LOCUS       BGC0000553              7440 bp    DNA     linear   CON 03-MAR-2022
DEFINITION  Streptomyces filamentosus NRRL 15998 supercont3.1, whole genome
            shotgun sequence.
ACCESSION   BGC0000553
VERSION     BGC0000553
KEYWORDS    .
SOURCE      Streptomyces filamentosus NRRL 15998
  ORGANISM  Streptomyces filamentosus NRRL 15998
            Bacteria; Actinobacteria; Streptomycetales; Streptomycetaceae;
            Streptomyces.
COMMENT     REFSEQ INFORMATION: The reference sequence is identical to
            DS999644.1.
            The annotation was added by the NCBI Prokaryotic Genome Annotation
            Pipeline (PGAP). Information about PGAP can be found here:
            https://www.ncbi.nlm.nih.gov/genome/annotation_prok/
            Genome Coverage: 11.9X (11.4X Q>20)
            Annotation was added to the scaffold in March 2010.
            ##antiSMASH-Data-START##
            Version      :: 6.2.0-924c3663(changed)
            Run date     :: 2022-11-07 19:51:02
            ##antiSMASH-Data-END##
FEATURES             Location/Qualifiers
     protocluster    1..7440
                     /aStool="rule-based-clusters"
                     /category="RiPP"
                     /contig_edge="True"
                     /core_location="[66:>1750]"
                     /cutoff="20000"
                     /detection_rule="(micKC and not PKS_KS)"
                     /neighbourhood="10000"
                     /product="lanthipeptide-class-iii"
                     /protocluster_number="1"
                     /tool="antismash"
     proto_core      67..>1750
                     /aStool="rule-based-clusters"
                     /tool="antismash"
                     /cutoff="20000"
                     /detection_rule="(micKC and not PKS_KS)"
                     /neighbourhood="10000"
                     /product="lanthipeptide-class-iii"
                     /protocluster_number="1"
     cand_cluster    1..7440
                     /candidate_cluster_number="1"
                     /contig_edge="True"
                     /detection_rules="(micKC and not PKS_KS)"
                     /kind="single"
                     /product="lanthipeptide-class-iii"
                     /protoclusters="1"
                     /tool="antismash"
     subregion       1..7440
                     /aStool="externally annotated by: MIBiG"
                     /contig_edge="True"
                     /label="BGC0000553"
                     /subregion_number="1"
                     /tool="antismash"
     region          1..7440
                     /candidate_cluster_numbers="1"
                     /contig_edge="True"
                     /product="lanthipeptide-class-iii"
                     /region_number="1"
                     /rules="(micKC and not PKS_KS)"
                     /subregion_numbers="1"
                     /tool="antismash"
     gene            67..>1750
                     /gene="lanKC"
                     /locus_tag="SSGG_RS0133190"
                     /old_locus_tag="SSGG_04748"
     CDS             67..>1750
                     /GO_function="GO:0005524 - ATP binding [Evidence IEA];
                     GO:0004672 - protein kinase activity [Evidence IEA]"
                     /GO_process="GO:0005975 - carbohydrate metabolic process
                     [Evidence IEA]; GO:0006468 - protein phosphorylation
                     [Evidence IEA]"
                     /codon_start=1
                     /gene="lanKC"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     lanthipeptide-class-iii: micKC"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Pkinase"
                     /gene_functions="regulatory (smcogs)
                     SMCOG1030:serine/threonine protein kinase (Score: 96.7;
                     E-value: 2.7e-29)"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_010072047.1"
                     /locus_tag="SSGG_RS0133190"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="SSGG_04748"
                     /product="class III lanthionine synthetase LanKC"
                     /protein_id="WP_205382163.1"
                     /sec_met_domain="Pkinase (E-value: 4.6e-15, bitscore: 44.5,
                     seeds: 54, tool: rule-based-clusters)"
