LOCUS       BGC0000648             11979 bp    DNA     linear   BCT 13-SEP-2010
DEFINITION  Myxococcus xanthus carotenoid gene cluster.
ACCESSION   BGC0000648
VERSION     BGC0000648
KEYWORDS    .
SOURCE      Myxococcus xanthus
  ORGANISM  Myxococcus xanthus
            Bacteria; Proteobacteria; Deltaproteobacteria; Myxococcales;
            Cystobacterineae; Myxococcaceae; Myxococcus.
COMMENT     On Nov 24, 2006 this sequence version replaced Z21955.1.
            ##antiSMASH-Data-START##
            Version      :: 6.2.0-924c3663(changed)
            Run date     :: 2022-11-07 20:08:02
            NOTE: This is a single region extracted from a larger record!
            Orig. start  :: 0
            Orig. end    :: 11979
            ##antiSMASH-Data-END##
FEATURES             Location/Qualifiers
     source          1..11979
                     /clone="pMAR100, pMAR301 in E. coli (strain MC1061)"
                     /db_xref="taxon:34"
                     /mol_type="genomic DNA"
                     /organism="Myxococcus xanthus"
                     /strain="DK1050"
     protocluster    1..11979
                     /aStool="rule-based-clusters"
                     /category="terpene"
                     /contig_edge="True"
                     /core_location="[3700:4711]"
                     /cutoff="20000"
                     /detection_rule="(Terpene_synth or Terpene_synth_C or
                     phytoene_synt or Lycopene_cycl or terpene_cyclase or NapT7
                     or fung_ggpps or fung_ggpps2 or trichodiene_synth or TRI5)"
                     /neighbourhood="10000"
                     /product="terpene"
                     /protocluster_number="1"
                     /tool="antismash"
     proto_core      3701..4711
                     /aStool="rule-based-clusters"
                     /tool="antismash"
                     /cutoff="20000"
                     /detection_rule="(Terpene_synth or Terpene_synth_C or
                     phytoene_synt or Lycopene_cycl or terpene_cyclase or NapT7
                     or fung_ggpps or fung_ggpps2 or trichodiene_synth or TRI5)"
                     /neighbourhood="10000"
                     /product="terpene"
                     /protocluster_number="1"
     cand_cluster    1..11979
                     /candidate_cluster_number="1"
                     /contig_edge="True"
                     /detection_rules="(Terpene_synth or Terpene_synth_C or
                     phytoene_synt or Lycopene_cycl or terpene_cyclase or NapT7
                     or fung_ggpps or fung_ggpps2 or trichodiene_synth or TRI5)"
                     /kind="single"
                     /product="terpene"
                     /protoclusters="1"
                     /tool="antismash"
     subregion       1..11979
                     /aStool="externally annotated by: MIBiG"
                     /contig_edge="True"
                     /label="BGC0000648"
                     /subregion_number="1"
                     /tool="antismash"
     region          1..11979
                     /candidate_cluster_numbers="1"
                     /contig_edge="True"
                     /product="terpene"
                     /region_number="1"
                     /rules="(Terpene_synth or Terpene_synth_C or phytoene_synt
                     or Lycopene_cycl or terpene_cyclase or NapT7 or fung_ggpps
                     or fung_ggpps2 or trichodiene_synth or TRI5)"
                     /subregion_numbers="1"
                     /tool="antismash"
     regulatory      990..995
                     /regulatory_class="minus_35_signal"
     regulatory      1013..1018
                     /regulatory_class="minus_10_signal"
     regulatory      1045..1049
                     /regulatory_class="ribosome_binding_site"
     gene            1058..2143
                     /gene="ORF1"
     CDS             1058..2143
                     /codon_start=1
                     /db_xref="GOA:Q50891"
                     /db_xref="InterPro:IPR000092"
                     /db_xref="InterPro:IPR008949"
                     /db_xref="InterPro:IPR017446"
                     /db_xref="UniProtKB/TrEMBL:Q50891"
                     /gene="ORF1"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1182:Polyprenyl synthetase (Score: 207; E-value:
                     5.7e-63)"
                     /gene_kind="biosynthetic-additional"
                     /note="Homologous to geranylgeranyl pyrophosphate
                     synthetase of Rhodobacter capsulatus and Erwinia sp."
                     /product="geranylgeranyl pyrophosphate synthetase"
                     /protein_id="CAA79955.1"
                     /transl_table=11
                     /translation="MALTLPDAQPPTGLLPLEQAWLQLVQTEVETSLAELFELPDEAGL
                     DVRWTQALTQARAYTLRPAKRLRPALVMAGHCLARGSAVVPSGLWRFAAGLELLHTFLL
                     IHDDVADQAELRRGAPPLHRMLAPGRAGEDLAVVVGDHLFARALEVMLGSGLTCVAGVV
                     QYYLGVSGHTAAGQYLDLDLGRAPLAEVTLFQTLRVAHLKTARYGFCAPLVCAAMLGGA
                     SSGLVEELERVGRHVGLAYQLRDDLLGLFGDSNVAGKAADGDFLQGKRTFPVLAAFARA
                     TEAERTELEALWALPVEQKDAAALARARALVESCGGRAACERMVVRASRAARRSLQSLP
                     NPNGVRELLDALIARLAHRAA"
     regulatory      2142..2145
                     /regulatory_class="ribosome_binding_site"
     gene            2151..3704
                     /gene="ORF2"
     CDS             2151..3704
                     /codon_start=1
                     /db_xref="GOA:P54979"
                     /db_xref="InterPro:IPR002937"
                     /db_xref="InterPro:IPR008150"
                     /db_xref="InterPro:IPR014105"
                     /db_xref="UniProtKB/Swiss-Prot:P54979"
                     /function="unknown"
                     /gene="ORF2"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1222:dehydrogenase (Score: 470.9; E-value: 9.4e-143)"
                     /gene_kind="biosynthetic-additional"
                     /note="Homologous to phytoene dehydrogenase (carC gene at
                     an ulinked locus; EMBO J. vol 12, no 4) of Myxococcus
                     xanthus and to Rhodobacter capsulatus and Erwinia sp.
                     carotenogenic dehydrogenases."
