LOCUS       BGC0000875             28072 bp    DNA     linear   BCT 22-MAY-2009
DEFINITION  Streptomyces sp. MK730-62F2 caprazamycin biosynthetic gene cluster,
            complete sequence.
ACCESSION   BGC0000875
VERSION     BGC0000875
KEYWORDS    .
SOURCE      Streptomyces sp. MK730-62F2
  ORGANISM  Streptomyces sp. MK730-62F2
            Bacteria; Actinobacteria; Streptomycetales; Streptomycetaceae;
            Streptomyces.
COMMENT     ##antiSMASH-Data-START##
            Version      :: 6.2.0-924c3663(changed)
            Run date     :: 2022-11-07 20:55:00
            NOTE: This is a single region extracted from a larger record!
            Orig. start  :: 0
            Orig. end    :: 28072
            ##antiSMASH-Data-END##
FEATURES             Location/Qualifiers
     source          1..28072
                     /clone="cosmid 31C2"
                     /db_xref="taxon:643403"
                     /mol_type="genomic DNA"
                     /organism="Streptomyces sp. MK730-62F2"
                     /strain="MK730-62F2"
     protocluster    1..28072
                     /aStool="rule-based-clusters"
                     /category="other"
                     /contig_edge="True"
                     /core_location="[6642:21629]"
                     /cutoff="20000"
                     /detection_rule="(LipM or LipV or LipU or ToyB or TunD or
                     pur6 or pur10 or nikJ or nikO or truD)"
                     /neighbourhood="10000"
                     /product="nucleoside"
                     /protocluster_number="1"
                     /tool="antismash"
     proto_core      6643..21629
                     /aStool="rule-based-clusters"
                     /tool="antismash"
                     /cutoff="20000"
                     /detection_rule="(LipM or LipV or LipU or ToyB or TunD or
                     pur6 or pur10 or nikJ or nikO or truD)"
                     /neighbourhood="10000"
                     /product="nucleoside"
                     /protocluster_number="1"
     cand_cluster    1..28072
                     /candidate_cluster_number="1"
                     /contig_edge="True"
                     /detection_rules="(LipM or LipV or LipU or ToyB or TunD or
                     pur6 or pur10 or nikJ or nikO or truD)"
                     /kind="single"
                     /product="nucleoside"
                     /protoclusters="1"
                     /tool="antismash"
     subregion       1..28072
                     /aStool="externally annotated by: MIBiG"
                     /contig_edge="True"
                     /label="BGC0000875"
                     /subregion_number="1"
                     /tool="antismash"
     region          1..28072
                     /candidate_cluster_numbers="1"
                     /contig_edge="True"
                     /product="nucleoside"
                     /region_number="1"
                     /rules="(LipM or LipV or LipU or ToyB or TunD or pur6 or
                     pur10 or nikJ or nikO or truD)"
                     /subregion_numbers="1"
                     /tool="antismash"
     gene            103..1149
                     /gene="cpz9"
     CDS             103..1149
                     /codon_start=1
                     /gene="cpz9"
                     /product="AraC family transcriptional regulator"
                     /protein_id="ACQ63617.1"
                     /transl_table=11
                     /translation="MIFQASPTNRSIRQNGGFGMLRGFEAVPLGSSGHGKDRRVAGGAA
                     CAPLARRTGDTRHQSTAFRNARPVLETAELGSVTAHRIRFGAGCTGPHVLAPAPGQHAL
                     VLSARGETRIARGGREVVVQGEAVALCDTRHPLHISPRPATRTAEAVVMLFPGSAVPMT
                     QTETVPAQPEISDVTGSGSLLRAFLVEAATLASLSAHEAARLGDAALHLAAAVLEAYFF
                     DAGETRAQTQQQELMTRIRGFIDRNLGDPDLTPSLVASAHHISIRCLQRLFKAEGSTPS
                     EWIRQRRLDNSRRELCDVSLRSASIREIGLRNGFAQASDFSRVFRGRYGVPPGKFRDDW
                     FRWGAISQ"
     misc_feature    103..28072
                     /note="caprazamycin biosynthetic gene cluster"
     misc_feature    187..189
                     /note="tta leucine codon, possible target for bldA
                     regulation"
                     /tool="antismash"
     gene            1299..1847
                     /gene="cpz10"
     CDS             1299..1847
                     /codon_start=1
                     /gene="cpz10"
                     /product="beta-hydroxylase"
                     /protein_id="ACQ63618.1"
                     /transl_table=11
                     /translation="MPGRRKACFVTALTSRTELDIDPDKLRESVVELLERHPLVFEGTR
                     QLALQHRPEATDPWYEGCQRQSLISSDSDFTEVHGELRDTYLGEVFDRLPFKPIRTRIM
                     ALDPKYCYSVHRDLTPRYHLAVTTSEHARFVFIEHDKVLHIPADGDLYYVDTRQLHSAF
                     NGGDDMRIHIVFGTDGESK"
     gene            1867..2499
                     /gene="cpz11"
     CDS             1867..2499
                     /codon_start=1
                     /gene="cpz11"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1089:methyltransferase (Score: 65.2; E-value: 1e-19)"
                     /gene_kind="biosynthetic-additional"
                     /product="SAM-dependent methyltransferase"
                     /protein_id="ACQ63619.1"
                     /transl_table=11
                     /translation="MTNLVAHWDRRAESYDATPGNSLSPEQAAAWGALLAEVYPVHTGR
                     LLDIGCGTGTYSLLIAELGFDVHGVDTSERMVERARAKALERGAGPGVSFSTLPAQDIS
                     GQYDAVFSRNVLWTVADPGRLAETVREHTTESAVWIAVETMWDGHPRGDFREAGKDLPG
                     FGGWHPNVLRDVFTRHGFARTTWSSISNRPDLATQDRDVHVLFRVSR"
     gene            2496..3065
                     /gene="cpz12"
     CDS             2496..3065
                     /codon_start=1
                     /gene="cpz12"
                     /product="TmrB-like kinase"
                     /protein_id="ACQ63620.1"
                     /transl_table=11
                     /translation="MIIVVTGPWALPRMDIARSVVRRFGGVEAVDGEQLGFALMEFRSD
                     LPDNFQEDPVWEGLFTALCVFTARRRNGTSVLAPMNIHSSERLARVRAALTGQGEAVHV
                     VGLRSSREHCERLADTFSFFETGSPDYHRVRDWQLARMGEYLDFIADPHAPVDHWIDLG
                     PDASAEWVAASIAGAVSPLVAAEAAT"
     gene            3136..4461
                     /gene="cpz13"
     CDS             3136..4461
                     /codon_start=1
                     /gene="cpz13"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1019:aminotransferase (Score: 23.7; E-value: 3.5e-07)"
                     /gene_kind="biosynthetic-additional"
                     /product="amino-cyclopropyl transferase"
                     /protein_id="ACQ63621.1"
                     /transl_table=11
                     /translation="MTACREDVVAEISDAECVVAYRRLRDGVRTTRQIGYGRNMYPAAP
                     ELVARIRGLVTTLFEQQRMTDYSTEFDGADRQLISALVREWLGRPDIEPDDVFVMAGST
                     EAISVVTGYLAGRGYGYVLPLPCYYAFEQSAKRWGMPVHAHYNGDGVLHGTRPDSPWAL
                     VDIVPNGVTGRRFRLPDGTGDDFRVIDSVFQVSAAPGPGPAVDDRHLLDAVRGVDLGRS
                     CVMLTASKDLSVPGLRAGLLITREPGLRRYLEADRFERCYALNPLSTSVIALYVALMCA
                     RAARAKGAVAPGHPLVPPEVALGRPTADDPLARLLWQSPIVDALDRYLNGMARHYQAVL
                     DIYRNRLPPLGIDVAFRCPETGYSLFLPLPVRVEGPEGAVEWCNRVGREAGLKLNPAAI
                     FGGSDAPWTALYDCTRPWARFNCSVAEPDAVGTVDILATALR"
     gene            4466..5740
                     /gene="cpz14"
     CDS             4466..5740
                     /codon_start=1
                     /gene="cpz14"
                     /product="transaldolase"
                     /protein_id="ACQ63622.1"
                     /transl_table=11
                     /translation="MTVRAAGKTSADADPLALARAIADADRRAASALNLVPSENRVSPL
                     ASLPLASDFYNRYFFNTDGDPLFWEFRGGEDIAHIEALGAAALRRMAMARYCNLRPISG
                     MSAMILTVAALSKPGSTVVSVDQDSGGHYATPALLGRLGRRSRLLTCKDGAVDESELAD
                     VLAPGGVDLVYVDVQNCVRVPDFRLMSDVIRNVSPGTRLYVDASHYLGLVLGGLVDNPL
                     DCGADAYGGSTHKSFPGPHKGVIFTNAEDVDESLRSAQFDLVSSHHFAETLALSLAALE
                     VEDRIGDYARATNDNARRLAGALAEAGFRVCGDTGTGYTDTHQVWVELAGTDEAYALSN
                     RLAEAGIRVNLQSSMPGMSGVHLRLGSNEVTFEGAGPQAIEELAGALVQARERALGPHT
                     VSEIRGRFGAPFYTDPEKLKVEAGL"
     misc_feature    4727..4729
                     /note="tta leucine codon, possible target for bldA
                     regulation"
                     /tool="antismash"
     gene            5822..6646
                     /gene="cpz15"
     CDS             5822..6646
                     /codon_start=1
                     /gene="cpz15"
                     /product="Fe(II)-dependent UMP dioxygenase"
                     /protein_id="ACQ63623.1"
                     /transl_table=11
                     /translation="MQLMKSSYTDLPARGPVTDLLKPDETLDMLETYGLAVTQSPSATV
                     SPADAHSEMAAIRADFGLGEPYVPLLYRGRDTPIVTEVTRKGDSDHPVFHTGEAQGWHT
                     DGLLEDIGTIKTTLLYCVSPAYRGGRTFLLNAGRVFEELRTEDPEAADVLMRDTILGRR
                     STIPGVNREAVGPVFAELGDGHYATRYGEGRVERWYPGDAAQRRALDRALRHFRMRRDD
                     PDVRIDLLLQAGQCLIFRNDVLAHGRENFTDDPQSPRLLMRSLHTNAPKNTS"
     gene            6643..7344
                     /gene="cpz16"
     CDS             6643..7344
                     /codon_start=1
                     /gene="cpz16"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     nucleoside: LipM"
                     /gene_kind="biosynthetic"
                     /product="nucleotidyltransferase"
                     /protein_id="ACQ63624.1"
                     /sec_met_domain="LipM (E-value: 1e-136, bitscore: 444.5,
                     seeds: 5, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MKSSVIIAMAGEGTRFGAPYPKELHAVSPHRTVLHCCVAPLSGLD
                     LTQVRIIGVVGAGRARSMDVIGDALGKRGADVVFTVQNPQGHGPGLQGAVRAGLPFCEG
                     VTAVLLADQIFTTRKPDDLAEAMDAARQHGRSALVYPTTDPEVLRADGAVAFDRRTGVI
                     KACAEKPQKDLDRFDGLWVVPMVSPEHRELLPMIATDPAPVLSGARYVEVDSYVNVTRP
                     SDVWGWRCPES"
     misc_feature    7219..7221
                     /note="tta leucine codon, possible target for bldA
                     regulation"
                     /tool="antismash"
     gene            7344..8477
                     /gene="cpz17"
     CDS             7344..8477
                     /codon_start=1
                     /gene="cpz17"
                     /product="glycosyltransferase"
                     /protein_id="ACQ63625.1"
                     /transl_table=11
                     /translation="MDCTGHRVDWTSLGGIGLRARELAAEISRVADVCVFSPGSRPEAL
                     GAGVRLVTNETGWADELRRSDLVYSFDSPSPERLSAVADSGRPLIVENAPPLEHALYPS
                     LLRNADRENLYRRTVEAYRTQLANGAFFTARSAVERATLAANLCATGRVTVEAMQPSGT
                     LDALISTIPIGFSESAATRARRELDRTAPGQTFRVAWSGGLWTYLDPVFALDAVRIARS
                     RGVPAELEFLYGAGNADNAAVRSGLLDAIENRGCGDFVTLRPTPLSPAQYFQVLAGTSA
                     LICIGRRGIENETCVRLRARDSRLFGLPTVLDRHGPTFDELTRDGLAHGADDPEEGADA
                     LESIYRKGGRRAPLDRYSYRRTAHDLCAWIAKGSWGR"
     gene            8474..9748
                     /gene="cpz18"
     CDS             8474..9748
                     /NRPS_PKS="Domain: Aminotran_3 (27-367). E-value: 7.7e-71.