                     /sec_met_domain="micKC (E-value: 5.4e-146, bitscore: 476.5,
                     seeds: 18, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MNPEYAAYCQADRRFYDAPHRSAGPGGGAVDEENAYYAAVRGSAP
                     EGWTRSRRGDWLAYHPDGLRLPPQGWKIHVSAALDNAASVLGRVLAHCLEHRLAFKCIP
                     NAGLLALRNAKYADRAGSGKFITVYPPSEEAFPEVCTALMELLEGEHGPYILSDLRCGN
                     GPVHTRYGAFAARFCSGPDGRPVPAVADPRGRLVPDDRGPAFRVPSWVTPPGFLMPHLE
                     ARAAVGLAGLPYTVEKALHFSNGGGVYLGRDTRTGEQVVLKEARPYAGLAADGADAVAR
                     LERERAALEQLAGLDCVPDVRDVFEVGDHHFLVLQYIPGTTLNTVFARRFPLARQHPSP
                     DLLAEHAAWAEELYGQVERAVAAVHDRGIVISDLHMSNVMVDEEAGRIVLLDFEAASPA
                     AERRRQIVANPAFVAPPDRRGTDIDRYALACLRLALYLPLTTLFGIDRTKAAGLARDIA
                     RAFPVPEDALRPAVEEILRDVRDARDARDTGEAGEAVSRTAPGAASGTAFASAPGRAPG
                     TASGPGPGPASGTASGSASTSGRDSGEASASPADLRDWPRARDA"
     gene            <2676..2878
                     /locus_tag="SSGG_RS09930"
                     /old_locus_tag="SSGG_04749"
     CDS             <2676..2878
                     /codon_start=3
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_010072047.1"
                     /locus_tag="SSGG_RS09930"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="SSGG_04749"
                     /product="hypothetical protein"
                     /protein_id="WP_032798142.1"
                     /transl_table=11
                     /translation="AFPGEQLMRLSMDLATGTAGALLALGAASGRPTGLPFLPAAPAAR
                     PAATAAPQTGPARGRGNTTVQ"
     gene            2904..3035
                     /locus_tag="SSGG_RS09925"
                     /old_locus_tag="SSGG_04750"
     CDS             2904..3035
                     /codon_start=1
                     /gene_functions="biosynthetic-additional (lanthipeptides)
                     predicted lanthipeptide"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_015611153.1"
                     /locus_tag="SSGG_RS09925"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="SSGG_04750"
                     /product="SapB/AmfS family lanthipeptide"
                     /protein_id="WP_003966507.1"
                     /transl_table=11
                     /translation="MALLDLQAMDTPAEDSFGELATGSQVSLLVCEYSSLSVVLCTP"
     CDS_motif       2904..2969
                     /prepeptide="leader"
                     /note="peptide class: lanthipeptide"
                     /note="predicted sequence: MALLDLQAMDTPAEDSFGELAT"
                     /locus_tag="SSGG_RS09925_lanthipeptide"
                     /aSTool="lanthipeptides"
                     /tool="antismash"
     CDS_motif       2970..3035
                     /prepeptide="core"
                     /locus_tag="SSGG_RS09925_lanthipeptide"
                     /peptide="lanthipeptide"
                     /predicted_class="Class III"
                     /score="31.80"
                     /molecular_weight="2076.4"
                     /monoisotopic_mass="2075.1"
                     /core_sequence="GSQVSLLVCEYSSLSVVLCTP"
                     /aSTool="lanthipeptides"
                     /tool="antismash"
                     /leader_sequence="MALLDLQAMDTPAEDSFGELAT"
                     /leader_location="[2903:2969](+)"
                     /alternative_weights="2094.4"
                     /alternative_weights="2112.4"
                     /alternative_weights="2130.5"
                     /alternative_weights="2148.5"
     gene            3128..>4193
                     /locus_tag="SSGG_RS0133195"
                     /pseudo=""
     CDS             3128..>4193
                     /codon_start=1
                     /gene_functions="transport (smcogs) SMCOG1288:ABC
                     transporter related protein (Score: 87.3; E-value:
                     1.6e-26)"
                     /gene_kind="transport"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_010061642.1"
                     /locus_tag="SSGG_RS0133195"
                     /note="incomplete; too short partial abutting assembly gap;
                     missing C-terminus; Derived by automated computational
                     analysis using gene prediction method: Protein Homology."