                     /protein_id="CAA79956.1"
                     /transl_table=11
                     /translation="MSASTQGRRIVVVGAGVGGLAAAARLAHQGFDVQVFEKTQGPGGR
                     CNRLQVDGFTWDLGPTIVLMPEVFEETFRAVGRRIEDYLTLLRCDPNYRVHFRDRSDVT
                     FTSELCAMGRELERVEPGSYARYLAFLAQGRVQYRTSLDHLVGRNYAGLRDYLSPRVLA
                     RIFQVRAHRRMYADVSRFFQDERLRAAMTFQTMYLGVSPYASPAVYGLLPFTELGVGIW
                     FPKGGLYAIPQALERLAREEGVRFHYGAPVERILTDGGRTRGVRLEGGEVVEADAVLCN
                     ADLPYAYEKLLDPKATTLKRKEKLRYTSSGYMLYLGMKRRYPELLHHNVVFGRDYKGSF
                     DDIFEFRVPEDPSFYVNAPTRTDASLAPEGKDALYVLVPVPHQHPDLDWKVEGPKVRAK
                     FFARMAELGFPSLESDIEVERRSSTPDDWAGTFNLARGSGFGLSQNFTQIGPFRPSNQD
                     ARVKNLFFVGASTQPGTGLPTVLISARLVTERLMTWAHAQGVSLSPRTAAATPLEGVAA
                     "
     regulatory      3686..3690
                     /gene="ORF2"
                     /regulatory_class="ribosome_binding_site"
     gene            3701..4711
                     /gene="ORF3"
     CDS             3701..4711
                     /codon_start=1
                     /db_xref="GOA:Q50892"
                     /db_xref="InterPro:IPR002060"
                     /db_xref="InterPro:IPR008949"
                     /db_xref="InterPro:IPR019845"
                     /db_xref="UniProtKB/TrEMBL:Q50892"
                     /gene="ORF3"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     terpene: phytoene_synt"
                     /gene_kind="biosynthetic"
                     /note="GTG start codon. Homologous to phytoene synthetase
                     of Rhodobacter capsulatus and Erwinia sp."
                     /product="phytoene synthetase"
                     /protein_id="CAA79957.1"
                     /sec_met_domain="phytoene_synt (E-value: 2e-75, bitscore:
                     243.0, seeds: 8, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MSPPVDKALVARGYVLAKQVTRHHAKSFFFASYLLFGLRRRAAFA
                     LYAFCRRLDDMVDGDDAASAADALPVRLARARQRVAELYLPMPELASRELGPPADRVKG
                     SEAATPWDAREFAALEHTVRHFRIPEQPFQDLISGMEMDLTKHRYATWEELDLYCYRVA
                     GVVGLMLTPVLGCSDAAAVEPAADLGRAMQLTNILRDVREDLERGRVYLPAEELAAFGL
                     SEDDLRRGQVGARWRSFMRFQVERSRAYYARAAAGVRYLTGFGSQRMVRLMGAIYADIL
                     RDIEARDYDVFSARAHVTTRRKLALASAAMVRPAAVLPAPQGEVRMPLLPTGAGG"
     regulatory      4761..4766
                     /regulatory_class="ribosome_binding_site"
     gene            4772..6229
                     /gene="ORF4"
     CDS             4772..6229
                     /codon_start=1
                     /db_xref="GOA:Q50893"
                     /db_xref="InterPro:IPR002937"
                     /db_xref="InterPro:IPR014105"
                     /db_xref="UniProtKB/TrEMBL:Q50893"
                     /gene="ORF4"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1222:dehydrogenase (Score: 301.3; E-value: 2.6e-91)"
                     /gene_kind="biosynthetic-additional"
                     /note="Homologous to hydroxyneurosporene dehydrogenase of
                     Rhodobacter capsulatus"
                     /product="hydroxyneurosporene dehydrogenase"
                     /protein_id="CAA79958.1"
                     /transl_table=11
                     /translation="MKRTRVAVVGGGIGGLTAAGLLAKDGHEVTLFERGASLGGKAQAV
                     IVNGITLDTGPTLLTLPHLVRGTFQQLGAEDLLPRFTELEPQCAYRFEDGCDFTAYKDV
                     ERMAESAAGVRPGERDGIRGFYTEAAAIWRAAGEPYLEAPFEGMAGFMTRVAKRGVGAV
                     MAGMKMGTLHELAARHFKTDHLRQYVGRFATYTGASPYEASAAFALIPHIEHAYGVHHV
                     RGGIGALVDALGQAVRRLGMRIHLDTRVRFERTREGYQVGPQEGTERFDSVVVNADPLE
                     RLARAEEPVALSGFVLLLEVEGRMALPHHTVLFGGDYRREFDELFGGQLASDPTVYFCN
                     PSATDESMVPPGRTGLFVMVNAPALPVDARGREQATRDWEAGAERVKAQMLERLCRHYP
