LOCUS       BGC0000533             10050 bp    DNA     linear   BCT 23-SEP-1999
DEFINITION  Streptococcus mutans mutacin III biosynthetic gene locus, partial
            sequence.
ACCESSION   BGC0000533
VERSION     BGC0000533
KEYWORDS    .
SOURCE      Streptococcus mutans
  ORGANISM  Streptococcus mutans
            Bacteria; Firmicutes; Bacilli; Lactobacillales; Streptococcaceae;
            Streptococcus.
COMMENT     ##antiSMASH-Data-START##
            Version      :: False
            Run date     :: 2022-11-07 19:47:20
            NOTE: This is a single region extracted from a larger record!
            Orig. start  :: 0
            Orig. end    :: 10050
            ##antiSMASH-Data-END##
FEATURES             Location/Qualifiers
     source          1..10050
                     /db_xref="taxon:1309"
                     /mol_type="genomic DNA"
                     /organism="Streptococcus mutans"
                     /strain="UA787"
     subregion       1..10050
                     /aStool="mibig"
                     /contig_edge="True"
                     /label="RiPP"
                     /subregion_number="1"
                     /tool="antismash"
     region          1..10050
                     /contig_edge="True"
                     /product="unknown"
                     /region_number="1"
                     /subregion_numbers="1"
                     /tool="antismash"
     CDS             205..1059
                     /codon_start=1
                     /gene="mutR"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) TIGR01716"
                     /gene_kind="biosynthetic-additional"
                     /note="transcription regulator; similar to Streptococcus
                     gordonii Rgg and Streptococcus mutans mutacin II operon
                     encoded MutR"
                     /product="MutR"
                     /protein_id="AAD56141.1"
                     /sec_met_domain="TIGR01716 (E-value: 4.8e-67, bitscore:
                     214.8, seeds: 14, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MKVNQSMELGELYRELRIARGLKIKDIACKNLSKSQLSRFENGQT
                     MLAADKLLLAISGIHMSFSEFGYALSHYEESDFFKRGHKLSELYAQKDIKGLKKLLEFN
                     DNHEVFDVYNRLNKLVIQVTIHLLDTDYIISDDDKNFLTTYLYNIEEWTEYELYIFGNT
                     MSILSSDDLIFLGKAFVERDKLYISLPSHKKNAELTFLNLILILLERKKLYQAIYFVEN
                     LEKLLNYQDMFAITFLKFLKKIITYFHDKSVDMSELEHYINIVEEINPTIASILKSNLN
                     QLL"
     gene            205..1060
                     /gene="mutR"
     CDS             1646..1837
                     /codon_start=1
                     /gene="mutA"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Gallidermin"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) mature_b"
                     /gene_kind="biosynthetic-additional"
                     /note="prepropeptide of mutacin III; identical to mutacin
                     1140; similar to mutacin NY266, epidermin and gallidermin"
                     /product="MutA precursor"
                     /protein_id="AAD56142.1"
                     /sec_met_domain="Gallidermin (E-value: 6.7e-37, bitscore:
