LOCUS       BGC0000548             10610 bp    DNA     linear   BCT 21-JUN-2001
DEFINITION  Streptococcus salivarius salivaricin A gene cluster, complete
            sequence.
ACCESSION   BGC0000548
VERSION     BGC0000548
KEYWORDS    .
SOURCE      Streptococcus salivarius
  ORGANISM  Streptococcus salivarius
            Bacteria; Firmicutes; Bacilli; Lactobacillales; Streptococcaceae;
            Streptococcus.
COMMENT     On Nov 21, 2000 this sequence version replaced L07740.1.
            ##antiSMASH-Data-START##
            Version      :: False
            Run date     :: 2022-11-07 19:49:57
            NOTE: This is a single region extracted from a larger record!
            Orig. start  :: 0
            Orig. end    :: 10610
            ##antiSMASH-Data-END##
FEATURES             Location/Qualifiers
     source          1..10610
                     /db_xref="taxon:1304"
                     /mol_type="genomic DNA"
                     /organism="Streptococcus salivarius"
                     /strain="20P3"
     subregion       1..10610
                     /aStool="mibig"
                     /contig_edge="True"
                     /label="RiPP"
                     /subregion_number="1"
                     /tool="antismash"
     region          1..10610
                     /contig_edge="True"
                     /product="unknown"
                     /region_number="1"
                     /subregion_numbers="1"
                     /tool="antismash"
     gene            589..735
                     /gene="salA"
     CDS             589..735
                     /codon_start=1
                     /gene="salA"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) L_biotic_A"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) leader_d"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) lacticin_mat"
                     /gene_kind="biosynthetic-additional"
                     /note="lanbiotic salivaricin A prepropeptide"
                     /product="SalA"
                     /protein_id="AAA02867.2"
                     /sec_met_domain="L_biotic_A (E-value: 1.8e-21, bitscore:
                     65.0, seeds: 15, tool: rule-based-clusters)"
                     /sec_met_domain="leader_d (E-value: 2.3e-07, bitscore:
                     20.1, seeds: 16, tool: rule-based-clusters)"
                     /sec_met_domain="lacticin_mat (E-value: 1.8e-08, bitscore:
                     23.4, seeds: 18, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MKNSKDILNNAIEEVSEKELMEVAGGKRGSGWIATITDDCPNSVF
                     VCC"
     gene            820..2466
                     /gene="salB"
     CDS             820..2466
                     /codon_start=1
                     /gene="salB"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) DUF4135"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1070:lanthionine synthetase C family protein (Score:
                     434.7; E-value: 1.2e-131)"
                     /gene_kind="biosynthetic-additional"
                     /note="putative salivaricin A modification enzyme; amino
                     acid dehydration"
