LOCUS       BGC0000707              7581 bp    DNA     linear   BCT 25-JUL-2016
DEFINITION  Streptomyces kasugaensis DNA, kasugamycin biosynthesis responsible
            gene region, partial and complete cds.
ACCESSION   BGC0000707
VERSION     BGC0000707
KEYWORDS    .
SOURCE      Streptomyces kasugaensis
  ORGANISM  Streptomyces kasugaensis
            Bacteria; Actinobacteria; Streptomycetales; Streptomycetaceae;
            Streptomyces.
COMMENT     ##antiSMASH-Data-START##
            Version      :: 6.2.0-924c3663(changed)
            Run date     :: 2022-11-07 20:21:17
            NOTE: This is a single region extracted from a larger record!
            Orig. start  :: 0
            Orig. end    :: 7581
            ##antiSMASH-Data-END##
FEATURES             Location/Qualifiers
     gene            <1..756
                     /gene="kasA"
     CDS             <1..756
                     /codon_start=1
                     /gene="kasA"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1045:glycosyl transferase group 1 (Score: 148.6;
                     E-value: 4.8e-45)"
                     /gene_kind="biosynthetic-additional"
                     /product="deduced glucosyltransferase"
                     /protein_id="BAA25653.1"
                     /transl_table=11
                     /translation="LQRGLVDNLRADVMVCGSQAYRRWALDAGFTDDDIHVVEFGTDLD
                     RFRDDGAARARWRNRHGVADDETVFLVPARPVPRKCIEDAVAALAHLAGRHPRARLVLT
                     TPTARTLDSYAEKLRALADELGVADRVIWEQGLSWHDMPMLYAGADAVVLPSSHEGFGI
                     ALVEGMAGRRPVITSNVEGHDEVIDHERTGFLYPARDVEALAGCMARVITSDLENLVAA
                     AHAEAVRPFSSTAVAAGHERAYEVACGQR"
     source          1..7581
                     /db_xref="taxon:1946"
                     /mol_type="genomic DNA"
                     /organism="Streptomyces kasugaensis"
                     /strain="M338-M1"
                     /type_material="type strain of Streptomyces kasugaensis"
     subregion       1..7581
                     /aStool="externally annotated by: MIBiG"
                     /contig_edge="True"
                     /label="BGC0000707"
                     /subregion_number="1"
                     /tool="antismash"
     region          1..7581
                     /contig_edge="True"
                     /product="unknown"
                     /region_number="1"
                     /subregion_numbers="1"
                     /tool="antismash"
     regulatory      822..880
                     /note="hairpin loop (stem=22bp, loop=15bp), -36.18
                     kcal/mol"
                     /regulatory_class="terminator"
     gene            1145..1906
                     /gene="ORF B"
     CDS             1145..1906
                     /codon_start=1
                     /gene="ORF_B"
                     /protein_id="BAA25654.1"
                     /transl_table=11
                     /translation="MITHGLLSYGRRTGDQRLLSSGRAAARFLLDHLPTRGHPHPLATG
                     HRPEGTEPTWSNSGSAHLLKLVQALISADGAGVTGAAQAAERLVDTVLADPCPPSAAPV
                     TTCPDSDLISLHAACYAAEGLWIWDTARRRPQARERAVRITEWVWQQQLTGGGFTTYAH
                     RTGGPASDRMQSDVLAQAIRLAKLLDLRPDGLGSAVSTLANSLHTYDDKAAVLYRPQAA
                     EPHRNSWSSMFAGQALRLCGAEAGLAWHELV"
     regulatory      1918..1923
                     /regulatory_class="ribosome_binding_site"
     gene            1932..3242
                     /gene="kasC"
     CDS             1932..3242
                     /NRPS_PKS="Domain: Aminotran_3 (17-366). E-value: 1.9e-66.
