LOCUS       BGC0000542              9130 bp    DNA     linear   BCT 27-JAN-2014
DEFINITION  Paenibacillus terrae strain NRRL B-30644 paenicidin B biosynthetic
            gene cluster, complete sequence.
ACCESSION   BGC0000542
VERSION     BGC0000542
KEYWORDS    .
SOURCE      Paenibacillus terrae
  ORGANISM  Paenibacillus terrae
            Bacteria; Firmicutes; Bacilli; Bacillales; Paenibacillaceae;
            Paenibacillus.
COMMENT     ##antiSMASH-Data-START##
            Version      :: 6.2.0-924c3663(changed)
            Run date     :: 2022-11-07 19:48:55
            ##antiSMASH-Data-END##
FEATURES             Location/Qualifiers
     gene            1..177
                     /gene="pabA"
     CDS             1..177
                     /codon_start=1
                     /gene="pabA"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) TIGR03731"
                     /gene_functions="biosynthetic-additional (lanthipeptides)
                     predicted lanthipeptide"
                     /gene_kind="biosynthetic-additional"
                     /note="paenicidin B prepropeptide"
                     /product="PabA"
                     /protein_id="AHF21230.1"
                     /sec_met_domain="TIGR03731 (E-value: 2.9e-11, bitscore:
                     32.2, seeds: 23, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MANNLFDLDVQVNKSQGSVEPQVLSIVACSSGCGSGKTAASCVAT
                     CGNKCFTNVGSLC"
     CDS_motif       1..66
                     /prepeptide="leader"
                     /note="peptide class: lanthipeptide"
                     /note="predicted sequence: MANNLFDLDVQVNKSQGSVEPQ"
                     /locus_tag="pabA_lanthipeptide"
                     /aSTool="lanthipeptides"
                     /tool="antismash"
     CDS_motif       67..177
                     /prepeptide="core"
                     /locus_tag="pabA_lanthipeptide"
                     /peptide="lanthipeptide"
                     /predicted_class="Class I"
                     /score="11.20"
                     /molecular_weight="3237.8"
                     /monoisotopic_mass="3235.5"
                     /core_sequence="VLSIVACSSGCGSGKTAASCVATCGNKCFTNVGSLC"
                     /aSTool="lanthipeptides"
                     /tool="antismash"
                     /leader_sequence="MANNLFDLDVQVNKSQGSVEPQ"
                     /leader_location="[0:66](+)"
                     /alternative_weights="3255.8"
                     /alternative_weights="3273.8"
                     /alternative_weights="3291.8"
     source          1..9130
                     /culture_collection="NRRL:B-30644"
                     /db_xref="taxon:159743"
                     /mol_type="genomic DNA"
                     /organism="Paenibacillus terrae"
                     /strain="NRRL B-30644"
     misc_feature    1..9130
                     /note="paenicidin B biosynthetic gene cluster"
     protocluster    1..9130
                     /aStool="rule-based-clusters"
                     /category="RiPP"
                     /contig_edge="True"
