BGC0000841: alanylclavam biosynthetic gene cluster from Streptomyces clavuligerus ATCC 27064
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Location: 1,152,119 - 1,163,141 nt. (total: 11,023 nt).
This entry is originally from NCBI GenBank CM000914.1.

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core biosynthetic genes
additional biosynthetic genes
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General
Compounds
Genes
History
KnownClusterBlast
General information about the BGC
MIBiG accession BGC0000841
Short description alanylclavam biosynthetic gene cluster from Streptomyces clavuligerus ATCC 27064
Status Minimal annotation: no
A minimal annotation only contains information on the BGC loci and one or more linked chemical product(s)

Completeness: complete
Whether the loci encodes everything needed for the pathway producing the compound(s)
Biosynthetic class(es)
  • Other (Non-NRP beta-lactam)
Loci NCBI GenBank: CM000914.1
Compounds
  • alanylclavam
  • 2-hydroxymethylclavam
  • 2-formyloxymethylclavam
  • clavam-2-carboxylate
  • clavulanic acid
Species Streptomyces clavuligerus ATCC 27064 [taxonomy]
References
Chemical products information
alanylclavam
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C8H12N2O4
Chemical database entries
PubCHEM
2-hydroxymethylclavam
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C6H9N1O3
Chemical database entries
PubCHEM
2-formyloxymethylclavam
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C7H9N1O4
Chemical database entries
PubCHEM
clavam-2-carboxylate
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C6H7N1O4
Chemical database entries
PubCHEM
clavulanic acid [synonyms: clavulanate]
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C8H9N1O5
Chemical database entries
NPAtlas
PubCHEM
List of genes involved in compound(s) production
Identifiers Position Product Functions Evidence Extra
  • SCLAV_p1074
  • EFG04560.1
  • ceaS1
1152119 - 1153762 (+) Carboxyethyl arginine synthase isoenzyme 1
  • Precursor biosynthesis
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  • SCLAV_p1075
  • EFG04561.1
  • bls1
1153786 - 1155369 (+) Beta-lactam synthetase isoenzyme 1
  • Precursor biosynthesis
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  • SCLAV_p1076
  • EFG04562.1
  • pah1
1155366 - 1156739 (+) Proclavaminate amidinohydrolase
  • Precursor biosynthesis
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  • SCLAV_p1077
  • EFG04563.1
  • oat1
1156931 - 1158289 (-) Probable glutamate N-acetyltransferase 1
  • Precursor biosynthesis
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  • SCLAV_p1078
  • EFG04564.1
  • cvm6P
1158740 - 1160263 (-) Putative pyridoxal phosphate-dependent aminotransferase
  • Scaffold biosynthesis
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  • SCLAV_p1079
  • EFG04565.1
  • cvm7P
1160394 - 1163141 (-) Putative transcriptional regulator
  • Scaffold biosynthesis
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Annotation changelog
MIBiG version Submitter Notes
1.0
  • Hidden contributor (ID: FHMX74FQXDJKCZZPHECQNTZR, no GDPR consent given).
  • Submitted
2.0
  • Hidden contributor (ID: AAAAAAAAAAAAAAAAAAAAAAAA, no GDPR consent given).
  • Migrated from v1.4
  • Updated compound(s) information (NPAtlas curation)
3.0
  • Hidden contributor (ID: AAAAAAAAAAAAAAAAAAAAAAAA, no GDPR consent given).
  • Cleaned up synonym list
  • Updated bioactivity data
3.1
  • Hidden contributor (ID: AAAAAAAAAAAAAAAAAAAAAAAA, no GDPR consent given).
  • Update chemical activity to schema version 2.11
Similar known gene clusters
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