                     114.9, seeds: 3, tool: rule-based-clusters)"
                     /sec_met_domain="mature_b (E-value: 5.2e-16, bitscore:
                     47.2, seeds: 5, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MSNTQLLEVLGTETFDVQEDLFAFDTTDTTIVASNDDPDTRFKSW
                     SLCTPGCARTGSFNSYCC"
     gene            1646..1839
                     /gene="mutA"
     gene            1904..2098
                     /gene="mutA'"
     CDS             1904..2098
                     /codon_start=1
                     /gene="mutA_"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) TIGR03731"
                     /gene_kind="biosynthetic-additional"
                     /note="similar to MutA; not required for mutacin III
                     production"
                     /product="MutA'"
                     /protein_id="AAD56143.1"
                     /sec_met_domain="TIGR03731 (E-value: 9.9e-19, bitscore:
                     56.3, seeds: 23, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MLNTQLLEVLGTKTFDVQEDLFEFNITDTIVLQASDSPDTHSKVG
                     SFNICPPRKISVSFNSYCC"
     gene            2253..5225
                     /gene="mutB"
     CDS             2253..5225
                     /codon_start=1
                     /gene="mutB"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     lanthipeptide-class-i: Lant_dehydr_C"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     lanthipeptide-class-i: Lant_dehydr_N"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Lanthipeptide_LanB_RRE"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1155:Lantibiotic dehydratase domain protein (Score:
                     657; E-value: 7.5e-199)"
                     /gene_kind="biosynthetic"
                     /note="modifying enzyme for promutacin III; similar to
                     SpaB, NisB and EpiB"
                     /product="MutB"
                     /protein_id="AAD56144.1"
                     /sec_met_domain="Lant_dehydr_N (E-value: 1.7e-118,
                     bitscore: 385.4, seeds: 73, tool: rule-based-clusters)"
                     /sec_met_domain="Lant_dehydr_C (E-value: 2.7e-19, bitscore:
                     58.8, seeds: 35, tool: rule-based-clusters)"
                     /sec_met_domain="Lanthipeptide_LanB_RRE (E-value: 1.6e-12,
                     bitscore: 37.2, seeds: 20, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MNDFQFQDYFMYRKPLGNFSNFFSITDTMDPIELLHSDPIFAEGV
                     YLASSSLRAAINKLKNHTASTKDKKNARETIFQYYARYNTRSTPFGLFSSIGVGAFSAY
                     LKKEKSRYEKSINIDLFWAYKVADKLESMPEILNTLKVVANNALQKSDNFWLLDTRSHF
                     GLMNSRSDIHEDITVKSNQLIDYVINCAEQPICYPTLVDNIAEKFSQSSDGVKKYLQKL
                     IKEEFLITELKFSLIEDNPLDWFINILERTQNNLELLEKLTEIKAMIQDYTDCDIGEGN
                     NLILALENKMSQIAETNAYLRVDLYDHAELELSHHIKDSLQNILKVLSSFSPGINSRKE
                     IRNYHEKFISRYGYEQLVPLQLLLNSTSGLGFPKGYSQTKDFKQNNGDSRNQKITEFLQ
                     RKFEKSLRDGKEIILNDDDLKDLDFDKEQQISGELYCFYDFKNRKLEVSGLGVSPMIGD
                     TFGRFHAKLPNTIITENVNKTKEIFAKAYPNTIITQLNEVPYFGRSGNVMVSNSLKSHQ