                     /core_location="[2679:9130]"
                     /cutoff="20000"
                     /detection_rule="((LANC_like and (Lant_dehydr_N or
                     Lant_dehydr_C)) and not (YcaO or TIGR03604))"
                     /neighbourhood="10000"
                     /product="lanthipeptide-class-i"
                     /protocluster_number="1"
                     /tool="antismash"
     proto_core      2680..9130
                     /aStool="rule-based-clusters"
                     /tool="antismash"
                     /cutoff="20000"
                     /detection_rule="((LANC_like and (Lant_dehydr_N or
                     Lant_dehydr_C)) and not (YcaO or TIGR03604))"
                     /neighbourhood="10000"
                     /product="lanthipeptide-class-i"
                     /protocluster_number="1"
     cand_cluster    1..9130
                     /candidate_cluster_number="1"
                     /contig_edge="True"
                     /detection_rules="((LANC_like and (Lant_dehydr_N or
                     Lant_dehydr_C)) and not (YcaO or TIGR03604))"
                     /kind="single"
                     /product="lanthipeptide-class-i"
                     /protoclusters="1"
                     /tool="antismash"
     subregion       1..9130
                     /aStool="externally annotated by: MIBiG"
                     /contig_edge="True"
                     /label="BGC0000542"
                     /subregion_number="1"
                     /tool="antismash"
     region          1..9130
                     /candidate_cluster_numbers="1"
                     /contig_edge="True"
                     /product="lanthipeptide-class-i"
                     /region_number="1"
                     /rules="((LANC_like and (Lant_dehydr_N or Lant_dehydr_C))
                     and not (YcaO or TIGR03604))"
                     /subregion_numbers="1"
                     /tool="antismash"
     gene            347..1075
                     /gene="pabF"
     CDS             347..1075
                     /codon_start=1
                     /gene="pabF"
                     /gene_functions="transport (smcogs) SMCOG1000:ABC
                     transporter ATP-binding protein (Score: 185.2; E-value:
                     2.4e-56)"
                     /gene_kind="transport"
                     /note="ABC transporter ATP binding protein"
                     /product="PabF"
                     /protein_id="AHF21231.1"
                     /transl_table=11
                     /translation="MSDALLEVQQVTKKMGKRDLLNNISFELERGKIYGFIGPNGAGKT
                     TMMRIMTGLMQPTSGFVRIASYDVQTDREKALSKVGAIIESPVFFDYMTGRQVLRNLSR
                     LHMEIKSSDRENHIEELLKRVGLESRGDDKVKAYSLGMKQRLGIAQSMLGSPELLLLDE
                     PSNGLDPMGMRELRDIILRLRDSANYAFFISSHLLDELQQMCDELIVIKEGTLVWKGPA
                     DQLVEEGQRLEDAFIGLMGL"
     gene            1072..1872
                     /gene="pabE"
     CDS             1072..1872
                     /codon_start=1
                     /gene="pabE"
