BGC0000330: cupriachelin biosynthetic gene cluster from Cupriavidus necator H16
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Location: 1,886,949 - 1,923,310 nt. (total: 36,362 nt).
This entry is originally from NCBI GenBank AM260480.1.

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core biosynthetic genes
additional biosynthetic genes
transport-related genes
regulatory genes
other genes
resistance
TTA codons
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Gene details
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General
Compounds
Genes
NRP
History
NRPS/PKS domains
KnownClusterBlast
General information about the BGC
MIBiG accession BGC0000330
Short description cupriachelin biosynthetic gene cluster from Cupriavidus necator H16
Status Minimal annotation: no
A minimal annotation only contains information on the BGC loci and one or more linked chemical product(s)

Completeness: complete
Whether the loci encodes everything needed for the pathway producing the compound(s)
Biosynthetic class(es)
  • NRP (NRP siderophore)
Loci NCBI GenBank: AM260480.1
Compounds
  • cupriachelin
Species Cupriavidus necator H16 [taxonomy]
References
Chemical products information
cupriachelin
Copy SMILES
C33H57N7O16
Chemical database entries
NPAtlas
List of genes involved in compound(s) production
Identifiers Position Product Functions Evidence Extra
  • H16_B1676
  • CAJ96461.1
  • h16_B1676
 1886949 - 1887290 (-) hypothetical membrane spanning protein
  • Transport
Sequence-based prediction
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  • H16_B1677
  • CAJ96462.1
  • h16_B1677
 1887274 - 1888905 (-) iron regulated protein
  • Transport
Sequence-based prediction
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  • H16_B1678
  • CAJ96463.1
  • h16_B1678
 1888902 - 1889270 (-) hypothetical protein
  • Transport
Sequence-based prediction
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  • H16_B1679
  • CAJ96464.1
  • fhuE
 1889296 - 1891578 (-) outer membrane receptor, TonB dependent
  • Transport
Sequence-based prediction
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  • H16_B1680
  • CAJ96465.1
  • pvdA
 1891684 - 1893084 (-) ornithine N-monooxygenase
  • Tailoring (Hydroxylation)
Sequence-based prediction
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  • H16_B1681
  • CAJ96466.1
  • h16_B1681
 1893107 - 1894207 (-) N-acyltransferase
  • Tailoring (Acylation)
Sequence-based prediction
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  • H16_B1682
  • CAJ96467.1
  • h16_B1682
 1894240 - 1895922 (-) ABC-type transporter, ATPase and permease components: Pep3E family
  • Transport
Sequence-based prediction
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  • H16_B1683
  • CAJ96468.1
  • h16_B1683
 1895919 - 1899146 (-) non-ribosomal peptide synthetase
  • Scaffold biosynthesis
Sequence-based prediction
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  • H16_B1684
  • CAJ96469.1
  • fhuF
 1899397 - 1900152 (+) putative iron transport-related membrane protein
  • Transport
Sequence-based prediction
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  • H16_B1685
  • CAJ96470.1
  • nrpC
 1900165 - 1906191 (-) non-ribosomal peptide synthetase
  • Scaffold biosynthesis
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  • H16_B1686
  • CAJ96471.1
  • nrpB
 1906229 - 1909324 (-) non-ribosomal peptide synthetase
  • Scaffold biosynthesis
Activity assay
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  • H16_B1687
  • CAJ96472.1
  • nrpA
 1909317 - 1918601 (-) non-ribosomal peptide synthetase
  • Scaffold biosynthesis
Sequence-based prediction
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  • H16_B1688
  • CAJ96473.1
  • h16_B1688
 1918717 - 1919778 (-) pyoverdine biosynthesis regulatory gene
  • Tailoring (Hydroxylation)
Sequence-based prediction
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  • H16_B1689
  • CAJ96474.1
  • mbtH
 1920048 - 1920254 (+) MbtH-like protein
  • Activation / processing
Sequence-based prediction
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  • H16_B1690
  • CAJ96475.1
  • h16_B1690
 1920251 - 1921069 (+) thioesterase
  • Activation / processing
Sequence-based prediction
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  • H16_B1691
  • CAJ96476.1
  • h16_B1691
 1921056 - 1921889 (+) phosphopantetheinyltransferase family protein
  • Activation / processing
Sequence-based prediction
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  • H16_B1692
  • CAJ96477.1
  • h16_B1692
 1921886 - 1923310 (+) aminotransferase
  • Tailoring (Unknown)
Sequence-based prediction
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NRP-specific information
Subclass NRP siderophore
Cyclic? no
Release type
  • Hydrolysis
NRP-synthases
Gene Modules
nrpA
Module 0
Condensation domain type: Starter
Modification domains: Oxidation
Module 1
Specificity: aspartic acid
Evidence for specificity:
  • Structure-based inference
Condensation domain type: LCL
Modification domains: Oxidation
Module 2
Specificity: 2,4-diaminobutyric acid
Evidence for specificity:
  • Structure-based inference
Condensation domain type: LCL
Modification domains: Oxidation
nrpB
Module 3
Specificity: aspartic acid
Evidence for specificity:
  • Activity assay
Condensation domain type: LCL
h16_B1683
Module 4
Specificity: glycine
Evidence for specificity:
  • Sequence-based prediction
Condensation domain type: LCL
nrpC
Module 5
Specificity: N5-hydroxyornithine
Evidence for specificity:
  • Sequence-based prediction
Condensation domain type: LCL
Annotation changelog
MIBiG version Submitter Notes
1.0
  • Hidden contributor (ID: YETYK72PRB3MT456E3R3XHBM, no GDPR consent given).
  • Submitted
2.0
  • Hidden contributor (ID: AAAAAAAAAAAAAAAAAAAAAAAA, no GDPR consent given).
  • Migrated from v1.4
  • Updated compound(s) information (NPAtlas curation)
3.0
  • Hidden contributor (ID: AAAAAAAAAAAAAAAAAAAAAAAA, no GDPR consent given).
  • Corrected NRP module activity
  • Updated NRP substrate specificities
3.1
  • Hidden contributor (ID: AAAAAAAAAAAAAAAAAAAAAAAA, no GDPR consent given).
  • Update chemical activity to schema version 2.11
Detailed domain annotation
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