                     /product="ABC transporter ATP-binding protein"
                     /pseudo=""
                     /transl_table=11
                     /translation="VPLSHPDPSPGTASGTRRLARLHPAALSWLFLCSTGGALAALALP
                     AALGHTVDRLVSGGPEPWAGLLLCAALTLAETGFDAAAAVTGTTTTARLTASLRIRTAG
                     RILAAEPRRALALPTGDLTARLTARTADAASAPVTAAGAVAGVLLPLGALVGLLLIDVW
                     TAAALLLGAPLLVVLLRTFTRHTADAGADYQRAQSLIAHRLTEALDGADTIRAARTGAR
                     EHRRVLEPLAALADHGRRTWTVYGRAVGRSGLLLPLLMLLVLAVAGLRLAAGAIGVGEL
                     VAASRYASLAVGIGALTGALGSLARSRAAARSLDPLLSLAPLPHRGLGPVPDAPGHLEL
                     RDVGVEQDGRPLLSG"
     gene            <4477..>4822
                     /locus_tag="SSGG_RS0133200"
     CDS             <4477..>4822
                     /GO_function="GO:0005524 - ATP binding [Evidence IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_018956282.1"
                     /locus_tag="SSGG_RS0133200"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="ATP-binding cassette domain-containing protein"
                     /protein_id="WP_032798144.1"
                     /transl_table=11
                     /translation="ARAARADGFLALLPYGYATPVADAPLSGGERQRLGLARAFAHPGR
                     LLILDDALSSLDTVTEHHVRRALDARAGHCTRIIVAHRLSSAARADRVAWLEDGRLRAT
                     GRHDELWQDPE"
     gene            5090..6866
                     /locus_tag="SSGG_RS34700"
                     /old_locus_tag="SSGG_04751"
                     /pseudo=""
     CDS             5090..6866
                     /GO_function="GO:0005524 - ATP binding [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="transport (smcogs) SMCOG1288:ABC
                     transporter related protein (Score: 104; E-value: 1.4e-31)"
                     /gene_kind="transport"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_010061641.1"
                     /locus_tag="SSGG_RS34700"
                     /note="frameshifted; Derived by automated computational
                     analysis using gene prediction method: Protein Homology."
                     /old_locus_tag="SSGG_04751"
                     /product="ATP-binding cassette domain-containing protein"
                     /pseudo=""
                     /transl_table=11
                     /translation="ILRLAGWSLLEFAQTFLGGYGVARALDDGFLAGRPATGLLWLAAA
                     AVAVLPSVLAARGVFGRLADLVEPLRDGLVRRAVARALSGALGRSGDVSTRSLSQVTHQ
                     SEIARDGWAGLVLTLRSFVFTAAGAVTGLLALSPALLLIVLPPLVLGAALFLGTLPPMA
                     ASQRAYLAADEAYAAHAGELAASVRDIAAAGTAGRTVAESRALAGAQLAASRSLARWSA
                     VRVVALAVCGRFPPLLLLLGAPWLLRNGLTPGGLVGALTYLTQALAPAVQALMTMLGTA
                     GGRLVVVLDRFTDAPPPPADDPAPAASADSPPPPRNPARNPARHTPVAELDEVTFAYGP
                     RAHPVLDRLSLTVGAGEHLAVVGPSGSGKSTLVAVLAGTERPTGGAVRWRGRPARPADA
                     TSVRVLLPQHAYVFTGTLRDNLRYLRPDARDREIAAMADAVGTRSTWNTLLARLGSLDA
                     ESRTGPALPGRTAARRPRPRLSRRTAAADPRRGHQPARPGRRDPRRAGVRRPAGRAGRR
                     RPPDRLGPPRRPDPGDGRPAHPVRHPRRTPAYQRPLPRPVRPLGAGRTGRAGRTGSAAW
                     RGARNHQIHPASFARL"
     gene            complement(6835..7440)
                     /locus_tag="SSGG_RS09915"
                     /old_locus_tag="SSGG_04752"
     CDS             complement(6835..7440)
                     /codon_start=1
