BGC0000373: holomycin biosynthetic gene cluster from Streptomyces clavuligerus ATCC 27064
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Location: 6,204,480 - 6,222,797 nt. (total: 18,318 nt).
This entry is originally from NCBI GenBank CM000913.1.

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core biosynthetic genes
additional biosynthetic genes
transport-related genes
regulatory genes
other genes
resistance
TTA codons
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Gene details
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General
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NRPS/PKS domains
KnownClusterBlast
General information about the BGC
MIBiG accession BGC0000373
Short description holomycin biosynthetic gene cluster from Streptomyces clavuligerus ATCC 27064
Status Minimal annotation: yes
A minimal annotation only contains information on the BGC loci and one or more linked chemical product(s)

Completeness: Unknown
Whether the loci encodes everything needed for the pathway producing the compound(s)
Biosynthetic class(es)
  • NRP
Loci NCBI GenBank: CM000913.1
Compounds
  • holomycin
Species Streptomyces clavuligerus ATCC 27064 [taxonomy]
References
Chemical products information
holomycin
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C7H6N2O2S2
Chemical database entries
NPAtlas
PubCHEM
List of genes involved in compound(s) production
Identifiers Position Product Functions Evidence Extra
  • SCLAV_5266
  • EFG10339.1
 6204480 - 6204707 (+) Hypothetical protein
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  • SCLAV_5267
  • EFG10340.1
 6205318 - 6206172 (-) Putative acetyltransferase
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  • SCLAV_5268
  • EFG10341.1
 6206255 - 6207394 (-) Acyl-CoA dehydrogenase domain protein
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  • SCLAV_5269
  • EFG10342.1
 6207391 - 6208194 (-) Gramicidin S biosynthesis protein grsT
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  • SCLAV_5270
  • EFG10343.1
 6208191 - 6209864 (-) Glucose-methanol-choline oxidoreductase
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  • SCLAV_5271
  • EFG10344.1
 6209861 - 6213151 (-) Non-ribosomal peptide synthetase
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  • SCLAV_5272
  • EFG10345.1
 6213315 - 6213920 (+) Lantibiotic biosynthesis protein, flavoprotein
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  • SCLAV_5273
  • EFG10346.1
 6213920 - 6214384 (+) Globin
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  • SCLAV_5274
  • EFG10347.1
 6214454 - 6215926 (-) Putative transmembrane efflux protein
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  • SCLAV_5275
  • EFG10348.1
 6215992 - 6217056 (-) Thioredoxin reductase
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  • SCLAV_5276
  • EFG10349.1
 6217621 - 6218391 (-) Thioesterase
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  • SCLAV_5277
  • EFG10350.1
 6218391 - 6219857 (-) condensation domain-containing protein
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  • SCLAV_5278
  • EFG10351.1
 6220002 - 6222797 (+) AmphRI-like transcriptional regulator
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Annotation changelog
MIBiG version Submitter Notes
1.0
  • Hidden contributor (ID: AAAAAAAAAAAAAAAAAAAAAAAA, no GDPR consent given).
  • Submitted
2.0
  • Hidden contributor (ID: AAAAAAAAAAAAAAAAAAAAAAAA, no GDPR consent given).
  • Migrated from v1.4
  • Updated compound(s) information (NPAtlas curation)
3.0
  • Hidden contributor (ID: AAAAAAAAAAAAAAAAAAAAAAAA, no GDPR consent given).
  • Updated bioactivity data
3.1
  • Hidden contributor (ID: AAAAAAAAAAAAAAAAAAAAAAAA, no GDPR consent given).
  • Update chemical activity to schema version 2.11
Detailed domain annotation
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