BGC0000369: hassallidin C biosynthetic gene cluster from Anabaena sp. Syke748
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Location: 1 - 67,299 nt. (total: 67,299 nt).
This entry is originally from NCBI GenBank KJ502174.1.

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core biosynthetic genes
additional biosynthetic genes
transport-related genes
regulatory genes
other genes
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General
Compounds
Genes
Biosynthesis
History
NRPS/PKS domains
KnownClusterBlast
General information about the BGC
MIBiG accession BGC0000369
Short description hassallidin C biosynthetic gene cluster from Anabaena sp. Syke748
Status Quality: questionable
The quality level of this entry.

Status: active
The status of this entry.

Completeness: complete
Whether the entry covers everything needed for the pathway producing the compound(s)
Biosynthetic class(es)
  • NRPS (Type I)
  • saccharide (hybrid/tailoring)
Loci
KJ502174.1
via
Compounds
  • hassallidin C
  • hassallidin D
Species Anabaena sp. Syke748 [taxonomy]
References
Chemical products information
hassallidin C Evidence: NMR [1], MS/MS [1]
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C80H126N12O35
hassallidin D Evidence: NMR [1], MS/MS [1]
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C84H127N11O35
List of genes involved in compound(s) production
Identifiers Position Product Functions Evidence Extra
  • AHZ20758.1
 154 - 1275 (+) phage integrase
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    • AHZ20759.1
    		 1472 - 2344 (-) IS5 family IS5 ssgr transposase
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      • AHZ20760.1
      • hasA
      		 2620 - 4380 (-) ABC transporter transmembrane domain/ATP-binding domain protein
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        • AHZ20761.1
        • hasB
        		 4713 - 6743 (-) alpha amylase catalytic domain-containing protein
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          • AHZ20762.1
          • hasC
          		 6951 - 7991 (-) methyltransferase domain-containing protein
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            • AHZ20763.1
            • hasD
            		 8047 - 8835 (-) glycosyl transferase family 2 protein
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              • AHZ20764.1
              • hasE
              		 8832 - 9344 (-) GtrA-like protein
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                • AHZ20765.1
                • hasF
                		 9348 - 10988 (-) putative membrane protein
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                  • AHZ20766.1
                  • hasG
                  		 11023 - 12405 (-) AMP-dependent synthetase/ligase
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                    • AHZ20767.1
                    • hasH
                    		 12405 - 12740 (-) acyl carrier protein
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                      • AHZ20768.1
                      • hasI
                      		 12748 - 13854 (-) hypothetical protein
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                        • AHZ20769.1
                        • hasJ
                        		 13892 - 15223 (-) putative esterase
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                          • AHZ20770.1
                          • hasK
                          		 15220 - 16560 (-) major facilitator transporter
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                            • AHZ20771.1
                            • hasL
                            		 16657 - 17421 (-) 3-oxoacyl-acyl-carrier-protein reductase
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                              • AHZ20772.1
                              • hasM
                              		 17666 - 18238 (+) aspartyl/asparaginyl beta-hydroxylase
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                                • AHZ20773.1
                                • hasN
                                		 18328 - 27489 (+) non-ribosomal peptide synthase
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                                  • AHZ20774.1
                                  • hasO
                                  		 27532 - 38469 (+) non-ribosomal peptide synthase
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                                    • AHZ20775.1
                                    • hasP
                                    		 38488 - 39546 (+) NAD dependent epimerase/dehydratase
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                                      • AHZ20776.1
                                      • hasQ
                                      		 39630 - 40835 (+) glycosyltransferase MGT family
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                                        • AHZ20777.1
                                        • hasR
                                        		 40926 - 42032 (-) putative acyltransferase
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                                          • AHZ20778.1
                                          • hasS
                                          		 42120 - 42644 (-) transcription factor jumonji domain-containing protein
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                                            • AHZ20779.1
                                            • hasT
                                            		 42721 - 43488 (-) glycosyltransferase DXD motif-containing protein
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                                              • AHZ20780.1
                                              • hasU
                                              		 43558 - 43779 (-) hypothetical protein
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                                                • AHZ20781.1
                                                • hasV
                                                		 43869 - 50324 (-) non-ribosomal peptide synthase
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                                                  • AHZ20782.1
                                                  • hasW
                                                  		 50526 - 50897 (+) hypothetical protein
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                                                    • AHZ20783.1
                                                    • hasX
                                                    		 50903 - 51844 (+) glycosyl transferase family 2 protein
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                                                      • AHZ20784.1
                                                      • hasY
                                                      		 51868 - 60414 (+) non-ribosomal peptide synthase
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                                                        • AHZ20785.1
                                                        • hasZ
                                                        		 60476 - 61759 (+) major facilitator transporter
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                                                          • AHZ20786.1
                                                          		 61873 - 62229 (+) IS1380 family transposase
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                                                            • AHZ20787.1
                                                            		 62268 - 63722 (+) hypothetical protein
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                                                              • AHZ20788.1
                                                              		 63681 - 64994 (-) CemA family protein
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                                                                • AHZ20789.1
                                                                		 65053 - 67245 (+) hypothetical protein
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                                                                  Biosynthesis information

