LOCUS       BGC0000676             15629 bp    DNA     linear   PLN 18-MAR-2021
DEFINITION  Neocamarosporium betae PbGGS, ACS, PbP450-1, PbTP, PbP450-2, PbTF
            genes for geranylgeranyldiphosphate synthase, aphidicolan-16b-ol
            synthase, P450 monooxygenase 1, transporter protein, P450
            monooxygenase 2, transcription factor, complete cds.
ACCESSION   BGC0000676
VERSION     BGC0000676
KEYWORDS    .
SOURCE      Neocamarosporium betae
  ORGANISM  Neocamarosporium betae
            Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina;
            Dothideomycetes; Pleosporomycetidae; Pleosporales; Pleosporineae;
            Pleosporaceae; Neocamarosporium.
COMMENT     ##antiSMASH-Data-START##
            Version      :: False
            Run date     :: 2022-11-07 20:14:19
            NOTE: This is a single region extracted from a larger record!
            Orig. start  :: 0
            Orig. end    :: 15629
            ##antiSMASH-Data-END##
FEATURES             Location/Qualifiers
     source          1..15629
                     /db_xref="taxon:1979465"
                     /mol_type="genomic DNA"
                     /organism="Neocamarosporium betae"
     subregion       1..15629
                     /aStool="mibig"
                     /contig_edge="True"
                     /label="Terpene"
                     /subregion_number="1"
                     /tool="antismash"
     region          1..15629
                     /contig_edge="True"
                     /product="unknown"
                     /region_number="1"
                     /subregion_numbers="1"
                     /tool="antismash"
     gene            complement(622..1653)
                     /gene="PbGGS"
     CDS             complement(622..1653)
                     /codon_start=1
                     /gene="PbGGS"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     terpene: fung_ggpps"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1182:Polyprenyl synthetase (Score: 222.7; E-value:
                     9e-68)"
                     /gene_kind="biosynthetic"
                     /product="geranylgeranyldiphosphate synthase"
                     /protein_id="BAD29970.1"
                     /sec_met_domain="fung_ggpps (E-value: 1.2e-138, bitscore:
                     449.2, seeds: 66, tool: rule-based-clusters)"
                     /transl_table=1
                     /translation="MAYTVEPREHSKNTTLPTVAMPPSPPSSFSASFGPFRYDTKEVNF
                     DHWTSTKEKVVTGPYDYIAAKPGKEVRTLLLACFDEWLQVPPESLEVIGQVVRMLHTAS
                     LLIDDIQDNSELRRGKPVAQNIFGTALTINSANYVYFLALEKLNSLKNPNITDIFTEEL
                     LRLHRGQAMDLYWRDTLTCPTEEEYFEMVANMTGGLFWLMYRMMNAESSMPIDLLPVVE
                     LLGVIFQVLDDYKNLCSREYGKLKGFGEDLTEGKFSFPVIHSIRSNPEDLQLLHVLQQK
                     SSNEHVKLYAIEIMESTGSLEYTKHVVENIVSQIQEIIYSTDEGQGRGKGILDLLHKIT
                     RLS"
     gene            3293..6300
                     /gene="ACS"
     CDS             join(3293..4120,4181..4301,4359..4645,4702..6300)
                     /codon_start=1
                     /gene="ACS"
                     /product="aphidicolan-16b-ol synthase"
                     /protein_id="BAD29971.1"
                     /transl_table=1
                     /translation="MVPISTRSEVQDGLIAQARSLITRIVHNSDDVYGFGTLSCTVYDT
                     AWVALVTKHVNGIKHWLFPESFHYILASQCDDGTWCEDKTAQFDGVLNTIAGLLVLKRY
                     RRDPLQLKVDNRDLDSRIKLATSALHSLLEEWDVSTTNNVGFEIIVPTMLDLLVQEDPS
                     LSFELKGREALTEIREAKMNRFQPELLYQGKLMTLTHSLEALLGRIDYDNVARYTVKGS
                     MFASPSSTAAYLMSASTWDDEAETYLRYTITASTGKGSGGVPGVFPTTYFEYTWILSTL
                     FRAGFQSSELDSPELTAMTDTLLKAFKAFSGAIGLDSGIEPDVDDSAKIVTTLNMLGKP