                     /product="SalB"
                     /protein_id="AAG32536.1"
                     /sec_met_domain="DUF4135 (E-value: 8.2e-86, bitscore:
                     277.5, seeds: 79, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MIKRDELKLDYQRHQFYEYFNSIFNYDILDASISENIYLLRKTTD
                     KLFYIEFENQLFETVMFLSMKTLVLDINSFSKEIGNKSEAYEQYIQQIKEENGINNFFD
                     RYPYLLKQINREVRLIEESYSLLFDRFLKDLSELRSCFNITEPLSNVEFSLGDSHSQKQ
                     TVVKIEFKGKSIYYKPKSYDSYNILLELISLLKSNNIPSFSLPESLIKADYCWQLGVDY
                     INSNNDEVKRIYFKYGVLAAFSEIFSITDLHMENVIVSGGDLYLIDVETFFQRKLNVQT
                     NNFEGITVDTYQRIYETSLSNGLFPVQFEKNSAPNISGISGKGGKRKKGKYELINKNRG
                     DMKLVKTDYFQEDSYNIPTLNEKMVEPLDYANEVIAGFRECYTFLMTQRAKVKKILYGF
                     PKLRTRAIFRNTSDYGKFLQASTNPKYLFSEKKRENLFSILYESKHIEQFIVDSEIKDL
                     MNGDIPYFSMDPNGNVYNSLGTVIGNLGKTTSLFDNIATLNDERMKFTCELIGIVLKKP
                     IKHWERKDGKSYYFPSISSKQSFNEEILRQR"
     gene            2722..3657
                     /gene="salC"
     CDS             2722..3657
                     /codon_start=1
                     /gene="salC"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) LANC_like"
                     /gene_kind="biosynthetic-additional"
                     /note="putative salivaricin A modification enzyme;
                     thioether bridge formation"
                     /product="SalC"
                     /protein_id="AAG32537.1"
                     /sec_met_domain="LANC_like (E-value: 4.2e-70, bitscore:
                     225.3, seeds: 47, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MSVFLGKGGLIYLYFSLWKRLKLTQYQKLYLDIIKEFSSQSLEEQ
                     NIDYISGVSGLLVVLCNIYNVEQNKTVYHLINRVSEFIIDNVKKEDDKVYWVSDFSDSE
                     VLNGLSHGQSGIAYALLLSWEINKNLNYFKIAKSAIDFENTRISDGNWIDFRNKGKRSE
                     LGMPDPIYWCHGATGIGLTRYRESKWLNDKELKNNYEMAKQTVLNNGYLNSDCLCHGKM
                     GNMELFMNLDDSLKNEVDIEGIMLNIVRNSQKFGWESGLPQHTRVFNMMVGEIGIAYQL
                     LRYISNYEVPSLLLLDVPKGSVESEKNYTD"
     gene            3611..5779
                     /gene="salT"
     CDS             3611..5779
                     /codon_start=1
                     /gene="salT"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Peptidase_C39"
                     /gene_functions="transport (smcogs) SMCOG1288:ABC
                     transporter related protein (Score: 194.8; E-value:
                     4.2e-59)"
                     /gene_kind="transport"
                     /note="putative salivaricin A ABC transport peptide;
                     contains an N-terminal protease domain with motifs
                     characteristic of lantibiotic proteases"
                     /product="SalT"
                     /protein_id="AAG32538.1"
                     /sec_met_domain="Peptidase_C39 (E-value: 1.5e-24, bitscore:
                     75.4, seeds: 36, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MFQKGVLKVRKITPIEQTTPTECGLCCLYMMLDYFDISETYFKLK
                     QQVNLGRNGLSIKNISDIASIYGVTCKTYRFSKYPENLPVMVFVSDSHFVILEDIRNDV