                     LELRNYTSKKDMSINDIYVGATSEELYFYSKKYGKRVIFIMNNMFNYINGSKLLRFLLE
                     VSNSDFQNITPIMFDNLDSYNHVPTIIYKDIIIKPETWNIRKSEVKTLDSLKNWLSDND
                     VPSLVRMKYTDQIIYLDLSRTIDLTMLFRSIKKHSFIQLLATHSEFVNDTKILELVVPF
                     TRSDVNARQIYHYAQNIYTLEDSDSKEKYFYVKIYVNKQRQTSFLQKEYPLLLNYLKLP
                     ENLQWFYIRYEDDEKDSIRLRIRYVEDKQLVQLYSRFIEWATEARKNIQILGYEISEYI
                     PESARYGGKKYSTIIHSFFYYDSILSLLLQKKTDQAIEVRTSLSIIRMFLMMKLNLQDQ
                     QELMKNLFDGEHKLKYEKEYHNSISLLLDSLCTRNQIDEADTFCVMNMKIITEEVSSVL
                     KQEDLTTDWQRILGSLIHMRCNRVYGINSELERKTMFIVDKVVNSKRYTDMFLEVDNET
                     K"
     gene            5212..6486
                     /gene="mutC"
     CDS             5212..6486
                     /codon_start=1
                     /gene="mutC"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     lanthipeptide-class-i: LANC_like"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1140:Lanthionine synthetase C family protein (Score:
                     264.5; E-value: 2.5e-80)"
                     /gene_kind="biosynthetic"
                     /note="modifying enzyme for promutacin III; similar to
                     EpiC, SpaC, NisC, EciC and PepC"
                     /product="MutC"
                     /protein_id="AAD56145.1"
                     /sec_met_domain="LANC_like (E-value: 3.8e-55, bitscore:
                     176.1, seeds: 47, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MRQSKRVEKIKNILTEQTYLFDYQEVLKKISQVKQTDFWNLLSLS
                     SGITSLLIFYQEYENLEGVNLKPQKQSLIGLISYYINQIADKSSLFDGLAGVGFAINYV
                     SNNGKYYQKLLNQIDSKICQNVKRNLADCNSEEYTNPMNYDVISGNAGVARYLMERESS
                     EDWRIVEMILEVFYKALEQGWRVQPKYQFLESEKQYYLKGNINFGLAHGLLGPTTIMSL
                     YQQRYPQNTRNAEKLQETYHFIKRYAQLRDEGLRWPIRYDLLRKEGSFILRNGWCYGDN
                     GIYSTLFLMGKVLSNQKICETAQKVIPSIIKDDYEKMESPTFCHGFAGKANFFLLQYQR
                     TKESIFLVKAEEEIDKILIVYNSENMFGFKDIEDNIDNTEERLTYWDNFGLLSGTVGVL
                     LVLMEYCNIVNAGKVSEWNKIFLLT"
     gene            6509..7075
                     /gene="mutD"
     CDS             6509..7075
                     /codon_start=1
                     /function="may function in C-terminal oxadative
                     decarboxylation of promutacin III"
                     /gene="mutD"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Flavoprotein"
                     /gene_kind="biosynthetic-additional"
                     /note="modifying enzyme for promutacin III; similar to EpiD
                     and other flavoproteins"
                     /product="MutD"
                     /protein_id="AAD56146.1"
                     /sec_met_domain="Flavoprotein (E-value: 1.6e-35, bitscore:
                     110.9, seeds: 143, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MEEQNTEKKILLCLTGSGALLGITEYITFLTVRFKHVRVIVSDNA
                     AKMLPVAAITQLCEKVYTDEVSFTDKQKNHIALTRWADITVVLPATANIIGKVANGIAD
                     NFMTTTLLSSSKPVLIYPCMNNIMWENPVVQKNVEVLSGTQYKVIVGQESESFELASGK
                     MKKNIAIPSLDELQRVVLENLQEER"
