1
                                  Genes
                                  SCO3230
                                  Substrates
                                  threonine (evidence: Sequence-based prediction)
                                  Integrated Monomers
                                  Domains
                                  condensation (LCL), adenylation
                                  Name
                                  3
                                  Type
                                  nrps-type1
                                  Genes
                                  SCO3230
                                  Substrates
                                  tryptophan (evidence: Structure-based inference [1], [3])
                                  Integrated Monomers
                                  Domains
                                  condensation (LCL), adenylation, epimerase
                                  Name
                                  4
                                  Type
                                  nrps-type1
                                  Genes
                                  SCO3230
                                  Substrates
                                  aspartic acid (evidence: Sequence-based prediction)
                                  Integrated Monomers
                                  Domains
                                  condensation (DCL), adenylation
                                  Name
                                  5
                                  Type
                                  nrps-type1
                                  Genes
                                  SCO3230
                                  Substrates
                                  aspartic acid (evidence: Sequence-based prediction)
                                  Integrated Monomers
                                  Domains
                                  condensation (LCL), adenylation
                                  Name
                                  6
                                  Type
                                  nrps-type1
                                  Genes
                                  SCO3230
                                  Substrates
                                  4-hydroxyphenylglycine (evidence: Sequence-based prediction)
                                  Integrated Monomers
                                  Domains
                                  condensation (LCL), adenylation, epimerase
                                  Name
                                  7
                                  Type
                                  nrps-type1
                                  Genes
                                  SCO3231
                                  Substrates
                                  aspartic acid (evidence: )
                                  Integrated Monomers
                                  Domains
                                  condensation (DCL), adenylation
                                  Name
                                  8
                                  Type
                                  nrps-type1
                                  Genes
                                  SCO3231
                                  Substrates
                                  glycine (evidence: Sequence-based prediction)
                                  Integrated Monomers
                                  Domains
                                  condensation (LCL), adenylation
                                  Name
                                  9
                                  Type
                                  nrps-type1
                                  Genes
                                  SCO3231
                                  Substrates
                                  asparagine, 3S-hydroxyasparagine (evidence: Structure-based inference)
                                  Integrated Monomers
                                  Domains
                                  condensation (LCL), adenylation, epimerase
                                  Name
                                  10
                                  Type
                                  nrps-type1
                                  Genes
                                  SCO3232
                                  Substrates
                                  glutamic acid, 3R-methylglutamic acid (evidence: )
                                  Integrated Monomers
                                  Domains
                                  condensation (DCL), adenylation
                                  Name
                                  11
                                  Type
                                  nrps-type1
                                  Genes
                                  SCO3232
                                  Substrates
                                  tryptophan (evidence: Structure-based inference [1], [2], [3])
                                  Integrated Monomers
                                  Domains
                                  condensation (LCL), adenylation
                                  Annotation changelog

                                  Entry version: 4

                                  Date
                                  Changes
                                  Submitters
                                  Reviewers
                                  2022-10-07
                                  Update chemical activity to schema version 2.11
                                  • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                                  • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)

                                  Entry version: 3

                                  Date
                                  Changes
                                  Submitters
                                  Reviewers
                                  2022-09-15
                                  Removed duplicate citation
                                  • (ID: 3UOU7PODQJXIM6BEPUHHRRA5)
                                  • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                                  2022-09-15
                                  Fix duplication in gene evidence (issue #1)
                                  • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                                  • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                                  2022-09-15
                                  Corrected NRP module activity
                                  • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                                  • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                                  2022-09-15
                                  Corrected NRP gene names
                                  • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                                  • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                                  2022-09-15
                                  Updated NRP substrate specificities
                                  • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                                  • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)

                                  Entry version: 2

                                  Date
                                  Changes
                                  Submitters
                                  Reviewers
                                  2019-10-16
                                  Migrated from v1.4
                                  • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                                  • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                                  2019-10-16
                                  Updated compound(s) information (NPAtlas curation)
                                  • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                                  • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)

                                  Entry version: 1

                                  Date
                                  Changes
                                  Submitters
                                  Reviewers
                                  2015-06-12
                                  Submitted
                                  • (ID: JEQAH6TWUDBPITIQUEGTRXT6)
                                  • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                                  Detailed domain annotation
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