BGC0000668: 12-epi-hapalindole C isonitrile biosynthetic gene cluster from Hapalosiphon welwitschii UTEX B 1830
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Location: 1 - 36,570 nt. (total: 36,570 nt).
This entry is originally from NCBI GenBank KF811479.1.

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General
Compounds
Genes
Terpene
History
KnownClusterBlast
General information about the BGC
MIBiG accession BGC0000668
Short description 12-epi-hapalindole C isonitrile biosynthetic gene cluster from Hapalosiphon welwitschii UTEX B 1830
Status Minimal annotation: no
A minimal annotation only contains information on the BGC loci and one or more linked chemical product(s)

Completeness: complete
Whether the loci encodes everything needed for the pathway producing the compound(s)
Biosynthetic class(es)
  • Terpene (Monoterpene/Unknown)
  • Alkaloid
Loci NCBI GenBank: KF811479.1
Compounds
  • 12-epi-hapalindole C isonitrile
  • 12-epi-hapalindole E
  • 12-epi-fischerindole U isonitrile
  • fischerindole L
  • 12-epi-fischerindole I isonitrile
  • welwitindolinone A isonitrile
  • welwitindolinone B isothiocyanate
  • welwitindolinone C isothiocyanate
  • N-methylwelwitindolinone C isothiocyanate
  • N-methylwelwitinsolinone C isonitrile
  • 3-epi-welwitindolinone B isothiocyanate
  • 3-(Z-2'-isocyanoethenyl)-indole
Species Hapalosiphon welwitschii UTEX B 1830 [taxonomy]
References
Chemical products information
12-epi-hapalindole C isonitrile
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C21H24N2
Chemical database entries
NPAtlas
12-epi-hapalindole E
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C21H23Cl1N2
Chemical database entries
NPAtlas
12-epi-fischerindole U isonitrile
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C21H24N2
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NPAtlas
fischerindole L
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C21H23Cl1N2
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NPAtlas
12-epi-fischerindole I isonitrile
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C21H21Cl1N2
Chemical database entries
NPAtlas
welwitindolinone A isonitrile
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C21H21Cl1N2O1
Chemical database entries
NPAtlas
ChemSpider
welwitindolinone B isothiocyanate
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C21H21Cl1N2O2S1
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NPAtlas
welwitindolinone C isothiocyanate
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C21H19Cl1N2O2S1
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NPAtlas
N-methylwelwitindolinone C isothiocyanate
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C22H21Cl1N2O2S1
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NPAtlas
N-methylwelwitinsolinone C isonitrile
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C22H21Cl1N2O2
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NPAtlas
3-epi-welwitindolinone B isothiocyanate
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C22H23Cl1N2O2S1
Chemical database entries
NPAtlas
3-(Z-2'-isocyanoethenyl)-indole
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C11H8N2
List of genes involved in compound(s) production
Identifiers Position Product Functions Evidence Extra
  • AHI58816.1
 126 - 998 (-) halogenase, 2OG-Fe(II) oxygenase family
  • Tailoring (Halogenation)
Activity assay
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  • AHI58817.1
 1779 - 2822 (-) N-methyl transferase
  • Tailoring (Methylation)
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  • AHI58818.1
 2892 - 3572 (-) Unknown
  • Unknown
Sequence-based prediction
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  • AHI58819.1
 3593 - 4672 (-) Rieske oxygenase
  • Scaffold biosynthesis
Sequence-based prediction
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  • AHI58820.1
 4840 - 5928 (-) Rieske oxygenase
  • Scaffold biosynthesis
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  • AHI58821.1
 6124 - 7197 (-) Rieske oxygenase
  • Scaffold biosynthesis
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  • AHI58822.1
 7404 - 8486 (-) Rieske oxygenase
  • Scaffold biosynthesis
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  • AHI58823.1
 8668 - 9354 (-) Unknown
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  • AHI58824.1
