BGC0000422: saframycin A biosynthetic gene cluster from Streptomyces lavendulae
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Location: 1 - 62,804 nt. (total: 62,804 nt).
This entry is originally from NCBI GenBank DQ838002.1.

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core biosynthetic genes
additional biosynthetic genes
transport-related genes
regulatory genes
other genes
resistance
TTA codons
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Gene details
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General
Compounds
Genes
NRP
History
NRPS/PKS domains
KnownClusterBlast
General information about the BGC
MIBiG accession BGC0000422
Short description saframycin A biosynthetic gene cluster from Streptomyces lavendulae
Status Minimal annotation: no
A minimal annotation only contains information on the BGC loci and one or more linked chemical product(s)

Completeness: Unknown
Whether the loci encodes everything needed for the pathway producing the compound(s)
Biosynthetic class(es)
  • NRP
Loci NCBI GenBank: DQ838002.1
Compounds
  • saframycin A
  • saframycin B
Species Streptomyces lavendulae [taxonomy]
References
Chemical products information
saframycin A
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C29H30N4O8
Chemical database entries
PubCHEM
PubCHEM
saframycin B
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C28H31N3O8
Chemical database entries
PubCHEM
List of genes involved in compound(s) production
Identifiers Position Product Functions Evidence Extra
  • ABQ41256.1
 245 - 1069 (-) tyrosinase
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  • ABQ41257.1
 1066 - 1488 (-) tyrosinase co-factor
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  • ABQ41258.1
 1663 - 2169 (-) putative translation initiation inhibitor
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  • ABQ41259.1
 2141 - 3703 (+) putative transcriptional regulator
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  • ABQ41260.1
 3929 - 5161 (+) hypothetical protein
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  • ABQ41261.1
 5283 - 5921 (-) putative methyltransferase
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  • ABQ41262.1
 6034 - 6405 (+) hypothetical protein
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  • ABQ42336.1
 6490 - 7125 (+) hypothetical protein
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  • ABQ41263.1
 7185 - 7598 (+) glyoxalase/bleomycin resistance protein/dioxygenase
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  • ABI22116.1
 7628 - 8062 (+) hypothetical protein
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  • ABI22117.1
  • sfmR1
 8229 - 8816 (+) transcriptional regulator
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  • ABI22118.1
  • sfmO1
 8813 - 9727 (+) oxidoreductase
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  • ABI22119.1
  • sfmR2
 9930 - 10439 (+) transcriptional regulatory protein
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  • ABI22120.1
  • sfmCy1
 10609 - 12147 (+) oxidoreductase
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  • ABI22121.1
  • sfmG
 12181 - 13620 (+) transmembrane efflux protein
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  • ABI22122.1
  • sfmH
 13732 - 16191 (-) UV-repair protein
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  • ABI22123.1
  • sfmO2
 16262 - 17827 (-) monooxygenase
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  • ABI22124.1
  • sfmM1
 17903 - 18502 (-) SAM-dependent methyltransferase
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  • ABI22125.1
  • sfmI
 18655 - 19137 (-) hypothetical protein
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  • ABI22126.1
  • sfmJ
 19134 - 19631 (-) pyridoxamine 5'-phosphate oxidase-related protein
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  • ABI22127.1
  • sfmO3
 19815 - 21002 (+) cytochrome P450 hydroxylase
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  • ABI22128.1
  • sfmK
 21056 - 21241 (+) ferredoxin-like protein
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  • ABI22129.1
  • sfmCy2
 21317 - 22831 (-) oxidoreductase
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  • ABI22130.1
  • sfmO4
 22963 - 24390 (-) cytochrome P450 hydroxylase
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  • ABI22131.1
  • sfmA
 24414 - 29924 (+) putative non-ribosomal peptide synthetase
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  • ABI22132.1
  • sfmB
 30061 - 33309 (+) putative non-ribosomal peptide synthetase
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  • ABI22133.1
  • sfmC
 33306 - 37763 (+) putative non-ribosomal peptide synthetase
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  • ABI22134.1
  • sfmD
 37760 - 38857 (+) hypothetical protein
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  • ABI22135.1
  • sfmE
 38854 - 41223 (+) putative peptidase
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  • ABI22136.1
  • sfmF
 41220 - 41441 (+) MbtH-like domain protein
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  • ABI22137.1
  • sfmM2
 41474 - 42574 (+) SAM-dependent methyltransferase
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  • ABI22138.1
  • sfmR3
 42666 - 43202 (+) transcriptional regulatory protein
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  • ABI22139.1
  • sfmO5
 43343 - 44512 (-) prephenate dehydrogenase
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  • ABI22140.1
  • sfmS1
 44539 - 45993 (-) putative adenosylhomocysteinase
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  • ABI22141.1
  • sfmS2
 46023 - 46964 (-) N5, N10-methylen-tetrahydrofolate reductase
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  • ABI22142.1
  • sfmS3
 47000 - 50383 (-) putative methionine synthase
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  • ABI22143.1
  • sfmS4
 50479 - 51462 (-) putative adenosine kinase
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  • ABI22144.1
  • sfmS5
 51464 - 52669 (-) putative S-adenosylmethionine synthetase
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  • ABI22145.1
  • sfmM3
 52690 - 53694 (-) SAM-dependent methyltransferase
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  • ABI22146.1
  • sfmO6
 54002 - 55132 (+) oxygenase
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  • ABI22147.1
 55498 - 55959 (+) cofilin
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  • ABI22148.1
 55865 - 56869 (-) putative RNA polymerase ECF-subfamily sigma factor
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  • ABQ41264.1
 57211 - 57681 (+) putative DNA ligase
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  • ABQ41265.1
 57871 - 58239 (-) hypothetical protein
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  • ABQ41266.1
 58327 - 59604 (+) unknonw
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  • ABQ41267.1
 60002 - 60475 (+) neuromedin U receptor 1
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  • ABQ41268.1
 60426 - 60995 (-) hypothetical protein
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NRP-specific information
Subclass N/A
Cyclic? no
NRP-synthases
Gene Modules
sfmA
Module ?
Specificity: alanine
Evidence for specificity:
  • ATP-PPi exchange assay
  • Structure-based inference
  • Homology
sfmB
Module ?
Specificity: glycine
Evidence for specificity:
  • ATP-PPi exchange assay
  • Structure-based inference
  • Homology
sfmC
Module ?
Specificity: 3-hydroxy-O-methyl-5-methyltyrosine
Evidence for specificity:
  • ATP-PPi exchange assay
  • Structure-based inference
  • Homology
Annotation changelog
MIBiG version Submitter Notes
1.0
  • Hidden contributor (ID: AAAAAAAAAAAAAAAAAAAAAAAA, no GDPR consent given).
  • Submitted
2.0
  • Hidden contributor (ID: AAAAAAAAAAAAAAAAAAAAAAAA, no GDPR consent given).
  • Migrated from v1.4
  • Updated compound(s) information (NPAtlas curation)
3.0
  • Hidden contributor (ID: AAAAAAAAAAAAAAAAAAAAAAAA, no GDPR consent given).
  • Updated bioactivity data
  • Added NRP substrate specificities
3.1
  • Hidden contributor (ID: AAAAAAAAAAAAAAAAAAAAAAAA, no GDPR consent given).
  • Update chemical activity to schema version 2.11
Detailed domain annotation
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