                     ALKGRVRVIGQRSPVDLAAQGAPGGSIYGFLPHGKFGPFRRPRIRGNTPGLFFAGGGTH
                     PGGGVPLVMLSGRFAAELASQHLRRDA"
     regulatory      6216..6220
                     /gene="ORF4"
                     /regulatory_class="ribosome_binding_site"
     gene            6226..7152
                     /gene="ORF5"
     CDS             6226..7152
                     /codon_start=1
                     /db_xref="GOA:Q50894"
                     /db_xref="InterPro:IPR010791"
                     /db_xref="UniProtKB/TrEMBL:Q50894"
                     /gene="ORF5"
                     /note="Homologous to neurosporene hydroxylase of
                     Rhodobacter capsulatus"
                     /product="neurosporene hydroxylase"
                     /protein_id="CAA79959.1"
                     /transl_table=11
                     /translation="MMRLAKLPALPDAAGTYRWFYADVTAGPYSAVCIFMLGSLFSPRY
                     SVAARRGGRPLEHSAVNFALYHAGVRRLWVLSEYARAELAAPGRLRIGRSTLSYEGDGT
                     VRMAVDDGTAPWGRPVRASLTLEPMTPVGEVVQLMPGLPHYWQALAPRSQARLEVSSLG
                     IEASGLGYHDTNHGGELLGARLSGWHWARTHREDETVVDYHLPEGVAPLRVVAGARGVR
                     CERGPTLVESRPTHITGWGLRVPSRLHAGNVVVGQPKLLESSPFYARLEARQGPLDSLG
                     EVADFRRFHSPFIRWMAHFRTRMGRAA"
     regulatory      7138..7142
                     /gene="ORF5"
                     /regulatory_class="ribosome_binding_site"
     gene            7149..8261
                     /gene="ORF6"
     CDS             7149..8261
                     /codon_start=1
                     /db_xref="UniProtKB/TrEMBL:Q50895"
                     /function="unknown"
                     /gene="ORF6"
                     /protein_id="CAA79960.1"
                     /transl_table=11
                     /translation="MSALVLASLAWCAVATGFSAVACVRLSRARAGAAPQPGAVPPVLL
                     LRPVDAPTPRELENLAQSIDYAGPLEQVVVSPYRPRLAPGVRWLPSEPLTPNRKVGHLL
                     YALDVLPVGDRVVLSVDADVAVTGALVEGLAVPVAAGPPEHRGLPVGPRDGASRAMAGL
                     LRYTHHSFRALDAMSAGAKAVCGKALGLSPVAVESLRRLADHIGEDLELAKRLHAQGLV
                     LSSAPAVVPLDAEVLWAAPLSRFTRWMQVLASHRPALYPTVPLLFTPTLPLAVLAAALG
                     SPVLAGSVVGLVAVRTLLALRLAGLHAPVADAGRAYAVTDWLLGEALLLAAFLRSLWRQ
                     GTVTWRGQTYVLRPGGRMIRVAPELSGGPG"
     regulatory      8247..8251
                     /gene="ORF6"
                     /regulatory_class="ribosome_binding_site"
     gene            8258..8644
                     /gene="ORF7"
     CDS             8258..8644
                     /codon_start=1
                     /db_xref="InterPro:IPR017825"
                     /db_xref="UniProtKB/TrEMBL:Q50896"
                     /function="unknown"
                     /gene="ORF7"
                     /protein_id="CAA79961.1"
                     /transl_table=11
                     /translation="MTYARFLGLFVVVPILFLAWRYRRTFTARSLAPMGLLLIVVYAAT
                     SPWDNLAVKWGLWGFDPERIWGIKLGYLPLEEYLFFALQTLLVGLWAQARLARALAPDA
                     QASRPAAETGERREGALTAREVAP"
     regulatory      8629..8633
                     /gene="ORF7"
                     /regulatory_class="ribosome_binding_site"
     gene            8641..8991
                     /gene="ORF8"
     CDS             8641..8991
                     /codon_start=1
                     /db_xref="InterPro:IPR017825"
                     /db_xref="UniProtKB/TrEMBL:Q50897"
                     /function="unknown"
                     /gene="ORF8"
                     /protein_id="CAA79962.1"
                     /transl_table=11
                     /translation="MMETKWAYLIHLLGWTLPVIAFQLVVLVRHYKERSGAVLKAVLPP
                     AFIMGLYLSIADHLAISTGIWNFGEGKHLGVYLGVVPLEEVVFFLITSVLVSLGLALFT
                     GLVALLGEARAS"