                     FTIVDPAVGKYVLAKNEFFELSPKFYTEFFYDKVTNSSKKIVKRGLVGRNVKEMIFVNR
                     KDIFLTILYTLIFQIITVSIPFFIRGIIDGNWVFLKKFGYLESAVLLSIIIFFQGGFYF
                     LKNISLVKLQNKFHSTISEKFVTKLLKLPIEYIGKIDKTDIIHRYNGLMIVRELLSERI
                     ISIWLDIILMFASISYITYVSTPLGIILGIVFIVEMMIFFLSLSIKQEKLGKEVLRQKN
                     SLQTFFSLMDGLFLFKAKNSEKELLSKWDKSFKDYINSTYDRNRYFNLLGAVNYVITFS
                     IPILLILLFLYYSPNSGSGELILLYMMVLNFINPINNILNSIDEILYGVKHYERVLEIS
                     TLDNETNDTYKLSEDTDIEINLKNINYQYELNGAKVLNGINLKVHSGEFVAIIGKSGSG
                     KTTLAKMLLGYVSPSSGDITYNNISYSKIDKKDFRNISAFVSQDSPMFDGDVMYNISLG
                     RESVSGEQVIETCKRVSIYDDIRSMPMKFHTLLFRDNPSISGGQKQRISLARELVTTPR
                     ILVLDEPTSALDVKTERIIQKNVEALHCTRVLVTHRLNTVEKADKILIMDNGKIIDYGN
                     HYYLYKNNKYYCDLYDSYMNKYQEEEVK"
     gene            5776..6513
                     /gene="salX"
     CDS             5776..6513
                     /codon_start=1
                     /gene="salX"
                     /gene_functions="transport (smcogs) SMCOG1000:ABC
                     transporter ATP-binding protein (Score: 198.2; E-value:
                     2.7e-60)"
                     /gene_kind="transport"
                     /note="putative salivaricin A ABC transporter"
                     /product="SalX"
                     /protein_id="AAG32539.1"
                     /transl_table=11
                     /translation="MKQLVLKDVCKKYPNQLNYALDHINLIVEKGEFVAVMGRSGSGKT
                     TLLNVTSIIDKIDSGNIYCADKEISTFSDKEATNFRKNDIGFVFQDYMLLDSLTIRENI
                     SVALSLKNVDSSKIDDLINSYAKRFNLYEQLKKYPYQLSGGQRQRVSIIRAIIKDPEII
                     FADEPTGALDLKSSEETMMILSEINKTEKVTILMVTHDVLSASYADRVILLKDGKLHME
                     IDKKDCGESFYDVISQALSDRGE"
     gene            6515..8422
                     /gene="salY"
     CDS             6515..8422
                     /codon_start=1
                     /gene="salY"
                     /gene_functions="transport (smcogs) SMCOG1243:ABC
                     transporter, permease component (Score: 156; E-value:
                     2.5e-47)"
                     /gene_kind="transport"
                     /inference="non-experimental evidence, no additional
                     details recorded"
                     /note="hypothetical protein"
                     /product="SalY"
                     /protein_id="AAG32540.1"
                     /transl_table=11
                     /translation="MIWSITKSNIKKNFPLYRIYFLATIGLLSIFIAFLNFISDKIIAE
                     KIGDSGQALVIANGSLLFLIVFLVVFLIYFNNFFVKKRSQDLGVLAILGFSKRELTKLL
                     TLENLVILVLSYLVSLLLGPTLYFLAVLVITHLLDLTMEVQWFITVKEIIESLGILVVV
                     FLINFITNGVIIAKQSLIEFVNFSKKAEKKIRIRKVRAIIAITALLLSYVLCLTTVFSS
                     TRKMLLSVGMVPISLLIIILVILGSIFTIRYGLTFVISFLKEKKKRLYRPLSNIIYPKF
                     NYRIATKNKLLTVLGGLLTLTVSVTGIMVMLYAYSLNGIERLTPSAIEYNVESENGQVN
                     VTNILENGQVSLVDINLLRLNTNPEVTITESGQTIPYFDIINYSDYKELMKAQGRKNSI
                     EGSESLPLLINYFPTEISLGKTFNLENAYDVTVKQVSTNNVFSFSTSVTTLVVSDKLYA