                     AHARYLCDNFEVETHFRVYPRERDPSFSANCNALAAFLHQPDVEVYSSQILKAASYLCE
                     RMWNADEKIDDKWNKSHLYSSFLYTQVMTDLMAITEAGRLDGVFTKELLTRVCVTIFQS
                     CLRAMLKQSHDGSWNQSLEETAYAILHLTEARRLCFFEQISEPLENSIYRGITFLTTID
                     KPPMEYLWSDKVSYGSAYLAETYVLAARRAAESTSVTNLVGFSIWKDNASTKMHKLVGL
                     FHRTPLLKALPKWELQASMIEASIYQGLLQDARLEVLQRPKVDGGEYLSIIPFTWTSCS
                     NSARTNASASHLWELMALSFFTYQVDEFMEAVAGPAFKGRMTHLHAIIDEAVHCSQNRE
                     RTPGECENTNHVTSELLQAVRFILDNPTVRKASPYDRNTLLQELRIFLHAHVTQVEDNA
                     SFGRERLTGDKALTSYRSQLYRWVHTISSDHIAGPFCFYYATCLLGATLTAHPPNDCFP
                     KSSQKYLAAATCRHLSCMCRMYNDIGSWNRDHREGNLNCLHFPEFSETTSDDAERKASL
                     LTLAQYERKQWCNALQQLEKEMVHGASEPAAARLAKRRACLIDMFCKVTDLYGQIYVLR
                     DVSSVIKDVVRNGE"
     gene            6699..8429
                     /gene="PbP450-1"
     CDS             join(6699..6740,6802..7584,7641..7949,8045..8211,
                     8270..8429)
                     /codon_start=1
                     /gene="PbP450-1"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) p450"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1034:cytochrome P450 (Score: 318.2; E-value: 1.5e-96)"
                     /gene_kind="biosynthetic-additional"
                     /product="P450 monooxygenase 1"
                     /protein_id="BAD29972.1"
                     /sec_met_domain="p450 (E-value: 8.3e-65, bitscore: 207.9,
                     seeds: 50, tool: rule-based-clusters)"
                     /transl_table=1
                     /translation="MSHFLPTLILTSLTLVAYVLARMIYNVFYHPLSAFPGDAFFCATG
                     LTKAYHMIAGDLQLKVKDMHDKYGSVVRIAPTELSFSYCSAWKDIYGSRGGRELSKFYD
                     FYRVDEAMPQHIISAGKAKHSILRRYLAHGFSENAMKAQEPVILDLVNLLMQRLREHAE
                     EGARVVDVNKWFNFATFEIIGKLTFGADLGNLRNRDWHPWVKGSANNNMVVGFMAAANS
                     VGLGPIIKWCISNEILPRQKYLDELAEMVQKRTGVTVERPDFIQGLLRDDVQLSNGEIV
                     ANVEALIGAGSESTATLLTGTVCALLQNPDQLAKVIDEVRSTFRTEDEITLHSVQRLDY
                     MLACLNETFRYYPPVTNGMPRVTPKEGAIIGGRLVPGNTVVAIWQWAICHDPALWKDPY
                     TFRPERFLEAPEFSTDVREALNPFSVGTRNCIGRNLSYAETRLILARLFYYFDLELADP
                     DQDWFGAQKAYLVWDAPALNMYLKPVVR"
     gene            complement(8957..10846)
                     /gene="PbTP"
     CDS             complement(join(8957..10091,10157..10406,10472..10551,
                     10617..10846))
                     /codon_start=1
                     /gene="PbTP"
                     /gene_functions="transport (smcogs) SMCOG1005:Drug
                     resistance transporter, EmrB/QacA (Score: 354.6; E-value:
                     1e-107)"
                     /gene_kind="transport"
                     /product="transporter protein"
                     /protein_id="BAD29973.1"
                     /transl_table=1
                     /translation="MHPDQADTAAMQQQTTTECSDRSRPEKAEEGHAREHTVTRTCSRE
                     PEQTATATKPTGLKLICLTTAICLTIFLISVDFSILATAIPAITAEFKSVADIGWYGSS
                     YLLTTASSQLLLGKCYTVFDLKWTFLLALLTFEVGSIICATAPSSVVLIIGRAIAGCGN
                     AGLLSGALLILTHSVPLEKRPLFMAMTGGTYGVAAIAGPPLGGVFTDKLSWRWCFWINL
                     PIGALTFLVIVFLFKSPPRSGFDGSRSWLAKVMRFDPVGTLMFMPAIICVLLALQWGGT
                     THAWNSGIVVALLVVGGVLVIAFGIVQWLMHDDATIPLRIIKKRTIWACAAYQFALGAA
                     FFVFIYFLPIWFQGVQGASAIQSGVRTLPMLVGNIVATAVSGVLVTIIGYYAPFMILGT
                     ILASVGAGLLLLFTPNVTAASWIGYQAIVGLGIGFGWQQPFVAVQTVLDIKDVPIATAT
                     LSFAQTLGGTLFVSVAQTAFSTKLTQELVSQVPQLDPASILHEGGAAELDKLVPEQYLP
                     DVVLSYNNSLLSAFFVATIMAIMSLVGCTFVEWNSVKGKKADAVPAA"