                     Score: 230.6. Matches aSDomain:
                     nrpspksdomains_cpz18_Aminotran_3.1"
                     /codon_start=1
                     /gene="cpz18"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Aminotran_3"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1013:aminotransferase class-III (Score: 295.4;
                     E-value: 1.1e-89)"
                     /gene_kind="biosynthetic-additional"
                     /product="aminotransferase"
                     /protein_id="ACQ63626.1"
                     /sec_met_domain="Aminotran_3 (E-value: 3.3e-73, bitscore:
                     237.2, seeds: 13, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MNHGEQAASALGRPWRAPRDHSGPTFVTARGAWLADREGHRVIDA
                     TSGALNVFCGHGVESIVDAYLSQLRTLAHVDMSQGLAEPAHLLAERLRDIPGHGGDRFF
                     FANSGSEAIELAVKISSLYWVAVDSRRTDIVTFERGYHGSTSLCQSLSGLPQTGTTPDR
                     CGSGVHRLGFGEFTGAGQRSSEAREHIAEQLRTMLADTAAGTVLVEPFLNVGGGIRLPE
                     GLLADIRRICDEYGTLLVLDEVFTGLGRTGAWFAQEHDGVRADLTAFSKGLTNGVCALS
                     AVAVGSGLLERLPAGGIVSYGHTMSASAAACTAASATLEYMRRTGAVDAAAGIGRRLLG
                     ELGRALHGTDGVLDVRGHGLALSVEFDSADTAESVQQVAYDLGAYTRQQGGTVMLAPPA
                     CLSGEEEDRLADHVVTAVRKVVAAQ"
     aSDomain        8555..9574
                     /aSDomain="Aminotran_3"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_cpz18_Aminotran_3.1"
                     /evalue="7.70E-71"
                     /label="cpz18_Aminotran_3.1"
                     /locus_tag="cpz18"
                     /protein_end="367"
                     /protein_start="27"
                     /score="230.6"
                     /tool="antismash"
                     /translation="TARGAWLADREGHRVIDATSGALNVFCGHGVESIVDAYLSQLRTL
                     AHVDMSQGLAEPAHLLAERLRDIPGHGGDRFFFANSGSEAIELAVKISSLYWVAVDSRR
                     TDIVTFERGYHGSTSLCQSLSGLPQTGTTPDRCGSGVHRLGFGEFTGAGQRSSEAREHI
                     AEQLRTMLADTAAGTVLVEPFLNVGGGIRLPEGLLADIRRICDEYGTLLVLDEVFTGLG
                     RTGAWFAQEHDGVRADLTAFSKGLTNGVCALSAVAVGSGLLERLPAGGIVSYGHTMSAS
                     AAACTAASATLEYMRRTGAVDAAAGIGRRLLGELGRALHGTDGVLDVRGHGLALSVEFD
                     "
     gene            9745..11127
                     /gene="cpz19"
     CDS             9745..11127
                     /codon_start=1
                     /gene="cpz19"
                     /product="pyrimidine-nucleoside phosphorylase"
                     /protein_id="ACQ63627.1"
                     /transl_table=11
                     /translation="MRSRPNDAIGVDDALEHIERLRHGETLTTEWASAVLDLYQTGRLA
                     DYQLSAWLATIAARGLRFTETVALTKAYLGPAVRERGAVPRNGRTVVDKHSTGGIGDKT
                     TLVVVPLVAALGVRVCKLSGRGLGIAGGTIDKLESVPGLKLEFTASELATRLAADDVVI
                     GSFSDALVPGDTATYDLRSVSGCVRSAPLIAASIVSKKVAVNADAVVFDVRYGAGALLD
                     DRTSARRLAGLLVRLGGAFGLRCRAVLSDGSVPLGTAVGNAAEVDEAVEFLRGTGDRRL
                     RAECEAIAVQMVRVTEPGEPEHRIRERLRSAIESGTALSMFVRMLESQGGDAGPVLGGG
                     GYCTPRARTAVLARDTGWVTDISALDIGRAALKLGAGKVRADDVIDPNAGIRLIRRLGE
                     RVAEGDVVAEVLHDGPDVGDAVALVSRAVSVGRREDCREPGEPEPLSEEDVRTDETGTV
                     HV"
     gene            11120..12184
                     /gene="cpz20"
     CDS             11120..12184
                     /NRPS_PKS="Domain: AMP-binding (79-304). E-value: 4.5e-13.