     regulatory      8973..8977
                     /gene="ORF8"
                     /regulatory_class="ribosome_binding_site"
     gene            8988..9665
                     /gene="ORF9"
     CDS             8988..9665
                     /codon_start=1
                     /db_xref="GOA:Q50898"
                     /db_xref="InterPro:IPR002123"
                     /db_xref="UniProtKB/TrEMBL:Q50898"
                     /function="unknown"
                     /gene="ORF9"
                     /note="gtg start codon"
                     /protein_id="CAA79963.1"
                     /transl_table=11
                     /translation="MIHAAKGGPLGWAWDRYIGWKFRSAFRGLWVRGALPPGGPGRLVY
                     LNHSNWWDGFVLNQLCQTAGWDGYCLMDEENLRRYRFLTRIGAFSIRRKDATSPVAPLR
                     YAKELLRKPRAVVFVFPEGEHRPFGVLPLRLERGVELLARVSKVECLPIAVRYGFFEHE
                     RPDVLLEVGTPHPPGDMSVFQEGLETVVRRLAAVTSMEGFTRRVSGARGVAERWDAARG
                     LAS"
     regulatory      9649..9653
                     /gene="carA"
                     /regulatory_class="ribosome_binding_site"
     gene            9649..9653
                     /gene="carA"
     gene            9662..10528
                     /gene="carA"
     CDS             9662..10528
                     /codon_start=1
                     /db_xref="GOA:Q50899"
                     /db_xref="InterPro:IPR000551"
                     /db_xref="InterPro:IPR006158"
                     /db_xref="InterPro:IPR009061"
                     /db_xref="UniProtKB/TrEMBL:Q50899"
                     /gene="carA"
                     /note="H-T-H domain to that of yehV of E.coli and merR (Hg
                     resistence) proteins. The C-terminal domain (amino acid
                     residues 79 to 288) contains a cobalamin-binding motif of
                     the type found in methionine synthase"
                     /product="transcriptional repressor of the light-inducible
                     carB operon"
                     /protein_id="CAA79964.1"
                     /transl_table=11
                     /translation="MTLRIRTIARMTGIREATLRAWERRYGFPRPLRSEGNNYRVYSRE
                     EVEAVRRVARLIQEEGLSVSEAIAQVKTEPPREQPEAERLRERFWSSVGALEGDEVTRV
                     LDDAQTVMDVEAYCDGFLLPLLREMGVRLDVAREHLASALIRQRLRQVYDALSPAPAGP
                     RALLACPSGDHHEGGLLVLGIHLKRKGWRVTMLGADTPAAALQGACVQVRPDVVALSFV
                     RARAPEEFASVLEDALRACAPFPVVVGGLGAREHLKAIFSLGAQYAESSEELVAIWNQV
                     RNAQNRP"
     gene            10544..11443
                     /gene="carH"
     CDS             10544..11443
                     /codon_start=1
                     /db_xref="GOA:Q50900"
                     /db_xref="InterPro:IPR000551"
                     /db_xref="InterPro:IPR003759"
                     /db_xref="InterPro:IPR006158"
                     /db_xref="InterPro:IPR009061"
                     /db_xref="UniProtKB/TrEMBL:Q50900"
                     /gene="carH"
                     /note="H-T-H domain similar to that of yehV of E.coli and
                     merR (Hg resistence) proteins. The protein C-terminal
                     domain (residues 83-299) contains a cobalamin-binding motif
                     of the type found in methionine synthase"
                     /product="CarH protein"
                     /protein_id="CAA79965.2"
                     /transl_table=11
                     /translation="MAERTYRINIAAELAGVRVELIRAWERRYGVLTPRRTPAGYRAYT
                     DRDVAVLKQLKRLTDEGVAISEAAKLLPQLMEGLEAEVAGRGASQDARPHAETWRESML
                     AATQAYDQPRVSDVLDEVLAALPPLKAFDEVLAPLLCDVGERWESGTLTVAQEHLVSQM
                     VRARLVSLLHAAPLGRHRHGVLACFPEEEHEMGLLGAALRLRHLGVRVTLLGQRVPAED
                     LGRAVLALRPDFVGLSTVASRSAEDFEDTLTRLRQALPRGLPVWVGGAAARSHQAVCER