                     Score: 216.2. Matches aSDomain:
                     nrpspksdomains_kasC_Aminotran_3.1"
                     /codon_start=1
                     /gene="kasC"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1013:aminotransferase class-III (Score: 277.7;
                     E-value: 2.7e-84)"
                     /gene_kind="biosynthetic-additional"
                     /product="deduced aminotransferase"
                     /protein_id="BAA25655.1"
                     /transl_table=11
                     /translation="MSDSVLLSARQPLPPIDYSHAAGAWIHTAEGDSLLDAASGLVCVN
                     IGHAHPHVVEQITRQARTATFASPGVLLPAVQEELAGRLTEAVNRPGDGVSLACSGTSA
                     VELAISYARLIQRSRGQDGRHHILTARLGYHGNSALTLGLSGHRRRRPHPDDALGLAPA
                     FDPPYPGHHRDCPHDRCRASCADAVAEAIDRRGPESVAAVLIEPVNGTTGGAYTPPPGY
                     LAALRRACHERGVLVIHDEVLTGLGRTGLPLGADHCTDAAADIVVLSKGLSAGYLPLAA
                     VLVNPEGVARLRSGPRPLPLMGTMSATPLQAAAGLAVLDVLGEIGALDPARVRGGDVAA
                     AVRAVAALPVVQETRGVGYFHAVELAPGTQAAALAAARDERLLLYPFNGFHADGTGEGL
                     IVAPPLNSTPSEVEFLAQGLRRALERTAARSEDRSHR"
     aSDomain        1983..3029
                     /aSDomain="Aminotran_3"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_kasC_Aminotran_3.1"
                     /evalue="1.90E-66"
                     /label="kasC_Aminotran_3.1"
                     /locus_tag="kasC"
                     /protein_end="366"
                     /protein_start="17"
                     /score="216.2"
                     /tool="antismash"
                     /translation="YSHAAGAWIHTAEGDSLLDAASGLVCVNIGHAHPHVVEQITRQAR
                     TATFASPGVLLPAVQEELAGRLTEAVNRPGDGVSLACSGTSAVELAISYARLIQRSRGQ
                     DGRHHILTARLGYHGNSALTLGLSGHRRRRPHPDDALGLAPAFDPPYPGHHRDCPHDRC
                     RASCADAVAEAIDRRGPESVAAVLIEPVNGTTGGAYTPPPGYLAALRRACHERGVLVIH
                     DEVLTGLGRTGLPLGADHCTDAAADIVVLSKGLSAGYLPLAAVLVNPEGVARLRSGPRP
                     LPLMGTMSATPLQAAAGLAVLDVLGEIGALDPARVRGGDVAAAVRAVAALPVVQETRGV
                     GYFHAVELA"
     regulatory      3241..3246
                     /regulatory_class="ribosome_binding_site"
     gene            3256..4245
                     /gene="kasD"
     CDS             3256..4245
                     /NRPS_PKS="Domain: NAD_binding_4 (14-186). E-value:
                     8.6e-20. Score: 62.7. Matches aSDomain:
                     nrpspksdomains_kasD_NAD_binding_4.1"
                     /codon_start=1
                     /gene="kasD"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1010:NAD-dependent epimerase/dehydratase (Score:
                     275.1; E-value: 1.4e-83)"
                     /gene_kind="biosynthetic-additional"
                     /product="deduced dNDP-hexose 4,6-dehydratase"
                     /protein_id="BAA25656.1"
                     /transl_table=11