                     Score: 40.3. Matches aSDomain:
                     nrpspksdomains_cpz20_AMP-binding.1"
                     /codon_start=1
                     /gene="cpz20"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) AMP-binding"
                     /gene_kind="biosynthetic-additional"
                     /product="acyl-CoA synthase"
                     /protein_id="ACQ63628.1"
                     /sec_met_domain="AMP-binding (E-value: 3.4e-16, bitscore:
                     49.3, seeds: 400, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MSDGITAPASGRHVREYLSKMLRWHFDEETGSRFWVEHRDALPFD
                     PVTDIRTFDDLRRFPSRVNELRESRVEDLVPRGLAEEPPPYVVESGGTTGSPKRAVLSH
                     TRIEQLVDLYCAYAPEAAGHTMLSLFPTGPHLAGNWQRRWARRLGVLYLQVDIDPRWVK
                     SGIGTELQEQYAQHVLAQARDVLRTQHVGHLLVTPPLLRRIARSEELTELVRATVRVIT
                     WGGARMTREELYEYAQLVFPHTDFVATYASSITGTRALLRRSTAFDDLPVFDPVGPELF
                     VRVVDPRTREPVPNGTRGQVLMHTLTRDMFLPNNLERDLAVRVSGGEDWRGDSLADVVP
                     LSEFEGSRVVEGIY"
     aSDomain        11357..12031
                     /aSDomain="AMP-binding"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_cpz20_AMP-binding.1"
                     /evalue="4.50E-13"
                     /label="cpz20_AMP-binding.1"
                     /locus_tag="cpz20"
                     /protein_end="304"
                     /protein_start="79"
                     /score="40.3"
                     /specificity="consensus: X"
                     /tool="antismash"
                     /translation="AEEPPPYVVESGGTTGSPKRAVLSHTRIEQLVDLYCAYAPEAAGH
                     TMLSLFPTGPHLAGNWQRRWARRLGVLYLQVDIDPRWVKSGIGTELQEQYAQHVLAQAR
                     DVLRTQHVGHLLVTPPLLRRIARSEELTELVRATVRVITWGGARMTREELYEYAQLVFP
                     HTDFVATYASSITGTRALLRRSTAFDDLPVFDPVGPELFVRVVDPRTREPVPNGTRGQV
                     LMH"
     gene            12184..13686
                     /gene="cpz21"
     CDS             12184..13686
                     /codon_start=1
                     /gene="cpz21"
                     /product="acyltransferase"
                     /protein_id="ACQ63629.1"
                     /transl_table=11
                     /translation="MANGRDGQKVPVVRTTTAGRVGGVQYRPSGFCVWRGIPYGAIPAD
                     GGRFAGPVRPHPWDRVRPALRHGSMSWQLPPVYDKVCDVMREFDFAHTADPEHEDCLNL
                     NVYTPDPGHAGLPVLVWFHPGMQVAGSGNMPGRRPEVLSRNHGVVVVTMNFRLGCWGHL
                     FLDDLLGRDTANLRLRDQLLALTWVKENIAAFGGDAANVTVFGESAGARNIGSLLGCPA
                     ADGLFERAALYSGGCENVVPREEATEFAREFLDCAGLTGAPQRILSVPNVHLKVAHQRL
                     LKRRELVHYRDVLDGVHLPRLPIEAMRAGTVSGKVDLLVSHTADEAGLWDRLMPGGARV
                     VAQGARTAAAGTAGYESDHVRFINEELFLRPARDLLRAKAAAGGGRCWYQVYDYVPTDH
                     SFADAERALHGMDLASLLLDVSAPGAASESDVAVARTVQSALVDFASGRVPATDGLTWP
                     VYERGAERLVRIRRRPSVDTAVWPQEDDTAAAGRWRGEDHRW"
     gene            13683..17399
                     /gene="cpz22"
     CDS             13683..17399
                     /codon_start=1
                     /gene="cpz22"
                     /gene_functions="transport (smcogs) SMCOG1288:ABC
                     transporter related protein (Score: 285.7; E-value:
                     1.3e-86)"
                     /gene_kind="transport"
                     /product="ABC multidrug resistance transporter"
                     /protein_id="ACQ63630.1"
                     /transl_table=11
                     /translation="MSTEVRVSPSWMVRLLASWAADRRSAVGAVTLALAGAGIDLAAPL
                     VIRSVVDGLSAGRSVAVGALVLLIVAALLRFAAQFGQRATASRIAVRVQHDLRVALLSS
                     VCRYSGERQDALRRGEVVSRSITDLQIVQSLLALAPQAAAAVLHVTVQLVIMFFLSPVL
                     ALATLVTIPLAGALVVRSRRRIYAATWLSQQATADLTSFTGEAIAGLPVTKVFGREELI
                     ERRFLDLARELYGRRQRVARLNAAFSPGLTVLPQFALVLVIGLGGTMTLRGEISVGTFI
                     VFATYLLTMTGLIRLLAGVVSAIALARSSAERIHALIDSAEHRPDAVGKGTGTNRGGAI
                     GMLLSDVDLTLGPDARYVLRGLNIEVRRGECLGVAGKAGSGKSVLGLVLQGQYRPRAGR
                     VALMGDSVETGDGTEPVALGDPDVVLVTEEPFLFSGTIRHNVLLGREFDADRYASALAD
                     AAVDTMLERLADGDRTCVGESGARLSGGERQRIALARALYESPGLLVLDDATSALDTLT
                     EARVFDALRRRLGRGRTLVVTGRRRAVLSLADRIAVVEGGRVVEEGDARTLLRDSVRLK
                     ALLGEETPTPTLGADEVTGDEPQARAALPANTRPVAATALEADPAEALAHHVTALPPVV
                     DEPVGADVDNGRRSGPLVLREVLLPVRSAAVTALMCIGVEVVAAVALPAVARAVLGRSK
                     DGDATAVGLLFVLGLVITAVSWIAGWGTVRASTRVCDRVLFTVRLRCFRHIQRLPLDYV
                     DRVRSGGVLTRMTADIDSLSAFLQTGLLSLIINLMLVFGAALAVVLMAPGFWPVLVAAG
                     LVVLVGTAAFRRIVSRSYPRARELLAAVNADLYEKVHGVRTAQIFRCTDRITAEFAKKS
                     AAYRDERQAGQRAVAWFFPLVAMTIDMALICVLLPAVVDGLPWAAGDDGGTIAALILYV
                     SMLYYPIQQMATVYDSAQQAKVGLRRINGLLSEPTEGALAGVPAGTPGAGGAIRFDHVG
                     FTYRQDAPYSLLDVVLDVRPGQSLAVVGPTGAGKSTIVKLLARFYRPQRGAIHLDGVDI
                     ATIPLRDYRRRAAIVPQEAHLFSGSVGENIAFGRPDASRAEIMRAVRSFGASEMINSLP
                     GGLDYDVGPRGSALSAGQRQVVALLRAIVSDPDLLLLDEATGALDLESERSIVSALREA
                     NGGRKTVVVAHRLATASQADVIAVVERGRLLETGGHEALMLRSGGLYAGLWAASEASGH
                     DGATSNPGQGDEA"
     gene            17396..18430
                     /gene="cpz23"
     CDS             17396..18430
                     /codon_start=1
                     /gene="cpz23"
                     /product="acyltransferase"
                     /protein_id="ACQ63631.1"
                     /transl_table=11
                     /translation="MKSLTHGEEFRFNGAVSLQQGENWIAPWRVPFDEARLYFPEGGIG
                     RAAMPSGVSVALMTDAGHLELDYLCSRCPDNIIELAEDVQQLESVDVVVDGRRVARHAL
                     CALKTEETLRLDLENESGGSRLVEIWLPIYAQFRLIDLRIEQGATASSPAPNPRRWVHY
                     GGSLSQGMGADSPLTNYVQSSRWRGDLDLVSVARGKGTHMEPVFADLIAGLRPRYVTMA
                     VGGMVYLTGSLNQYTYLTNMLGFVKRIVDTAPDCEVVVLVPPMSPRYRDHKGPNGMTAA
                     EMLETHYATVQTVMKWGDRRVHHVPQWGDVDESDFLADGIHLTSSAHRRYGEYLAQGIR
                     KCLG"
     gene            18716..20512
                     /gene="cpz24"
     CDS             18716..20512
                     /codon_start=1
                     /gene="cpz24"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     nucleoside: LipU"
                     /gene_kind="biosynthetic"
                     /product="hypothetical protein"
                     /protein_id="ACQ63632.1"
                     /sec_met_domain="LipU (E-value: 0.0, bitscore: 1247.5,
                     seeds: 3, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MGSSQLSAVVDVEVEDRQRDVLQWYASRSSGSEAGRTWPEGAVVV
                     LESDLLPDDDDLAALGCGTVTQASPKDLLGGAAQRSVPASARYVLVVAAREAFDLRLAR
                     DIVEFGRRMGLPVGTLPARSAGELGFMLKRMALARRVRAGKHVVVDAADSTSVVGDAAQ
                     FTGLGTQDVHSVSVYGHGNESHIKIGDGFICSHSASRSPEQDCMCAEHGLRLCRLDEIR
                     CVWIHLGSCGALLPDWRRSVPASNFVDSFASSYAATVCGSLYRMPTSREAIVVHELHQL
                     AGSAPGGGDPSAGTLCLGDPVLLRYTDAVLDRGTAVTGLRAELHAAASGRVPWSEDRAR
                     LRALTRTLDDARAAVTSLRLAGGPAARAALDACTARIDSASGWAARAARALSGANERNL
                     YDGTARAEVTRCLAGITALADRFEQDLLGFVGTVPAIGARAIERAMRSGLLFGSKRPGE
                     LCACRLCGLPAYVVTASDVASDRESHWAQCDVCGHLAKSPDGDRFPLITVPAPGSVGVR
                     FFGRRRTDPGARVLIDIDDSAGSLHTRSVHEIAAGDEARMRCDPSGSGPSLRVRALVVS
                     GFSIWFARATVPTAELLASPPP"
     gene            20604..21629
                     /gene="cpz25"
     CDS             20604..21629
                     /NRPS_PKS="Domain: PKS_ER (23-319). E-value: 3.3e-29.