                     /note="ABC transporter membrane-bound subunit"
                     /product="PabE"
                     /protein_id="AHF21232.1"
                     /transl_table=11
                     /translation="MKLLIYSEFERLWKRKWFLLLILCTPVLAYSTGGYFLRIMKVPME
                     VLSKSFMVTGLRENLYLVCNIAVAALVAAVYTEEFRSGQMRLLFMRRFTRGQIFWSKLF
                     VVNISILLLLVVFAVSSQVIVEVWRSSYDLGDTSFLGNKWIYVFEYYGWAFASLLAISS
                     LYSFIAMCSKSVTYAIGACMTYNLGALLFDGLYLKLASLAPHTSYLHDVIAFLLIPYMQ
                     YTGLDGSLEGNGSVNGAITTVVAFYLIFFTWAAYRRFAAGDYLY"
     gene            1885..2652
                     /gene="pabG"
     CDS             1885..2652
                     /codon_start=1
                     /gene="pabG"
                     /note="ABC transporter membrane-bound subunit"
                     /product="PabG"
                     /protein_id="AHF21233.1"
                     /transl_table=11
                     /translation="MLGIWRSEMERIWNRKSTILLYIAFVLIVIANIWSLKITDTMRFR
                     FGEGIVAVNNLNLPWLMMSEVSLFLITAMLPILYVDQLSGDIHSGAYRLYVLRPYRRFQ
                     FWLGKLLALSVTTIFFTGTTLLIGVFAGWMLFPNAATFFKYGSTLPSTSTEAVSYTLAF
                     YLLLTLVCLAKLMLSSVVCLFISRPLFAFIAILALSMFLYPIFKPLVVLMDPFQQILLA
                     LRVDGSFKFWMCLGMTVLLCSIVSFTRWQKKVI"
     gene            2680..5871
                     /gene="pabB"
     CDS             2680..5871
                     /codon_start=1
                     /gene="pabB"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     lanthipeptide-class-i: Lant_dehydr_C"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     lanthipeptide-class-i: Lant_dehydr_N"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Lanthipeptide_LanB_RRE"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1155:Lantibiotic dehydratase domain protein (Score:
                     908.9; E-value: 5.8e-275)"
                     /gene_kind="biosynthetic"
                     /note="lantibiotic dehydratase"
                     /product="PabB"
                     /protein_id="AHF21234.1"
                     /sec_met_domain="Lant_dehydr_N (E-value: 6.4e-182,
                     bitscore: 594.8, seeds: 73, tool: rule-based-clusters)"
                     /sec_met_domain="Lant_dehydr_C (E-value: 1.7e-41, bitscore:
                     131.6, seeds: 35, tool: rule-based-clusters)"
                     /sec_met_domain="Lanthipeptide_LanB_RRE (E-value: 8.7e-16,
                     bitscore: 47.5, seeds: 20, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MKTKENLYKTLDFFMLRTPVLPIEEFAKCFPTCVGEDENVREVTL
                     HHLSEWSSNPFIREALAASSPTLLESLLHISNPDNSRKQGQVIKAFMRYIIRMMTRPTP
                     FGLLSGVTYGQFTEQSQLCLRGTDTYQKRARPDMEWLLKVMELIEGRQEVVRQLRIQRN
                     TLIYRQGNRAKIPYTTRHGSMVDGEDQSVSVRTTQVFDCVMDVSSVPIPYLELVDHLQK
                     EFVGASPETIDRYVWQLFEQEFLISELIPPTTTPDPLNHILSTLKHVTGMDEFKQKLIY
                     IADAIHEYNGLPIGQGEEFLAELRRYMDDMFSVKSSLQIDLSMEDRGMSLPHAIRKDVE
                     RVADLLTKLSTRENRPLDEFCVEFLEKYGPYREVPLLELLDEDTGLGAPAGYKHPLSRR