                                                                  Biosynthetic modules

                                                                  Name
                                                                  0
                                                                  Type
                                                                  nrps-type1
                                                                  Genes
                                                                  hasG
                                                                  Substrates
                                                                  2,3-dihydroxyhexadecanoic acid (evidence: Sequence-based prediction)
                                                                  Integrated Monomers
                                                                  Domains
                                                                  adenylation
                                                                  Name
                                                                  3
                                                                  Type
                                                                  nrps-type1
                                                                  Genes
                                                                  hasN
                                                                  Substrates
                                                                  threonine (evidence: Sequence-based prediction)
                                                                  Integrated Monomers
                                                                  Domains
                                                                  condensation (LCL), adenylation, epimerase
                                                                  Name
                                                                  4
                                                                  Type
                                                                  nrps-type1
                                                                  Genes
                                                                  hasN
                                                                  Substrates
                                                                  tyrosine (evidence: Sequence-based prediction)
                                                                  Integrated Monomers
                                                                  Domains
                                                                  condensation (DCL), adenylation, epimerase
                                                                  Name
                                                                  5
                                                                  Type
                                                                  nrps-type1
                                                                  Genes
                                                                  hasO
                                                                  Substrates
                                                                  threonine (evidence: Sequence-based prediction)
                                                                  Integrated Monomers
                                                                  Domains
                                                                  condensation (DCL), adenylation
                                                                  Name
                                                                  6
                                                                  Type
                                                                  nrps-type1
                                                                  Genes
                                                                  hasO
                                                                  Substrates
                                                                  glutamine (evidence: Sequence-based prediction)
                                                                  Integrated Monomers
                                                                  Domains
                                                                  condensation (DCL), adenylation, epimerase
                                                                  Name
                                                                  7
                                                                  Type
                                                                  nrps-type1
                                                                  Genes
                                                                  hasO
                                                                  Substrates
                                                                  glycine (evidence: Sequence-based prediction)
                                                                  Integrated Monomers
                                                                  Domains
                                                                  condensation (DCL), adenylation
                                                                  Name
                                                                  1
                                                                  Type
                                                                  nrps-type1
                                                                  Genes
                                                                  hasV
                                                                  Substrates
                                                                  threonine (evidence: Sequence-based prediction)
                                                                  Integrated Monomers
                                                                  Domains
                                                                  condensation (Starter), adenylation
                                                                  Name
                                                                  2
                                                                  Type
                                                                  nrps-type1
                                                                  Genes
                                                                  hasV
                                                                  Substrates
                                                                  threonine (evidence: Sequence-based prediction)
                                                                  Integrated Monomers
                                                                  Domains
                                                                  condensation (DCL), adenylation
                                                                  Name
                                                                  8
                                                                  Type
                                                                  nrps-type1
                                                                  Genes
                                                                  hasY
                                                                  Substrates
                                                                  threonine (evidence: Sequence-based prediction)
                                                                  Integrated Monomers
                                                                  Domains
                                                                  condensation (LCL), adenylation, methyltransferase
                                                                  Name
                                                                  9
                                                                  Type
                                                                  nrps-type1
                                                                  Genes
                                                                  hasY
                                                                  Substrates
                                                                  glutamine, tyrosine (evidence: Sequence-based prediction)
                                                                  Integrated Monomers
                                                                  Domains
                                                                  condensation (LCL), adenylation
                                                                  Annotation changelog

                                                                  Entry version: next

                                                                  Date
                                                                  Changes
                                                                  Submitters
                                                                  Reviewers
                                                                  2024-04-23
                                                                  MIBiG v4 annotathon
                                                                  • (ID: SDAWYQYFQDDVDNDD7ZO2XI6Z)
                                                                  • (ID: UAIKQNFE72FIDYEOFTEFDYN6)
                                                                  • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)

                                                                  Entry version: 4

                                                                  Date
                                                                  Changes
                                                                  Submitters
                                                                  Reviewers
                                                                  2022-10-07
                                                                  Update chemical activity to schema version 2.11
                                                                  • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                                                                  • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)

                                                                  Entry version: 3

                                                                  Date
                                                                  Changes
                                                                  Submitters
                                                                  Reviewers
                                                                  2022-09-15
                                                                  Remove negative molecular mass
                                                                  • (ID: 3UOU7PODQJXIM6BEPUHHRRA5)
                                                                  • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                                                                  2022-09-15
                                                                  Corrected NRP module activity
                                                                  • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                                                                  • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                                                                  2022-09-15
                                                                  Updated NRP substrate specificities
                                                                  • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                                                                  • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)

                                                                  Entry version: 2

                                                                  Date
                                                                  Changes
                                                                  Submitters
                                                                  Reviewers
                                                                  2019-10-16
                                                                  Migrated from v1.4
                                                                  • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                                                                  • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)

                                                                  Entry version: 1

                                                                  Date
                                                                  Changes
                                                                  Submitters
                                                                  Reviewers
                                                                  2015-06-12
                                                                  Submitted
                                                                  • (ID: BAJIZJS2YANDM4M7JHS5DFUK)
                                                                  • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                                                                  Detailed domain annotation
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