                     Score: 93.8. Matches aSDomain:
                     nrpspksdomains_cpz25_PKS_ER.1"
                     /codon_start=1
                     /gene="cpz25"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     nucleoside: LipV"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) ADH_N"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) ADH_zinc_N"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1028:crotonyl-CoA reductase / alcohol dehydrogenase
                     (Score: 208.1; E-value: 3.2e-63)"
                     /gene_kind="biosynthetic"
                     /product="acyl-CoA dehydrogenase"
                     /protein_id="ACQ63633.1"
                     /sec_met_domain="LipV (E-value: 3.9e-237, bitscore: 775.9,
                     seeds: 3, tool: rule-based-clusters)"
                     /sec_met_domain="ADH_N (E-value: 1.6e-07, bitscore: 21.8,
                     seeds: 66, tool: rule-based-clusters)"
                     /sec_met_domain="ADH_zinc_N (E-value: 2.8e-22, bitscore:
                     69.7, seeds: 86, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MKAVFATAPDPDDPLSAVVVGHRPDPEVPQGWVRVRVRAASLNHK
                     DLWTLRGVGINRDQYPRILGCEAAGEGPGGTRVVLYPLLDSPPGMSDETLVMPAAQLVG
                     ARPGTLAEYFAAPPESLLPVPDHLTWEEAACLVCTWLPAYRMLFTKAALRPGDTVLIQG
                     AAGGLSTALVSLAAASGMRTWVTGRSADKRDLARRLGASAAFEPGAVLPEPVDAVIDSV
                     GKETWTHSLRSVRHGGTVVVAGATTGDVPPARLHRVYFHQINVVGSFSGTREEYRRLVT
                     LMRTTGIRPLVDDVLPVQEARAALKRLADGDVRGNLVLTWSEDDREAHCEATRRMSVWI
                     P"
     aSDomain        20673..21560
                     /aSDomain="PKS_ER"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_cpz25_PKS_ER.1"
                     /evalue="3.30E-29"
                     /label="cpz25_PKS_ER.1"
                     /locus_tag="cpz25"
                     /protein_end="319"
                     /protein_start="23"
                     /score="93.8"
                     /tool="antismash"
                     /translation="PDPEVPQGWVRVRVRAASLNHKDLWTLRGVGINRDQYPRILGCEA
                     AGEGPGGTRVVLYPLLDSPPGMSDETLVMPAAQLVGARPGTLAEYFAAPPESLLPVPDH
                     LTWEEAACLVCTWLPAYRMLFTKAALRPGDTVLIQGAAGGLSTALVSLAAASGMRTWVT
                     GRSADKRDLARRLGASAAFEPGAVLPEPVDAVIDSVGKETWTHSLRSVRHGGTVVVAGA
                     TTGDVPPARLHRVYFHQINVVGSFSGTREEYRRLVTLMRTTGIRPLVDDVLPVQEARAA
                     LKRLADGDVRGNLVL"
     CDS_motif       21069..21131
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_cpz25_0001"
                     /evalue="1.20E-05"
                     /label="PKSI-ER_m5"
                     /locus_tag="cpz25"
                     /protein_end="176"
                     /protein_start="155"
                     /score="17.9"
                     /tool="antismash"
                     /translation="GDTVLIQGAAGGLSTALVSLA"
     gene            21682..22935
                     /gene="cpz26"
     CDS             21682..22935
                     /codon_start=1
                     /gene="cpz26"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1089:methyltransferase (Score: 73.8; E-value:
                     2.5e-22)"
                     /gene_kind="biosynthetic-additional"
                     /product="SAM-dependent methyltransferase"
                     /protein_id="ACQ63634.1"
                     /transl_table=11
                     /translation="MTVIPDRWRARSAIDLVREAGDGADLPPCDSRFHYVPPWRSEALE
                     TLAEKVVPAVAGIAARYAAAGRPDDLITADETATLVGACAYVRLRGDGDGCTLAFGGLP
                     SELTGHAQHDRMTVRAALECVGWFDANQRLLTATGITPGRPGGTAAADGALYGPELARR
                     YDPARQVTEQFNDVLRGFAKEFLGMRRVLELGTGTGRVARNIAPFAGSYVGIEASRAMI
                     DAGRRDGLDVRQGDMMAMPFETGSVDVVVEHESVDFCTEPLLAATEIERVLALGGQFYR
                     IELETVPAAGITRLQDEITARLAKLSGGVFPYWTKGQRRRLHSRLTGRGFAHRRIRLAR
                     WHETRTLRNWLQGLVNASYPSFSGVDEETASSTCVELARAASMGDLDTKWPGEAGVVVH
                     QYEAVEWCCAAHRPRPTT"
     gene            22932..23510
                     /gene="cpz27"
     CDS             22932..23510
                     /codon_start=1
                     /gene="cpz27"
                     /product="TmrB-like kinase"
                     /protein_id="ACQ63635.1"
                     /transl_table=11
                     /translation="MTRTEKPLLVWINGPFGAGKSTVTDELSRAAGEVIVFDPEEVGFH
                     LRTWVPLPASGDFQDLACWRDVVGQTCAAFARHYPSRLLLVPMTVVNDDYRQEIFDIIR
                     KSTDQVLHVWLSVTRQTLADRITHQVIWPDDPERDAEVRAWRLAQIDGAMTAESRLGAD
                     TVVLPTDDTRPRQLAERILAEAARRTGKA"
     gene            23591..24781
                     /gene="cpz28"
     CDS             23591..24781
                     /codon_start=1
                     /gene="cpz28"
                     /product="sugar O-methyltransferase"
                     /protein_id="ACQ63636.1"
                     /transl_table=11
                     /translation="MAVWKDIEFLDRLIVAAGGDERGLVEITKNLPLDELTSVLVDEIV
                     FRANTNAAGSAFRREEAQVPEIGTVLLGVHHDGLTQERALGVRADGTVEQTTGTRGDIA
                     LRLDYDLHDLIRVLFGPTRLRPAGTYSSAFLPATAGHQRMPPLETVYQGMEVAGTVLSG
                     LSQHHPDLSELARRYRTDKWGGLHWFTGLYERHLREFRELPVRILEIGIGGYGNATLGG
                     ESLRMWKRYFPRGLVFGVDIFDKSAVDEQRITTLRADQNDPQALIEVEEKYGPFDLVID
                     DGSHVNGHVRTSLETLFPRLRAGGLYVIEDLWTSYCPGYGGQDRVPVDRTTSVGMLKDI
                     VEGIQYEEQPRPPGRPPAHLERNVVGAHVYHNLAFLEKGVNAEGGVPSWVPRHPRY"
     gene            24825..25622
                     /gene="cpz29"
     CDS             24825..25622
                     /codon_start=1
                     /gene="cpz29"
                     /product="sugar O-methyltransferase"
                     /protein_id="ACQ63637.1"
                     /transl_table=11
                     /translation="MTTAGPATAHDNAADAYLDLLKRCLTRYDGHQIFLGPPLAKPRTM
                     EQIERGRFAHQDADTMVGWPRLDNVRHCVETVLREQVPGDLLEAGVWRGGCCVYMRGIL
                     KARAVDDRTVWVADSFAGFPEPDIDRYPDDSVYDSPVAREILDGFGYPIAISLDEVKSR
                     FRSYGLLDSQVRFLAGYFADTLPQAPVERLAVLRLDGDMYQSTLESLEHLYPKLSAGGY
                     CIIDDYSLEGCRKAVEHFREAHGIGEPIEKIDWTGVFWRRTSA"
     gene            25619..26878
                     /gene="cpz30"
     CDS             25619..26878
                     /codon_start=1
                     /gene="cpz30"
                     /product="sugar O-methyltransferase"
                     /protein_id="ACQ63638.1"
                     /transl_table=11
                     /translation="MTGALRGPRAEASSVDSTVARVISAAGCRDEEITSVIESAGPERV
                     AGILVDEIVCRADLPPVELGEGVVVQLLFGHGTRTISHLVQAGPAGVTYEPGGAESPHA
                     RIEQDLCEAVRAVFGPHGDRAAATRRLELRGSDTPQAYVLPPTAFWVAQRLLATMDDRD
                     EIGLTELASRYGSDKWGIHRYTQHYQHHFAPLRDRPLTVLEIGVGGLSGGTTGYRAPDK
                     GGGSLRMWKRYFPRALVYGIDIADKRALSEQRITVLRADQSNADELHEVVEQTGPLDIV
                     IDDGSHRSEHVLTSFTTLFPHLRDGGLYVIEDLQTSYWPRFGGNSDVFDSPTTSVGFLK
                     SLVDALHYEEILDSGGRAPGAYDRLVKGLHFYHNIGFVEKGLNAEGGGPSWLRHPPRRR