                     ELSSRFPEKKMTIRTFNGDSIRSSETFYNQFSTVPDVISSYSREHTVKTANIATYIFIT
                     FLSILFIICTGSILYFTSLIEIMENKEEYSYLSKLGYSKKMINRIVGYEIGILFLIPVL
                     IGIINGSMLLIFYKYLFMDTLVAGNIIMLSLLLFLFFFLIIYGTFYLLTLRSVKSIINN
                     "
     gene            8462..10024
                     /gene="salK"
     CDS             8462..10024
                     /codon_start=1
                     /gene="salK"
                     /note="putative histidine kinase"
                     /product="SalK"
                     /protein_id="AAG32541.1"
                     /transl_table=11
                     /translation="MMRIEKIAKSKFLGITIILLQQLIAFLILVYNRENLSLLFSEKVA
                     LVMTLIDTGFIWLAAILRQKQDGIFKKIISIVFLTIWQYLVSVLSRETPLFFSSGLQII
                     LLYCYTVEITDLILYGQKQFKDKLDKSLLMIIFVSIISLLVNRTLFNFLFLVVFTILHL
                     YPLLVIVLYYRYFRQQISVVRRSLILFSLLLLAILGSEFYGEMLDVNQAFNNLGWYLFP
                     LIMSTIYYFKVIHDKFSLVTRRWLGNYKTRIELLFILLIICWVILIKGLVKDFLLFFIV
                     VDASTFFCLVVISCIFCYLENFKQNFDYENRRLNYFMKSEENMRVEFSNYLHDDVLQNV
                     IAIKNLLSLENSDITHGFIVNGLNDLVSGIRDEIDTYHPIVPSNRTMKENIQSLFDDIV
                     KRRKSNKLLYFNCSSSTIIPPPYGDIVYRFIKELINNAIKYGVSKDIHLSLKVQSDIII
                     IEESNQVVEKVQSINYGRGLKSFQETLVAFDGDMELQIDNKQYNIRILLPIDWKLCYED
                     FIN"
     gene            10005..10610
                     /gene="salR"
     CDS             10005..10610
                     /codon_start=1
                     /gene="salR"
                     /gene_functions="regulatory (smcogs) SMCOG1016:LuxR family
                     DNA-binding response regulator (Score: 86.2; E-value:
                     3.1e-26)"
                     /gene_kind="regulatory"
                     /note="putative response regulator"
                     /product="SalR"
                     /protein_id="AAG32542.1"
                     /transl_table=11
                     /translation="MKILLIDDHKLFAKSIQLLCQQYDEVDVIDTITSNFNDVTIDLSK
                     YDIILLDINLTNISKENGLEIAEELIQSTPNLKVVMLTGYVKSIYEERAKTIGAYGFVD
                     KNIDPKQLISILKKVDSGKKYFEQIESQDYVEALTDREIVILNLSKKGLSVKDIEETLQ
                     ISRRTVFNHLNHIYSKLLVNNKQEAIYKAEQLGYFMDF"
ORIGIN
        1 agagaagacc tatctggtcc tctcagatgt tagcttttcg tcacccacta cagttgacaa
       61 agagccatta ttgattgtca taaattgaaa tgttttagat atttggaata gccgtctgtt
      121 caatatttgg ttagaaattt tctttatgtt caaaaggagt cagaatgact ccttttgaat
      181 aaagtttata aaaaaggtag tgatgaaaat attataataa ttacctcaaa aagaagtatg
      241 tataagttaa attgtttttt catactcaaa cctctcggca agaaacaaga ataagagcta
      301 gaaaatttag acagtagaca aacactattt tgagtgtttg tcttttttaa gtcacctagt
      361 ctgaatttaa gggattaatt ttataataag aaggtattgg attgtaaaat agctacaaaa
      421 aatgaaattt gagagactgc ttttttataa agcgatattt tacattttaa aaatattaat
      481 aaaaaaacaa tatttgcact ttttactcac taaaaataaa gatgtattgg ttacaataag
      541 agcgtagaaa atatttacta catactaaca gaagggagaa tggatgccat gaaaaactca
      601 aaagatattt tgaacaatgc tatcgaagaa gtttctgaaa aagaacttat ggaagtagct
      661 ggtggtaaaa gaggttcagg ttggattgca actattactg atgactgtcc aaactcagta