                     VRLENMSPSKSRTHYEKLLFQWFVSCIHEGKNEVVLTDAMIDEIVKGQEQGEWLAAPSM
                     ELIFQLSASDQLAVDRGEYTLLLGPNQGSDGAGKTFGRFLDLFGQPFADLFSQIQLEEQ
                     RLQPEKLLAEISYLPSSGRTANVVLTQHTRPYEIAIGTNHIMPEERQIHVSDLAVGVRN
                     DHFYLKSMSRNREIIARAGHMLNAELTPNIYRFLLEVSDDGYRHWSPMEWGFVAHAPFT
                     PRLRYEHIILHPATWRMICDSTLNASKDAGLFEKWVRQFQKKWSLPRYVYMIELDNRIL
                     LDMEHPLHLEQICKELQSKGKVTLIEHIGAVEDMPVSRSGSRVAAEFVFPLVRRNQVVD
                     AYRFGEEVAASLYIDQEETNHHPTEVAFAYLPGSRWFYAKLYGMNSRQDEFIGGYWEEF
                     VRQQQDSSVILQGYFIRYADPDKHIRVRFEQSENREGNAFLSLFHQWTETLLHEGLISR
                     VVIDTYEPEIERYGGKEPMACAERMFSCDSEVAARLVHLIRFNQTSLQQDVIAILSVIN
                     LLSQFGYSEEDTFNLLNQHFDVKEYLNDFRKERKFFLQWMASDQENLNSIQSSRDSIES
                     IFNMRKEAVARYNRVIHEQEAKGEATNTRDDIVYSVIHMHLNRLLGIDRDRERKVMIMA
                     RHAMHSLIQYRWNCQ"
     gene            5868..7751
                     /gene="pabT"
     CDS             5868..7751
                     /codon_start=1
                     /gene="pabT"
                     /gene_functions="transport (smcogs) SMCOG1288:ABC
                     transporter related protein (Score: 189.3; E-value: 2e-57)"
                     /gene_kind="transport"
                     /note="lantibiotic ABC transporter"
                     /product="PabT"
                     /protein_id="AHF21235.1"
                     /transl_table=11
                     /translation="MSSVQESTKLEVESIWRSIRQGLKLFGLVFGMNKPYMVSSIFLHI
                     VQGLMPVLTLIIMQNLLNSIVSSSPQGISLIMLQFGLFIAIHVLKSVVTMSQSYVEGTL
                     EAVLSKFLNIMIGEKSGSLGLADYENSEINDQLKRASQEASYRPYQLYTQMAGIISSLV
                     TMLSSATLLFLWKWWVVVILFIISLVSVYSIFKLNKEQFEIYMNRTPLYRESWYMTYLL
                     TNDRAVKEVKMFNLGPYLLKRYGALLQRFFVEDRRILGKRVRITFLYSLLELTVLLWVV
                     WLAIRETFEQKLLIGSLYGYIQAIMLTQSQMQALIQGIVQFSQNNLYMEQLFLFLQLPT
                     SDPVRRQQEQALPIRPECSTGFGIEQISIEGVSFTYPGQTEPSIRDIHLTMDKGQTIAI
                     VGKNGSGKSTLMKVLMQLYSDYSGVLKLNGRPVQDYDLEQIQEKIGVVFQDFMHYEMSA
                     RHNIGFGSLEHMGQDEELMHAAEYAAIDRIITQLPQGLDTQLGKWFEDGYQLSGGQWQR
                     VAIARAFLRKADVYILDEPSSFLDPVAERDLLVLFLDLMKDSIGIFITHRISSARLAQK
                     IVVMDNGLIVEQGTHRELILLDGLYAEMYRIQASSFSEEDSLIEAGGRVSG"
     gene            7748..9130
                     /gene="pabC"
     CDS             7748..9130
                     /codon_start=1
                     /gene="pabC"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     lanthipeptide-class-i: LANC_like"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1140:Lanthionine synthetase C family protein (Score:
                     340.7; E-value: 1.8e-103)"
                     /gene_kind="biosynthetic"
                     /note="lantibiotic cyclase"
                     /product="PabC"
                     /protein_id="AHF21236.1"
                     /sec_met_domain="LANC_like (E-value: 1.8e-63, bitscore:
                     203.3, seeds: 47, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MTTISYTCDSWIPVEGEMKDRISAVLLEIAERYRDPEQVRLWMKK
                     VPPIESDGMKIERWSDESLGSGFTGICLLMGQLDRLYPEDGWDRVGHQYLERIRLVMEQ
                     QGIHDLSLYSGLAGILLAIRSLSRKGTRYQGMLDTLASWFEESALHSVALCQEQWEKGQ
                     LQMSQYDAISGFTGIGRIAMLFSDRPTMCTVWNQTIELFQVMCSDRIRNGHSVPGWHIS
                     SEHQFQENEKLQYPQGNFNLGLSHGIAGPLCFLSLSALHGADSLLLVNDIHKLAKFIHH
                     WRVQDKEGIIWPGRVSFEEWLDDQPLPDSAQNHRDSWCYGVPGIARSIWLAGQAVQNEE
                     WIETGLSAYLDIEKRLYRNGGLTSATLCHGVGGLLQLVQRMYSDTGHEQLGAMRNRLLE
                     DVLNMFDSESLFGFYDHSLLAGRMEEVDEAGFLNGSAGVALVLASLIGGENPEWDAAFL
                     IR"
ORIGIN
        1 atggctaaca atttatttga tctggatgtt caagtaaaca aatctcaagg ttctgtggaa
       61 cctcaagtat tgagcattgt ggcatgttct agcggatgcg gtagcggcaa aacagctgcc
      121 agttgtgttg caacctgcgg aaacaaatgc tttaccaacg ttggttcact ttgttaatcc
      181 aagtgttgcc tttataaaat aatgaatggc tattgtatat taataatcaa gcaaaagaag
      241 aagggaccta gaaatccctt cttcttcctt gaaaaaaaca tggatttttc agctgtgaaa
      301 cggttggaaa catcctttat atcggtttgg taatggagga aaacatatgt ctgatgcctt
      361 attggaagtc cagcaggtaa ccaaaaaaat ggggaaacga gatttgttaa ataacatttc
      421 cttcgagctt gaaagaggga agatatatgg tttcatcgga ccgaatggag ccgggaaaac
      481 gacgatgatg cggattatga caggactcat gcagccaact agcggctttg taaggattgc
      541 ctcttacgat gtgcagacgg accgggaaaa ggcgttgtct aaagtaggcg ctatcattga
      601 atccccggtc ttttttgatt atatgacagg cagacaggta ttgcgtaatt tgtctcggct
      661 gcacatggaa attaaatctt cggatcggga gaatcatatt gaggagctac taaaaagggt
      721 ggggctggaa tcgcggggag atgacaaggt caaagcttat tctctgggga tgaagcagcg
      781 gctcggtatt gcccaatcta tgctgggtag cccggagctc cttctgcttg atgagccatc
      841 caatggtctt gatcctatgg gaatgcgaga gctgagagat attattcttc gtttgcgcga
      901 ttcagcgaat tatgcttttt ttatctccag tcatctgctg gatgaattgc agcaaatgtg
      961 tgacgagctg attgtcatca aagagggaac gctagtttgg aaggggcctg ctgatcaact
     1021 ggttgaggaa ggtcaacggc tagaggatgc ctttataggg cttatgggac tatgaagcta
     1081 ctcatttaca gcgagtttga aagattgtgg aaaaggaaat ggttcttgct cctgatttta
     1141 tgtacacccg tgttggctta ttctacaggg ggatattttc tacgcattat gaaggttcct
     1201 atggaggtat tatctaaaag ctttatggtt acaggcttgc gtgaaaattt gtatttagta
     1261 tgcaatattg ccgtagctgc cttggttgct gctgtgtata cagaagaatt tcggagtggg
     1321 cagatgcgtt tgctatttat gcgtcgattt acccgtggcc agatattttg gagcaagcta
     1381 ttcgtggtta acatctctat tttgcttctt ctagtggttt ttgcggtatc ctcgcaggtg
     1441 atcgttgaag tatggagatc ctcatacgat ctaggcgata ctagttttct agggaataaa
     1501 tggatctacg tattcgaata ttacggttgg gcgtttgctt cgctactcgc tataagctcc
     1561 ctctattcct ttattgctat gtgcagcaaa agtgtaacgt atgcgattgg tgcctgtatg
     1621 acttacaatc tgggtgcctt gctgtttgat ggattatacc taaaattagc ttcccttgcc
     1681 cctcatactt catatttaca cgatgtcatt gcttttttgc ttattcctta tatgcaatat
     1741 acagggctgg atggatcgct ggagggaaat gggtctgtaa atggggcgat taccacagtt
     1801 gtcgcttttt atttaatctt ttttacgtgg gccgcatacc gtcgttttgc tgccggtgat