                     GDRGPAGDRSSSQPPSHGPR"
     gene            26882..28072
                     /gene="cpz31"
     CDS             26882..28072
                     /codon_start=1
                     /gene="cpz31"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) MGT"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1062:glycosyltransferase, MGT family (Score: 295.3;
                     E-value: 1.5e-89)"
                     /gene_kind="biosynthetic-additional"
                     /product="rhamnosyltransferase"
                     /protein_id="ACQ63639.1"
                     /sec_met_domain="MGT (E-value: 2.4e-125, bitscore: 409.3,
                     seeds: 193, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MRVLFTTSPGLGHMFPVVSLAWALRAAGHEILLATAGRAESHVRA
                     MAEAGLPVVEVLSVERTTRAFAFGISAWLKQEGKGIAGRPDWPRRVGRELARGGGGLET
                     VAPMYGPLSMAMSDEVVAVAEQWRPDLLVHTPMEGAGPLAAARLGVPAVEHPFGFSRND
                     KIAPVLRESMDRAYRAHGVAGLPERRIALSVTPASMAGEATTAWPMRYVPFNGGGVLAD
                     WLRVRPDRPRVALTLGSEVVQWHSELGPLSWVTEVAANVDAEFVLAVGGDIDPAQLGEL
                     PENVRPAGYVPLNQLLPTCTAVIHHGGSGSTMAALDAGIPQLVLPQSADQFINANAVVG
                     RGCGLATEDKVDLELIVRLLTDPRPAEAAAQVRAELHGMPSPAEVVPRLAELARRA"
ORIGIN
        1 gcggcggcgc ccgcaggatt gacgcaaagc aagtggatgt cgtcacgtct gatgtcgtag
       61 taatgaagcg agtcatatga ccggcggtct ttctgagaat cggtgatctt ccaggcgtca
      121 ccgacgaacc ggagtattcg ccagaacggg ggattcggta tgttgcgcgg cttcgaggcg
      181 gtgccgttag gcagctcagg ccacggcaaa gacaggaggg tggccggagg agccgcgtgc
      241 gcaccgttgg cgcggcgtac cggggacacg cggcatcaga gcaccgcgtt ccgcaatgcc
      301 cgtccggttc tggagacggc tgaactgggc agcgtcacgg cgcaccggat caggttcggc
      361 gccgggtgca ccggtccgca cgtgctggcg cctgctcccg ggcagcacgc cctcgtcctc
      421 agtgcgcgcg gtgagacgag gatcgcgcga ggcgggcgcg aggtcgtcgt ccagggcgag
      481 gcggtggcac tgtgcgacac ccggcacccg ctgcacatca gcccgaggcc ggcgacccgg
      541 acggccgaag cggtcgtgat gctcttcccg ggttcggccg taccgatgac gcagacggaa
      601 actgtcccgg cgcaacccga gatctccgac gtcacgggat cgggatcact gctccgcgcg
      661 ttcctcgtcg aggccgccac cctggcgtca ctgagcgcac acgaggcggc ccggctcggc
      721 gacgccgcac tgcacctggc cgcagcggtg ctggaggcgt acttcttcga cgccggagag
      781 acgagggcac agacgcagca gcaggagctc atgacgcgga tccgaggatt catcgaccgc
      841 aacctcggcg atcccgacct cacgccgagc ctggtcgcct cggcccacca catctccatc
      901 cgctgtctgc aacggctgtt caaggccgag ggcagtactc cgtcggaatg gatccgtcag
      961 cgccggctgg acaacagccg gcgtgaactc tgcgacgtga gtctccgctc ggcatccatc
     1021 cgggaaatcg gcctgcgtaa cggtttcgcc caggcgtccg acttcagccg ggtgtttcgt
     1081 ggccgctacg gtgtcccgcc gggtaaattc cgcgacgact ggttccggtg gggcgcgatc
     1141 agtcaatagc cggtcgcatg aggacaatga cagagcccga agtgaccggg aaaatagtgt
     1201 gagacaggga gcgttcgacc tcgctcgccc ttgagtcccc aggtggctcg tccattcctg
     1261 ccaggacatc aacggcggag cagagaaggc gcgccgctgt gcccggccgt cgaaaggctt
     1321 gcttcgtgac agcactcacg tccaggaccg aactcgacat cgaccccgac aagctccgcg
     1381 aatccgtcgt ggagttgttg gaaagacatc ccttggtctt cgagggaaca cggcagttgg
     1441 cgctccagca tcggccggag gcgacggacc cgtggtacga aggctgccag aggcagtcgc
     1501 tgatctcctc ggactccgac ttcaccgaag tgcacggcga actccgggac acatatctgg
     1561 gcgaggtctt cgaccggctt ccgttcaagc ccattcgcac gaggatcatg gcgctcgatc
     1621 cgaagtactg ctattcggtg caccgtgacc tgacaccgcg ataccacctc gccgtcacca
     1681 cgagtgaaca cgccaggttc gtgttcatcg agcacgacaa ggtgctgcac attcccgcag
     1741 acggagacct gtactacgtc gacacgcggc agctgcacag cgcgttcaat ggtggtgacg
     1801 acatgcggat ccacattgtt ttcgggacgg acggcgagtc gaagtagcgg ccggaggagt
     1861 cggggcgtga cgaacttggt ggcgcattgg gaccgccgcg ccgagagcta tgacgcaaca
     1921 ccggggaact cgctgtcgcc ggaacaggcg gcggcgtggg gcgcgctgct ggccgaggtc
     1981 tacccggtcc acaccggcag gctgctcgac atcggctgcg ggacgggcac ctactcgttg
     2041 ctgatcgcgg aactgggatt cgacgtgcat ggggtggaca cctcggagcg gatggtcgag
     2101 cgggcgcggg cgaaggcact cgaacgcggc gccggccccg gtgtcagttt ctccaccctc
     2161 cccgcgcagg acatcagcgg ccagtacgac gccgtgttct cccggaacgt gctgtggacc
     2221 gtcgcggacc ccggccgact ggccgagaca gtgcgggagc acaccacgga gtccgcggtg
     2281 tggatcgccg tcgagacgat gtgggacggc caccccaggg gcgacttccg ggaagcggga
     2341 aaggacctgc caggattcgg cggctggcac cccaatgtgc tccgagacgt gttcacgcgg
     2401 cacggattcg cacggacgac gtggtccagc atctccaacc ggccggatct ggcgacccag
     2461 gacagggacg tccacgtgct gttccgggtg agccggtgat catcgtcgtc acgggcccct
     2521 gggcgctgcc gaggatggac atcgcccgat cggtcgtacg ccggttcggc ggcgtcgagg
     2581 ccgtcgacgg ggaacagttg ggattcgccc tgatggagtt ccgttccgac ctgccggaca
     2641 acttccagga ggaccccgtc tgggagggac tgttcaccgc gctgtgcgtg ttcaccgccc
     2701 ggcgccggaa cggcaccagc gtactggcac cgatgaacat ccactcgagc gagcgcctgg
     2761 ccagagtacg ggccgccctc accggccagg gagaggcggt ccacgtagtg ggcctgcggt
     2821 cgtcccggga gcactgcgag cgcctggcgg acaccttctc gttcttcgag acgggatcgc
     2881 cggactacca ccgcgtgcgc gactggcagt tggcacggat gggcgagtac ctggacttca
     2941 tcgccgatcc gcacgcaccg gtcgaccact ggatcgacct gggaccggac gcgtcggccg
     3001 agtgggtggc cgcgtcgatc gccggggcgg tgagccctct ggtcgcggcg gaggcagcca
     3061 catgaggacc tgggccggac ctccgtaccc gcccgtcccg gccgcccggc ggcgtcacag
     3121 cggtgggtcg tgcccatgac ggcctgtcgg gaggacgtcg tggcggagat cagcgacgcc
     3181 gagtgcgtgg tggcgtaccg gcgtctgcgc gacggggtcc gcaccacgcg gcagatcggc
     3241 tacggccgca acatgtaccc ggccgctccc gaactcgtcg cacggatccg cgggttggtc
     3301 accacactgt tcgagcagca gcgcatgacg gactactcca ccgagttcga cggcgccgac
     3361 cggcaactga tcagcgcctt ggtccgggag tggctggggc gccccgacat cgagccggac
     3421 gacgtgttcg tcatggccgg gtcgaccgag gcgatcagcg tggtcaccgg gtacctcgcc
     3481 ggacgcggat acgggtacgt gctgccgctg ccgtgctact acgccttcga gcagtccgcc
     3541 aagcgctggg ggatgccggt ccacgcccac tacaacggcg acggcgtgct gcacggcacc
     3601 cggccggact cgccgtgggc cctggtcgac atcgtgccga acggtgtgac cggccgccgc
     3661 ttccggctgc cggacggcac cggcgacgac ttccgcgtca tcgactcggt cttccaggtc
     3721 tcggctgcgc ccggccccgg gcccgcggtc gacgacaggc atctgctcga tgcggtccgg
     3781 ggcgtcgacc tcggcaggag ttgcgtgatg ctgaccgcca gcaaggacct gtccgtcccc
     3841 ggactgcgtg cgggcctgct gatcaccagg gagcccggcc tcaggcggta cctggaggcg
     3901 gaccgcttcg agcggtgcta tgcgctgaat ccgctgtcca ccagcgtcat cgccctgtac
     3961 gttgccctca tgtgcgcgcg ggcggcgcgg gcgaagggcg ccgtggcacc gggacaccca
     4021 ctggtacctc ccgaggtcgc gctgggccgg ccgaccgccg acgatccgct cgcgcggctg
     4081 ctgtggcagt caccgatcgt cgacgccctc gaccggtatc tgaacggcat ggcccggcac
     4141 taccaggccg ttctggacat ctaccggaac cgcctcccgc cgctcggaat cgatgtcgcg
     4201 ttccggtgcc cggagaccgg ctactccctg ttcctgccgc tgccggtgcg cgtcgaggga
     4261 ccggagggcg ccgtggagtg gtgcaaccgg gtcggccggg aggcgggact caagctcaat
     4321 ccggcagcga tcttcggggg aagcgacgca ccgtggacgg ccctttacga ctgcacgcgc
     4381 ccttgggcgc ggttcaactg ttcggtcgcg gagccggatg ccgtcggcac cgtggacatt
     4441 ctcgcgacag cattgaggtg atgaggtgac ggtgagggct gctggaaaga catccgcgga
     4501 cgccgacccg ctcgcgctgg ccagggcgat agccgacgcc gaccggcggg cggcgtccgc