      721 ttcgtttgtt gttaattaaa acaatcttga taagtagact aaaaaaaatc ctgtttagac
      781 ttagtctaag caggattttt gagtaatggt aagataaata tgataaaaag agacgaatta
      841 aagctagatt atcaacggca tcagttttac gaatacttta actcaatttt taattacgac
      901 atactagatg cttctattag tgaaaatatt tatttattga ggaaaacgac agataagtta
      961 ttttatattg agtttgaaaa tcaattattt gaaaccgtaa tgttcctttc aatgaaaaca
     1021 ctagttttag atataaatag tttttccaag gaaattggaa ataagtcaga ggcatatgag
     1081 caatatatac agcaaataaa ggaagaaaat ggaataaata atttttttga taggtatccg
     1141 tatttgttaa aacaaatcaa tagagaagtc agattaatag aagaatcata ttctttacta
     1201 tttgatagat ttttaaaaga cttgtctgag ttaaggtcat gttttaatat tactgaaccc
     1261 ctaagtaatg ttgagttttc acttggagat agtcattctc aaaaacaaac agttgttaag
     1321 attgaattta aagggaaatc catttactac aagcctaaaa gttatgattc atacaacatt
     1381 ttgttagaac ttattagttt attgaaatct aataatatac cctcgttcag tcttcctgaa
     1441 agcttaatta aagcggatta ttgttggcaa ctcggtgtgg attatataaa ttctaataat
     1501 gatgaagtaa agagaatata ctttaagtat ggtgttttag cagcattttc tgaaattttt
     1561 tccattacgg acttacatat ggaaaatgtg attgtttcag gtggagattt atatttaatt
     1621 gatgttgaaa cattttttca aagaaagttg aatgtacaaa ctaataattt tgaagggatt
     1681 actgttgata cttatcagag aatttatgag acatcacttt caaatggttt atttcctgta
     1741 caatttgaga aaaacagcgc tcctaacatt tctggaataa gtggaaaagg tggaaaaaga
     1801 aaaaagggga agtatgaact gataaataaa aatcgtgggg atatgaagtt agtgaaaact
     1861 gactattttc aggaagatag ctataatatt ccaacattaa atgagaaaat ggtggaacct
     1921 ctcgactatg ctaatgaggt aattgcagga tttagagaat gctatacatt tctcatgacg
     1981 caacgtgcaa aggtcaaaaa aattttatat ggtttcccga aattgagaac tagagccata
     2041 ttcagaaata cttccgacta tggaaaattt ttgcaagcct ctacgaatcc aaaatatctt
     2101 ttctcagaaa aaaagaggga gaatctattt tcgatactat atgagtcaaa acatattgaa
     2161 caatttattg ttgatagtga aattaaagac ttgatgaatg gtgatattcc ttacttttca
     2221 atggatccca atggaaatgt atataattct ttaggaacag taattggaaa tctaggaaag
     2281 acaacctcgt tatttgataa tatagccacc ctgaatgatg aaagaatgaa gttcacttgt
     2341 gaattgattg gaatagtctt gaaaaaaccg attaaacatt gggagaggaa agatgggaaa
     2401 tcttattatt ttccatcgat atcctcaaaa caaagtttta atgaggaaat cttaagacag
     2461 cgttagacag atatttattg atgcaaataa ggatagtttt tcttcagagg aggagatgac
     2521 atggctcaat attgatatta cggagaccga acaatgggta atatctcctc agaacattac
     2581 cttgtataat ggtgttaatt gggaatgcct taagttattt atatgcttaa caaattcctg
     2641 gtgaagagcg atatctaatc tcattaaata agatattgag aaacactgga aaccacaaag
     2701 aatcttatag aaagtagtga tatgtcagtc tttttaggaa aaggaggttt gatttatcta
     2761 tactttagtt tgtggaaaag acttaaatta actcaatacc agaaattata tttagatata
     2821 atcaaagaat tttccagcca gtcactggag gagcaaaata tagattatat ttctggagta
     2881 tcgggcttat tagttgttct gtgcaacata tataacgtag agcaaaataa aacagtatat
     2941 catttaatta atagggtatc tgaatttatt attgataatg tgaaaaaaga agatgataag
     3001 gtttattggg tatcggattt ttcagattca gaagttctaa atggattatc tcacggacaa
     3061 tctggaattg cttatgcatt acttttatca tgggaaatca ataaaaattt aaattatttt
     3121 aaaatagcga agtcagctat tgattttgaa aatacccgta tttctgatgg aaattggatt