                     /translation="MSPTTTHWAGRQVLVTGADGFIGSHLTETLVSRGARVTAVVRRVS
                     AAQVTHRLRNLSAATVDALERVVHVDLAGPSAVDVLGRLEADTWFHLAADAYVPASLDQ
                     PADVVRTNVMSTLHVLLAAQQRQPAHLLVTSSSEVYGSQPDAITERHPLEPATPYAASK
                     VACDRLAWSWHHTYGLPLTIVRPFNSYGPRHVYDAVPLFLARALRGEPITINGSGEQTR
                     DLTFVADTVAGFLALAELPATGETYNIGTGTDHRIIDVARAIVALTGSQSEIVHGPPRS
                     GEVLKLQADPAKLTEATGWRAEYDLARGLADNLVWMREHVETVWPTRS"
     CDS_motif       3295..3363
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_kasD_0001"
                     /evalue="2.00E-03"
                     /label="PKSI-KR_m1"
                     /locus_tag="kasD"
                     /protein_end="36"
                     /protein_start="13"
                     /score="10.9"
                     /tool="antismash"
                     /translation="LVTGADGFIGSHLTETLVSRGAR"
     aSDomain        3298..3813
                     /aSDomain="NAD_binding_4"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_kasD_NAD_binding_4.1"
                     /evalue="8.60E-20"
                     /label="kasD_NAD_binding_4.1"
                     /locus_tag="kasD"
                     /protein_end="186"
                     /protein_start="14"
                     /score="62.7"
                     /tool="antismash"
                     /translation="VTGADGFIGSHLTETLVSRGARVTAVVRRVSAAQVTHRLRNLSAA
                     TVDALERVVHVDLAGPSAVDVLGRLEADTWFHLAADAYVPASLDQPADVVRTNVMSTLH
                     VLLAAQQRQPAHLLVTSSSEVYGSQPDAITERHPLEPATPYAASKVACDRLAWSWHHTY
                     GLPLTIVRP"
     gene            4245..5042
                     /gene="ORF E"
     CDS             4245..5042
                     /codon_start=1
                     /gene="ORF_E"
                     /protein_id="BAA25657.1"
                     /transl_table=11
                     /translation="MDAGGVLFNNVTEETDFLDRLAARHGADTQRLRGEIDARDAAYET
                     GRAHVHDVLRDALAAAGAPAGVAVDARWLDDLYRDCLAVHPGAFTAIDGIRRHRPDILL
                     VLTNNEAAHWDRVKDDRYGHLGRFDVIASSWQVGEVKPTGEFFEAVARRCGRPLDDAVL
                     LDDNPDVLAEARHHGLRTLHVESPATLPEAVARLPGLPATGPIRRPDMNATSPEDTPAA
                     QRTPLLPEQRRFLTTAIPNLQGGGGRRGVRSHLIGHGRRGLLR"
     gene            5039..5755
                     /gene="ORF F"
     CDS             5039..5755
                     /codon_start=1
                     /gene="ORF_F"
                     /protein_id="BAA25658.1"
                     /transl_table=11
                     /translation="MTAAAASPEDLAPIQARTLFVMRDGRLTAINDVGRPAPPRCFLSY
                     TATAVTAWTSTAVPADLTDELDRWAADQTPAPLTELVSPPAGALRLLARHAPVTESFVG
                     PAYAVPDSADTPAPPGITLRDCGPSESSRFRETFPEVADTLAERQPTVAAFDGHRAVAV
                     CCAARDGGEAYEAGTETLPSHRGRGLASALVTRWARLVRARGARPLYSTEWDNHSSLSV
                     AKRLAMELYAVNVSLY"