     4561 cctcaacctt gtgcccagcg agaaccgggt ctcgccactg gcctccctgc cgctcgcctc
     4621 cgacttctac aaccggtact tcttcaacac cgacggcgac ccgctgttct gggagttccg
     4681 cggcggggag gacatcgcgc acatcgaggc gctcggagcc gcggcgttac gccggatggc
     4741 catggcgcgg tactgcaacc tgcgccccat atcggggatg agcgcgatga tcctgactgt
     4801 cgccgccctg tcgaaacccg gatcgaccgt cgtgagcgtg gaccaggact ccggcggcca
     4861 ctacgccacc ccggcgttgc tcggccgtct gggccgacgg tcccggctgc tcacctgcaa
     4921 ggacggagca gtcgacgagt cggaactcgc ggacgtgctc gcacccggcg gcgtggacct
     4981 cgtctacgtg gacgtgcaga actgcgtcag ggtgccggac ttccgcctga tgtcggacgt
     5041 gatcagaaat gtcagcccgg gcacgcggct gtacgtcgac gccagccact acctcggcct
     5101 cgttctcggc ggccttgtcg acaaccccct ggactgcggt gcggacgcct acggcggatc
     5161 gacccacaag tcgttccccg ggccgcacaa gggagtgatc ttcaccaacg ccgaggacgt
     5221 cgacgagagt ctgcggtccg cccagttcga cctggtcagc agccaccact tcgccgagac
     5281 gctggcgctg tccctggcag cgctggaggt cgaggaccgg atcggggact acgcccgggc
     5341 gacgaacgac aacgcgcgac gactcgcagg cgcgctggcc gaggcgggtt tccgggtgtg
     5401 cggcgacacc ggcaccggat acaccgacac gcaccaggtg tgggtggaac tggccggcac
     5461 cgacgaggcc tacgcgctgt cgaaccggct ggccgaggcg ggaatccggg tcaatctgca
     5521 gtcgtcgatg ccggggatgt ccggtgtgca cctgcgtctc ggctcgaacg aggtcacctt
     5581 cgagggcgcc ggtccgcagg cgatcgagga gctcgcgggc gccctggtcc aggcgagaga
     5641 gcgagcgctg ggaccgcaca cggtgagtga gatccgcggg cggttcggtg cccccttcta
     5701 caccgatccg gagaagctga aagtggaggc agggctgtga acatgctgac caagggtcct
     5761 gtggtggcgc cgaggcaggg gcgcggccga tcgccgtatt cgatgcgtac gggcgcctga
     5821 catgcaactg atgaagtcga gttacacgga tctccccgcc cgcggccctg tgaccgacct
     5881 gctgaagccg gacgagaccc tcgacatgct ggagacctat ggcctcgcgg tgacgcagag
     5941 cccgtcggcg accgtgtcac cggccgatgc ccacagcgag atggccgcga tacgcgccga
     6001 cttcggcctg ggggagccct atgtcccgct gctctaccgc ggccgggaca caccgatcgt
     6061 caccgaggtg acacggaagg gggactcgga ccacccggtc ttccacaccg gcgaggcgca
     6121 gggctggcac accgacgggc tcctcgagga catcgggacc atcaagacga cactgctgta
     6181 ctgcgtgtcc ccggcgtacc gaggtggcag gacgttcctg ctcaacgccg ggcgggtctt
     6241 cgaggagctg aggacggagg accccgaggc ggccgacgtg ctgatgcggg acacgatcct
     6301 cggcaggcgg tcgacgattc ccggcgtgaa ccgggaggcc gtcgggcccg tgttcgccga
     6361 actcggcgac ggccactacg ccacccggta cggcgaggga cgcgtggaac gctggtaccc
     6421 cggggacgcc gcgcaacggc gcgcgctcga tcgtgcgctg cgccacttcc ggatgcgccg
     6481 tgacgacccg gacgtccgca tcgacctgct cctccaagcc ggccagtgcc tgatcttccg
     6541 caacgacgtg ctggcccacg gccgggagaa cttcaccgac gacccgcaaa gtccccgcct
     6601 gctcatgcgc agcctgcaca ccaacgcccc gaagaacacg tcatgaagtc ttccgtcatc
     6661 atcgccatgg ccggggaggg cacacggttc ggggcgccct accccaagga actgcatgcc
     6721 gtgagtccgc accgcaccgt gctgcactgc tgcgtcgcgc cactgtccgg gctcgatctg
     6781 acgcaggtgc ggatcatcgg cgtcgtcggc gccggccggg cccggtcgat ggacgtgatc
     6841 ggggacgcac tgggcaagcg gggcgcggac gtggtgttca ccgtgcagaa cccgcagggg
     6901 cacgggcccg gcttgcaggg cgccgtccgc gccggcctgc cgttctgcga gggagtgacc
     6961 gccgtgctac tcgcggacca gatcttcacc accaggaaac ccgacgacct cgcggaggcg
     7021 atggatgcgg cgcggcagca cggacggtcg gcactggtgt acccgacgac cgaccccgag
     7081 gtgctgcgcg ccgacggcgc ggtggcgttc gaccggcgca ccggcgtcat caaggcctgc
     7141 gcggagaagc cgcagaaaga cctcgacagg ttcgacgggc tgtgggtggt cccgatggtc
     7201 tctcccgagc accgggaatt actgccgatg atcgccaccg atcccgcccc ggtcctgtcc
     7261 ggcgcgaggt acgtcgaggt cgacagctac gtcaacgtga cgcggccgtc cgacgtctgg
     7321 ggctggcgat gcccggaatc ctgatggact gcaccggcca tcgcgtcgac tggacgtcgc
     7381 tcggtggaat cgggctgcgc gcgagggaac tcgccgcgga gatctcgcgg gtcgccgacg
     7441 tctgcgtctt ttcgccgggt tcccggcccg aagctctggg cgccggtgtc aggctggtga
     7501 ccaacgagac cgggtgggcg gacgaactgc ggcgaagcga cctggtgtac tcgttcgact
     7561 cgccgtctcc cgagcgtctg tcggccgtgg ccgacagcgg cagaccgctg atcgtggaga
     7621 acgccccacc cctcgaacac gcgctgtacc cctccctgtt gcgaaacgcc gaccgcgaga
     7681 acctctaccg gaggaccgtc gaggcgtacc ggacccaact ggcgaacgga gcgttcttca
     7741 ccgcccggtc ggccgtggag cgggcgacgc tggcggcgaa cctctgtgcc accgggcgcg
     7801 tcacggtgga ggcgatgcag ccctcgggga cgctggatgc gctgatctcc acgatcccca
     7861 tcgggttctc cgaatcggcc gccacgcggg cacggcgcga actcgaccgg acggcaccgg
     7921 ggcagacctt ccgagtggcc tggtccggcg gcctgtggac ctacctcgac ccggtgttcg
     7981 cgctggacgc cgtacggatc gcccgcagcc gcggagtgcc cgcggagctc gagttccttt
     8041 acggagccgg gaacgccgac aacgcggcgg tacgttccgg actactcgac gccatcgaga
     8101 accggggctg cggcgacttc gtgacgctgc gcccgactcc gctcagcccc gcccagtact
     8161 tccaggtgct ggccgggacg tccgcgctga tctgcatcgg ccggcgcgga atcgagaacg
     8221 agacctgcgt gcggttgcgg gccagggact cgaggctgtt cggcctccct acggtgctcg
     8281 accggcacgg accgacgttc gacgaactga ccagggacgg actggcccat ggtgcggacg
     8341 accccgagga aggcgccgac gccctggagt cgatctaccg gaagggcggc cgccgcgccc
     8401 ctctcgaccg gtactcgtac cgccgcacgg cgcacgacct gtgcgcatgg atcgcgaagg
     8461 ggagctgggg acgatgaatc acggggaaca ggcagcttca gctctggggc gcccctggcg
     8521 ggccccccgc gaccactcgg gtccgacgtt cgtcacggca cgcggcgcgt ggctggccga
     8581 ccgtgaggga catcgagtga tcgacgcgac ttcgggcgca ctgaacgtgt tctgcggaca
     8641 cggggtcgag tcgatcgtgg acgcctatct gtcgcagctg cggactctgg cacacgtcga
     8701 catgtcccag ggactcgcgg agcccgcgca cctgctcgcg gaacggctgc gggacatccc
     8761 cgggcacggc ggtgaccgct tcttcttcgc caacagcggt tcggaggcga tcgaactcgc
     8821 cgtcaagatc tcctcgctgt actgggtcgc cgtcgacagc cggcgcacgg acatcgtcac
     8881 cttcgagcgc ggctaccacg gctcgacctc gctgtgccag tcgctgtccg gcctgccgca
     8941 gaccggcacc acaccggacc ggtgcggttc gggcgtccac cgcctgggct tcggcgagtt
     9001 caccggcgcg gggcaacgct cgtccgaggc gcgtgagcac atcgcggagc aactgcggac
     9061 catgctggcc gatacggccg cgggcaccgt gctcgtggag ccgttcctga acgtcggcgg
     9121 cggcatccgg ctgcccgagg gactgctcgc cgacatccgc cgcatctgcg acgagtacgg
     9181 gacgctgctg gtgctggacg aggtgttcac cggcctcggc aggacggggg cgtggttcgc
     9241 acaggagcac gacggcgtcc gcgccgacct gacggccttc agcaagggcc tgaccaacgg
     9301 cgtgtgcgcg ctgtccgcgg tcgcggtcgg cagcgggctg ctcgagcggc ttcccgccgg
     9361 cggcatcgtc tcgtacggcc acaccatgtc ggcctcggcc gcggcctgta cggcggcgag
     9421 cgcgacgctg gagtacatgc gccggaccgg ggccgtcgac gcggccgccg gcatcggccg
     9481 cagactcctc ggtgagctcg gccgggccct gcacggcacc gacggtgtgc tcgacgtgcg
     9541 cggacacggc ttggcgctga gcgtcgaatt cgacagtgcc gacaccgccg agagtgttca
     9601 gcaggtggcg tatgacctcg gcgcgtacac ccggcagcag ggcggcaccg tcatgctcgc
     9661 gccccccgcg tgtctgagcg gcgaggagga ggaccggctc gccgaccacg tggtcaccgc
     9721 ggtccgcaag gtggtcgcag cgcagtgagg agccggccga acgacgcgat aggcgtggac
     9781 gacgctctgg agcacatcga gcggctccgg cacggcgaaa cgctcaccac cgagtgggcg
     9841 tcggccgttc tcgacctgta ccagaccggc agactcgccg attaccagct ctccgcctgg
     9901 ctggcgacca tcgcggccag aggactgcgg ttcaccgaga cggtggccct gaccaaggcg
     9961 tacctcgggc cggcggttcg ggaacgcggg gccgtaccgc gcaacgggcg gaccgtcgtg
    10021 gacaagcaca gcacaggtgg catcggcgac aagacgacgt tggtggtggt gccgctggtc
    10081 gccgcgctcg gggtccgggt gtgcaagctg agcggccgcg gactcggcat cgccgggggc