                     /gene_functions="regulatory (smcogs) SMCOG1016:LuxR family
                     DNA-binding response regulator (Score: 89; E-value:
                     4.3e-27)"
                     /gene_kind="regulatory"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_006127364.1"
                     /locus_tag="SSGG_RS09915"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="SSGG_04752"
                     /product="response regulator transcription factor"
                     /protein_id="WP_006127364.1"
                     /transl_table=11
                     /translation="MTTVLLVHTVPLWRASLASLLGTGRGIEVRTAERGAIRAALNGHG
                     PDVLLTDLDCPGARDVLDELKTVTAPHGGTYPLAVLTRSDQPRGLRRAYEAGALGYIDK
                     YRPVDDLSEVMHKLADGGRHIDESLAFSLLQVADMPLSPRELSVLSMAEEGDNVAGIAG
                     RLHLTPGTVRNYLAAAIRKSGARNRLDAIRRAKEAGWI"
ORIGIN
        1 ctggtcgtta tggcaatttc tctctcgccg cgaacgacgc ggaggaaccg agcgaggggg
       61 ccgtgcgtga atccggagta cgccgcgtac tgccaggcgg accgccgctt ctacgacgca
      121 ccccaccgtt ccgccggacc gggcggcgga gccgtcgacg aggagaacgc gtactacgcg
      181 gccgtccgcg gctccgcacc cgaggggtgg acccgctccc ggcgcggtga ctggctcgcg
      241 taccaccccg acgggctgcg gctgccgccc cagggctgga agatccacgt ctcggccgcc
      301 ctcgacaacg cggcctccgt gctcggccgg gtcctcgccc actgtctgga gcaccggctc
      361 gccttcaagt gcataccgaa cgcggggctg ttggccctgc ggaacgccaa gtacgcggac
      421 cgggcgggca gcgggaagtt catcaccgtc tacccgccgt ccgaggaagc gttccccgag
      481 gtgtgcaccg ccctgatgga gctcctggag ggcgagcacg gcccgtacat cctgagcgat
      541 ctgcggtgcg ggaacgggcc cgtgcacacc cggtacggcg cgttcgccgc ccgcttctgc
      601 tccggtccgg acggccggcc cgtgcccgcc gtcgccgacc cgcggggccg gctcgtcccg
      661 gacgaccggg gccccgcctt ccgcgtcccc tcctgggtga ccccgcccgg ctttctgatg
      721 ccgcacctcg aagcccgggc cgccgtgggc ctcgccggcc tcccgtacac cgtggagaag
      781 gcgctgcact tctcgaacgg cggcggggtc tacctcggcc gtgacacccg caccggcgaa
      841 caggtcgtcc tcaaggaggc ccggccgtac gccggtctgg ccgccgacgg ggcggacgcg
      901 gtggcccgtc tggagcggga gagggccgcg ctggaacaac tggccgggct ggactgcgta
      961 ccggacgtcc gggacgtgtt cgaggtcggc gaccaccact tcctggtcct ccagtacatc
     1021 cccggcacca ccctcaacac cgtcttcgcc cgccgcttcc cgctcgcccg gcagcacccg
     1081 tcgcccgatc tcctcgccga acacgctgcg tgggccgagg agttgtacgg gcaggtcgag
     1141 cgggccgtcg cggcggtgca cgaccggggc atcgtcatca gcgatctgca catgagcaac
     1201 gtgatggtcg acgaggaggc cgggcggatc gtcctgctcg acttcgaggc ggcctccccg
     1261 gccgccgaac gccgccgcca gatcgtcgcc aacccggcct tcgtcgcccc gcccgaccgg
     1321 cgcggcaccg atatcgaccg ctacgcgctc gcctgtctgc ggctcgccct gtatctgccg
     1381 ctcaccacac tgttcggcat cgaccgcacg aaggccgccg ggctcgcccg ggacatcgcc
     1441 cgcgccttcc cggtgccgga ggacgcgcta cgtccggcgg tcgaggagat cctgcgggac
     1501 gtacgggatg cgcgggacgc acgggacacg ggggaggctg gggaggctgt ctcccggacg
     1561 gctccgggag cggcttccgg tacggctttc gcttctgccc caggccgcgc ccctggtacg
     1621 gcgtccggcc ccggccccgg ccccgcttcc ggtacggctt ccggctccgc ctccacgtcc
     1681 ggccgagact ccggcgaggc ttccgcttca cccgccgacc tccgcgactg gccgcgcgcc
     1741 cgcgacgcgc nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn
     1801 nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn
     1861 nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn
     1921 nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn
     1981 nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn
     2041 nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn
     2101 nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn
     2161 nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn
     2221 nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn
     2281 nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn
     2341 nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn
     2401 nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn
     2461 nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn
     2521 nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn
     2581 nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn
     2641 nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnntcgcc ttcccgggcg agcagttgat
     2701 gcgcctgtcg atggacctgg ccaccgggac cgccggcgct ctcctcgccc tgggcgccgc
     2761 ttccggccgc cccaccggac ttcccttcct gcccgccgct ccggcggcgc gcccggccgc
     2821 cacggcggcc ccacagaccg gccccgccag gggtcgtggc aacaccaccg ttcagtaagc
     2881 aaccgtcccc gaaaggacac atcatggcgc ttctcgacct tcaggcgatg gacaccccgg
     2941 ccgaggactc cttcggcgag ctcgccacgg gcagccaggt ctcgctgctg gtctgtgagt
     3001 acagctccct cagcgtggtc ctctgcaccc cgtgacccgc accggccggc ccgtcggtgc
     3061 gcaccaccga cgggccggcc ggccacgtgc ccgcagggcc gcccctgccg acccgaaagg
     3121 cgaccccgtg ccgctgtcgc acccggaccc gagccccggc acggcgtccg gcacccggcg
     3181 gctcgcccgg ctccacccgg ccgccctctc ctggctgttc ctctgctcca ccggcggggc
     3241 gctcgccgcc ctcgccctgc ccgccgccct cggccacacc gtcgaccggc tcgtctccgg
     3301 cgggcccgag ccctgggccg ggctgctgct ctgcgccgcc ctgaccctcg ccgagaccgg
     3361 gttcgacgcg gcggccgccg tgaccggcac gaccaccacc gcccggctca ccgcgtccct
     3421 gcgcatccgc accgccggcc ggatcctggc cgccgagccg cgcagggccc tcgccctgcc
     3481 caccggtgac ctcaccgccc ggctcaccgc ccgcaccgcc gacgccgcgt ccgcgcccgt
     3541 gaccgccgcc ggagccgtcg cgggcgtcct gctcccgctc ggcgcgctcg tcggcctcct
     3601 cctcatcgac gtctggacgg ccgccgccct cctcctgggc gccccgctcc tcgtcgtcct
     3661 gctgcgcacg ttcacccggc acaccgccga cgccggggcc gactaccagc gcgcccagtc
     3721 gctcatcgcc caccggctca ccgaggccct ggacggcgcc gacaccatcc gcgccgcccg
     3781 caccggcgcc cgcgaacacc gccgggtcct ggaacccctg gccgccctcg ccgaccacgg
     3841 ccgccgtacc tggaccgtgt acgggcgggc cgtcggccgc agcggactcc tgctgcccct
     3901 gctcatgctg ctggtcctcg cggtcgccgg actccggctc gccgcgggcg cgatcggcgt
     3961 cggcgagctc gtcgccgcct cccgctacgc gagcctcgcc gtcggcatcg gcgccctcac
     4021 cggagcgctc ggctccctgg cccgcagccg cgccgccgcc cggagcctcg accccctcct
     4081 cagcctcgcc ccgctgccgc accgcggcct gggcccggta cccgacgccc ccggacacct
     4141 cgaactccgg gacgtcggcg tcgaacagga cggccgaccc ctgctgagcg gcgnnnnnnn
     4201 nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn
     4261 nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn
     4321 nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn
     4381 nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn
     4441 nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnngccc gagcggcccg cgccgacggg
     4501 ttcctcgccc tgctcccgta cgggtacgcc accccggtcg ccgacgcacc gctctccggc
     4561 ggcgaacgcc aacgcctggg gctggcacgc gcattcgccc acccgggccg gctgctgatc
     4621 ctcgacgacg cgctgtccag cctcgacacc gtgaccgagc accacgtccg ccgcgccctc
     4681 gacgcgcggg ccgggcactg cacccggatc atcgtcgccc accggctctc ctcggccgcg