     1861 tatttgtatt aggaggatct ttgtatgctg ggaatttggc gaagtgaaat ggaacggata
     1921 tggaatcgaa aatccacaat tttattatat atagcttttg tacttatcgt tattgcaaac
     1981 atttggagcc tgaaaataac agatacaatg aggttccggt tcggggaagg gattgttgct
     2041 gttaacaatt tgaacttgcc gtggctcatg atgagtgaag tttccttatt tctgatcacg
     2101 gcgatgttac ccattttgta tgtggatcag ttaagcgggg atattcattc tggtgcgtat
     2161 cgcttatacg tattgcggcc gtaccggcgt tttcaattct ggttgggtaa gctgctcgca
     2221 ttatcagtta cgacgatatt ttttacagga acgaccctgc ttataggtgt gtttgccggg
     2281 tggatgttgt tcccgaacgc cgctaccttt tttaaatacg gttcgacatt accctccacc
     2341 tcaacggaag ctgtctcata cacccttgcg ttttatctgt tgctcacgct ggtttgtctg
     2401 gcaaagctca tgctgagtag tgtcgtgtgc ttgttcatct ccagaccttt gtttgccttt
     2461 attgccattt tggctttatc tatgtttctc taccccattt tcaagccgct tgtggtattg
     2521 atggaccctt ttcagcaaat tctgcttgcg ttaagagtgg atggttcctt caaattctgg
     2581 atgtgtttag gtatgactgt actactgtgc tccatcgtta gtttcactcg ttggcaaaaa
     2641 aaggttatct agaagcttgg tttagaacgg aggtttcaca tgaagacgaa agaaaacctt
     2701 tataaaacct tagatttctt tatgctccgt accccggtgc tgcctataga agagtttgca
     2761 aaatgctttc caacctgtgt cggagaagat gagaatgtca gagaggtcac attgcatcat
     2821 ctatccgaat ggtccagcaa cccattcata cgtgaagcac tggcagcttc cagccctacg
     2881 ttgcttgaat ctttattaca tattagcaac ccggacaatt cgcgcaaaca gggacaggtc
     2941 atcaaagcct tcatgcgcta tatcatcaga atgatgacac gacccacacc gttcggcttg
     3001 ttatcggggg tcacatacgg gcaattcacg gaacaatcac agctttgttt acgagggacg
     3061 gatacttatc aaaagcgtgc aagacccgac atggagtggc tgctgaaagt gatggagctg
     3121 atcgaaggcc gtcaagaggt ggtacgtcag ttaaggattc agcgtaacac cttaatttac
     3181 cgtcagggca accgtgctaa aattccctat acgacaaggc atggaagtat ggttgacggt
     3241 gaagatcaga gtgtgtccgt tcgtacgacc caagtgtttg attgtgtgat ggacgtaagc
     3301 tcggtcccca tcccttatct ggaactggtc gatcatctcc aaaaggaatt tgtgggtgct
     3361 agtcctgaaa cgattgaccg ttatgtgtgg cagctatttg agcaagaatt tctgatttct
     3421 gagcttattc ctcctacgac gactcctgac ccgctaaatc atatactatc caccttgaaa
     3481 cacgtaacgg gtatggatga attcaaacaa aagcttattt acattgcaga tgctattcat
     3541 gaatataatg gtttacctat cggtcaggga gaagaatttc tggctgaatt aagacgctac
     3601 atggacgata tgttcagtgt gaaatccagt ttgcaaatcg acctgtctat ggaggatcga
     3661 gggatgtccc ttccgcacgc cattcgtaaa gatgttgagc gtgttgctga cttgttgacc
     3721 aagctttcga cgcgtgaaaa cagacccttg gacgaatttt gtgtggaatt tctggagaag
     3781 tacgggccgt accgagaggt tcccttgctg gagctgctgg atgaggatac gggcttaggg
     3841 gctcctgcag gctacaagca tcccctgagc cgccgagtgc gactagagaa tatgtctcca
     3901 tccaagtcga gaacgcatta tgaaaaactt ttatttcaat ggttcgtgtc ctgcattcat
     3961 gaaggaaaga atgaagtcgt gctgacagat gccatgatag acgaaattgt aaaggggcag
     4021 gagcaggggg aatggctcgc agcaccttct atggaattga tctttcagct ttctgcctcg
     4081 gaccaactgg ctgtggatcg cggcgaatat accttgctgt taggacctaa ccaggggtct
     4141 gatggggcgg ggaagacatt cgggagattt ttggacctgt ttgggcagcc ttttgcggac
     4201 ctattctctc aaattcagct agaagagcaa cgattacagc ctgaaaagtt gctggctgag
