BGC0000344: entolysin biosynthetic gene cluster from Pseudomonas entomophila L48
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Location: 3,206,616 - 3,277,103 nt. (total: 70,488 nt).
This entry is originally from NCBI GenBank CT573326.1.

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core biosynthetic genes
additional biosynthetic genes
transport-related genes
regulatory genes
other genes
resistance
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Gene details
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General
Compounds
Genes
NRP
History
NRPS/PKS domains
KnownClusterBlast
General information about the BGC
MIBiG accession BGC0000344
Short description entolysin biosynthetic gene cluster from Pseudomonas entomophila L48
Status Minimal annotation: no
A minimal annotation only contains information on the BGC loci and one or more linked chemical product(s)

Completeness: Unknown
Whether the loci encodes everything needed for the pathway producing the compound(s)
Biosynthetic class(es)
  • NRP
Loci NCBI GenBank: CT573326.1
Compounds
  • entolysin
Species Pseudomonas entomophila L48 [taxonomy]
References
Chemical products information
entolysin
(no structure information available)
List of genes involved in compound(s) production
Identifiers Position Product Functions Evidence Extra
  • PSEEN3032
  • CAK15802.1
 3206617 - 3207276 (-) putative DNA-binding response regulator, OmpR family
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  • PSEEN3033
  • CAK15803.1
 3207486 - 3207824 (+) conserved hypothetical protein
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  • PSEEN3034
  • CAK15804.1
 3207821 - 3208477 (+) conserved hypothetical protein; putative signal peptide
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  • PSEEN3035
  • CAK15805.1
 3208639 - 3209640 (+) conserved hypothetical protein; putative membrane protein, TerC family
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  • PSEEN3036
  • CAK15806.1
 3209728 - 3210021 (-) conserved hypothetical protein
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  • PSEEN3037
  • CAK15807.1
  • ribB_A-2
 3210100 - 3211212 (+) 3,4-dihydroxy-2-butanone 4-phosphate synthase/GTP cyclohydrolase II
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  • PSEEN3038
  • CAK15808.1
 3211816 - 3212841 (+) putative polyamine ABC transporter, periplasmic polyamine-binding protein
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  • PSEEN3039
  • CAK15809.1
 3212838 - 3213755 (+) putative polyamine ABC transporter, permease protein
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  • PSEEN3040
  • CAK15810.1
 3213762 - 3214571 (+) putative polyamine ABC transporter, permease protein
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  • PSEEN3041
  • CAK15811.1
 3214591 - 3215703 (+) putative polyamine ABC transporter, ATP binding protein
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  • PSEEN3042
  • CAK15812.1
  • macB
 3215810 - 3217813 (-) macrolide ABC efflux protein MacB
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  • PSEEN3043
  • CAK15813.1
  • macA
 3217816 - 3218970 (-) macrolide efflux protein MacA
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  • PSEEN3044
  • CAK15814.1
 3219057 - 3233567 (-) putative non-ribosomal peptide synthetase, terminal component
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  • PSEEN3045
  • CAK15815.1
 3233564 - 3259045 (-) putative non ribosomal peptide synthetase
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  • PSEEN3046
  • CAK15816.1
 3259324 - 3260205 (-) putative transcriptional regulator, LysR family
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  • PSEEN3047
  • CAK15817.1
 3260362 - 3261618 (+) hypothetical protein
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  • PSEEN3048
  • CAK15818.1
  • pobA
 3261697 - 3262884 (-) p-hydroxybenzoate hydroxylase (4-hydroxybenzoate 3-monooxygenase)
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  • PSEEN3049
  • CAK15819.1
  • pobR
 3263042 - 3263917 (+) transcriptional regulator PobR
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  • PSEEN3050
  • CAK15820.1
 3264003 - 3265058 (+) conserved hypothetical protein; TPR domain protein
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  • PSEEN3051
  • CAK15821.1
 3265081 - 3267060 (-) putative sensory box histidine kinase/response regulator (hybrid)
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  • PSEEN3052
  • CAK15822.1
  • ccd
 3267128 - 3267553 (-) Cytosine deaminase
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  • PSEEN3053
  • CAK15823.1
 3267721 - 3268410 (+) conserved hypothetical protein; ThiJ/PfpI family protein
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  • PSEEN3054
  • CAK15824.1
  • hpd
 3268500 - 3269573 (-) 4-hydroxyphenylpyruvate dioxygenase (4HPPD) (HPD) (HPPDase)
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  • PSEEN3055
  • CAK15825.1
 3269608 - 3269853 (-) conserved hypothetical protein
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  • PSEEN3057
  • CAK15826.1
 3269930 - 3271474 (+) putative phosphodiesterase (EAL domain)
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  • PSEEN3058
  • CAK15827.1
  • rarD-2
 3271508 - 3272395 (+) chloramphenicol-sensitive protein rarD
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  • PSEEN3059
  • CAK15828.1
 3272358 - 3273929 (-) conserved hypothetical protein; putative CBS domain; putative membrane protein, TerC/CorC family
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  • PSEEN3060
  • CAK15829.1
 3274319 - 3276322 (+) putative peptidase, U32 family
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  • PSEEN3061
  • CAK15830.1
  • nfxB
 3276546 - 3277103 (+) transcriptional regulator NfxB
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NRP-specific information
Subclass N/A
Cyclic? no
NRP-synthases
Gene Modules
PSEEN3044
Module ?
Specificity: valine
Evidence for specificity:
Module ?
Specificity: isoleucine / leucine
Evidence for specificity:
Module ?
Specificity: serine
Evidence for specificity:
Module ?
Specificity: isoleucine / leucine
Evidence for specificity:
PSEEN3045
Module ?
Specificity: glutamine
Evidence for specificity:
Module ?
Specificity: valine
Evidence for specificity:
Module ?
Specificity: isoleucine / leucine
Evidence for specificity:
Module ?
Specificity: glutamine
Evidence for specificity:
Module ?
Specificity: valine
Evidence for specificity:
Module ?
Specificity: isoleucine / leucine
Evidence for specificity:
Module ?
Specificity: glutamine
Evidence for specificity:
Module ?
Specificity: serine
Evidence for specificity:
Annotation changelog
MIBiG version Submitter Notes
1.0
  • Hidden contributor (ID: AAAAAAAAAAAAAAAAAAAAAAAA, no GDPR consent given).
  • Submitted
2.0
  • Hidden contributor (ID: AAAAAAAAAAAAAAAAAAAAAAAA, no GDPR consent given).
  • Migrated from v1.4
3.0
  • Hidden contributor (ID: AAAAAAAAAAAAAAAAAAAAAAAA, no GDPR consent given).
  • Refined reference coordinates
  • Updated bioactivity data
  • Added NRP substrate specificities
3.1
  • Hidden contributor (ID: AAAAAAAAAAAAAAAAAAAAAAAA, no GDPR consent given).
  • Update chemical activity to schema version 2.11
Detailed domain annotation
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