BGC0000445: thiocoraline biosynthetic gene cluster from Micromonospora sp. ML1
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Location: 1 - 64,650 nt. (total: 64,650 nt).
This entry is originally from NCBI GenBank AM113472.1.

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core biosynthetic genes
additional biosynthetic genes
transport-related genes
regulatory genes
other genes
resistance
TTA codons
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Gene details
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General
Compounds
Genes
Biosynthesis
History
NRPS/PKS domains
KnownClusterBlast
General information about the BGC
MIBiG accession BGC0000445
Short description thiocoraline biosynthetic gene cluster from Micromonospora sp. ML1
Status Quality: questionable
The quality level of this entry.

Status: active
The status of this entry.

Completeness: complete
Whether the entry covers everything needed for the pathway producing the compound(s)
Biosynthetic class(es)
  • NRPS (Type I)
Loci
AM113472.1
via Knock-out studies, Heterologous expression
Compounds
  • thiocoraline
Species Micromonospora sp. ML1 [taxonomy]
References
Chemical products information
thiocoraline Evidence:
Copy SMILES
C48H56N10O12S6
Chemical database entries
NPAtlas
List of genes involved in compound(s) production
Identifiers Position Product Functions Evidence Extra
  • CAJ34355.1
 2 - 538 (+) putative transposase
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    • CAJ34356.1
    		 990 - 1130 (-) hypothetical protein
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      • CAJ34357.1
      • tioA
      		 1517 - 2134 (+) OmpR family regulator
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        • CAJ34358.1
        • tioB
        		 2151 - 2822 (-) putative regulator
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          • CAJ34359.1
          • tioC
          		 2967 - 3791 (-) ABC transporter (permease subunit)
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            • CAJ34360.1
            • tioD
            		 3791 - 4777 (-) ABC transporter (ATPase subunit)
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              • CAJ34361.1
              • tioE
              		 4904 - 5614 (+) MerR family regulator
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                • CAJ34362.1
                • tioF
                		 5698 - 6426 (-) Tryptophan 2,3-dioxygenase
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                  • CAJ34363.1
                  • tioG
                  		 6423 - 7688 (-) kynurenine aminotransferase
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                    • CAJ34364.1
                    • tioH
                    		 7730 - 8524 (-) NAD or NADP oxidoreductase
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                      • CAJ34365.1
                      • tioI
                      		 8791 - 10005 (+) quinaldate 3-hydroxylase
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                        • CAJ34366.1
                        • tioJ
                        		 10019 - 11590 (-) putative 3-hydroxy-quinaldate-AMP-Ligase
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                          • CAJ34367.1
                          • tioK
                          		 11847 - 13637 (+) NRPS protein
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                            • CAJ34368.1
                            • tioL
                            		 13731 - 15005 (-) hypothetical protein
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                              • CAJ34369.1
                              • tioM
                              		 15002 - 16354 (-) V-chloroperoxidase
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                                • CAJ34370.1
                                • tioN
                                		 16438 - 18744 (-) NRPS protein
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                                  • CAJ34371.1
                                  • tioO
                                  		 18771 - 19055 (-) putative 3-hydroxy-quinaldate Carrier Protein
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                                    • CAJ34372.1
                                    • tioP
                                    		 19260 - 20039 (+) thioesterase
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                                      • CAJ34373.1
                                      • tioQ
                                      		 20143 - 20880 (-) thioesterase
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                                        • CAJ34374.1
                                        • tioR
                                        		 21188 - 28972 (+) NRPS protein
                                        • Scaffold biosynthesis
                                        • Knock-out
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                                        • CAJ34375.1
                                        • tioS
                                        		 28979 - 38401 (+) NRPS
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                                          • CAJ34376.1
                                          • tioT
                                          		 38449 - 38664 (+) MbtH homologue
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                                            • CAJ34377.1
                                            • tioU
                                            		 38642 - 41266 (+) DNA excisionase
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                                              • CAJ34378.1
                                              • tioV
                                              		 41835 - 42371 (+) OmpR family regulator
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                                                • CAJ34379.1
                                                • tioW
                                                		 42392 - 43255 (-) putative regulator
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                                                  • CAJ34380.1
                                                  • tioX
                                                  		 43337 - 43741 (-) hypothetical protein
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                                                    • CAJ34381.1
                                                    • tioY
                                                    		 44152 - 49566 (+) NRPS protein
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                                                      • CAJ34382.1
                                                      • tioZ
                                                      		 49635 - 53672 (+) NRPS protein
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                                                        • CAJ34383.1
                                                        		 53746 - 55305 (-) putative permease for glucides
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                                                          • CAJ34384.1
                                                          		 55381 - 57222 (-) putative permease for glucides
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                                                            • CAJ34385.1
                                                            		 57895 - 58470 (+) putative MarR family regulator
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                                                              • CAJ34386.1
                                                              		 58532 - 59206 (-) putative anti-sigma factor
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                                                                • CAJ34387.1
                                                                		 59295 - 59564 (-) hypothetical protein
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                                                                  • CAJ34388.1
                                                                  		 59608 - 60114 (-) putative anti-sigma factor
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                                                                    • CAJ34389.1
                                                                    		 60202 - 60891 (+) putative response regulator
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                                                                      • CAJ34390.1
                                                                      		 60960 - 62243 (+) putative histidine kinase
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                                                                        • CAJ34391.1
                                                                        		 62300 - 62836 (+) hypothetical protein
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                                                                          • CAJ34392.1
                                                                          		 62925 - >64650 (+) putative chaperone
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                                                                            Biosynthesis information