     regulatory      5549..5608
                     /gene="ORF F"
                     /note="hairpin loop (stem=23bp, loop=14bp), -32.34
                     kcal/mol"
                     /regulatory_class="terminator"
     gene            complement(5749..6117)
                     /gene="ORF G"
     CDS             complement(5749..6117)
                     /codon_start=1
                     /gene="ORF_G"
                     /protein_id="BAA25659.1"
                     /transl_table=11
                     /translation="MPWTSTTASIPHRRKVTRRTRPRRAAVKLPISATLLRGAPGSGPP
                     LSRMRLRERISPVSPLSTSSRTSCRGVVCASSRTASGHGAAGLGPSRCPAPGFGLSAAG
                     RVHGTCGRQQVGGGQEGQ"
     regulatory      6306..6309
                     /regulatory_class="ribosome_binding_site"
     gene            6318..6743
                     /gene="kac338"
     CDS             6318..6743
                     /codon_start=1
                     /gene="kac338"
                     /note="AAC(2')"
                     /product="Kasugamycin acetyltransferase"
                     /protein_id="BAA25689.1"
                     /transl_table=11
                     /translation="MPRWAGTYDGGVTITYEWRGGFDNAALNALHADGFGPPIAQTDWR
                     TRLERHSLGWVCAWEDGLIGFVNVVWDGGAHAFILDTVVARHCRSRGVGAALVAKAADE
                     ARAANCEWLHVDFEEHLRAFYFDACGFKETTAGLIAL"
     gene            7085..7321
                     /gene="ORF I"
     CDS             7085..7321
                     /codon_start=1
                     /gene="ORF_I"
                     /protein_id="BAA25660.1"
                     /transl_table=11
                     /translation="MRPLCLAEDGCVSWEAYHSHEEPGRFVLVERWASRAHWEAHDAGD
                     AIQKIYIPELMPRIEREVHPSMRVPSKHEAVTG"
     regulatory      7359..7406
                     /note="hairpin loop (stem=23bp, loop=2bp), -36.70 kcal/mol"
                     /regulatory_class="terminator"
ORIGIN
        1 ctgcagcgcg ggctcgtcga caacctccgg gccgatgtga tggtatgcgg ctcgcaggct
       61 taccggcgct gggcactcga cgccggcttc acggacgacg acatccacgt cgtggagttc
      121 ggcaccgacc tcgaccgctt ccgtgacgac ggcgccgccc gcgcccgctg gcgtaaccgc
      181 cacggcgtcg ccgacgacga aacggtcttc ctggtccccg cgcggcccgt accacgcaag
      241 tgcatcgagg acgccgtggc cgcgctggcc cacctggccg ggcggcaccc gcgggcccgc
      301 ctcgtcctga ccaccccgac cgcgcgcacg ctcgactcct acgccgagaa gctgcgggcc
      361 ctggcggacg aactcggcgt cgcggaccgg gtgatctggg agcagggact ctcctggcac
      421 gacatgccca tgctgtacgc gggcgccgac gcggtggtac tgccctcctc tcacgagggg
      481 ttcggcatcg ccctcgtcga gggaatggcc ggccggcgcc ccgtgatcac ctcgaatgtc
      541 gagggccacg acgaagtcat cgaccacgaa cggaccgggt tcctctaccc ggcccgcgac
      601 gtcgaggcgc tggccgggtg catggcgcgc gtcatcacct cggacctgga gaacctcgtg
      661 gcggcggcgc acgccgaagc ggtgcgcccc ttctcgtcga cggcggtcgc cgccgggcat