     gene            11482..13230
                     /gene="PbP450-2"
     CDS             join(11482..11745,11809..12706,12767..13230)
                     /codon_start=1
                     /gene="PbP450-2"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) p450"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1034:cytochrome P450 (Score: 139.2; E-value: 3.2e-42)"
                     /gene_kind="biosynthetic-additional"
                     /product="P450 monooxygenase 2"
                     /protein_id="BAD29974.1"
                     /sec_met_domain="p450 (E-value: 1.2e-43, bitscore: 138.1,
                     seeds: 50, tool: rule-based-clusters)"
                     /transl_table=1
                     /translation="MIKHSLSDCLADPDHLIRIKSYVEANVRFLGLSLVTLLVTIQMFR
                     ALGSPLRLNKPLVGRRSILEPRWLVGLRFTKGGRELLRQAYKKYKDEIFKVQCNDTEIC
                     VLPHRYVEELRGLPASKVSSPQALYNKGLGSYTGLEVIVESHLHFQAIQGHLTPNLASA
                     LGIVLDELQDALKTVLPDCSDEWVPFDVHTVLSELVSRLSSRVFGGLELARNQQWIQLS
                     TAYPRNAFACTMALRMVPRIIRPLLAAVLPTYWRTRSNIRDAKRIVGGIITKRRADEGA
                     TDMSAKEHPCDLLQWMMNAAAGTETHADDLAHRLLFISDASVMTTSLLISHCLYDLVAH
                     PEALSCIREEVHNVLREGDNFQKTTLHKMRSLDSALKESQRLNPPFLMTFDRVVREPLL
                     LSDGTQIPVGTHLAMPTDAMLQDSSLLPQGGVAPDQFDPFRYARAREDPENAQRFQLAT
                     TEAKSLVFGHGKHACPGRFFASSEAKIILSHLLLLYDFRYPEGKGRPESWLFSENVAID
                     PNARLLIKKRNDAASNLAMLAKAL"
     gene            complement(13451..14838)
                     /gene="PbTF"
     CDS             complement(join(13451..14407,14458..14765,14826..14838))
                     /codon_start=1
                     /gene="PbTF"
                     /product="transcription factor"
                     /protein_id="BAD29975.1"
                     /transl_table=1
                     /translation="MTPSDICPAIELPSSSRCMRIDYVGHPDAFSSCSNLCPTNLLRCI
                     YSVRKYVLVRALSNFEDNTMFCTLRRSKDANKSYAIHMDDPPFARTKGRLSAIACVDCR
                     ASKTRCTGEPEGCKRCTFRKRPCQYPNLRRSNTTQHGEQIEASSSTFTMSDEQGSLGME
                     VSGQGSLDAQDINFANELTPVETAATMSDTMMSSECVTLNDSTITSSTIPFSIDSDIDL
                     WNDVTGMAGSDTTSLWDYNAGSNDNIAAISTKEYVCACFAQALKTYESAEVHLVWSGRA
                     HTADIMGLLQQQKNTISDCERLLDCVQCIEKSAFVVLLISICGKVLRSVEDASRELRPR
                     DSVTEPTTKSKDPSQACLNIDANSISRHQLDDDDRLVVLGSLFLNRVTKLRSLIAAIEM
                     LVMKRNWHIQRDMVRQLKSRVRLIDT"
ORIGIN
        1 ggtttagaag aacctcgaat aagcctttaa gtataatagc aatctagata actagctatt
       61 aagagtgtat atgctatata taaatataag tattaatata ataagtaata tagagtaagc
      121 cttatataag tttcttagag tattcttaaa tgcgtactat aatatactat actatatatt
      181 aaggttacta ctaagcctag attatatact agttcttata actaaatatt tagccttacg
      241 tttacagcgc ctagtaacgc gaagtttaac tctaatatag tttaattctt agtaaacatg
      301 ctaagcgact agatatagtt actacagcta gttttagtag ccgcacgaac tacaatagaa
      361 attatagtac actatattcc ttttgcaaat ttcctgtaaa gatttactta tatcttaaac
      421 tagatttaga tagttagagt taattagtgt ttagttactc tatgttatct acacttagat
      481 atagaaagtt atctagatgc aataatgcga agtatcaagt attatacttg cgactgtagt
      541 gttattaaag attgaacgag ttgataacat agttgtatct aaatacatgt tgtcgacatt
      601 gaattgaaga tataagaaat gttacgacag cctagtaatc ttatgcagta gatcaagtat
      661 tccttttccc cttccttgac cctcatcggt cgagtagata atctcttgta tctgagatac
      721 tatgttttca acaacatgct ttgtatattc aaggctcccc gtgctctcca tgatttcgat
      781 agcataaagt ttgacatgtt cgttggagga cttctgttgc agaacgtgca gaagttgtaa
      841 gtcctcggga ttggacctga tactatgaat tactggaaag gagaacttgc cttcagtcag
      901 gtcctcccca aaacccttca gcttgccgta ttcccgactg cacaggttct tgtaatcatc