                     LAVHVFQGEEDWDRLAGT"
ORIGIN
        1 ggatccgcgc cgcgcgtgcc gccgtagtag ccaatggcgg acgccgatac gaagcgccgc
       61 accgtgcccg cgccccgcat cgccgccacc agcgcgcgcg tgcccagcac ccggctgtcg
      121 tggatgcggt gcttgccttc gtgcgtccag cgctgggcca ccggctcgcc cgccaggtgc
      181 acgacggcct ccgcgtccgc cagcgcctcc gggggcaggg acgagccggc ggtaaagggc
      241 gcccccgtca cgccggcggg caggcgggcc agggcgtgtt caacgttccg ggccaggacg
      301 tggacctggt gtccacgctc cagcaaacct tggacaagcc ctggacccag gaagccggtc
      361 gcaccggtga cggccacctt cacggggagg gctccgaggg cgccgggctg ttcaggtcca
      421 cgcccaccag gcggctcagg acggcgaaga aggtcatcag ctcatccggc ttcatccggc
      481 cggagtgccg gtagaccagg gccccttcgg cgtccagcag cacgatgttg gacgttttca
      541 gcggcagctt ccacggcgcc tttcccagtg ctccatccat atccaccagg ataggcacgc
      601 ccaccttctt ctcctcgtcc cggacgaagg agagggcaat ctgccgggcc ggaaaaaagt
      661 cgaaattctg aaggtttgcg accgccagca cccaggccgc gtccaggatt ccgcgctcct
      721 gcccccgggc gaacagctcc ttcttcaggg tcgaattgag cttggtcgag tccttgtcct
      781 catagaacag gatgaccggc tttccgcgcc acttggagag ccggacctcc tttcccgcgg
      841 aggtgcgtaa cgtcgcgtcc accggctccg gggccggcgc cgcgcccagg gcgcttcccg
      901 ctgccagaga gatggagagc gcacctgcga tccacgcctt catgagggga cctctgtgta
      961 caaggttatc gcaaacctta gacataccct tgacaagctc tggacgcaaa cgctacctct
     1021 aggaaacaaa ggaacgggtt cttcggagga aagaagcatg gcactcacgc ttcccgatgc
     1081 gcagccgccg acgggcctgc ttcctctgga gcaggcctgg ctgcaactgg tccagacgga
     1141 ggtggagacc tcgctggcgg agttgttcga gctccccgac gaggccggcc tggacgttcg
     1201 ttggacacag gcactgacgc aggcccgggc gtataccttg cggcccgcca agcggctccg
     1261 ccccgcgctg gtgatggccg gacactgcct ggcgcgtggg agcgcggtgg tgccctccgg
     1321 gttgtggcgc ttcgccgcgg ggctggagct gctgcacacc ttcctcctca tccatgacga
     1381 cgtggcggat caggcggagc tgcggcgggg cgcgccgccc ctccaccgga tgctggcgcc
     1441 aggacgcgcg ggcgaggacc tggccgtggt ggtgggggac cacctcttcg cgcgcgccct
     1501 ggaggtcatg ctgggctcgg ggctgacgtg cgtcgcgggc gtggtgcagt actacctggg
     1561 cgtgtccggt cacacggcgg ccgggcagta cctggacctg gacctgggcc gcgcgccgct
     1621 ggcggaggtg acgctcttcc agacgctgcg cgtggcgcat ctcaagacgg cgcgctacgg
     1681 cttctgcgcc ccgctggtgt gcgcggccat gctcggcggt gccagcagcg gcttggtgga
     1741 ggagttggag cgcgtgggcc gtcacgtcgg tcttgcctac cagcttcggg acgatttgct
     1801 gggccttttt ggtgattcga acgtcgctgg caaggccgct gacggcgact tcctccaagg
     1861 caagcgaacc tttccagtgc tggccgcctt cgcgcgcgcc accgaggccg agcgcacgga
     1921 gctggaggcg ctgtgggcgc tgccggtgga gcagaaggac gccgccgcgc tggcgcgggc
     1981 ccgcgcgctg gtggagtcct gcggaggccg ggccgcgtgt gagcgcatgg tggtgcgtgc
     2041 ctccagggcc gcccgccgct cgttgcagtc gctgcccaat cccaacggtg tgagagagct
     2101 gctcgacgcg ctcatcgccc ggctggccca ccgcgccgcc tgaggacgcc atgagtgcat
     2161 cgacacaggg caggcgcatc gtggtggtgg gcgcgggcgt gggcgggctg gccgccgctg
     2221 cccggctggc gcaccagggc ttcgacgtcc aggtcttcga gaagacgcag ggaccgggtg
     2281 ggcgctgcaa ccgattgcag gtggatggct tcacgtggga cctgggcccc accatcgtgc
     2341 tgatgccgga ggtgttcgag gagaccttcc gcgcggtggg ccgccgcatc gaggactacc
     2401 tgacgctgct caggtgcgac ccgaactatc gggtccactt ccgggaccgt tcggatgtca
     2461 ccttcacgtc agagttgtgc gccatgggcc gagagttgga gcgcgtggag cccggcagtt
     2521 acgcgcgcta cctcgccttc ctggcccagg gccgcgtcca gtatcgaacg agcctggacc
     2581 acctggtggg gcgcaactac gcgggcctgc gtgactacct ctcgccgcgc gtgctcgcgc
     2641 gcatcttcca ggtccgcgct caccgccgaa tgtacgcgga cgtcagccgc ttcttccagg
     2701 acgagcggct gcgcgcggcg atgaccttcc agacgatgta cctgggcgtg tcaccctacg
     2761 cgtcgcccgc ggtgtacggc ctgctgccct tcaccgagct gggtgtgggc atctggttcc
     2821 cgaagggcgg cctgtatgcc attccccagg ccctggagcg gctggcgcgc gaggagggtg
     2881 tgcgcttcca ctacggcgcg cccgtggagc gcatcctcac cgatggcggc cggactcgag