     3181 gattttagaa ataaaggaaa acgttcagag ttaggaatgc cagatcctat ttattggtgt
     3241 catggtgcaa caggtatcgg attaacgaga tatagagaat caaaatggtt aaacgataaa
     3301 gagttgaaaa ataattatga aatggctaaa caaacggtat taaataatgg ttatttgaat
     3361 tcggattgcc tttgtcacgg gaaaatgggt aatatggaat tatttatgaa tttagatgac
     3421 tccttgaaga atgaagtaga tatagaaggt atcatgctta atattgttcg taattctcaa
     3481 aaatttggtt gggaatctgg cttgccacaa cacacaaggg tgtttaatat gatggttggt
     3541 gaaataggga tagcatatca gttgcttaga tatatatcca attatgaagt accatcatta
     3601 ttgttattag atgttccaaa agggagtgtt gaaagtgaga aaaattacac cgattgaaca
     3661 aacaactcca actgaatgtg gattatgttg tttatatatg atgttggatt attttgatat
     3721 ttcagaaaca tattttaaat tgaaacaaca agtcaattta gggagaaatg gactgagtat
     3781 aaagaatata tcagatattg catctatcta cggagttaca tgtaagactt atcgtttttc
     3841 caaatatccc gaaaacttac ctgtcatggt atttgtttca gattcacatt ttgtaatttt
     3901 agaggatatc cgtaatgatg tctttactat tgttgaccct gctgttggga aatatgtctt
     3961 agcaaagaat gaattttttg aattgtctcc taaattttat accgaatttt tttatgataa
     4021 ggtgactaat tcttcaaaaa aaatagtcaa acgagggttg gttggcagaa acgtaaagga
     4081 aatgatattt gtaaatagga aggatatttt tttaaccatt ctatatactc tgatttttca
     4141 gattatcaca gtgtcaattc cattttttat aaggggaatt attgatggaa attgggtttt
     4201 ccttaaaaag tttggctatt tagaaagtgc cgtcctactt tctataataa ttttttttca
     4261 gggaggattt tattttctaa agaatatctc tttagtgaaa ttgcaaaata aatttcacag
     4321 cactatttca gaaaagtttg tgactaagtt attgaaactt cccatagaat atattggaaa
     4381 aatagataaa acagacatca ttcatagata taatggtttg atgattgtga gggagttact
     4441 atcagaaaga attatttcta tctggttgga tattatctta atgtttgcga gtattagtta
     4501 tatcacatat gtttccacac ctttgggaat tatattaggt atagttttta ttgtagaaat
     4561 gatgattttt ttcttgtcac taagcattaa acaagaaaag ttaggtaaag aagttttaag
     4621 acaaaagaac tctttacaaa cattcttttc actgatggac gggctatttc tttttaaagc
     4681 taaaaattct gaaaaagaac ttttgtcaaa atgggataaa agttttaagg actatatcaa
     4741 ttcaacatat gatagaaata gatatttcaa tcttttagga gcagtaaatt atgtgataac
     4801 tttttccata cctattttgt taattctgtt gtttctatat tattcaccaa atagtggcag
     4861 tggtgagctt attcttcttt atatgatggt tttaaatttt attaatccca ttaataatat
     4921 tttgaattcg attgatgaga ttctatatgg tgttaagcat tacgaaaggg tattagagat
     4981 atcaactctt gataatgaga cgaatgatac ttataagtta tcagaggata cagatataga
     5041 gataaattta aaaaatataa actatcaata tgagttaaat ggggcaaagg tgttaaatgg
     5101 aataaaccta aaagtccatt caggagaatt tgttgcaatt atagggaaaa gtggaagtgg
     5161 aaagacaact ctagctaaga tgttgttagg ctatgtaagc cctagtagtg gagacatcac
     5221 atacaacaat atatcctact ctaaaattga taaaaaagat tttaggaata tatcggcttt
     5281 tgtatctcaa gattctccca tgtttgatgg ggatgtgatg tataatattt cgctagggag
     5341 agaatctgtt tcaggagaac aggttattga aacttgtaaa agagtatcaa tatatgatga
     5401 tatcaggagt atgccaatga agtttcatac tctacttttt cgagataatc cgtcaatatc
     5461 tggggggcaa aaacaacgga tttctttagc aagagaactt gtaaccaccc ctagaatctt
     5521 agttcttgac gaacctacat cagctttaga tgtaaaaact gaaagaataa tccaaaaaaa
     5581 tgttgaggct ttacattgta cgagggtttt ggttactcac agacttaata cagttgaaaa