     4261 atatcctact tgcctagctc gggaagaacg gcgaatgtgg tgttaacgca gcacacccgg
     4321 ccttatgaaa ttgcaatagg aaccaatcac atcatgccag aggaacggca aattcatgtt
     4381 tcggacctcg ccgtaggagt acggaacgac catttctatt tgaagtcgat gagccgcaat
     4441 cgtgagatca ttgccagagc cggacatatg ctcaatgcgg aattgacccc taacatatac
     4501 cgctttctct tggaggtcag cgacgacggt taccgacatt ggtcgcctat ggagtggggg
     4561 ttcgtcgcgc acgctccttt tactccgcgt ctaagatatg agcatattat tcttcacccg
     4621 gcgacatgga gaatgatatg tgattcaaca ctgaatgcat ccaaggacgc ggggcttttt
     4681 gagaagtggg tgcgtcagtt ccaaaaaaaa tggagtctgc cgcgttatgt gtacatgatt
     4741 gaattagata atcgcattct gctggatatg gaacacccgc tgcatttgga gcagatttgc
     4801 aaggagcttc aatccaaagg caaagtcact ctgattgagc atataggtgc agtcgaagat
     4861 atgcccgttt ctcgcagcgg tagccgtgta gcggccgaat ttgtgtttcc gctagtgcgt
     4921 cgcaaccagg ttgttgatgc gtatcgtttt ggagaagaag tggctgcttc tctatatata
     4981 gatcaggagg aaaccaatca tcaccccaca gaagtggcct ttgcttattt gccgggtagc
     5041 cgctggttct atgcgaagct atatggtatg aacagtcggc aggatgagtt tattggtggg
     5101 tactgggagg aatttgtgcg ccagcaacaa gatagtagtg tgatccttca gggctacttt
     5161 atccgctatg ctgatccaga taagcatatt cgcgttcggt tcgaacagtc ggagaatcgg
     5221 gagggcaatg cgttcctttc cctgttccat caatggacag agacgctttt gcatgaagga
     5281 ttgatatcca gagtggtcat tgatacctat gaacctgaaa tagagcgtta cggcgggaag
     5341 gagcctatgg cgtgcgcgga gcgaatgttt tcctgcgaca gtgaggtagc ggctaggctt
     5401 gtacatctga tccggttcaa ccagacctcc ttgcagcagg atgtgatcgc aatcctaagc
     5461 gtcattaacc tcctgtctca gtttgggtac agcgaggaag ataccttcaa cctcctgaat
     5521 cagcattttg acgtcaaaga gtatttgaat gatttccgca aggaaagaaa gttcttttta
     5581 caatggatgg catcggatca ggaaaatcta aattcgattc aatccagccg tgactccata
     5641 gagagtattt ttaacatgag aaaagaagca gtagcgcggt ataaccgagt gatccatgaa
     5701 caggaagcga agggggaagc caccaataca agagatgata tcgtatatag tgtgatccat
     5761 atgcatctaa accgattact agggatagac agggatcggg agcgtaaggt gatgattatg
     5821 gccagacatg cgatgcacag cttgattcag tatcggtgga attgtcaatg agcagcgtgc
     5881 aggaaagtac aaagcttgag gttgagtcca tctggaggtc catacgacaa ggtttaaagc
     5941 tttttggact ggtatttggc atgaataagc catatatggt ttccagtatt tttttgcaca
     6001 tcgtccaagg cttgatgcct gttcttacat tgattattat gcaaaatctg ctcaatagca
     6061 ttgtttcttc cagcccacag ggcatctccc tgattatgct tcaatttggt ctgtttatag
     6121 ccattcatgt attaaaaagt gtggtgacga tgagtcaaag ctatgtagag ggcacgcttg
     6181 aagctgtact gtccaagttc ctgaatatta tgatcggaga aaagtcaggt tccttgggac
     6241 tggcggatta tgaaaattcg gagatcaacg atcagctaaa gcgggcttct caagaggctt
     6301 cttatcgtcc gtatcagtta tacacacaaa tggcaggcat tatatcgagc ttggttacca
     6361 tgctgtcttc tgcaacgcta cttttcctat ggaaatggtg ggttgtcgtc attcttttta
     6421 taatctcttt ggtatctgtg tattccattt tcaaattaaa taaagaacag tttgaaattt
     6481 acatgaatcg taccccgtta tatcgggagt cctggtatat gacctatttg ctgaccaatg
     6541 atcgtgcggt caaggaagtg aaaatgttta atctgggacc ttatttgctg aaaagatacg
     6601 gggctttatt acaacgattt tttgtagagg acagacgaat attgggcaaa agggttagga
     6661 ttacgtttct gtatagccta ctggagctga cggttttgtt atgggtcgta tggctggcga