     gene            7080..8423
                     /gene="mutP"
     CDS             7080..8423
                     /codon_start=1
                     /function="processing of premutacin III"
                     /gene="mutP"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Peptidase_S8"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1075:alkaline serine protease, subtilase family
                     (Score: 242.6; E-value: 1.6e-73)"
                     /gene_kind="biosynthetic-additional"
                     /note="serine protease; similar to NisP, EpiP and serine
                     proteases"
                     /product="MutP"
                     /protein_id="AAD56147.1"
                     /sec_met_domain="Peptidase_S8 (E-value: 8.2e-46, bitscore:
                     145.6, seeds: 43, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MKKKGLLVIIFLTFFFFYPKAKAAEYTIISNNSEQTVNGLNNLGV
                     TVNSHIAEIGYIEAQGDVNIDQIKKLSNIKSIQNMADTSQNITTRVPSTYINQTIQLPQ
                     LFSYQWDMQKITNNGVSYSLNKENRKNVTVALVDSGIDVDHNAFTGMIDSRSKNFVPAG
                     GYDNSESSETGSINDIDDKKGHGTAVAGQIAANGQIFGVSPGTNLLVYRVFGKSKSKEC
                     WILKAIIDATNNGANVINLSLGQYIKIPNGDIWESAEALRYKFAIDYATRHNVIVVAAT
                     GNDGLSDDNGEVKTYYNSQHSGQDMSQNDTVEDYPSVLPNAIAVGSSDNNNQRSSFSNY
                     YNQYQDNFILAPGGGTPLLDQYGQEEWYNQKLFMKEQVLSTSNNGNYDYADGTSISTGK
                     VSGELAEIISNYHLQGDSSKARSILLNQVNYTSDGYKEISTYKALRGY"
     gene            8424..10049
                     /gene="mutT"
     CDS             8424..10049
                     /codon_start=1
                     /function="transportation of premutacin III"
                     /gene="mutT"
                     /gene_functions="transport (smcogs) SMCOG1288:ABC
                     transporter related protein (Score: 229.5; E-value:
                     1.3e-69)"
                     /gene_kind="transport"
                     /note="ABC transporter; similar to LmrA, PepT and ABC
                     transporters"
                     /product="MutT"
                     /protein_id="AAD56148.1"
                     /transl_table=11
                     /translation="MKWLEVLQISKKEKILYLIGCIFSIMTGLITLRITYLLKNLVDSK
                     SSFNNLFLFLVLGLVLFIIDAGSQYLISLIGNQVVFNSRNNIWKKISDWTDSKDDSSEM
                     AGHLINDSELIENFIISTIPQSINSVIVGSGSLVMLFVINSKMSLEVIGICFLLLFIMQ
                     PFSRILSKISKRIQEDKAELINIASQLRGQVKTIKSYNAQDYAFQKFDEQNRQLFQDIL
                     NRIKIFSIYSPFLNILILFMIIIVVWLGNTEVRSGNLTVGSATIFVVYMTQLINPIMQL
                     SQLVAHMGMLNGGVERLLEYNQAIPEKNGIKKIDEIINIAFDNVSFAYDNQENIIENVN
                     LTFQKGTYISIVGESGVGKSTLLDLLEHNYVPSKGRILINGIDLEELNIKTLRNKISYV
                     SQEPTILSGTIRELLDFNQQQHTETSLWNVLDTVELSELIRNLPRKLDSKVDEYGGNLS
                     GGQMQRISLARGLLKAGDVLLLDESFANIDEETCLKIKLKIAAYAESHKQIVIEVIHNL
                     NRITPSSIVYRLADKKLEILRSGF"
ORIGIN
        1 aaaactaggg agttttttaa taatgcccaa atgtcacttt aatatttgga atgttttttt
       61 gtgatgaaca aatccttatc atttccttaa atttgttttt tatactaaaa gcgggaatga
