BGC0000359: fuscachelin A biosynthetic gene cluster from Thermobifida fusca YX
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Location: 2,172,724 - 2,196,882 nt. (total: 24,159 nt).
This entry is originally from NCBI GenBank CP000088.1.

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core biosynthetic genes
additional biosynthetic genes
transport-related genes
regulatory genes
other genes
resistance
TTA codons
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Gene details
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General
Compounds
Genes
NRP
History
NRPS/PKS domains
KnownClusterBlast
General information about the BGC
MIBiG accession BGC0000359
Short description fuscachelin A biosynthetic gene cluster from Thermobifida fusca YX
Status Minimal annotation: no
A minimal annotation only contains information on the BGC loci and one or more linked chemical product(s)

Completeness: Unknown
Whether the loci encodes everything needed for the pathway producing the compound(s)
Biosynthetic class(es)
  • NRP
Loci NCBI GenBank: CP000088.1
Compounds
  • fuscachelin A
  • fuscachelin B
  • fuscachelin C
Species Thermobifida fusca YX [taxonomy]
References
Chemical products information
fuscachelin A
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C42H59N15O16
Chemical database entries
PubCHEM
fuscachelin B
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C42H61N15O17
Chemical database entries
PubCHEM
fuscachelin C
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C42H62N16O16
Chemical database entries
PubCHEM
List of genes involved in compound(s) production
Identifiers Position Product Functions Evidence Extra
  • Tfu_1865
  • AAZ55898.1
 2172724 - 2176758 (-) amino acid adenylation
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  • Tfu_1866
  • AAZ55899.1
 2176783 - 2180007 (-) amino acid adenylation
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  • Tfu_1867
  • AAZ55900.1
 2180004 - 2190893 (-) non-ribosomal peptide synthase:Amino acid adenylation
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  • Tfu_1868
  • AAZ55901.1
 2190924 - 2191178 (-) isochorismatase
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  • Tfu_1869
  • AAZ55902.1
 2191209 - 2192525 (-) putative peptide monooxygenase
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  • Tfu_1870
  • AAZ55903.1
 2192529 - 2193194 (-) isochorismatase
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  • Tfu_1871
  • AAZ55904.1
 2193191 - 2194822 (-) 2,3-dihydroxybenzoate-AMP ligase
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  • Tfu_1872
  • AAZ55905.1
 2194843 - 2196024 (-) isochorismate synthase
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  • Tfu_1873
  • AAZ55906.1
 2196100 - 2196882 (-) 2,3-dihydro-2,3-dihydroxybenzoate dehydrogenase; RBL00455
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NRP-specific information
Subclass N/A
Cyclic? no
NRP-synthases
Gene Modules
Tfu_1865
Module ?
Specificity: N5-hydroxyornithine
Evidence for specificity:
  • Structure-based inference
Tfu_1866
Module ?
Specificity: serine
Evidence for specificity:
  • Structure-based inference
Tfu_1867
Module ?
Specificity: arginine
Evidence for specificity:
  • Structure-based inference
Module ?
Specificity: glycine
Evidence for specificity:
  • Structure-based inference
Module ?
Specificity: glycine
Evidence for specificity:
  • Structure-based inference
Tfu_1871
Module ?
Specificity: 2,3-dihydroxybenzoic acid
Evidence for specificity:
  • Structure-based inference
Annotation changelog
MIBiG version Submitter Notes
1.0
  • Hidden contributor (ID: AAAAAAAAAAAAAAAAAAAAAAAA, no GDPR consent given).
  • Submitted
2.0
  • Hidden contributor (ID: AAAAAAAAAAAAAAAAAAAAAAAA, no GDPR consent given).
  • Migrated from v1.4
  • Updated reference publication(s) (MIBiG Annotathon)
  • Updated compound(s) information (NPAtlas curation)
3.0
  • Hidden contributor (ID: AAAAAAAAAAAAAAAAAAAAAAAA, no GDPR consent given).
  • Updated bioactivity data
  • Added NRP substrate specificities
3.1
  • Hidden contributor (ID: AAAAAAAAAAAAAAAAAAAAAAAA, no GDPR consent given).
  • Update chemical activity to schema version 2.11
Detailed domain annotation
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