     6721 ttcgggaaac ctttgagcaa aaattattaa taggcagttt atacggctac attcaagcta
     6781 ttatgctgac ccaaagccag atgcaggcct tgattcaagg gattgtccaa ttttcgcaaa
     6841 ataatctgta tatggagcag ttatttctat ttttacagtt acccacatcg gatccggttc
     6901 gtcgtcaaca ggaacaggcg cttccgatcc gcccagaatg cagtaccggc tttggtattg
     6961 agcaaatttc aatagaaggc gtttctttta cctatcccgg tcaaaccgag ccgtccattc
     7021 gggatattca tttaacaatg gataaaggcc agaccatagc cattgtaggg aaaaatggtt
     7081 cagggaaatc aacgctcatg aaggtgctga tgcagctcta ttcggattac agcggtgtgc
     7141 tcaaattgaa tgggcgtcct gttcaagatt acgatctgga acagattcag gagaaaatag
     7201 gcgtagtatt tcaggatttt atgcattatg aaatgtctgc tcgtcacaat atcggctttg
     7261 gttcgctgga gcatatgggg caggatgagg agctaatgca tgctgccgaa tacgcagcta
     7321 tagaccgcat tataacccaa ttgccacagg gcttggacac acagcttgga aaatggttcg
     7381 aggatggcta ccagctctcg ggaggccagt ggcagcgggt ggctatcgca agggcctttt
     7441 tacggaaagc ggatgtgtat attttggatg aacctagttc ttttttggac ccggtggcag
     7501 agagggactt gctcgtcttg tttctggatt taatgaaaga cagcatcgga atttttatta
     7561 ctcatcgcat ttcctcagca cgtctggctc agaaaattgt ggtgatggat aatggtttaa
     7621 ttgtggagca ggggacccat agggaattga tcttactgga tgggttgtat gcagagatgt
     7681 ataggattca ggccagttcg ttcagtgaag aagattcctt aatcgaagcc ggagggagag
     7741 tttcaggatg acgacgattt catatacatg cgacagttgg atacccgtcg agggggaaat
     7801 gaaagatagg atatctgcgg tcttgctgga gattgccgag cgttatagag acccggagca
     7861 ggttcgttta tggatgaaaa aagtacctcc gatcgaatct gacggaatga agattgagcg
     7921 ttggtcagat gaaagcttgg gaagcgggtt tacgggcata tgtttgctga tgggtcagtt
     7981 ggatcgactc tatcccgagg atggctggga tagggtagga catcaatatc tggagcggat
     8041 tcgtttggtc atggaacagc aaggtatcca tgatctgtcg ctgtatagtg ggttagcagg
     8101 tattttgctg gccattcgct ccttatcgag aaagggtacg cgctatcaag ggatgctgga
     8161 cactctcgcc tcctggttcg aagaatccgc gctgcatagt gtggctttat gccaagagca
     8221 atgggaaaaa ggacagctac aaatgagtca gtatgacgcc atatcaggtt ttacggggat
     8281 aggacgcatc gccatgttat tttctgaccg ccccactatg tgtacggtat ggaaccagac
     8341 cattgagttg tttcaagtga tgtgcagcga ccgaattagg aatggccatt ctgtacctgg
     8401 ctggcacatt tcttcagaac atcagtttca ggagaatgaa aagctacaat atcctcaggg
     8461 gaatttcaat ttaggacttt cgcatggtat tgcaggtccc ttatgttttc tgagtctatc
     8521 tgctctacat ggagcggact cccttctttt agtgaacgat atacataaac tggccaagtt
     8581 tatacatcat tggcgtgttc aggataaaga gggcataatt tggcctggtc gggtttcttt
     8641 tgaggagtgg ctggatgacc aacctttgcc ggacagcgct caaaatcatc gtgattcttg
     8701 gtgctacggt gtaccaggca ttgcacgttc gatctggctg gcaggacaag cagttcaaaa
     8761 tgaagaatgg attgaaacgg gactcagtgc atatttggat atagaaaaac ggctttatcg
     8821 caacggggga ttaacctctg ccacattgtg tcatggtgtc ggaggattgc tgcaattggt
     8881 tcagcgtatg tattcagata ccggacatga gcagctaggt gcgatgcgga ataggctact
     8941 ggaagatgta ttaaatatgt tcgattctga atcgctgttt ggtttttatg atcacagtct
     9001 actggctgga agaatggaag aagtggatga ggctggtttt ctgaatggca gtgcgggtgt
     9061 tgctttggtg ttggcttcat tgattggggg agaaaatccg gagtgggacg ctgctttttt
     9121 aattcgctaa
//