     4741 cgggcggacc gggtcgcctg gctggaggac ggccggctcc gcgcgacggg ccgccacgac
     4801 gagttgtggc aggacccgga gtnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn
     4861 nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn
     4921 nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn
     4981 nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn
     5041 nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnncga tcctgcggct
     5101 ggccgggtgg tccctgctgg agttcgcgca gaccttcctc ggcggatacg gggtcgcccg
     5161 cgccctcgac gacggcttcc tcgccggacg tccggccacc gggctcctct ggctggccgc
     5221 cgccgccgtc gccgtgctgc cctccgtgct cgccgcccgc ggggtgttcg gccggctcgc
     5281 cgatctggtc gagccgctgc gcgacgggct ggtccggcgc gcggtggcgc gggcgctgtc
     5341 gggcgcgctc ggccgctccg gcgacgtcag cacccggtcc ctctcccagg tcacccatca
     5401 gagtgagatc gcccgcgacg gctgggccgg actcgtcctg accctgcggt cgttcgtgtt
     5461 cacggccgcc ggagccgtca ccggcctgct ggccctctcg cccgccctcc tgctcatcgt
     5521 gctgccgccg ctggtcctgg gggccgcgct gttcctgggc accctgccgc cgatggccgc
     5581 cagccagcgc gcctacctcg ccgccgacga ggcgtacgcc gcgcacgcgg gcgagctcgc
     5641 cgcctccgta cgggacatcg ccgccgccgg aaccgccggg cggacggtgg ccgagtcccg
     5701 ggccctcgcc ggcgcgcagc tcgccgcctc ccgttcgctg gcccgatggt cggcggtgcg
     5761 ggtggtggcc ctcgcggtct gcggccggtt cccgccgctc ctgctgctcc tgggggcgcc
     5821 gtggctgctg cggaacgggc tcacgccggg cggtctcgtc ggcgcgctga cctacctcac
     5881 ccaggcgctc gcccccgccg tgcaggcgct gatgaccatg ctgggcacgg cgggcggccg
     5941 cctcgtcgtg gtcctggacc ggttcacgga cgccccgccc ccgcccgccg acgacccggc
     6001 cccggccgcc tccgccgact ccccgccacc ccctcggaac cccgccagga accccgcccg
     6061 gcacaccccg gtcgccgaac tcgacgaggt caccttcgcg tacggacccc gcgcccaccc
     6121 cgtcctggac cggctctccc tgacggtcgg ggcgggcgag cacctcgcgg tcgtcggccc
     6181 gagcggcagc ggcaagtcga ccctggttgc cgtcctcgcc gggaccgagc ggcccaccgg
     6241 gggagcggtg cggtggcgag ggcgcccggc gcggccggcc gacgccacgt ccgtacgcgt
     6301 cctgctgccc cagcacgcct atgtgttcac cggcacgctg cgggacaacc tccgctacct
     6361 ccggcccgac gcccgtgacc gggagatcgc ggccatggcg gacgcggtcg ggacgcgttc
     6421 gacctggaac acgctgctcg cccggctcgg ctccctcgac gcggaaagtc gaaccggacc
     6481 ggctctccca gggcgaacgg cagctcgtcg ccctcggccg cgcctatctc gccgcaccgc
     6541 cgctgctgat cctcgacgag gccaccagcc ggctcgaccc ggccgccgag acccgcgccg
     6601 agctggcgtt cgccgccctg ccgggcgcgc tggtcgtcgt cgcccaccgg atcggctcgg
     6661 cccgccgcgc cgaccggacc ctggtgatgg acggcccgcg cacccagtgc ggcacccccg
     6721 gcgaactcct gcgtaccagc gccctctacc gcgacctgtc cggcctctgg gagccggaag
     6781 aaccggcagg gctggaagga ccggaagcgc ggcgtggcga ggagcacgga atcatcagat
     6841 ccaccccgcc tccttcgccc gtctgatcgc gtccagccga ttccgcgccc cggacttccg
     6901 gatggcggcg gccagataat tgcggaccgt ccccggtgtc aggtgcagtc gtccggctat
     6961 gcccgccacg ttgtcaccct cctcggccat cgagagcaca ctcaattccc ttggcgataa
     7021 cggcatgtcg gccacctgga ggagactgaa ggccagcgat tcgtcgatat gccgtccgcc
     7081 gtccgccagt ttgtgcatca cctcggacag gtcgtccacc gggcggtact tgtcgatgta
     7141 gccgagcgcc cccgcctcgt acgcccgccg caggccgcgc ggctgatcgc tgcgggtgag
     7201 gacggcgagg ggatacgttc ctccatgcgg tgcggtgacc gtcttcagct cgtcgagtac
     7261 gtcgcgtgcg cccggacagt cgaggtcggt gagcagcaca tcggggccgt ggccgttcaa
     7321 tgcggcgcgt atcgcgccgc gttcggcggt gcggacctct attccccgcc ccgtgccgag
     7381 gagcgatgcc agcgacgcgc gccacaacgg cacggtgtgg accagcagca cggttgtcat
//