 9427 - 10686 (-) 4-hydroxy-3-methylbut-2-enyl diphosphate reductase(IspH)
  • Other enzymatic
Sequence-based prediction
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  • AHI58825.1
 10723 - 11727 (-) geranyl diphosphate synthase
  • Precursor biosynthesis
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  • AHI58826.1
 13352 - 14056 (+) LuxR family transcriptional regulator
  • Regulation
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  • AHI58827.1
 14278 - 15009 (-) LuxR family transcriptional regulator
  • Regulation
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  • AHI58828.1
 15577 - 16668 (+) putative two component response regulator
  • Regulation
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  • AHI58829.1
 16776 - 17420 (-) phosphoglycerate mutase family protein
  • Precursor biosynthesis
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  • AHI58830.1
 17445 - 18542 (-) anthranilate phosphoribosyltransferase (TrpD)
  • Precursor biosynthesis
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  • AHI58831.1
 18567 - 19814 (-) tryptophan synthase subunit beta (TrpB)
  • Precursor biosynthesis
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  • AHI58832.1
 19954 - 20778 (-) tryptophan synthase subunit alpha (TrpA)
  • Precursor biosynthesis
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  • AHI58833.1
 20861 - 21724 (-) indole-3-glycerol phosphate synthase (TrpC)
  • Precursor biosynthesis
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  • AHI58834.1
 21867 - 24071 (-) anthranilate synthase (TrpE)
  • Precursor biosynthesis
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  • AHI58835.1
 24125 - 25030 (-) 3-deoxy-D-arabinoheptulosonate 7-phosphate (DAHP) synthase
  • Precursor biosynthesis
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  • AHI58836.1
 25171 - 26397 (-) 4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase (IspG)
  • Precursor biosynthesis
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  • AHI58837.1
 26470 - 28413 (-) 1-deoxy-D-xylulose-5-phosphate synthase (DXS)
  • Precursor biosynthesis
Sequence-based prediction
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  • AHI58838.1
 28667 - 29593 (-) aromatic prenyl transferase
  • Scaffold biosynthesis
Activity assay
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  • AHI58839.1
 29910 - 30731 (-) isonitrile indole synthase B (IsnB)
  • Scaffold biosynthesis
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  • AHI58840.1
 30728 - 31723 (-) isonitrile indole synthase A (IsnA)
  • Scaffold biosynthesis
Activity assay
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  • AHI58841.1
 32131 - 33102 (-) isonitrile indole synthase A (IsnA)
  • Scaffold biosynthesis
Activity assay
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  • AHI58842.1
 33386 - 33895 (+) transposase
  • Unknown
Sequence-based prediction
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  • AHI58843.1
 33931 - 34446 (+) transposase
  • Precursor biosynthesis
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  • AHI58844.1
 34708 - 35877 (-) 1-deoxy-D-xylulose 5-phosphate reductoisomerase (IspC, Dxr)
  • Precursor biosynthesis
Sequence-based prediction
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  • AHI58845.1
 35993 - >36568 (-) dephospho-CoA kinase-like protein
  • Precursor biosynthesis
Sequence-based prediction
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Terpene-specific information
Carbon count subclass Monoterpene
Structural subclass Unknown
Isoprenoid precursor GPP
Prenyltransferases AHI58838.1, AHI58825.1
Annotation changelog
MIBiG version Submitter Notes
1.0
  • Hidden contributor (ID: XU7PTWDFW5UJ7GLIWVSFLQRF, no GDPR consent given).
  • Submitted
2.0
  • Hidden contributor (ID: AAAAAAAAAAAAAAAAAAAAAAAA, no GDPR consent given).
  • Migrated from v1.4
  • Updated compound(s) information (NPAtlas curation)
3.0
  • Hidden contributor (ID: AAAAAAAAAAAAAAAAAAAAAAAA, no GDPR consent given).
  • Fixed incorrect prenyltransferase identifiers
  • Updated bioactivity data
3.1
  • Hidden contributor (ID: AAAAAAAAAAAAAAAAAAAAAAAA, no GDPR consent given).
  • Update chemical activity to schema version 2.11
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