      721 gaacgggcct acgaagtggc gtgtggccag cggtgaccgg acacggcgtc aagcacccgt
      781 cagcccctga gaccgaagag cgggatatga gttcacacca agccctggcc gatcagacgt
      841 cgcaggtacc ccccgaacgc gaggaccggt tggccagggc actgggcgcc tggctcgcgg
      901 cggcggcacc cagcgggccg acggcgccta ctgcggatgg caggcacccg acggccgcct
      961 ctcctacccg tatccggaga tcaccggata catcctgacg ttcttcgccc acgagacact
     1021 ggacgcgtcc gagcggcagc gggcggacgc ggcggcctcg tggctggccg accgcatcga
     1081 cagcggggac tactcgtgcc gtcccgacca cggcgacggc ggagtcttcc tcttcgacat
     1141 cggcatgatc acccacggtc tgctctccta cggccggcgc accggtgacc agcgactgct
     1201 ctcctcggga cgcgccgcgg cccgcttcct cctcgaccac ctgccgaccc gtggccaccc
     1261 ccaccccctg gccacgggac accggcccga aggaaccgag ccgacctggt cgaactccgg
     1321 cagcgcccac ctgctcaagc ttgtacaagc actgatcagc gcggacggcg cgggcgtcac
     1381 cggagcggca caagccgccg aacggctggt ggacaccgtg ctcgccgacc cctgcccgcc
     1441 ctccgcggcg cccgtcacga cctgcccgga cagcgatctg atcagcctgc acgccgcttg
     1501 ctacgccgcc gagggcctgt ggatctggga cacggcccgc cgccggccgc aggcgcggga
     1561 acgcgcggtc cgcatcaccg agtgggtgtg gcaacagcag ctcaccgggg gcggcttcac
     1621 cacgtacgca caccgcacgg gcggccccgc ctccgaccgg atgcagtccg acgtcctggc
     1681 tcaggcgata cgcctggcca agttgctgga cctgcgcccc gacggcctcg gcagcgcggt
     1741 ctcgacgctg gccaacagcc tccacaccta cgacgacaag gcagcggtcc tctaccggcc
     1801 ccaggccgcc gagccgcacc gcaacagctg gagctccatg ttcgccggcc aggccctgcg
     1861 cctgtgcggc gccgaggccg gtctggcctg gcacgaactg gtctaaggcg cccctgcgaa
     1921 aggctcacga catgagtgac tcggttctgc tgtcggcgcg tcagccactg ccgccgatcg
     1981 actacagcca tgccgcggga gcatggatcc acaccgccga aggcgacagt ctgctggacg
     2041 cggccagcgg tctggtgtgc gtcaacatcg gccacgccca cccgcacgtg gtcgaacaga
     2101 tcacccgcca ggcccgcacc gccaccttcg cctcccccgg ggtgctgctc ccggcggtgc
     2161 aggaagagct ggccggccgg ctgaccgaag ccgtcaaccg gccgggggac ggagtgagcc
     2221 tcgcctgctc cggaacctcc gcggtggaac tggccatctc ctacgcccgg ctcatccagc
     2281 gctcgcgcgg ccaggacggc aggcatcaca tcctcaccgc ccggctcggc taccacggca
     2341 acagcgcgct gaccctgggg ctgtccggac accgccggcg acgcccgcac cccgacgacg
     2401 ccctgggcct ggcaccggcc ttcgacccgc cctacccggg acaccaccgc gactgccccc
     2461 acgaccggtg ccgggcgagc tgtgccgacg ccgtggccga ggccatcgac cgccgtgggc
     2521 ccgagtccgt tgcggccgta ctcatcgaac cggtcaacgg cacgacgggc ggcgcctata
     2581 cgccaccccc cggctatctg gcggcgctgc gccgggcctg ccacgaacgc ggtgtgctgg
     2641 tcatccacga cgaggtcctg accggcctgg gacggaccgg cctgccactc ggcgcggacc
     2701 actgcacgga cgccgcggcg gacatcgtgg tgctctccaa gggactgtcc gccggatacc
     2761 ttccgctggc ggcggtgctc gtgaaccccg agggagtggc ccggctccgc tccggccccc
     2821 ggccactgcc cctgatgggc accatgtcgg cgaccccgct ccaggccgcg gcggggctcg
     2881 cggtgctcga tgtgctcggc gagatcggcg cgctggaccc ggctcgcgtc cggggcgggg
     2941 acgtcgccgc cgccgtacgg gcggtggcag cgctgcccgt ggtgcaggag acccggggag