      961 caatacttga aagattacgc caagaagctc caccacggga aggaggtcaa tgggcattga
     1021 tgactccgca ttcatcatcc tgtacatcag ccaaaacaga ccgcctgtca tgtttgcgac
     1081 catttcaaag tattcctctt cagttgggca ggtcagtgtg tccctccagt acagatccat
     1141 agcttggcct cggtgtaggc gaagcagttc ttcggtaaat atatcggtaa tattcggatt
     1201 cttcagagag ttgagctttt ccaatgcgag gaagtagaca tagttcgctg agttgatggt
     1261 caatgctgtg ccgaagatgt tttgtgcaac aggtttgcct cgtcgtaact ctgaattgtc
     1321 ctggatgtcg tcgatgagta gcgaagccgt atgtagcatg cgaacaacct ggccaataac
     1381 ctccagagac tctggtggca cttggagcca ttcgtcgaaa catgccagga gtagcgtacg
     1441 tacttccttt ccgggcttgg ctgcaatata atcgtacggg ccagtcacca ctttctcttt
     1501 tgtcgaggtc cagtggtcaa agttgacttc cttcgtatcg tagcggaaag gaccaaagga
     1561 tgcggagaag ctacttggag gagaaggggg catggcaacc gttgggaggg tggtgttctt
     1621 agaatgttct ctgggttcga ccgtatatgc cataatgata gaagagtggt aggtatgcct
     1681 cttgaaggta tagaaattca aaagagggtt gataagatgg tgtagcttta ccgtgaatat
     1741 tgatattaaa atgcttcctc gctagatgat acagcttggc tatttttggg aagataatat
     1801 gggtgaaacg cgagaggact ggcgatcggg cattcgagat aaaaatgagc tccaagacca
     1861 acaaatgatc attttgtatg acttgagatg ggtcttctct ccggaaggca tcctctacgt
     1921 gtagagctgt ccgaacgtca tcttccgaat ttcctgcttg ggacacatga atgggctcat
     1981 gtaagcactt acggaaagta gctgatttcc gaatatcgac agatcttgtg tgaggcacgt
     2041 aatatattgc aatgtggcta gcgtcggctg taaggtcggt ataaccgtat cgggaacatg
     2101 ccaatccggt aggaccgaat gtaatcattg atgatggccc gctactaaca ttggtcacga
     2161 aactgtcgac atgacgttgc tgcgttgagc gctggagtct gactccatag gacacgtgat
     2221 tgacaaggat aatagtcgga ctcagtatgt atctgtaatt gcctcgttgt gtgtttttgt
     2281 acgcagtgtt gagccgagcg caatgcacgc aatatctcga ttcagcttat catatacaga
     2341 tgactacgtc acaaggttac acagcctctg gatactttaa gattctaggc ccgatcattt
     2401 gtgagaaaat tttatcgttg ggaaacatgt ttgaaagtct gcttggaatt ttgcttatca
     2461 taggtaccca tatgtctgtg agcaattaaa agcgcatgca tacacattct tgcagacatc
     2521 acagtctcaa ataccgaatg acgcggttct ttcagcagtt attaaagcat tatgtacatc
     2581 tcagccaaaa gtcgatatgg tttatatcat gactgaaaca acaacagaca gtggtggccg
     2641 ttgtacaaat gtccttgata aatttttctc aattcatcgg atcttgcgat atactacact
     2701 tgaaacataa gtcttcgaat gcgagacgca ataattaaag agagcttata ccatatatgt
     2761 tccatttcat gtagacagcc gagaatgcta gggcaaagca gtgcaatgca ccgaatacca
     2821 ataccagaac gagttgcacg ttggtgggac cgggctttag tagggtgaca gcagcggagg
     2881 cgctaacagc cataccaacg tcgcaacaat aaccggagac ctcccggacg acggcgtggt
     2941 ctgttttgcc tgtcttttgt tccatatcgc tttcgttagg taggtggtcg tacttgttgt
     3001 gtaaaatggt ccgtggatga tattctcaac ataagatttc aggatggcag caccttgacc
     3061 ttatgaactc tcaagggttc tgtaagctct atcagtggcc ttaaaattgg gatagggctt
     3121 tcctaattag gaaaccccga gcatgcaaag gatcatgggt tttaatggtc ctccatatct
     3181 tcaccactgt ctatgctttg acatatcttc atctcaacct tcaatttcaa tattgccttg
     3241 tccatatccc ccacttaact cattcaacaa aacccagtct ccaatatcag agatggttcc
     3301 aatttcgact cgttcagaag tccaggatgg cttaatcgcc caagccagat ccttgatcac
     3361 acggatcgtc cacaactccg acgacgttta cgggtttgga acactaagtt gcactgtcta
     3421 tgatactgct tgggtggctt tggttacgaa acatgtcaat ggtatcaagc attggctgtt
     3481 tcctgaaagc ttccattaca ttctcgcgtc acagtgcgac gatgggactt ggtgcgagga
     3541 caaaacagca cagttcgacg gagttctgaa cacgatcgct ggactgcttg tcctaaaacg
     3601 gtacaggaga gaccctcttc aactaaaagt tgacaacaga gatctcgatt ctcgtatcaa
     3661 actcgcaacc tctgcgctac attccctgtt ggaagagtgg gacgtttcga caacgaacaa
     3721 tgttggcttt gagatcatcg tcccaaccat gctggacctg ttagtccaag aagatccatc
     3781 actctccttc gagctcaagg gtcgtgaagc attgacagag atacgggagg ctaagatgaa
     3841 tcgattccag ccagaacttc tataccaagg aaaattgatg accttgaccc actccttgga