     2941 gcgtgcggct ggagggcggc gaggtggtgg aggcggacgc ggtgctgtgc aacgcggacc
     3001 tgccctacgc gtacgagaag ctgctggacc cgaaggcgac gacgctcaag cgcaaggaga
     3061 agctgcgcta cacgtccagc ggctacatgc tctatctggg catgaagcgg cgctacccgg
     3121 agctcttgca ccacaacgtg gtgttcggcc gggactacaa gggctccttc gacgacatct
     3181 tcgagttccg cgtgccagag gaccccagct tctacgtcaa cgcgcccacg cgcaccgacg
     3241 cgtccctggc gcccgagggc aaggatgcgc tctatgtgct ggtgcccgtg ccgcaccagc
     3301 acccggacct ggactggaag gtggaggggc cgaaggtgcg cgcgaagttc ttcgcgcgca
     3361 tggcggagct gggcttcccg tcgctggagt cggacatcga ggtggagcgg cggtcttcca
     3421 ccccggatga ctgggccggc accttcaacc tggcgcgtgg cagcggcttc ggtctgtccc
     3481 agaacttcac gcagattggc cccttccgtc cgtccaacca ggacgcgcgg gtgaagaacc
     3541 tcttcttcgt cggtgcttcc acgcagccgg gaacggggct gcccacggtg ctcatctccg
     3601 cgcggctggt gacggagcgg ctgatgacgt gggcccacgc gcagggcgtt tcgttgtcgc
     3661 ctcggacggc cgccgccacg ccactggaag gggtggccgc gtgagcccgc ctgtcgacaa
     3721 ggcgctggtg gcgcgcggct atgtgctggc gaagcaggtg acgcgccatc acgccaagag
     3781 cttcttcttc gcctcgtacc tgctcttcgg cctgcgccgg agggcggcgt tcgcgctcta
     3841 cgccttctgc cggcgcctgg acgacatggt ggacggggac gacgcggcga gcgcggccga
     3901 tgcgttgccg gtgcggctgg cgcgggcgcg gcagcgcgtg gcggagctgt acctgcccat
     3961 gccggagctg gcctcgcgcg agctggggcc gcccgcggac cgggtgaagg gcagcgaggc
     4021 cgcgacgccg tgggacgcgc gggagttcgc tgcgctcgag cacacggtgc gccacttccg
     4081 gattccggag cagcccttcc aggacctcat ctccggcatg gagatggacc tgacgaagca
     4141 ccgctacgcc acctgggagg agctggacct ctactgctac cgggtggcgg gcgtggtggg
     4201 gctgatgctg acgccggtgc tggggtgctc ggacgcggcg gcggtggagc ccgcggccga
     4261 cctgggccgg gccatgcagc tcaccaacat cctccgcgac gtgcgcgagg acctggagcg
     4321 cggccgggtg tacctgcccg cggaggagtt ggccgccttc ggattgtcgg aggacgactt
     4381 gcggcgcgga caggtgggcg cgcgctggcg gtccttcatg cgcttccagg tggagcgctc
     4441 gcgggcgtac tacgcgcggg cggcggccgg ggtgcgctac ctgacgggct tcggcagtca
     4501 gcggatggtg cggctgatgg gcgccatcta cgccgacatc ctgcgcgaca tcgaagcgcg
     4561 cgactacgac gtgttcagcg cccgggccca cgtgacgacg cgccgcaagc tcgcgctggc
     4621 ttccgcggcc atggtgcggc ccgccgcggt gctgcccgcc ccccagggcg aggtgcgcat
     4681 gccgctgctt cccaccgggg cgggagggtg agggcgtcat gcgtggcgag ggaatgaaga
     4741 cggagcttcg gcggcgcatg ggaggtggag catgaagcgc acccgcgtcg cggtggtagg
     4801 cggcggcatc ggtggactga cggccgccgg gctgttggcg aaggacgggc atgaggtgac
     4861 gctgttcgag cggggcgcct cgctgggcgg caaggcccag gccgtcatcg tgaatggcat
     4921 caccctggac acggggccca cgttgctgac gctgccgcac ctggtgcgtg gcaccttcca
     4981 gcaactgggc gccgaggacc tgctgccgcg cttcacggag ctggagccgc agtgtgccta
     5041 ccgcttcgag gacgggtgtg acttcacggc ctacaaggac gtggagcgga tggcggagag
     5101 cgcggcgggt gtccgcccgg gtgagcgcga cggcatccgc ggcttctaca cggaggccgc
     5161 ggccatctgg cgggccgcgg gcgagccata cctggaggcc cccttcgagg gcatggcggg
     5221 cttcatgacg cgcgtggcga agcgtggcgt gggggccgtc atggcgggga tgaagatggg
     5281 cacgctgcac gagctggcgg cccggcactt caagacggac cacctgcggc agtacgtggg
     5341 ccgcttcgcc acgtacacgg gcgcgtcccc ctacgaggcc agcgcggcct tcgcgctgat
     5401 tccccacatc gagcatgcct atggcgtgca ccacgtccgc ggcggcatcg gtgcgctggt
     5461 ggacgcgctg gggcaggccg tgcgccggct gggcatgcgc atccacctgg acacgcgggt
     5521 tcgcttcgag cgcacgcgcg agggctacca ggtgggcccg caggagggca cggagcgctt
     5581 cgacagtgtg gtggtgaacg cggacccgct ggagcggctc gctcgcgcgg aggagcccgt
     5641 ggcgctgtct ggcttcgtgt tgctgttgga ggtggagggc cgcatggctc taccgcacca
     5701 cacggtgctc ttcggcggtg actaccggcg cgagttcgac gagctgttcg gcgggcagct
     5761 cgcgtccgac ccgacggtgt acttctgcaa cccctccgcc accgacgaga gcatggtgcc
     5821 tccgggccgc accgggttgt tcgtcatggt gaacgcgccc gcgctgcccg tggatgcgcg
     5881 cggccgggag caggccaccc gcgactggga agcaggcgcc gagcgcgtga aggcgcagat
     5941 gctggagcgc ctgtgccggc actacccggc gctcaagggg cgcgtgcgtg tcatcggcca