                                                                            Biosynthetic modules

                                                                            Name
                                                                            1
                                                                            Type
                                                                            nrps-type1
                                                                            Genes
                                                                            tioR
                                                                            Substrates
                                                                            cysteine (evidence: Sequence-based prediction)
                                                                            Integrated Monomers
                                                                            Domains
                                                                            condensation, adenylation, epimerase
                                                                            Name
                                                                            2
                                                                            Type
                                                                            nrps-type1
                                                                            Genes
                                                                            tioR
                                                                            Substrates
                                                                            glycine (evidence: Sequence-based prediction)
                                                                            Integrated Monomers
                                                                            Domains
                                                                            condensation, adenylation
                                                                            Name
                                                                            3
                                                                            Type
                                                                            nrps-type1
                                                                            Genes
                                                                            tioS
                                                                            Substrates
                                                                            cysteine (evidence: Sequence-based prediction)
                                                                            Integrated Monomers
                                                                            Domains
                                                                            condensation, adenylation, methyltransferase
                                                                            Name
                                                                            4
                                                                            Type
                                                                            nrps-type1
                                                                            Genes
                                                                            tioS
                                                                            Substrates
                                                                            cysteine (evidence: Sequence-based prediction)
                                                                            Integrated Monomers
                                                                            Domains
                                                                            condensation, adenylation, methyltransferase
                                                                            Annotation changelog

                                                                            Entry version: 4

                                                                            Date
                                                                            Changes
                                                                            Submitters
                                                                            Reviewers
                                                                            2022-10-07
                                                                            Update chemical activity to schema version 2.11
                                                                            • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                                                                            • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)

                                                                            Entry version: 3

                                                                            Date
                                                                            Changes
                                                                            Submitters
                                                                            Reviewers
                                                                            2022-09-15
                                                                            Updated bioactivity data
                                                                            • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                                                                            • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                                                                            2022-09-15
                                                                            Updated NRP substrate specificities
                                                                            • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                                                                            • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)

                                                                            Entry version: 2

                                                                            Date
                                                                            Changes
                                                                            Submitters
                                                                            Reviewers
                                                                            2019-10-16
                                                                            Migrated from v1.4
                                                                            • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                                                                            • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                                                                            2019-10-16
                                                                            Updated compound(s) information (NPAtlas curation)
                                                                            • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                                                                            • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)

                                                                            Entry version: 1

                                                                            Date
                                                                            Changes
                                                                            Submitters
                                                                            Reviewers
                                                                            2015-06-12
                                                                            Submitted
                                                                            • (ID: IROSGRAECON7XFWB774QFHDN)
                                                                            • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                                                                            Detailed domain annotation
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