     3901 agcattgctt ggcagaatag actacgacaa tgttgctcga tatacagtta aaggctccat
     3961 gtttgcgtca ccttcatcca cggcggccta tttgatgagt gcgtctacat gggatgacga
     4021 ggccgagact tacctacggt acaccatcac tgcatcgacg gggaagggaa gcggtggtgt
     4081 tcctggcgtc ttccctacca catactttga gtacacatgg gtaagtcgaa tgtggaagat
     4141 gcacgatcta ctccaagaat actaagaatg ctccttacag attttgtcta cactgtttcg
     4201 agcgggattc caatcctcag aactcgactc tcccgaactg accgcaatga ccgatacact
     4261 gctcaaagct ttcaaggcat tcagcggtgc gatcgggcta ggtatgtcgc ttgctcgcag
     4321 ctcacgtcca tcgtttagag actaatactt ttgcgcagat tccgggatcg agccagatgt
     4381 tgatgacagt gctaaaattg tcactacact caacatgctg ggtaagccgg ctcatgcacg
     4441 gtacttatgt gataactttg aggttgagac ccattttcgc gtatacccga gggaaagaga
     4501 cccaagcttt agcgccaact gtaacgcgct tgctgcattc ttacatcaac ctgacgttga
     4561 ggtgtactca tcacagatac tcaaggcagc aagctattta tgtgagagga tgtggaacgc
     4621 agacgagaag atcgacgaca aatgggtaag tggctgttgt cagttttaca acagtaccca
     4681 ggtagctaac acatactgta gaacaagagc cacctctatt caagcttcct ctacactcag
     4741 gtaatgacgg acctgatggc aatcactgag gctggaagac tagatggtgt gtttaccaaa
     4801 gagctcttga ccagagtctg tgtgaccatc tttcaaagtt gcctgagggc aatgttgaag
     4861 cagtcacatg atgggtcatg gaaccaatct ttagaggaga cagcctacgc gatcttgcat
     4921 ctgacggaag cacgccggct ctgcttcttt gagcaaattt cggagccatt ggagaactcc
     4981 atctatcgtg gaataacatt tcttacaacc attgacaagc caccaatgga gtatctctgg
     5041 tctgacaagg tcagctacgg ctcagcctat ctggcagaga catatgtctt agctgcccga
     5101 agggcagcag aatccacctc agtcaccaat cttgtcggtt tcagcatctg gaaggacaac
     5161 gcttcgacga agatgcacaa actcgttgga ctttttcacc ggacacccct cctcaaagca
     5221 cttcctaaat gggagctcca agcttccatg atagaagctt ccatctatca aggccttctg
     5281 caggatgcac gattagaagt actgcagaga cccaaggtag atggaggcga gtatctttcc
     5341 atcattcctt tcacctggac aagctgtagc aacagtgctc gtacaaatgc ttctgcatct
     5401 catttatggg agttgatggc tttgtcattc tttacatatc aggtggacga gttcatggaa
     5461 gccgtcgcag gaccagcatt caaaggacgg atgacgcatc ttcatgcaat catcgacgaa
     5521 gccgtacatt gttcgcagaa ccgggaaaga acaccaggag agtgtgaaaa taccaatcac
     5581 gtcacttccg agcttctgca agcagttcgc ttcatactag acaaccctac cgtccgtaaa
     5641 gccagcccgt atgaccgcaa cactttgtta caggagttac gaatcttcct tcacgcacat
     5701 gtaacacaag ttgaggataa cgccagcttt ggaagagaga ggttgacagg cgacaaggcc
     5761 cttacaagct atcgcagtca gctctaccgt tgggtgcaca ccatatcatc cgaccatatt
     5821 gccgggcctt tttgcttcta ttatgcaacc tgcttgttgg gagctacctt gacagcacac
     5881 cctccgaacg actgctttcc caagtcatcg caaaagtatc tggcagcagc gacatgtcga
     5941 cacttgtcct gtatgtgtcg catgtacaac gacatcggct cgtggaatcg agatcaccgc
     6001 gagggcaatc tcaactgcct tcacttccct gaattcagcg aaacgacctc ggacgatgct
     6061 gaaagaaagg cttctctact tactctcgct cagtacgagc gaaagcaatg gtgcaatgca
     6121 ctacagcagc ttgagaaaga aatggtacac ggggcatcgg agcctgctgc agcgaggctc
     6181 gcgaagcgtc gcgcatgtct gatagacatg ttttgcaaag tgacggatct ctatggacag
     6241 atctatgttc tccgcgatgt ttcctccgtc atcaaggatg ttgttcggaa cggggaatag
     6301 ctgttttcga tattcagacc tatctagaga atgacgtatc ctttcttcac tacagcctca
     6361 caaaaggccc aagcgtagca atgatatgca tagagaagct agtcggtagt gtgattgata
     6421 gtggaaacat agcgatagac tgctatgagc tcacaaaacc ccacttgccg aatcatgcat
     6481 tctccaattc aggcattttc atgcgtcccg atgcggaaag tccgtattga gctaagcatg
     6541 tatttggtaa gctccaaagt cagtataaaa agatatgtca gcacatttca acaagtacac
     6601 tgaaacatat gcggcttcaa tagtggtctt tctcacgata tacgtacttc gattcgttac
     6661 gtcttctggt tcaataagat accaatcaga atcacagcat gtcacacttt ctacctacat
     6721 taatcctcac ctctttaact gtaagtatat gggagaagaa attattaccg tcgcatagtc
     6781 aatactgatc acctcatcta gttggttgcg tatgttctcg caagaatgat atataacgtt