     6001 gcgctcgccg gtggacctgg ccgcgcaggg cgctccgggc ggctccatct acggcttcct
     6061 gccgcacggg aagttcggcc ccttccgccg accgcgcatc cgcggcaaca cgccgggcct
     6121 gttcttcgcg ggcggtggca cgcatccagg cggcggcgtg ccgctggtga tgttgtccgg
     6181 tcgcttcgcc gcggagctgg cttcgcagca cctccggagg gatgcatgat gcgcctggcg
     6241 aaactccccg ccctgccgga cgcggcgggc acctaccgct ggttctatgc ggacgtcacc
     6301 gcgggaccct acagcgcggt gtgcatcttc atgctgggct cgctgttctc gccccggtac
     6361 tcggtggcgg cgcggcgggg cggacggccg ctggagcaca gcgcggtgaa cttcgcgctg
     6421 taccacgcgg gggtgcggcg gctgtgggtc ctcagcgagt acgcgcgcgc ggagttggct
     6481 gctccgggcc ggctgcgcat cggtcgctcc acgctgtcgt acgaggggga cggcacggtg
     6541 cggatggccg tggacgacgg gacggcgccg tggggccggc ccgtgcgcgc gagcctgacg
     6601 ctggagccga tgacgcccgt gggcgaggtg gtgcagctca tgccggggct gccgcactac
     6661 tggcaggcgc tggcgcctcg ttcgcaggca cggctggagg tgtcctcgct gggcatcgag
     6721 gcgagcggcc tgggctacca cgacaccaac cacggcggag agctgctggg cgcgcggttg
     6781 tcggggtggc actgggctcg cacgcaccgc gaggacgaga cggtggtgga ctaccacctg
     6841 cctgaaggtg tcgcgccgct gcgagtggtg gccggcgcgc gcggagtgcg ctgcgaacgg
     6901 ggccccacgt tggtggagtc gcggcccacc cacatcaccg gctggggcct gcgcgtgccg
     6961 tcacgcctgc acgcgggaaa cgtggtggtg ggacagccga agctgctgga gtcgtcgcct
     7021 ttctatgcac gactggaggc gcgccagggg cctctggact ccctgggcga ggtggcggac
     7081 ttccgtcgct tccactcgcc cttcatccgc tggatggcgc acttccgcac gcgcatggga
     7141 cgggcggcat gagcgcgctc gtcctcgcgt ccctggcgtg gtgcgccgtg gccacgggct
     7201 tcagcgcggt ggcgtgcgtg cgtctgtcgc gcgcgcgggc tggcgctgct ccccagcccg
     7261 gcgccgtgcc gccagtgttg ctgctgcgcc cggtggacgc gcccacgcct cgagagctgg
     7321 agaatctggc gcagtccatc gactacgccg ggccgttgga gcaggtggtg gtgtcgccct
     7381 accgtccccg gctcgccccg ggcgtgcggt ggcttccgag cgagccgctg acgcccaacc
     7441 ggaaggtggg acacctgctt tatgcgctgg atgtgttgcc cgtgggcgac cgggtggtgc
     7501 tgtcggtgga cgcggacgtg gcggtgacgg gcgcgctggt ggaaggcctg gccgtgccag
     7561 tggccgcggg gccgcctgag caccgcggcc tgccagtagg gcctcgggac ggcgcgagcc
     7621 gggccatggc gggcctgctg cgttacaccc accacagctt ccgggccctg gatgcgatga
     7681 gcgcgggcgc caaggccgtg tgtggcaagg ctttgggctt gtctcccgtg gccgtggagt
     7741 cgctgcggcg gctcgcggac cacatcggcg aggacctgga gctggccaag cgtcttcacg
     7801 cccagggact ggtgctgagc agcgccccgg cggtggtccc cctggacgcc gaggtgctct
     7861 gggcggcgcc cctgtcgcgc ttcacgcgct ggatgcaggt actggccagt caccggcccg
     7921 cgctgtatcc cacggtgccg ctgctcttca cgccgacgct gccgctggcg gtgctggccg
     7981 cggcgctggg gtcgcccgtg ttggcgggct cggtggtggg attggttgcc gtgcgaacct
     8041 tgctggcgct tcgattggcc gggctccacg cgccggtggc ggacgcgggg agggcctatg
     8101 cggtgacgga ctggttgttg ggcgaagcgc tcttgcttgc ggccttcctg cgctcgctgt
     8161 ggcggcaggg aacggtgacg tggcgggggc agacctatgt gttgcgaccc gggggccgaa
     8221 tgatacgggt ggctccggag ctgagtggag gacccggatg acgtacgcgc gattcctcgg
     8281 gctgttcgtg gtggtgccca tactcttcct ggcgtggcgc taccgccgca ccttcacggc
     8341 caggagcctg gcgcccatgg ggctcctgct catcgtcgtg tacgcggcga cgtcgccctg
     8401 ggacaacctg gcggtgaagt ggggcctgtg gggtttcgac cccgagcgca tctggggcat
     8461 caagctgggg tacctgcctc tggaggagta cctcttcttc gcgctgcaga cgctgttggt
     8521 ggggctgtgg gcccaggccc ggctggcgcg tgcgctggcg ccggatgccc aggcgtctcg
     8581 gcccgcggcg gagacgggtg agcgccgcga aggcgcgctg acggctcggg aggtggcgcc
     8641 atgatggaga cgaagtgggc atacctcatc cacctgttgg gctggacgct gccggtcatc
     8701 gccttccagt tggtggtgct ggtgcgccac tacaaggaac gctccggcgc ggtgctcaag
     8761 gcggtgctgc cgccggcctt catcatgggg ctgtacctgt ccatcgcgga ccacctggcc
     8821 atctccaccg gcatctggaa ctttggtgaa ggcaagcacc tgggcgtgta cctgggcgtg
     8881 gtgccgctgg aagaggtggt cttcttcctg attaccagcg tgttggtgtc gctgggcctg
     8941 gcgctgttca ccgggttggt ggcgctgctg ggggaggccc gggcgtcgtg attcacgcgg