     3001 tgggctactt ccacgccgtg gagctggcgc ccggcaccca ggccgccgcc ctcgccgccg
     3061 cccgcgacga gcggctgctg ctgtacccct tcaacggatt ccacgccgac ggcacgggcg
     3121 aaggactgat cgtcgctcct ccgctgaact ccaccccgtc cgaagtcgaa ttcctggcac
     3181 aggggctgcg tcgtgcgctg gagcgcacgg ccgcccggtc cgaagaccga tcccaccgct
     3241 gaaaggcacc tcttgatgtc acccacgacc acgcactggg caggacgcca ggtgctcgtc
     3301 acgggagccg acggtttcat cggttcgcat ctcaccgaga ccctggtgag ccgcggcgcc
     3361 cgagtcaccg cggtcgtccg acgcgtctcg gccgcacagg tgacgcaccg gctccgcaat
     3421 ctctccgccg cgaccgtcga cgccctcgaa cgggtggtgc acgtggacct cgcgggacct
     3481 tcggcggtcg acgtcctcgg ccggctggag gccgacacct ggttccacct cgccgcggac
     3541 gcctacgtac cggcatcgct ggaccagccc gccgatgtgg tgcgcaccaa tgtgatgtcc
     3601 actctccacg tcctgctggc agcccagcag cggcagcccg cgcacctcct ggtgacgagt
     3661 tcgagcgagg tctacggcag ccagccggac gcgatcaccg aacggcatcc gctggaaccg
     3721 gccacgccct acgcggcgtc caaggtggcc tgcgaccgcc tggcctggtc ctggcaccac
     3781 acctacggcc tgccgctcac catcgtccgg ccgttcaaca gctacgggcc ccgccacgtc
     3841 tacgacgcgg taccgctctt cctggccaga gcgctgcggg gcgagccgat caccatcaac
     3901 ggcagcggtg agcagacgcg cgacctcacc ttcgtggccg acaccgtcgc ggggttcctc
     3961 gccctggcgg agctgccggc caccggcgag acgtacaaca tcggcaccgg cacggaccac
     4021 cgcatcatcg acgtggcccg cgccatcgtg gccctgaccg ggtcgcagag cgagatcgtg
     4081 cacggcccac cgcgctccgg cgaagtgctc aagctgcagg ccgatccggc gaaactcacc
     4141 gaggccaccg ggtggcgtgc cgagtacgac ctggccaggg gcctggcgga caacctggtc
     4201 tggatgcggg aacacgtgga gacggtatgg ccgacacgat cctgatggac gccggcggcg
     4261 tcctcttcaa caacgtcacc gaagagacgg acttcctgga ccgcctcgcc gcccggcacg
     4321 gtgccgacac ccagcggctg cgcggggaga tcgacgcccg cgacgccgcg tacgagaccg
     4381 ggcgcgccca tgtccacgac gtcctgcgtg acgccctcgc cgccgcgggg gccccggccg
     4441 gcgtcgcggt ggacgcccga tggctggacg acctgtaccg ggactgcctg gccgttcacc
     4501 ccggggcgtt cacggcgatc gacggtatcc gccggcaccg ccccgacatc ctgctggtac
     4561 tgacgaacaa cgaggccgcc cactgggacc gggtcaagga cgaccggtac gggcacctcg
     4621 gacgcttcga cgtcatcgcc tcgtcgtggc aagtgggcga ggtcaaaccc accggggagt
     4681 tcttcgaggc cgtcgcccgg cggtgcggcc gcccgctcga cgacgccgtc ctgctggacg
     4741 acaatccgga cgtactcgcc gaggcccgcc accacggcct gcgcaccctg cacgtcgaat
     4801 cgcccgccac gctccccgag gcagtggccc gccttcctgg acttcccgcc accggcccga
     4861 tacgaaggcc ggacatgaac gcgacctcgc ccgaagacac cccggccgcg cagcgcacac
     4921 ccctcctgcc ggagcagcgc cgcttcctca ccaccgcgat ccccaacctc cagggcgggg
     4981 gcggacgccg cggagtgcgc tcccacctca tcggccacgg tcgccggggc ctgctgcgat
     5041 gacggccgcc gccgcttcac cggaggacct ggcaccgata caggcacgga cgctgttcgt
     5101 gatgcgggac ggcagactca ccgcgatcaa cgacgtcggc cgccccgccc cgccccggtg
     5161 cttcctctcg tacacggcca ccgccgtgac ggcgtggacc agcaccgccg tgccggcgga
     5221 cctcaccgac gagctggacc gatgggccgc ggaccagacc ccggccccgc tgaccgagct