     6841 ttctatcatc ctctaagcgc ctttcctggc gatgctttct tttgtgccac ggggcttacc
     6901 aaagcgtacc acatgatcgc cggggatctt caactcaaag tcaaagacat gcacgacaag
     6961 tatggctcag tagtacgaat agctcccact gaattgagct tttcctattg ttccgcgtgg
     7021 aaggacatct atggaagccg cgggggtcgc gaactatcta aattttacga cttctaccgg
     7081 gtcgacgaag cgatgccgca acacatcata tcggcgggaa aagcaaaaca cagtattcta
     7141 cgacgttatt tggcgcatgg tttctcagag aacgccatga aagctcagga gcctgtcatt
     7201 cttgaccttg tgaatctcct aatgcagcgt ttgagagaac atgcagaaga gggtgcacga
     7261 gtcgtggatg tgaacaaatg gttcaatttt gctaccttcg aaatcattgg aaaactgacc
     7321 ttcggggctg atcttggaaa cttaaggaac cgtgactggc atccttgggt gaaaggcagt
     7381 gcaaacaaca atatggtggt tggtttcatg gcggccgcaa atagcgtggg acttgggccc
     7441 attatcaaat ggtgcataag caacgagatc cttccgagac aaaaatatct tgatgagctg
     7501 gcagaaatgg tccaaaagcg tacgggggtg acggtcgagc gtcctgactt cattcaaggc
     7561 cttttgcgtg acgatgtcca gctggtaaga tactgcatcc ctttcagcgc tctgcatttc
     7621 cgctaaggta ctgcttacag tcaaacggag agatcgttgc aaatgtcgaa gctctcattg
     7681 gagcaggatc cgaatcaaca gcgaccctac tgacgggcac cgtctgcgct cttctacaga
     7741 accccgacca actggcgaag gtgatcgacg aggtacggtc aacctttcgc accgaggacg
     7801 aaatcacttt acactcggtt caacgcctcg actatatgct tgcatgcttg aacgagacct
     7861 tccgatatta ccctccagtg acgaacggta tgcctagggt tacgcctaaa gaaggggcaa
     7921 tcataggcgg acgcttggtg ccaggaaatg taagtggttg cctttaccta tactatattc
     7981 tattctattc ttaagtatca agttatttca gggtgcttgc tgaccacttg ctggtaactc
     8041 acagacagtt gtcgcgattt ggcaatgggc tatatgccat gatcctgcat tatggaaaga
     8101 tccatacaca ttccgacctg agagattttt ggaggcccca gagttctcaa cagatgtgcg
     8161 cgaagctctg aatccattca gtgtcggcac gaggaactgt attggtagaa agtaagtttt
     8221 tgttcgcaac tcccatctgc tccatccgta cttatcaatt gactaccagt ctatcgtatg
     8281 ctgaaacgcg cctgatcctc gcccgtttgt tttactactt cgacttggaa ttggcggacc
     8341 ctgatcaaga ctggttcgga gctcagaagg cttatcttgt atgggacgca cctgcgttaa
     8401 acatgtatct taagccggtt gttcgatgaa agcttgccaa ttgtatataa gatcaattac
     8461 gcttcacata ataacagcta gttgccgttc atatgaactc tcaggatatt ttaagtagtc
     8521 ttctagtttt aaactcgggt gtaagacaca taaccgtagg attgaggcag tatgaagaaa
     8581 ttgtatgtag aatatcacgc aaggagtgat gtaaaagtat tgatctagtt aggtactatg
     8641 aaacattcaa gctcagtacc aaaacatact acttatcttg atcaccaccg tataacagaa
     8701 caaaatgccc attagaaaac ctgcgcctac tgtcacgcct aaaatccata gggtgtagat
     8761 taaagcgtaa ggcaaattga agaactctta ttacccaggt aaaactgcaa tttatccctg
     8821 tcctacaaat tccctcgccc atgattacaa ttccaaaaac atgtgcaata gctgcatacc
     8881 tagtggggca aaaatgaaaa ccactctaca cgactttttc cgtacgtcct acaccttggc
     8941 ttcgctgaac agaccctcaa gcagctggca cggcatcagc cttcttgccc ttaacactgt
     9001 tccattccac gaaggtgcag ccgacgagag acataatcgc catgatagta gcaacaaaga
     9061 aagcgctaag caagctattg ttgtatgaca gaacaacgtc gggaagatat tgttccggaa
     9121 cgagcttgtc aagctcggca gcaccacctt cgtgtaagat ggaggcagga tccagttgag
     9181 gtacttgact tacaagctcc tgtgtaagct tggtggagaa agccgtctgc gcaacgctga
     9241 cgaaaagagt accgccgaga gtctgggcga aagacaaagt ggcagtggcg atcggtacat
     9301 ctttgatatc gaggactgtt tgcacagcaa caaagggttg ctgccatcca aatcctatac
     9361 ccaggccgac tatggcctga tacccaatcc atgaagccgc agtcacgtta ggggtgaaaa
     9421 gcaataggag accggcgccc acagatgcga ggatagtgcc gaggatcatg aaaggagcgt
     9481 aatatccaat aatggtgacc aggacgccag atacggctgt agcgacgatg tttccgacga
     9541 gcattggaag tgttcgaact cctgactgga tggcgctggc tccttgcaca ccctggaacc
     9601 agatgggaag gaagtagatg aagacaaaaa aggcagcacc gagtgcaaat tggtaggcag
     9661 cgcatgccca aattgtacgc tttttgatga tgcgaagggg tatagtggca tcatcatgca
     9721 tgagccattg aacgatgcca aatgcaataa cgagtacacc tccaacaacc agcaatgcga