    10141 acgatcgaca agctggagag cgtaccgggg ctcaagctgg agttcaccgc gtcggagctg
    10201 gccacgcggc tcgccgccga cgacgtcgtc atcgggtcct tctccgatgc actcgttccg
    10261 ggcgacacgg cgacctacga cctccgctcg gtcagtggat gcgtccgctc ggcaccgttg
    10321 atcgccgcga gcatcgtcag caagaaggtg gcggtcaacg ccgacgcggt cgtgttcgac
    10381 gtcaggtacg gcgccggggc actgctggac gaccgaacgt cggcgcgccg gctggccgga
    10441 ctcctggtta ggctcggggg cgcgttcggg ctgcgttgcc gggcggtcct cagcgacggt
    10501 tccgtgcccc tgggcacggc cgtcggcaac gcggcggagg tcgacgaggc ggtcgagttc
    10561 ctgcgcggaa ccggtgaccg cagactgagg gcggagtgcg aggccatcgc ggtgcagatg
    10621 gtccgtgtca cggaacccgg cgaacccgag caccggatcc gtgaacggct ccgctcggcg
    10681 atcgagtccg ggaccgcgct gtcgatgttc gtccggatgc tggagtcgca ggggggcgac
    10741 gcggggccgg tgctcggcgg aggcgggtac tgcacgcccc gagcgcgcac ggcggtcctc
    10801 gcccgggaca ccggatgggt caccgacatc tcggcgctgg acatcggccg ggccgcgctg
    10861 aagctgggcg cgggcaaggt gcgcgccgac gacgtcatag accccaacgc gggcatccgg
    10921 ctcatccggc gcctcgggga gcgcgtggcc gagggagacg tcgtcgccga ggtgctccac
    10981 gacggacccg acgtcggcga cgcggtggcg ctggtgtccc gggcggtctc ggtgggccgg
    11041 cgggaggact gccgggagcc gggcgaaccg gagccgttgt ccgaagagga cgtccgcacc
    11101 gacgaaacgg ggaccgttca tgtctgacgg gatcaccgcc cccgcatccg gacgacacgt
    11161 gcgggagtac ctgtcaaaga tgctccgatg gcacttcgac gaggagaccg gatcgcggtt
    11221 ctgggtcgag caccgcgacg cactgccctt cgacccggtc accgacatcc gcaccttcga
    11281 cgatctgcgc cggttcccgt cccgggtgaa cgagctgcgc gagagccggg tcgaggacct
    11341 ggtgccgcgg ggactggcgg aggaaccccc gccctacgtg gtggagtccg gcggcacgac
    11401 cggcagtccg aagcgggccg tcctgtcgca caccaggatc gagcagctgg tcgacctgta
    11461 ctgcgcgtat gcgccggagg ccgcgggaca caccatgctt tcgctgttcc cgaccggccc
    11521 ccacctcgcg ggcaactggc agcggcggtg ggcacgccgg ctgggtgtgc tctacctcca
    11581 ggtggacatc gacccgcggt gggtgaagtc cggcatcggc acggagctgc aggagcagta
    11641 cgcccagcac gtcctggcac aggcccggga cgtgctgcgc acccagcacg tcggacatct
    11701 gctggtgacc cctccgctgc tccgccgtat cgcgcggtcg gaggaactga cggaactggt
    11761 gcgtgccacg gtacgggtca tcacctgggg cggcgcgcgc atgacgcgtg aggaactgta
    11821 cgagtacgcg caactggtct tcccgcacac cgacttcgtc gccacctacg cgagttccat
    11881 cacgggcacc cgggcgctgc tcaggcgctc gacggccttc gacgacctcc cggtcttcga
    11941 cccggtcggc ccggagctgt tcgtccgagt ggtcgacccg cgcacccgcg agccggtgcc
    12001 gaacggcacc cggggccagg tgctgatgca cacgctcacc cgggacatgt tcctgccgaa
    12061 caacctggaa cgggatctgg ccgtgcgtgt gtccgggggc gaggactggc ggggcgactc
    12121 gctcgcggat gtcgtcccgc tgtcggagtt cgaaggcagt cgggtagtcg aggggatcta
    12181 ctgatggcga acggccgaga cgggcagaag gtccctgtcg tgcggacgac cacggccggc
    12241 cgggtcggcg gggtgcaata tcggccttcc ggcttctgcg tgtggcgggg catcccctac
    12301 ggcgcgatcc cggccgacgg cggccggttc gccggcccgg tgcgtccgca cccttgggac
    12361 cgggtacggc ccgcgctgcg ccacggcagc atgtcctggc agctcccgcc cgtctacgac
    12421 aaggtctgcg atgtcatgcg ggagttcgac ttcgcccaca ccgccgatcc ggaacacgag
    12481 gactgcctca acctcaacgt gtacaccccg gaccccggac acgccggtct tcccgtcctc
    12541 gtctggttcc acccgggcat gcaggtcgcc gggtcgggaa acatgcccgg cagacgcccg
    12601 gaggtgctca gccgcaacca cggcgtcgtg gtggtcacca tgaacttccg gctggggtgc
    12661 tggggccatc tcttcctcga cgacctgctc ggacgtgaca cggcgaacct gaggctgcgg
    12721 gaccaactgc tcgccctgac ctgggtgaag gagaacatcg cggctttcgg tggcgacgcc
    12781 gccaacgtga ccgtgttcgg ggagtccgcc ggagcgcgca acatagggtc cctcctgggg
    12841 tgccctgccg ccgacggcct cttcgagcgg gcagcgctgt acagcggcgg atgcgagaac
    12901 gtggtgccgc gggaggaggc gaccgagttc gcccgcgagt tcctcgactg cgccggcctg
    12961 accggtgccc cccagcggat cctctccgtc ccgaacgtgc acctgaaggt ggcgcaccag
    13021 cgtctgctca agcggcgcga gctcgtgcac taccgggacg tcctggacgg tgtccacctg
    13081 ccccgtctcc cgatcgaggc catgagggcg ggcacggtct ccggcaaggt cgacctcctg
    13141 gtgtcccaca ccgccgacga ggccggtctg tgggaccgcc tgatgcccgg cggagcgcgt
    13201 gtggtggcgc agggcgccag gaccgcggcg gcgggaaccg cggggtacga atccgatcac
    13261 gtgcggttca tcaatgagga gctgttcctc cgcccggcgc gcgacctgct ccgggcgaag
    13321 gccgcggcgg gcggtggcag gtgctggtac caggtgtacg actacgtccc cacggaccac
    13381 agcttcgccg acgcggagcg cgcactgcac ggaatggacc tcgcgtcact gctgctcgac
    13441 gtctccgccc ccggcgccgc gtcggagagc gatgtcgccg tcgcccgcac cgtccaatcg
    13501 gccctcgtgg acttcgcgag cgggcgggtc ccggcgaccg acgggctgac atggcccgtg
    13561 tacgagaggg gcgcggagcg gctcgtccgt atccgccgga ggccgagtgt ggacaccgcg
    13621 gtctggccgc aggaggacga caccgcggca gcgggccggt ggagaggcga ggaccaccgg
    13681 tggtgagcac ggaagtgcgg gtgtcgccgt catggatggt gcgcctgctc gcgtcgtggg
    13741 ccgccgaccg gcgatcggcg gtcggcgccg tgacactcgc gctggccggt gccggaatcg
    13801 acctggccgc gccgctggtg atccggtccg tggtggacgg actgtccgcc ggccggtccg
    13861 tcgccgtcgg cgcactcgtg ctgctcatcg tcgccgccct cctcaggttc gccgcccagt
    13921 tcggccagcg cgcgacggcg agccgcatcg cggtccgggt acagcacgac ctgcgcgtgg
    13981 ccctgctgtc ctcggtgtgc cgctactcgg gcgagcggca ggacgcgctg cgacgcggcg
    14041 aggtcgtctc caggtcgatc accgatctgc agatcgtcca gtcactgctc gccctcgccc
    14101 cgcaggcggc tgccgcggtg ctgcatgtca ccgtgcagtt ggtgatcatg ttcttcctct
    14161 ctccggtgct cgccctggcc acgctggtca ccatcccgct cgcgggcgcg ctggtggtcc
    14221 gctcccgtcg gcggatctac gcggccacct ggctctccca gcaggcgacc gccgacctga
    14281 cctcgttcac gggggaagcg atcgccggac tccccgtcac caaggtcttc gggcgtgagg
    14341 agctgatcga gcgacgcttc ctcgacctgg cccgcgaact gtacgggcgg cgccagcggg
    14401 tcgcccggct gaacgccgcg ttcagcccgg gcctgaccgt actgccgcag ttcgcgctcg
    14461 tcctggtcat cgggctcggc ggaacgatga ccctgcgcgg tgagatcagc gtcggtacgt
    14521 tcatcgtgtt cgccacctac ctgctcacca tgaccgggct gatccggctg ctggccggag
    14581 tcgtctccgc gatcgccctc gccagatcgt ccgccgaacg gatccacgcg ctcatcgaca
    14641 gcgccgagca ccggcccgac gcggtcggca agggcaccgg gacgaaccgc ggcggggcaa
    14701 tcggcatgct gctgtccgac gtggacctga ccctcgggcc ggacgcacgg tacgtgctgc
    14761 ggggcctgaa catcgaggtc aggcgaggag aatgtctcgg tgtcgcgggc aaggccgggt
    14821 ccggcaagtc agtgctcgga ctggtgctgc aggggcagta ccgaccccgt gcggggcgtg
    14881 tggcactcat gggcgacagc gtcgagaccg gcgatggcac ggagccggtg gccctcggcg
    14941 acccggacgt cgtgctcgtg acggaggagc cgttcctgtt ctccggcacc atccggcaca
    15001 acgtcctcct cggcagggag ttcgacgccg accggtacgc gtcggccctc gccgatgcgg
    15061 ccgtggacac gatgctcgag cgcctcgcgg acggggaccg gacctgcgtg ggagagagcg
    15121 gagccaggct ctccggcggc gagcggcagc ggatcgccct cgcccgggcc ctctacgagt
    15181 caccgggcct gctcgtgctc gacgacgcca catccgccct ggacaccctg acggaggccc
    15241 gggtgttcga cgcgctgcga cggcgactcg ggcgcggtcg caccctggtg gtcaccggtc
    15301 ggcggcgtgc cgtgctgtcc ctcgccgacc ggatcgcggt cgtcgagggc ggccgcgtcg
    15361 tcgaggaggg ggacgcccgc acactgctgc gtgactccgt gcggctcaaa gccctgctcg
    15421 gcgaggagac gccgaccccg acgctcggcg ccgacgaggt gaccggtgac gagccgcagg
    15481 cgcgtgcggc gctgcccgcg aacacccgac ccgtcgcggc gacggccctt gaggcagacc
    15541 cggccgaggc gctcgcacac catgtcaccg cgctgcctcc ggttgtcgac gagcccgtcg
    15601 gtgccgatgt cgacaacggc cggcgcagcg gcccgctcgt cctgcgcgag gtgctgctgc
