BGC0000450: triostin A biosynthetic gene cluster from Streptomyces triostinicus
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Location: 1 - 36,746 nt. (total: 36,746 nt).
This entry is originally from NCBI GenBank AB366635.1.

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core biosynthetic genes
additional biosynthetic genes
transport-related genes
regulatory genes
other genes
resistance
TTA codons
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Gene details
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General
Compounds
Genes
NRP
History
NRPS/PKS domains
KnownClusterBlast
General information about the BGC
MIBiG accession BGC0000450
Short description triostin A biosynthetic gene cluster from Streptomyces triostinicus
Status Minimal annotation: no
A minimal annotation only contains information on the BGC loci and one or more linked chemical product(s)

Completeness: Unknown
Whether the loci encodes everything needed for the pathway producing the compound(s)
Biosynthetic class(es)
  • NRP
Loci NCBI GenBank: AB366635.1
Compounds
  • triostin A
Species Streptomyces triostinicus [taxonomy]
References
Chemical products information
triostin A
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C50H62N12O12S2
Chemical database entries
NPAtlas
PubCHEM
List of genes involved in compound(s) production
Identifiers Position Product Functions Evidence Extra
  • BAH04156.1
  • trsD
1 - 984 (+) putative ABC transporter
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  • BAH04157.1
  • trsE
981 - 1805 (+) putative ABC transporter
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  • BAH04158.1
  • trsF
1912 - 3117 (+) putative esterase
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  • BAH04159.1
  • trsG
3236 - 3739 (-) putative DNA-binding response regulator
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  • BAH04160.1
  • trsH
3883 - 4095 (-) MbtH-like protein
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  • BAH04161.1
  • trsI
4142 - 13600 (-) putative non-ribosomal peptide synthetase
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  • BAH04162.1
  • MIPLSYAQRRMWFINRFEGPSSTYNIPLLLRFHGSLDTAALRAAFQDVLV
13608 - 21665 (-) trsJ
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  • BAH04163.1
  • trsK
21676 - 22374 (+) putative SAM-dependent methyltransferase
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  • BAH04164.1
  • trsL
22438 - 23823 (+) hypothetical protein
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  • BAH04165.1
  • trsM
24008 - 26386 (+) UvrA-like protein
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  • BAH04166.1
  • trsN
26468 - 27406 (+) putative oxidoreductase
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  • BAH04167.1
  • trsO
27803 - 29182 (-) putative FAD-dependent oxidoreductase
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  • BAH04168.1
  • trsP
29169 - 30257 (-) putative dehydrogenase
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  • BAH04169.1
  • trsQ
30254 - 31000 (-) putative thioesterase
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  • BAH04170.1
  • trsB
31154 - 32359 (+) putative cytochrome P450
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  • BAH04171.1
  • trsA
32373 - 33956 (+) AMP-binding ligase
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  • BAH04172.1
  • trsC
34035 - 34778 (-) putative tryptophan 2,3-dioxygenase
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  • BAH04173.1
  • trsR
34968 - 36746 (+) putative non-ribosomal peptide synthetase
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NRP-specific information
Subclass N/A
Cyclic? no
NRP-synthases
Gene Modules
trsI
Module ?
Specificity: cysteine
Evidence for specificity:
  • Structure-based inference
Module ?
Specificity: valine
Evidence for specificity:
  • Structure-based inference
MIPLSYAQRRMWFINRFEGPSSTYNIPLLLRFHGSLDTAALRAAFQDVLV
Module ?
Specificity: serine
Evidence for specificity:
  • Structure-based inference
Module ?
Specificity: alanine
Evidence for specificity:
  • Structure-based inference
trsA
Module ?
Specificity: quinoxaline-2-carboxylic acid
Evidence for specificity:
  • Structure-based inference
trsR
Module ?
Specificity: tryptophan
Evidence for specificity:
  • Structure-based inference
Annotation changelog
MIBiG version Submitter Notes
1.0
  • Hidden contributor (ID: AAAAAAAAAAAAAAAAAAAAAAAA, no GDPR consent given).
  • Submitted
2.0
  • Hidden contributor (ID: AAAAAAAAAAAAAAAAAAAAAAAA, no GDPR consent given).
  • Migrated from v1.4
  • Updated reference publication(s) (MIBiG Annotathon)
  • Updated compound(s) information (NPAtlas curation)
3.0
  • Hidden contributor (ID: AAAAAAAAAAAAAAAAAAAAAAAA, no GDPR consent given).
  • Updated bioactivity data
  • Added NRP substrate specificities
3.1
  • Hidden contributor (ID: AAAAAAAAAAAAAAAAAAAAAAAA, no GDPR consent given).
  • Update chemical activity to schema version 2.11
Detailed domain annotation
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