     9781 cgactatgcc gctattccaa gcgtgggtgg tacctcccca ttgcagcgca aggagcacgc
     9841 agatgatggc aggcatgaac atgagtgttc cgacgggatc gaaacgcatg accttagcga
     9901 gccaggatcg ggaaccgtca aatccgcttc tcggagggct tttgaagaga aagacgatga
     9961 ccaaaaatgt caacgctcca atgggaagat tgatccagaa gcaccaccgc cacgacagct
    10021 tatcagtgaa gactccaccg agcggtggtc ccgcgattgc ggcgactccg taggtaccgc
    10081 cagtcattgc cctaatcaaa atgttagtct gcggccgtgg ctgaggtaga gagctcacag
    10141 actaaatgta acttacatga aaagtgggcg tttctccagc ggtacgctat gagtgaggat
    10201 gagcagggct cctgacagga gcccggcatt tccacagcca gcaatagcgc ggccaattat
    10261 gagcacgaca gagctgggtg cagttgcaca tatgatactc ccgacttcga aggtgagtag
    10321 agcaagcaga aaggtccact tgagatcgaa cacggtgtaa cacttcccga ggagaagctg
    10381 tgaggaggca gttgtgagca agtaagctgc agtcccgtca gttctcaagt catatatcac
    10441 ggttggtcgt tagggtgttg gagtaacgta caacttccat accagccaat gtctgccaca
    10501 ctcttgaact cggctgtaat cgcagggatg gccgttgcaa gtatcgagaa gctgcagagg
    10561 tcagccagtc cgacgtgttt tagcgacaca atagggagcc cttggtgaca acgtactcaa
    10621 ccgagatcag aaagatagtt agacaaatcg ctgtcgtcaa gcagatgagt ttcaagccag
    10681 tcggtttggt cgctgtggct gtttgctccg gttctcgaga gcatgtacgc gtgactgtat
    10741 gctcgcgagc atgcccttct tcagccttct ccggccggga tcgatccgag cattcggttg
    10801 ttgtctgctg ctgcatcgct gcagtgtcgg cttgatctgg atgcatcgct tagatgagaa
    10861 agaggaagga cgccgtgttc tgcgagcagt gctgtcgttc tcgatttgga aacagcgaaa
    10921 atacttgcta tgatagctta gagtgcctta ggctgttgtg agtaagagga aaggagggta
    10981 gtgcgatggt gttgttaggg aacaaggtca aagtgttttt ttgatccgac gtgacgcgac
    11041 gtgacgtgac gcgacgtggc gcgtggtgca ttaatccacg tgattttgag ctgggtctat
    11101 gatgcaccaa tgaatatcag tcgtggtttg ttttgctccc gcggcgtggg aggcgtggtc
    11161 ggccttggct gttgccttgt tgacggggcc ctcggacctt ccgagagagg caatgcccgt
    11221 atatgcgacg caactgcttt cggatattag atcaaccaaa ctatcgggac gccgtgacct
    11281 gttcattacc cggatgctgc agtttcccca ctccttgaaa tggcagtccg atgcaaagtg
    11341 tgaatgtcgc aaacacgatc tgtgggaaga atttgagatg aaggaatcat caaagaagac
    11401 ttaaattacg agatcgatgt gatactccaa caaaagcgaa gtcaccctgc agatcgtttc
    11461 atccaatctt gcctcaacac tatgatcaaa cacagcctta gcgactgtct agctgaccca
    11521 gatcatctga tccggatcaa gagctatgtg gaagccaatg ttcgatttct tggtctctcc
    11581 ttggttaccc tccttgtcac catccagatg tttcgcgccc tcggctcgcc cttgcgtctc
    11641 aacaaaccgt tggttggacg tcggtcgatc ctcgaaccga gatggttggt gggactgcgt
    11701 ttcacaaagg gcggccggga gttacttcgc caggcataca aaaaggtacg tcttttgtcc
    11761 atcactctgg tcgcccaatc agctcaaagg gtctcacgca aactgcagta caaagatgag
    11821 attttcaaag tacaatgcaa tgacactgaa atttgtgttc ttccgcatag atatgtggaa
    11881 gagctccgcg gcttgcctgc aagcaaagtg agctctcctc aggctctcta taacaaaggc
    11941 ttgggaagct acaccggtct cgaggtcatc gtggaaagtc accttcactt tcaggcaata
    12001 caaggccacc tgacaccgaa tctcgcttcg gctcttggaa ttgtcctgga cgagttgcaa
    12061 gacgcattga aaacagtcct gccggattgt tcagatgaat gggttccatt tgacgtacac
    12121 acagtacttt ctgaattagt cagtcgcctc tcctcgcgtg tctttggagg tctcgagctt
    12181 gctcgaaacc aacaatggat acaactgagt actgcttatc ctaggaatgc attcgcctgc
    12241 accatggctt tgcgcatggt tcctcgtatc attcgcccac tcttagctgc agtcctgcct
    12301 acttactggc gtacgcgcag caacataagg gatgccaaac gcattgttgg tgggattatc
    12361 accaagcggc gtgcggatga aggagcaaca gatatgagcg cgaaagaaca tccctgtgat
    12421 ttgctgcaat ggatgatgaa tgccgcggca ggtacggaaa cccacgcaga tgatttagct
    12481 caccgattac ttttcatcag cgatgcttcg gtcatgacca cgagcctgtt gatttcccat
    12541 tgtctttacg acctggtcgc ccatcccgaa gctctttcat gcattcggga ggaagtacac
    12601 aatgtcttgc gcgaaggcga caactttcag aaaaccacac ttcacaagat gcgcagtttg
    12661 gatagtgctt tgaaggaatc ccagaggtta aacccaccat tcttgagtac gtaaaggaca