      121 ttcaaaacta aaaaagataa acgaagaatt gaaaaagtga tataatagca cagaagaggg
      181 cctttataat gaaaggagac tattttgaaa gtaaatcaat caatggaatt aggtgaactt
      241 tatcgagaat taagaattgc tagaggtttg aagataaaag atatagcttg taaaaatctg
      301 tccaagtcac aactctctag atttgaaaat ggacaaacca tgttggcagc tgataaattg
      361 ctattagcta tttcgggaat tcatatgagc ttttcggaat ttggatatgc tttgagccat
      421 tatgaggaga gtgatttttt caaaaggggt cataagttat cagaattata tgcccagaaa
      481 gatatcaaag gattaaaaaa gttattagaa tttaatgaca atcatgaggt atttgatgtc
      541 tacaatcgtt taaataaatt ggttattcaa gttactattc atttgctaga tactgattac
      601 ataatatcag atgatgataa gaatttttta acaacttatc tatataatat tgaagagtgg
      661 actgagtatg aactttatat ctttgggaat actatgtcta tattgtcatc tgatgattta
      721 atttttttgg gaaaagcttt tgtagaacgt gataagttgt atatatctct tcctagtcat
      781 aagaaaaatg cagagttaac ttttttaaat ttaatcttaa ttttgcttga aagaaaaaaa
      841 ttatatcaag caatctattt tgtagagaat ttagagaaat tattaaatta ccaagatatg
      901 tttgcaataa catttttaaa atttttaaaa aaaattatta cttactttca tgataagtca
      961 gtagatatgt ctgaattaga acattatatt aatatagttg aagaaataaa tcctacgatt
     1021 gcttcaattc ttaaatctaa tttgaatcag cttttataaa gttttagcca ttaaagccat
     1081 cttgataaat tttatatctt tcatattcat taaatgtgga gataatgaaa aagcaacggt
     1141 tatgctatcg ctgctttttt tgtgattaga agctatgtta tcatggagtt atagtaatga
     1201 aacatagtga cagttcatcc tttcttatta taaaagtggt aataagagaa gtggtaaaca
     1261 aagagttagt aaaataatac gtttaaccat aatatttcct cctttaattt attataagat
     1321 tcaaaaaggt aatatcctat atttgcaaat atgggataaa ataattttaa aaaagcagat
     1381 ttgcaatttt aaaaaaatag aggctaatgg tggtattata ttattgtaaa tatatgttta
     1441 ctcagtaata gtgatttact attacaacag attttgttgt tatcttagat atttctgcta
     1501 gcattagtta tctgtagatg tactacttaa taagtatata attataatta tataataact
     1561 attatcagat taccgttaaa agttttctga tatgcttcta ctgaacaatt tatgttcagt
     1621 tacacacatg aaaaaggagg atattatgtc aaacacacaa ttattagaag tccttggtac
     1681 tgaaactttt gatgttcaag aagatctctt tgcttttgat acaacagata ctactattgt
     1741 ggcaagcaac gacgatccag atactcgttt caaaagttgg agcctttgta cgcctggttg
     1801 tgcaaggaca ggtagtttca atagttactg ttgctgattg tataaaagat ttagattgtg
     1861 ccgcatgtta gcggcacaat cttttgatat tagaggtatt aatatgttaa atacacaatt
     1921 attagaagtc cttggtacta aaacttttga tgttcaagaa gatttatttg agtttaatat
     1981 aacagatact attgtactgc aggctagtga tagtccagat actcatagta aagtgggtag
     2041 tttcaatatc tgccctcctc gaaagatctc cgtcagtttc aatagttact gttgttaact
     2101 ataaattata cttaaattga taggaaactt ggtcgtgaca ttatcatatg ttgatattgg
     2161 aagagaatca aatttataaa gacaattaaa tctaaatttg atgaatattt agatgaatta
     2221 ttactaggtt gacagtcatg ttaggagaag agatgaacga ttttcaattt caagattatt
     2281 ttatgtacag aaaaccatta ggcaactttt ctaatttttt tagtataact gatacgatgg
     2341 atcccattga gttactacat agtgatccga tatttgctga aggagtatat ttggcctctt
     2401 catctcttag agcagccata aataaactta agaatcatac tgcgagtact aaggataaaa
     2461 agaatgcaag agagactatt tttcaatact atgcccgtta taacacgaga tcaactccgt
     2521 ttggcttgtt ttcgtccatc ggagtaggtg ctttttcggc ttaccttaaa aaagaaaagt
     2581 ctcgttatga aaaatctatt aatattgatc ttttttgggc ttataaagta gcagataaac