     5281 cgtcagcccc ccggccggcg cgctccggct gctggcgcgg cacgccccgg tgacggagag
     5341 cttcgtaggc cccgcctacg ccgtgcccga ctccgcagac acaccggcgc cgccaggcat
     5401 caccctgcgg gactgcggtc cgtcggagtc gtcccgcttc cgcgagacct tcccggaagt
     5461 ggccgacacc ctcgccgaac ggcagccgac cgtcgccgcg ttcgacggcc accgagcggt
     5521 cgccgtctgc tgcgcggccc gcgacggcgg cgaggcatat gaggcgggca ccgagacact
     5581 gccgagccac cgcggccgcg gcctcgcctc ggcactggtg acccgctggg cccggctggt
     5641 gcgcgcacgt ggcgcccggc cgctctacag caccgaatgg gacaaccact cgtccctgtc
     5701 cgtggcgaag cggctggcca tggagctgta cgccgtcaac gtcagcctct actgaccctc
     5761 ctgaccaccc ccgacctgct gccggccgca cgttccgtgg acgcggccgg cggcggaaag
     5821 gccgaacccc ggggccggac aacgagatgg cccgagacct gctgcgccgt gcccggaagc
     5881 cgtccgggac gacgcgcaca ccaccccacg acaactcgtc cgcgaactgg tcgacagcgg
     5941 cgacaccggc gagatcctct ccctcagccg catcctggag agcgggggac cacttcccgg
     6001 cgcgccccgc agcagagtgg cgctgatcgg cagtttcacc gctgcccttc tcggccgggt
     6061 cctgcgcgtc accttgcgcc ggtgcgggat cgacgccgtg gtggacgtcc acggcatcgg
     6121 acggtacggc agccggaccg cggatccggg cagtgacctc taccgcagcg accccgacac
     6181 cgccttggcg acacacctgg ccggccacgc ccggtacggc gcgcatcgcg gcatcgagat
     6241 tctcaggcgc cggacgttcg gccgcgcgga cggtcaactc cccgcaggcg gcgcctactc
     6301 actcggaaac ccggtcagtg ccgcgctggg ccgggacata cgatggcggc gtgacgatca
     6361 cgtacgaatg gcggggtggc ttcgacaacg ccgctctcaa cgcactgcac gccgacggtt
     6421 tcggtccccc aatcgcgcag accgactggc gaacgcggct tgagcgccac agcctcggct
     6481 gggtctgtgc gtgggaggac ggtctgatcg gatttgtcaa cgtcgtctgg gacggcggag
     6541 cccatgcctt catcctggac acggtcgtcg cccggcactg ccggtcgaga ggagtcggcg
     6601 ccgcgctcgt cgccaaggcg gccgacgaag cccgtgccgc gaactgcgag tggttgcacg
     6661 tcgacttcga ggagcacctg cgcgcgttct atttcgatgc ctgcggcttc aaggagacga
     6721 cggccgggct gatcgccctg taacgagggc gcccaagccc tcggcccttg cctacgaccg
     6781 ggggaaggca cgccggaccg acccaggatt gacgggcgat cgtgaggccc tgcttgatca
     6841 cacgagcgtt ccctcagaac tgatggggat ccgcgcatcc ttctggcccc gctgaccgcg
     6901 atgtcgtgaa accgaaggtc ggagcgagcg atgaaggatc gtttaccctg actggttgtc
     6961 cgagcctgcg cgccaccggc gggggcccag cccattcctg aggagcaagt tgttcgacct
     7021 catcgtcatc atccgggtcc ccgagagcac cgacatcgcc cccgttgccg acgccctgtc
     7081 ccggatgcgc cccttgtgtc tggcagaaga cggctgcgtc agctgggagg cgtaccactc
     7141 acacgaggaa cccggccgct tcgtcctggt cgagcgctgg gccagccgcg cccactggga
     7201 ggctcacgat gccggtgacg ccatccagaa gatctacatc ccggagctca tgccgcgcat
     7261 cgagcgcgag gtgcatccca gcatgcgcgt acccagcaag catgaagcgg taactggctg
     7321 aacccgtcac gttgttgggc cggcggcctc ggcggacacc cgtacccggg agcgccggcc
     7381 ttgagccggg cgaatgcggc gacggggctg cggagcaggc cggcccaggg cgcagccggt
     7441 aaggattgag tggtgccccg accgccgccg ttccacaacc ggctgttcca cggaacagca
     7501 gcggtcagag ccaccttcac ctctccccgt cacggcagat gaattcggtt gcggcgggac
     7561 cggtgagccc ggtggggtac c
//