    12721 tattcaagag cgtgaaatag tggctgacaa taatttctcg atgtagtgac attcgatcgc
    12781 gttgtgcggg agccacttct tctgtccgat ggaacgcaaa tccctgtagg gacgcatctc
    12841 gctatgccta cagatgcaat gctacaagac tcaagcctcc tgcctcaagg cggagttgcc
    12901 ccagaccaat tcgatccgtt tcgttatgcg cgggcgcgcg aagatccaga aaatgcacag
    12961 cgctttcaat tggctacaac ggaggcaaag agcttggtat ttggacatgg aaagcatgca
    13021 tgccctggtc gcttctttgc tagcagcgag gctaagataa tcttgagtca cctgttactt
    13081 ttgtacgatt ttcggtatcc tgagggcaag ggtcgtcccg aaagttggct cttctcggag
    13141 aatgttgcca tcgatcctaa tgccagattg ttaatcaaga agcgaaatga cgctgcaagt
    13201 aacctagcga tgctagccaa ggctttgtag cagatttgta tatataacga ccatcgaaat
    13261 ttcgtcatgt aaaacgagca gcatctcact ttgcacccac attctctcca tatttcattg
    13321 agtcactgat catattcaat gtcttttgaa cttaaacaag tggtatactc aaacattgta
    13381 ggaagatatc aggagctgga tcatttgatt tatcttgaca aaaccacccc ttgtctaaat
    13441 gaggagccgc tcaagtgtcg atgagcctca ctcgactctt taactgacga accatatctc
    13501 tttggatatg ccaatttcgt ttcatgacta gcatttcaat agccgcaatc aggctgcgta
    13561 acttggtgac gcggttaaga aaaagacttc ccagtacaac aaggcgatca tcatcgtcca
    13621 actggtgccg ggaaatactg ttggcgtcta tattcaggca tgcttggctt ggatccttcg
    13681 atttcgttgt cggttcggtc actgaatccc tgggccgtaa ttcgcgagaa gcgtcttcga
    13741 ctgaacgcaa cactttgccg cagattgaaa tgagcaatac tacaaaggcg gacttctcaa
    13801 tgcactgcac gcagtcaaga agtctttcgc aatcagagat cgtgttcttc tgctgctgca
    13861 gtagccccat gatatctgcg gtatgcgctc taccactcca gaccagatgt acttcagccg
    13921 actcataggt cttgagagcc tgagcaaaac atgcacacac atactcttta gtggagattg
    13981 ccgcgatgtt gtcattgctg cccgcattgt agtcccaaag cgaagttgtg tcgctaccgg
    14041 ccatccctgt tacgtcgttc catagatcaa tgtccgaatc gatggagaag ggaatagtcg
    14101 atgatgtgat ggtcgagtca ttgagcgtaa cgcattcgct cgacatcata gtatctgaca
    14161 tcgttgcggc tgtttccact ggtgtgagct cattggcgaa attgatgtct tgagcgtcta
    14221 ggcttccctg ccctgaaact tccataccaa gactaccctg ttcatccgac attgtgaaag
    14281 tactcgagga tgcctcgatt tgttccccat gttgcgtcgt gttacttcga cgaagattgg
    14341 gatactggca agggcgcttt ctgaacgtac accgtttgca gccctcaggc tcgcctgtgc
    14401 atctagtctg agcattgtgt tagaaatttc aaataagtgt atatggcgat cgaatacctt
    14461 gcttgctcta caatccacgc aagcgattgc gctaagcctg ccttttgttc tagcaaaagg
    14521 tgggtcgtcc atgtgtatcg cgtacgactt gttggcgtct ttcgaacgtc gaagtgtgca
    14581 gaacattgta ttgtcttcaa aattggataa agcccttact agtacgtact ttcggacgga
    14641 gtaaatacat ctcaacaaat ttgtcgggca taaattagaa caactcgaga aagcgtcagg
    14701 atggccaaca taatctattc tcatgcaccg cgatgaagag ggcagctcga tcgccggaca
    14761 tatatctgaa taggtcgcat aaatcagctt acgcgaacac catttctttg catgtgatga
    14821 ctcaccgctt ggtgtcatcc aaaatgttcc aaaatagccg acgatcgtcg gtgttcttca
    14881 tggcgctagt aggcaatacg tggtgttagc agaacacttt gcttgagggg tcaaagcaat
    14941 ttttgcatcc tcctgccata ggcgatgttg tcttttttac aatgcttaac actgtaatgg
    15001 gaccatgcaa ccatcccgat gctaccagct taataagctt tatggtgggt ggagtcagca
    15061 ttgcctaagt ctggtgcata aattgaagcg tgaaagcatc gccgatttaa aaaagaaaaa
    15121 aactggggaa gagggggtgc aaggtgatca gcaaaaatag ttcatatcat tctgttgggg
    15181 cgacctaaga ctccgaaacc tactagattt gatcagagac ttgaccctat taaccaagtg
    15241 gagcttacta aaacaacgat aatgtaagca ttctcttaag tcctccacga cttttaggca
    15301 aatatagagg tatttgtagt taacatgtgt attataattc gcgtccgaag tttggatagg
    15361 tggttcgata ggggtggtag tttggtaacc gcggcccgga ggtggcccgg accgtaccgg
    15421 caacagcttg cctacagtcc gtgcgcagcc aacgggctag tttagttact aagccactct
    15481 aagccttaca accttataag ctatccgaac tacaacgcgt tataaattta ctaatattaa
    15541 tctaatttaa gctatactta aagtaactac tttgcgtaaa gctattataa tctaatagta
    15601 ctaggagcta gggccgctta agagacgcc
//