     2641 tagaaagtat gcctgaaatt ttaaatactt taaaagtagt tgctaataat gctttgcaaa
     2701 agtcagataa tttttggctt ttggatacgc gaagtcattt tggtcttatg aattcacgtt
     2761 ctgatattca tgaggacatc acagttaaat ctaatcagct tatagattac gttattaatt
     2821 gtgcagaaca accaatttgt tacccaacat tagttgataa tattgccgag aaattttctc
     2881 agtctagtga tggtgtaaaa aaatatttac aaaaattaat caaagaagag tttttgatca
     2941 ctgagttaaa atttagtttg attgaagaca atcctttgga ttggtttatt aatatcttag
     3001 aaagaactca aaataaccta gaattacttg aaaagttgac tgagataaag gcaatgattc
     3061 aggactatac tgactgtgac attggtgagg gcaacaattt gattttagct ttagaaaata
     3121 agatgagcca aatagcagaa actaatgcat atttgcgggt tgatctttat gatcatgcag
     3181 agttggagtt atctcatcat atcaaggatt ctcttcagaa tattttaaaa gtactaagtt
     3241 ctttttcacc aggtattaat agtcggaaag aaattagaaa ttaccatgag aaatttattt
     3301 ccagatatgg atatgaacag ttagtacctc ttcaattact tttgaattct actagtggac
     3361 ttggctttcc aaaagggtat agtcagacaa aagattttaa acaaaataat ggagatagtc
     3421 ggaatcaaaa aataacagaa tttttgcaga gaaaatttga aaaatcttta agagatggta
     3481 aagaaattat tctgaatgat gatgatttaa aagatctaga ttttgataag gaacagcaga
     3541 tatcagggga actatactgt ttctatgatt ttaaaaatag aaaattggag gttagtggtt
     3601 taggtgtttc accgatgatt ggagatacct tcggacgttt tcatgctaaa ttgccgaata
     3661 cgataatcac agaaaatgta aataaaacga aagaaatttt tgctaaagcc tatcctaata
     3721 ctattattac tcaattaaat gaagtgccat attttgggag gagtggtaat gttatggtca
     3781 gtaacagtct taaaagccat cagttggagt tgagaaacta tacttcaaaa aaagatatga
     3841 gtatcaatga tatttatgta ggtgcaacca gtgaggaatt atacttttat tctaaaaaat
     3901 atggaaaaag agttattttt ataatgaata atatgtttaa ttatataaat ggttccaaac
     3961 ttttacgttt tttactagaa gtttcaaatt ctgactttca aaatattact ccgattatgt
     4021 ttgataatct ggattcttat aatcatgtgc ctactatcat ttataaagac attattatta
     4081 aaccagaaac atggaatatt agaaaatctg aagttaagac tttagattct ctcaaaaatt
     4141 ggctatctga taatgatgtt ccatctcttg tgcggatgaa atatactgat caaattattt
     4201 acttggattt gagtcggact attgatttaa ctatgttatt tcggagtatt aaaaaacaca
     4261 gttttataca attgttagct actcattccg aatttgtaaa cgatacgaag attttggagc
     4321 tagttgtgcc ttttacaagg agtgatgtca atgctcgcca gatttatcat tatgcccaga
     4381 atatttatac tttggaggat tcagatagta aagaaaaata tttttacgtt aaaatttatg
     4441 ttaacaaaca acgacaaact tctttcttac aaaaagaata tcctttatta ttaaactatt
     4501 tgaaactccc tgaaaatttg caatggttct atattagata tgaagatgat gaaaaagaca
     4561 gcatacgtct cagaatcaga tatgtagaag ataaacaatt agttcaactt tattcacgct
     4621 ttatagagtg ggcgacagaa gcacggaaaa atatacaaat tttaggttat gaaattagtg
     4681 aatacatccc tgaatcagca agatatggag gaaaaaaata ttccacaatt atccattctt
     4741 ttttctatta tgatagtatt ttgagtttac ttttacaaaa gaaaacagat caagctattg
     4801 aagtgagaac ttctctcagt attattcgca tgtttttaat gatgaaatta aacttgcaag
     4861 atcaacagga actcatgaaa aatttgtttg atggagaaca taaacttaaa tatgaaaagg
     4921 aatatcataa ttcaataagt ttattacttg atagtttatg tacaagaaat cagatagatg
     4981 aagctgatac tttctgtgta atgaatatga aaataatcac tgaagaagtt agttcagttc
     5041 ttaaacaaga ggacttaaca acagattggc agagaattct gggaagtctt attcatatgc