     9001 cgaaaggagg cccgctgggc tgggcgtggg accggtacat cggatggaag ttccgctcgg
     9061 cgttccgggg attgtgggtg cgtggggcgc ttccgccggg agggccgggc cggctggtgt
     9121 acctgaacca ctccaactgg tgggacggct tcgtgctcaa ccagctctgc cagacggcgg
     9181 gttgggacgg ctactgcctc atggatgagg agaacctgcg ccgctaccgc ttcctcacgc
     9241 gcattggcgc cttcagcatc cggcgcaagg acgcgacgtc gccggtggcg ccgctgcgct
     9301 acgcgaagga gttgctgcga aagccccgcg cggtggtgtt cgtcttcccg gagggcgagc
     9361 accgcccctt cggcgtgctc ccactgcgac tggagcgggg cgtggagcta ctggcgcggg
     9421 tgtcgaaggt ggagtgcctg cccatcgcgg tgcgctacgg cttcttcgaa cacgagcgtc
     9481 cagacgtgtt gctggaggtg ggcaccccgc atccgcccgg tgacatgtcc gtcttccagg
     9541 agggattgga gacggtggtg cggcgactgg cggcggtgac gtccatggag ggcttcacgc
     9601 gcagggtgtc cggtgcgcga ggcgtggcgg agcgctggga cgcggcccgg gggctggcgt
     9661 catgacgttg cgcatccgca ccatcgcgcg catgacgggc atccgcgagg cgacgctgcg
     9721 cgcctgggag cggcgctacg gtttcccgcg tccgctgcgc agcgaaggca acaactaccg
     9781 cgtctattcg cgcgaggagg tggaggccgt ccgccgtgtg gcccggctca tccaggagga
     9841 aggcctgtcg gtgagcgagg ccatcgccca ggtgaagacg gagccgccgc gtgagcagcc
     9901 cgaagccgag cgcctgcgcg agcgcttctg gtcctccgtg ggggccctgg aaggggacga
     9961 ggtgacgcgc gtgctggatg acgcacagac cgtcatggac gtggaggcct actgtgacgg
    10021 cttcctgctg cccctgctgc gggagatggg cgtgcggctg gacgtcgcgc gggagcacct
    10081 ggcctccgcc ctcatccgcc agcgcctgcg gcaggtgtat gacgcactgt cccccgcgcc
    10141 tgccggcccc cgtgcgctgc tcgcctgtcc gtcaggggac caccatgaag gcggcctgct
    10201 ggtgctgggc atccacctca agcgcaaggg gtggcgggtg acgatgctgg gcgcggacac
    10261 cccggcggcg gcgctgcagg gggcttgcgt gcaggttcgg ccggacgtgg tggcgctgtc
    10321 cttcgtgcgc gcccgtgcgc cggaggagtt cgcgtccgtc ctggaagacg cgctccgggc
    10381 ctgcgcgccc tttcccgtgg tcgtcggcgg gctgggggct cgcgagcacc tgaaggccat
    10441 tttctcgctc ggcgcgcagt acgcggagtc atcggaagag ctggtggcca tctggaacca
    10501 ggtgcgcaac gctcagaatc gcccgtagtc ttgccgtagc gacatggctg agcgcaccta
    10561 tcgaatcaac atcgccgcgg agttggcagg agtccgggtg gagctcatcc gggcctggga
    10621 gcgccgctac ggcgtgctca cgccgcgccg cacccccgcg ggctaccgcg cctatacgga
    10681 ccgggacgtg gcggtgctca agcagctcaa gcggttgacc gacgaaggcg tggccatcag
    10741 cgaagcggcg aagctgctgc ctcagttgat ggaggggctg gaggcggaag tcgcggggcg
    10801 gggtgccagc caggacgcgc ggccgcatgc ggagacgtgg cgggagtcca tgctcgccgc
    10861 cacccaggcg tatgaccagc cgcgcgtgtc ggacgtgctc gacgaggtgt tggccgcgct
    10921 gcccccgctc aaggccttcg atgaggtgct ggcgcccctt ctctgcgacg tgggcgagcg
    10981 ctgggagtcg ggcacgctga cagtggcgca ggagcacctg gtgtcgcaga tggtgcgggc
    11041 gcggctggtg agcctgctgc acgcggcgcc cctggggcgg caccggcatg gtgtcctggc
    11101 gtgctttccg gaagaggagc acgagatggg cctgctggga gcggcgctgc ggctgcggca
    11161 cctgggcgtg cgggtgacgc tgctggggca gcgcgttccc gcggaggacc tgggccgcgc
    11221 ggtattggcg ctgcggcccg acttcgtggg gctgtccacg gtggccagcc ggagcgcaga
    11281 ggacttcgag gacaccctga cgcgtttgag gcaggcgctg cccagggggc tgcccgtctg
    11341 ggtgggcggc gccgccgcgc gctcgcacca ggccgtgtgc gagcggttgg cggtgcacgt
    11401 cttccagggc gaggaggact gggaccgcct cgcgggtacg tgagtcaggg cgtgttgatg
    11461 gcggagtgat tgaagacgcg gctgccgtag tactgggcgg cctcctctgc gttgtcgcaa
    11521 atctccgcgc acttgcccgg ggcgtagggc gtgttcgggt ccctgcaatc gttcacgatg
    11581 ttgccgttcg catcgtagat ggggggattg agcggcacgc agggcgcggt caaggtgctt
    11641 ccagcgcagg tggctgaggc acgcggggcc cgcggtgttc caacccgcct cgaaggtcag
    11701 gtcattcgag ctggagtccg gcgagggcgc ggagatgatg gccggcgtca gggcgtccca
    11761 gggacggatg cgggtgccgt ccagggtgaa ggacgttccc tggccgcagt agtcggcgcg
    11821 cgccatgcgg gtgcaggacc agtgagcctc ggtgaatggg cccggatgtc gcgccgtcca
    11881 gccaccgggt ggtagcccca gcggtagcac ttggcgatga cgcccgcgat cacagcccag
    11941 cgtgaaggcc cgggggctct cgtaccggtc gccctgcag
//
