BGC0000316: capreomycin IA biosynthetic gene cluster from Saccharothrix mutabilis subsp. capreolus
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Location: 1 - 44,141 nt. (total: 44,141 nt).
This entry is originally from NCBI GenBank EF472579.1.

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core biosynthetic genes
additional biosynthetic genes
transport-related genes
regulatory genes
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resistance
TTA codons
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Gene details
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General
Compounds
Genes
NRP
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NRPS/PKS domains
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General information about the BGC
MIBiG accession BGC0000316
Short description capreomycin IA biosynthetic gene cluster from Saccharothrix mutabilis subsp. capreolus
Status Minimal annotation: no
A minimal annotation only contains information on the BGC loci and one or more linked chemical product(s)

Completeness: Unknown
Whether the loci encodes everything needed for the pathway producing the compound(s)
Biosynthetic class(es)
  • NRP
Loci NCBI GenBank: EF472579.1
Compounds
  • capreomycin IA
  • capreomycin IB
  • capreomycin IIA
  • capreomycin IIB
Species Saccharothrix mutabilis subsp. capreolus [taxonomy]
References
Chemical products information
capreomycin IA
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C25H44N14O8
capreomycin IB
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C25H44N14O7
capreomycin IIA
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C19H32N12O7
capreomycin IIB
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C19H32N12O6
Chemical database entries
PubCHEM
List of genes involved in compound(s) production
Identifiers Position Product Functions Evidence Extra
  • ABR67762.1
 141 - 644 (-) unknown
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  • ABR67763.1
 804 - 1376 (+) unknown
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  • ABR67764.1
 1383 - 2123 (-) unknown
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  • ABR67765.1
 2159 - 3442 (+) unknown
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  • ABR67766.1
 3462 - 4862 (-) unknown
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  • ABR67767.1
 5150 - 5752 (+) unknown
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  • ABR67768.1
 5861 - 6376 (-) unknown
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  • ABR67769.1
 6395 - 7591 (-) unknown
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  • ABR67770.1
 7588 - 8802 (-) unknown
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  • ABR67771.1
 8863 - 9531 (-) unknown
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  • ABR67772.1
 9528 - 10286 (-) unknown
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  • ABR67773.1
 10362 - 11108 (-) unknown
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  • ABR67760.1
  • cmnR
 11212 - 11925 (-) CmnR
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  • ABR67761.1
  • cmnU
 12265 - 12984 (-) CmnU
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  • ABR67744.1
  • cmnA
 13445 - 20650 (+) CmnA
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  • ABR67745.1
  • cmnB
 20668 - 21756 (+) CmnB
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  • ABR67746.1
  • cmnC
 21753 - 22769 (+) CmnC
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  • ABR67747.1
  • cmnD
 22766 - 23887 (+) CmnD
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  • ABR67748.1
  • cmnE
 23934 - 25181 (+) CmnE
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  • ABR67749.1
  • cmnF
 25196 - 28366 (+) CmnF
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  • ABR67750.1
  • cmnG
 28363 - 31221 (+) CmnG
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  • ABR67751.1
  • cmnH
 31218 - 31964 (+) CmnH
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  • ABR67752.1
  • cmnI
 31961 - 33607 (+) CmnI
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  • ABR67753.1
  • cmnJ
 33604 - 34755 (+) CmnJ
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  • ABR67754.1
  • cmnK
 34758 - 35756 (+) CmnK
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  • ABR67755.1
  • cmnL
 35753 - 36640 (+) CmnL
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  • ABR67756.1
  • cmnM
 36633 - 37838 (+) CmnM
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  • ABR67757.1
  • cmnN
 37847 - 38035 (+) CmnN
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  • ABR67758.1
  • cmnO
 38032 - 39786 (+) CmnO
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  • ABR67759.1
  • cmnP
 39792 - 41138 (+) CmnP
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  • ABR67774.1
 42340 - 43176 (+) unknown
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  • ABR67775.1
 43177 - 43914 (-) unknown
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NRP-specific information
Subclass N/A
Cyclic? no
NRP-synthases
Gene Modules
cmnA
Module ?
Specificity: serine / alanine
Evidence for specificity:
  • Structure-based inference
  • Sequence-based prediction
Module ?
Specificity: 2,3-diaminopropionic acid
Evidence for specificity:
  • Structure-based inference
  • Sequence-based prediction
cmnF
Module ?
Specificity: 2,3-diaminopropionic acid
Evidence for specificity:
  • Structure-based inference
  • Sequence-based prediction
cmnG
Module ?
Specificity: capreomycidine
Evidence for specificity:
  • Structure-based inference
  • Sequence-based prediction
cmnO
Module ?
Specificity: beta-lysine
Evidence for specificity:
  • Structure-based inference
  • Sequence-based prediction
Annotation changelog
MIBiG version Submitter Notes
1.0
  • Hidden contributor (ID: AAAAAAAAAAAAAAAAAAAAAAAA, no GDPR consent given).
  • Submitted
2.0
  • Hidden contributor (ID: AAAAAAAAAAAAAAAAAAAAAAAA, no GDPR consent given).
  • Migrated from v1.4
  • Updated compound(s) information (NPAtlas curation)
3.0
  • Hidden contributor (ID: AAAAAAAAAAAAAAAAAAAAAAAA, no GDPR consent given).
  • Updated bioactivity data
  • Added NRP substrate specificities
3.1
  • Hidden contributor (ID: AAAAAAAAAAAAAAAAAAAAAAAA, no GDPR consent given).
  • Update chemical activity to schema version 2.11
Detailed domain annotation
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