     5101 gatgtaatcg agtatatgga attaatagtg agttagaaag aaaaacaatg tttattgttg
     5161 acaaagttgt taattcaaaa agatatacag atatgttttt ggaggtggat aatgagacaa
     5221 agtaaacgtg tcgaaaaaat taaaaatatt ctaacagagc aaacttattt atttgattat
     5281 caagaggtat taaaaaaaat cagtcaagta aaacaaacag atttttggaa tttactttct
     5341 ttgtcttcgg gaataacttc tttattaatc ttttatcaag agtatgagaa tttagaagga
     5401 gtaaacttaa agccgcaaaa gcagtcattg atcggactta taagttatta tattaatcaa
     5461 atagcagata aatcctcttt atttgatggt ttagctgggg taggttttgc tattaattat
     5521 gtctctaata acggtaaata ttatcaaaaa cttcttaatc aaattgacag taaaatttgt
     5581 cagaacgtta agcggaacct tgctgattgt aatagtgaag agtatacaaa tcctatgaat
     5641 tatgatgtaa tttctggaaa tgctggagta gctcgttatc tgatggaaag agaatcctct
     5701 gaagattggc gaattgttga aatgatttta gaagtatttt ataaagcttt ggaacaaggc
     5761 tggcgagtgc aaccaaaata tcaattttta gaatctgaaa agcaatatta tttaaaggga
     5821 aatataaact ttggtttagc tcatggatta ttaggtccta caacaattat gtctctttat
     5881 cagcagaggt acccacagaa cacaagaaat gctgagaaac ttcaggagac ttatcatttt
     5941 ataaaaagat atgctcaact aagagatgag gggctacgat ggccaatacg atatgattta
     6001 cttcgtaaag agggttcttt tatattacga aatggctggt gttatggaga taatggcatt
     6061 tatagtacac tttttcttat gggaaaagta ctctcaaatc agaagatttg tgaaactgct
     6121 cagaaagtta taccatccat cataaaagat gattatgaga aaatggaaag tccaacattt
     6181 tgtcatgggt ttgctggaaa agcaaatttc tttcttctgc aatatcaaag aactaaagaa
     6241 tcaatatttt tagttaaagc agaagaagaa attgataaaa tattaattgt gtacaattct
     6301 gaaaatatgt ttggatttaa agatatagaa gataatattg ataatactga agagagatta
     6361 acttattggg ataattttgg tcttcttagt ggaactgttg gtgttctatt agttttgatg
     6421 gaatattgta atattgtaaa tgctggaaaa gtttcagagt ggaataaaat ttttctttta
     6481 acttaattaa ctgaacggag gaataattat ggaagaacaa aatacagaga aaaaaattct
     6541 cttgtgtcta acaggttctg gagccttgtt agggataact gaatatatta cgtttttgac
     6601 tgtgcgcttt aagcatgttc gagttattgt ctctgataat gctgcgaaga tgcttcccgt
     6661 tgctgctatt acacaattgt gtgagaaagt gtatactgat gaagtttcct ttacagataa
     6721 gcaaaagaat cacatagctt taactcgctg ggcagacata acagttgtct tacctgctac
     6781 agcaaatata attggaaaag ttgctaatgg tattgcagat aactttatga caacaactct
     6841 tctttcttct agcaagccag ttttaattta tccttgcatg aataatatta tgtgggaaaa
     6901 tccagtagtt caaaaaaatg ttgaagtttt atctggaacc caatataagg taattgttgg
     6961 acaagaatca gaatcttttg aattagccag tggaaagatg aaaaagaata ttgcaattcc
     7021 aagtttggat gaattgcaac gagttgtttt agaaaattta caagaagaga ggtaagagta
     7081 tgaagaagaa aggattacta gtaataatct ttctaacttt ctttttcttt tatcctaaag
     7141 ctaaagctgc tgaatataca attatatcaa ataatagtga acaaactgtt aatggcttga
     7201 ataatttagg agttacagtc aatagccata ttgcggaaat tggatatatt gaagctcaag
     7261 gagatgttaa cattgatcag attaaaaagc tgtcaaatat taaaagtatc cagaatatgg
     7321 ctgatacatc acagaatatc acgactagag ttccttcaac atatattaac cagacaatac
     7381 aattgcctca gcttttttct tatcagtggg atatgcaaaa aattactaat aatggtgttt
     7441 catattcatt aaataaagaa aatcgaaaaa atgtaacagt tgctttagtt gattctggga
     7501 ttgatgtaga ccataatgct tttacaggaa tgattgatag tcgttcaaaa aattttgtgc