     5641 agctgataag attttaataa tggataatgg caaaattatt gactatggaa accattatta
     5701 tttgtacaaa aataataagt attattgtga cttatatgac tcgtatatga ataaatatca
     5761 ggaggaagag gtaaaatgaa acaattagta ttaaaagatg tttgcaaaaa atatcccaat
     5821 caactgaatt atgctctaga ccatatcaat ttgattgtgg aaaaaggaga atttgtagct
     5881 gtcatggggc gtagcggtag tgggaaaacg acgcttttaa atgttacttc aattattgat
     5941 aaaattgata gtgggaatat ttattgtgcg gataaagaga ttagcacatt ctctgataag
     6001 gaggcaacta attttagaaa aaatgatatt ggttttgttt ttcaagatta tatgctgtta
     6061 gacagtctaa ccattaggga gaatatttct gttgctttgt ctctaaaaaa tgttgattct
     6121 tcaaagattg atgatttgat aaatagctat gcaaaaagat ttaatttata tgagcagttg
     6181 aaaaaatacc cttatcaact ttctggaggt caaagacaga gggtcagtat tatcagagca
     6241 atcattaaag acccagaaat tatttttgct gacgaaccaa caggagcact tgacttgaaa
     6301 tcttctgagg aaacaatgat gattttgagt gaaatcaata aaacggaaaa ggtaactatt
     6361 ctaatggtta ctcatgatgt tttatcagct tcttatgccg acagagttat actcctcaaa
     6421 gatgggaaac ttcacatgga gattgataaa aaagattgtg gagagtcgtt ttacgatgta
     6481 attagtcaag ctttatccga tagaggagag taatatgatt tggtcaatta caaaatctaa
     6541 cattaaaaag aattttccgt tatatcgtat ctattttcta gctacgatcg gtttattaag
     6601 tatttttata gcttttttaa attttatttc agataaaatc atcgcagaaa aaattgggga
     6661 tagtggtcaa gctctagtta tcgctaatgg ttcattgtta tttttgattg tatttttggt
     6721 ggtattctta atctacttca ataatttctt tgtaaaaaaa cgcagtcaag accttggagt
     6781 cttagcaata ctagggtttt caaaaagaga attaacaaaa ttactaactt tagaaaatct
     6841 tgttattcta gttctgagtt acttggtaag tttattgcta ggacctactt tatatttttt
     6901 agctgtactg gtaattactc atctattgga tttaacaatg gaagttcagt ggtttattac
     6961 agttaaagag attatagagt ctttaggaat attagtcgta gtttttctga ttaatttcat
     7021 cacaaatgga gttattattg ctaaacagtc attgattgaa tttgttaatt tctcaaaaaa
     7081 ggctgagaaa aaaatcagga taagaaaagt cagggctatt attgctatta ccgcattgct
     7141 attgtcatat gttttatgtt tgacgacagt gttttcatcc acacgaaaga tgctattaag
     7201 cgtagggatg gtaccaattt ctcttttgat aattatctta gttattttag gctcaatttt
     7261 tacaatcaga tatggattga cttttgtaat ttctttctta aaagaaaaga aaaaaaggtt
     7321 atatcgtcct ctctctaata ttatctatcc taaatttaac tatcgtattg cgacaaaaaa
     7381 taaattatta acagtcttgg gggggctttt aacactaacc gtttcagtta ctggaattat
     7441 ggtaatgctt tatgcttatt ctcttaatgg aatagaaaga ttgactccct ctgcgataga
     7501 atataatgtt gaatcagaaa atggtcaagt caatgttaca aatattttag agaatgggca
     7561 agtgagttta gttgatatta acctattgag attgaacact aacccagaag tgactatcac
     7621 agaatctggg caaacaattc cttattttga tataattaat tacagtgatt ataaagagtt
     7681 aatgaaagct caaggaagaa aaaattctat tgaaggtagt gagtcactac cattgttaat
     7741 aaattatttt ccaacagaaa ttagcctagg gaaaactttt aatttggaaa atgcatacga
     7801 tgttactgta aaacaagtat caacgaataa tgtttttagc ttctctacaa gtgtcacgac
     7861 tctggtggtt tctgataaat tatatgctga gcttagttct cgttttccag agaaaaaaat
     7921 gacaattagg acttttaatg gagattcaat taggtcaagt gaaacatttt acaatcagtt
     7981 tagtacggtt cctgatgtta tcagtagtta tagtagggaa cacacagtaa agactgctaa
     8041 tattgcgact tatatcttta taaccttcct atccatactc tttattattt gtacaggtag
     8101 tattctatac tttacaagcc tcatagaaat catggaaaat aaagaagaat atagctatct
