BGC0000353: tacrolimus biosynthetic gene cluster from Streptomyces sp. MA6548
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Location: 1 - 28,732 nt. (total: 28,732 nt).
This entry is originally from NCBI GenBank AF082100.1.

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core biosynthetic genes
additional biosynthetic genes
transport-related genes
regulatory genes
other genes
resistance
TTA codons
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Gene details
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General
Compounds
Genes
NRP
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NRPS/PKS domains
KnownClusterBlast
General information about the BGC
MIBiG accession BGC0000353
Short description tacrolimus biosynthetic gene cluster from Streptomyces sp. MA6548
Status Minimal annotation: no
A minimal annotation only contains information on the BGC loci and one or more linked chemical product(s)

Completeness: Unknown
Whether the loci encodes everything needed for the pathway producing the compound(s)
Biosynthetic class(es)
  • NRP
Loci NCBI GenBank: AF082100.1
Compounds
  • tacrolimus
Species Streptomyces sp. MA6548 [taxonomy]
References
Chemical products information
tacrolimus
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C44H69N1O12
Chemical database entries
NPAtlas
List of genes involved in compound(s) production
Identifiers Position Product Functions Evidence Extra
  • AAC68816.1
  • fkbP
 61 - 4575 (-) FK506 peptide synthetase
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  • AAC68817.1
  • fkbO
 4572 - 5570 (-) FK506 oxidase
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  • AAC68815.1
  • fkbB
 5798 - 28528 (+) FK506 polyketide synthase
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NRP-specific information
Subclass N/A
Cyclic? no
NRP-synthases
Gene Modules
fkbP
Module ?
Specificity: pipecolic acid
Evidence for specificity:
Annotation changelog
MIBiG version Submitter Notes
1.0
  • Hidden contributor (ID: AAAAAAAAAAAAAAAAAAAAAAAA, no GDPR consent given).
  • Submitted
2.0
  • Hidden contributor (ID: AAAAAAAAAAAAAAAAAAAAAAAA, no GDPR consent given).
  • Migrated from v1.4
  • Updated compound(s) information (NPAtlas curation)
3.0
  • Hidden contributor (ID: AAAAAAAAAAAAAAAAAAAAAAAA, no GDPR consent given).
  • Updated bioactivity data
  • Added NRP substrate specificities
3.1
  • Hidden contributor (ID: AAAAAAAAAAAAAAAAAAAAAAAA, no GDPR consent given).
  • Update chemical activity to schema version 2.11
  • Fix the chemical target
Detailed domain annotation
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