     7561 ctgctggagg atatgataat agtgaaagca gtgaaactgg aagtattaat gatattgatg
     7621 ataaaaaagg ccatggaaca gcagttgctg ggcaaattgc tgcaaatggt caaatctttg
     7681 gtgtgtcccc aggaacgaac cttcttgtct atagagtttt tggaaaatca aaatcaaagg
     7741 agtgctggat tttaaaagca attattgatg caacaaataa tggtgctaat gttattaatc
     7801 taagtttggg gcaatatatt aagattccta atggtgatat ttgggagtct gccgaagcat
     7861 taagatataa gtttgccatt gattatgcca caagacataa tgtcattgtt gtagcagcca
     7921 caggtaatga tggattaagt gatgacaacg gagaggttaa aacttattat aatagtcagc
     7981 attcaggaca agatatgtct caaaatgaca cggttgaaga ttatccttct gttttaccta
     8041 atgctattgc agttggctct tctgataata ataatcaaag atcatctttt agtaattact
     8101 ataatcaata ccaggacaat tttattttgg ctcctggtgg tggaacacct ttactagacc
     8161 aatatggtca agaagagtgg tataatcaga agctttttat gaaagaacaa gtattatcaa
     8221 caagtaataa tggaaattat gattatgcag atggtacttc tatttcaaca ggaaaagttt
     8281 ctggagagct tgcagaaatt attagtaact accatcttca aggagactct tcaaaagcta
     8341 gaagtattct actaaatcaa gttaattata ctagtgatgg ttataaagaa ataagcactt
     8401 acaaagcttt gcgaggttac taaatgaagt ggttagaagt tttgcagatt agtaaaaaag
     8461 aaaaaattct ttatcttatt ggttgtatat tttcaattat gacaggctta attactctac
     8521 gaatcaccta cttacttaag aatttagttg acagcaaatc gtcttttaat aatttgttct
     8581 tgtttcttgt tttgggatta gttcttttta tcatagatgc tggttcacag tatctaattt
     8641 cattgattgg taatcaagta gtgtttaaca gtcgaaataa tatttggaaa aaaatttctg
     8701 attggacaga tagtaaagat gattcttctg aaatggcagg ccaccttatt aatgatagtg
     8761 aactgataga aaattttata atttctacta ttcctcaatc aataaattca gttattgttg
     8821 gatcaggatc cttagttatg ctatttgtta ttaatagtaa aatgtcttta gaagttatag
     8881 ggatttgctt tcttttattg ttcattatgc aacccttttc tagaatatta agcaaaataa
     8941 gtaaaagaat ccaggaagac aaagctgaac ttattaatat tgcctcacag ttgagaggac
     9001 aagtcaaaac aataaaaagc tataatgctc aagattatgc ctttcaaaaa tttgatgagc
     9061 aaaatcgcca attatttcaa gatatcttaa atagaataaa aatttttagc atttactctc
     9121 cttttttaaa tatcttaatt ctttttatga ttataattgt tgtttggcta ggaaatacag
     9181 aagtacgttc aggaaatctc actgtaggtt cagcaactat ttttgttgtt tatatgacac
     9241 aattaattaa tccaattatg caattatcac aattagttgc tcatatgggg atgcttaatg
     9301 gcggcgtgga acgtcttttg gagtataatc aagctattcc agaaaaaaat ggaatcaaga
     9361 aaattgatga aataattaat atcgcgtttg ataatgtttc atttgcttat gataaccaag
     9421 aaaatattat tgaaaatgtg aatttaactt ttcaaaaagg tacttatatt tccattgttg
     9481 gtgaaagtgg agttgggaaa tcaaccttac ttgatctttt agaacataat tatgtaccat
     9541 caaaaggacg aatcttaata aacggaatag atttagaaga attgaatatt aagactttgc
     9601 gaaataagat aagctatgta tctcaagaac caacaattct ttctgggaca attcgtgaac
     9661 tattagactt taatcagcaa cagcatacag aaactagtct ttggaatgtt cttgatactg
     9721 tagaattatc agaacttatt agaaatttac cgcgaaaatt agattctaag gttgatgaat
     9781 atggtggtaa cctctctgga ggtcagatgc aacggatctc acttgcaaga ggattactga
     9841 aagcaggaga tgttttatta ttagatgaat cttttgccaa tattgatgaa gagacttgtc
     9901 ttaaaataaa attaaaaatt gctgcttatg ctgaatcaca caagcaaatt gttattgaag
     9961 ttattcataa tctaaataga ataactccca gtagtatcgt ttaccgattg gctgataaaa
    10021 aactagaaat tttgaggagc ggattctaat
//