     8161 gagtaagtta ggttatagta aaaaaatgat taatcggatt gtcggatatg aaataggtat
     8221 acttttcctt attcctgtat taattgggat aataaatggt agtatgttgc ttattttcta
     8281 taaatattta tttatggata cattggttgc aggcaatatt ataatgctat ctttgttgct
     8341 ttttctgttt ttctttttga taatatatgg cacattttat ttattgacat tgcggtcagt
     8401 gaaatcaata ataaacaatt aattctaaaa actttttaac tttaacgatt tagtaaataa
     8461 tatgatgaga atagaaaaaa tagcaaagag taaatttttg ggaatcacaa taatcttgtt
     8521 acaacaatta atagcctttt tgattttggt ctataatcga gaaaacttgt ctcttctttt
     8581 ctctgaaaaa gtagctcttg taatgactct tattgataca ggttttattt ggctggcagc
     8641 aatattacgc caaaaacaag atgggatttt taaaaaaatt atttctatcg ttttcttaac
     8701 aatttggcaa tacttggtat ctgtgctatc aagggaaact cctctctttt ttagtagtgg
     8761 tctgcaaatt atattgctct attgttatac cgttgagatt actgatttaa tattatatgg
     8821 gcagaaacag tttaaagata agctagacaa gagcttatta atgatcattt ttgtttctat
     8881 aattagcctt ttagttaata gaactttatt taatttctta ttcttagttg tttttactat
     8941 tttacacctt tatccattat tggttatagt gctatattat aggtatttta ggcaacaaat
     9001 atcagttgta agacgttcat tgatattatt ttctttgctt ttgctagcaa tacttggtag
     9061 tgaattttat ggagagatgc tagatgttaa tcaagccttt aataatttgg ggtggtatct
     9121 gtttcccctt ataatgagta caatatacta ttttaaggtc atacatgata aatttagtct
     9181 agttactcga agatggttag gtaattacaa aactcgtata gaacttttat ttatacttct
     9241 tatcatttgt tgggtaatac ttataaaggg actagttaaa gattttttac tattttttat
     9301 agttgttgat gcaagcacgt ttttttgtct agtggtaatt tcttgtatct tttgttattt
     9361 agaaaacttt aagcaaaatt ttgactatga aaatagaaga ttgaactatt ttatgaaatc
     9421 ggaggaaaac atgagagtgg agttctcaaa ttatttgcat gatgatgtct tgcaaaatgt
     9481 catagcgata aaaaacttac tctctttaga aaatagtgat ataacacatg gttttattgt
     9541 taatgggttg aatgatctag tttctggtat cagggatgaa attgatactt atcacccaat
     9601 agttccttct aatcgaacaa tgaaagaaaa catacagtct ctttttgatg atattgttaa
     9661 aaggaggaaa agtaataagt tgttgtattt caactgttcg agtagtacaa taatcccacc
     9721 tccatatgga gatattgttt acaggtttat aaaagaatta attaataatg ctataaaata
     9781 tggagtcagt aaagatattc atttatcttt aaaggttcaa tctgatatta ttatcataga
     9841 ggagagcaat caggtggtgg aaaaagttca atctataaat tatggcagag gtttgaaatc
     9901 atttcaagaa acactagtag cttttgatgg ggatatggag ctacaaatag ataataaaca
     9961 atacaatatc agaatattac ttcccataga ttggaaatta tgctatgaag attttattaa
    10021 ttgatgatca taaactattt gcaaagagta tccaactgtt atgccaacag tatgatgagg
    10081 tagatgttat agatacaatt acttctaatt ttaacgatgt gacgattgat ttatctaaat
    10141 acgatattat tttacttgat attaatttaa caaatatttc taaagagaat ggattggaga
    10201 tagcggagga actcatacag tctactccta acttgaaagt tgttatgctg acaggatatg
    10261 ttaagtcaat ctatgaagag agagcaaaaa caataggggc atacggtttt gtagataaaa
    10321 atatagaccc taagcaactc atttctatct taaaaaaagt ggattctggg aaaaagtatt
    10381 ttgaacaaat tgaatctcag gattatgttg aagctttaac tgaccgagaa atagtaatct
    10441 taaatttgag taagaaaggt ctctctgtta aagatataga ggaaacgtta caaattagta
    10501 ggagaacagt atttaatcat ttgaaccata tctattcaaa acttctagta aataataagc
    10561 aagaggctat ctacaaagct gagcaattag ggtattttat ggatttctga
//