    15661 ccgtccggtc ggcggccgtc acggcgctca tgtgcatagg ggtcgaagtc gtcgctgccg
    15721 tggcgctccc cgcggtggcg cgggccgtcc tcggccggtc gaaggacggt gacgccaccg
    15781 ccgtcggtct gctgttcgtg ctggggctcg tcatcaccgc ggtgagctgg atcgccgggt
    15841 ggggcacggt tcgcgcgtcc acgcgggtgt gcgaccgtgt gttgttcacc gtccgcctgc
    15901 ggtgtttccg ccacatccag cgccttccgc tggactacgt ggaccgtgtg cggtcggggg
    15961 gtgtgctgac ccggatgacg gcggacatcg actcgctgtc cgcgttcctg cagaccggcc
    16021 tgctgtccct gatcatcaac ctgatgctgg tgttcggtgc cgccctggcg gtggtgctga
    16081 tggcacccgg attctggccg gtcctggtgg cggcgggcct cgtggtgctc gtggggaccg
    16141 ccgcgttccg gcggatcgtc tcccggtcgt acccgcgagc gagggaactg ctcgccgcgg
    16201 tcaacgccga cctgtacgag aaggtgcacg gagtccgcac ggcacagatc ttccgctgca
    16261 ccgaccggat cacggccgag ttcgcgaaga agtcggcggc gtaccgcgac gaacgccagg
    16321 ccggacagcg cgcggtggcg tggttcttcc ccctggtggc gatgaccatc gacatggcac
    16381 tgatctgcgt gctgctgccg gccgtggtgg acggactgcc ctgggcggcc ggtgacgacg
    16441 gcggcacgat cgccgcactc atcctgtacg tgtccatgct gtactacccg atccagcaga
    16501 tggcgacggt ctacgacagt gcccagcagg ccaaggtggg gctccgccgc atcaacggcc
    16561 tgctgtcgga gccgaccgag ggagcactcg ccggtgtgcc ggccggtaca ccgggggccg
    16621 gcggtgccat ccgcttcgac cacgtcgggt tcacctaccg tcaggacgcc ccgtactcgc
    16681 tcctggacgt ggtcctcgac gtccggcccg ggcagtccct cgccgtcgtc ggtcccacgg
    16741 gcgccgggaa gtcgacgatc gtcaagctgc tggcccggtt ctaccggccg cagcgggggg
    16801 cgatccacct cgatggcgtg gacatcgcga cgattccgct gcgcgactac cgccgacggg
    16861 ccgccatcgt gccgcaggaa gcccatctgt tcagcggctc cgtcggcgag aacatcgcgt
    16921 tcggccgccc cgatgcctcc cgggcggaga tcatgcgcgc cgtccgctcg ttcggtgcgt
    16981 cggaaatgat caactccctg cccggcggac tggactacga cgtcggaccg cgaggatcgg
    17041 cgttgtccgc aggacagcgg caggtggtcg ccctgctgcg ggccatcgtc tcggaccccg
    17101 acctcctgtt gctggacgag gccaccggcg cgctcgacct ggagtcggag cggagcatcg
    17161 tcagcgccct ccgcgaggca aacggcgggc gcaagaccgt cgtggtcgcc caccggctcg
    17221 ccaccgcctc acaggccgac gtcatcgccg tcgtcgagcg gggccgcctg ctggagacgg
    17281 gaggacacga ggccctgatg ctgagatcgg ggggcctcta cgccggcctg tgggccgcct
    17341 ccgaagcctc cggccacgac ggagcaacga gcaacccagg acaaggagac gaagcgtgaa
    17401 gtcgttgacg cacggcgagg agttcaggtt caacggggcg gtctcgttgc agcagggcga
    17461 gaactggatc gccccgtggc gggtgccttt cgacgaggcg cgcctgtact tcccggaagg
    17521 gggcataggg cgggccgcga tgccgtccgg ggtgtccgtg gcgctgatga cggacgcggg
    17581 gcacctcgaa ctggactacc tgtgttcgcg gtgccccgac aacatcatcg aactcgccga
    17641 ggacgtacag cagctggaat ccgtcgacgt cgtcgtggac ggccgccggg tagcccggca
    17701 cgccctgtgt gccctgaaga ccgaggagac cctgcgactc gacctcgaga acgagagcgg
    17761 cggcagcagg ctggtcgaga tctggttgcc gatctacgcc cagttccgtt tgatcgacct
    17821 gcggatcgaa cagggcgcga ccgcgtcgtc gccggccccg aacccgaggc ggtgggtgca
    17881 ctacggcggc tccctgtcgc aggggatggg ggccgactcc ccgctgacca actacgtcca
    17941 gtcgagcagg tggcgcggcg acctcgatct ggtgtcggtg gctcggggca aaggcacgca
    18001 catggagccg gtgttcgcgg atctgatcgc cggtctgcgg ccgcggtacg tgaccatggc
    18061 ggtcggagga atggtctacc tcaccggatc cctgaaccag tacacctacc tcaccaacat
    18121 gctcggtttc gtcaaacgca tcgtcgacac ggcgcccgac tgcgaagtgg tcgtcctcgt
    18181 accgccgatg agtcctcgct accgagacca caaaggcccg aacgggatga ccgcggcgga
    18241 aatgctcgag acgcactacg cgaccgttca gacggtcatg aagtggggcg accggagggt
    18301 ccaccacgtg ccccagtggg gggacgtcga cgagtccgac ttcctcgccg acggcatcca
    18361 tctgacgtcg agcgcgcacc gccgctacgg ggagtacctg gcgcagggca tccggaagtg
    18421 cctcggatga accgctcggc cccgtgacga acagccacac atgacgacat ccgcagacaa
    18481 ggagcaacgc tgtgcaggac gcagagcacg tacaaggtga cgagccgacc gagccgaccg
    18541 agccgacccg ttcggtcaca ccggcggagg aggccgagcc ggccggaacg gccgggaagg
    18601 cggccgcgga ggacctcgac tggttcgagg acgtacccga ggagaacgtc ggtgccgtgc
    18661 tgtcgctgga cgaaacagcc ccgctcccgt ggatctagag acccggggga gtgacgtggg
    18721 ctcttctcag ctctcagccg tggtcgacgt cgaggtcgag gacagacagc gggacgtgct
    18781 gcagtggtat gcctcgcggt cgagcgggtc cgaggccggc cggacatggc ccgagggcgc
    18841 ggtggtcgtc ctggaaagtg atctcctccc ggacgacgac gacctcgccg cgctcggctg
    18901 cggcacggtc acgcaggcct cccccaagga cctgctcggc ggcgccgccc agcggtccgt
    18961 accggcgtcg gcgcgatacg tcctggtggt cgccgcccgc gaggcgttcg acctccgact
    19021 cgcccgcgac atcgtggagt tcgggcgccg gatgggcctg ccggtgggaa cgctgccggc
    19081 ccgctccgcc ggggaactgg gcttcatgct gaagcgcatg gctttggcac ggcgggtgcg
    19141 ggccggcaaa cacgtcgtcg tcgatgccgc cgattcgacg tccgtcgtgg gcgacgcggc
    19201 ccagttcacg ggcctcggga cgcaggacgt gcacagcgtc tccgtgtacg gacacggcaa
    19261 cgagtcccac atcaagatcg gggacgggtt catctgctcg cacagcgcga gccggtcgcc
    19321 cgagcaggac tgcatgtgcg ccgagcacgg tctcagactg tgcaggctcg acgagatccg
    19381 ctgcgtgtgg atccacttgg gatcctgcgg agcgctgcta cccgactggc gccggagtgt
    19441 gcccgcgtcc aacttcgtcg actccttcgc gagttcgtac gcggcgacgg tgtgcgggtc
    19501 gctgtatcgc atgccgacgt cccgcgaagc catcgtcgtc catgagctgc accaactggc
    19561 cgggtccgct ccgggcggag gcgatccgtc ggcggggacc ctgtgcctgg gcgacccggt
    19621 cctgctgagg tacaccgacg ccgtcctcga ccgggggaca gccgtcaccg ggctgcgggc
    19681 cgaactccac gccgctgctt ccggccgggt gccctggtcc gaggaccgcg cgcgattgcg
    19741 ggcgctgacg cgcaccctcg acgacgcgcg tgcggcggtc acctccctgc gcctggcggg
    19801 cggccccgcc gcgcgcgcgg cgctggacgc ctgcacagcc cggatcgaca gcgcgtcggg
    19861 ctgggcggcc cgggccgcga gagcgctgtc gggggcgaac gaacggaatc tgtacgacgg
    19921 gaccgcccgg gccgaggtca cccggtgcct cgccggcatc accgctctcg ccgaccggtt
    19981 cgagcaggac ctgctgggct tcgtggggac ggttccggcc atcggcgccc gcgccatcga
    20041 acgcgccatg agaagcggac tgctgttcgg gtcgaaaagg ccgggggagc tctgtgcttg
    20101 ccggctgtgc gggctcccgg cgtacgtggt caccgccagt gatgtggcga gtgaccgaga
    20161 gagccactgg gcgcagtgcg acgtctgcgg acacctggcg aaatcacctg acggagaccg
    20221 cttcccgctg atcacggtac cggccccggg gagcgtcggc gtccggttct tcgggagacg
    20281 acggacggac ccgggtgccc gggtgctcat cgacatcgac gacagtgccg ggagcctgca
    20341 caccaggagc gtgcacgaga tcgcggcagg ggacgaggcg cgcatgcgct gcgacccgag
    20401 tggctccggc ccctcgttgc gggtgcgggc gctggtggtg tccggattct cgatctggtt
    20461 cgcgcgagcg accgtgccga cggccgaact gctcgcctct ccgcccccct gacacgcgcc
    20521 caggcgccct gctggccgta agccgaactg gaaggaagtc acatgcgtgg gaacgccatc
    20581 cggcagcccg aggacgacga ctcatgaagg cagtgttcgc gaccgccccc gatccggacg
    20641 atcccctgtc cgccgtcgtc gtcggacacc gccccgatcc cgaggtgcct cagggctggg
    20701 tgcgggtcag agtccgggcg gcgtccctga accacaagga cctgtggacc ttgcgcggcg
    20761 tcggcatcaa ccgcgaccag tacccccgaa tcctcggctg cgaggcggcg ggggagggac
    20821 ccggcggcac gagggtggtg ctgtacccct tgctggactc cccacctggc atgagcgacg
    20881 agacgctggt gatgcccgcg gcccagctgg tcggtgcccg gcccggcacc ctggccgagt
    20941 acttcgcagc accccccgag agcctgctgc cggtccctga ccatctgacc tgggaggagg
    21001 cggcgtgcct ggtgtgcacc tggctgcccg cgtaccggat gctgttcacg aaggcggcgc
    21061 tgcgccccgg ggacaccgtg ctcatccagg gggcggccgg cggactgtcc accgcgctgg
    21121 tcagcctggc agcggcgagc ggaatgcgca cctgggtgac cggccggtcc gccgacaagc
    21181 gggacctggc ccgccgcctg ggagcgagcg ccgccttcga accgggagcc gtgctgcccg
    21241 aaccggtcga cgcggtcatc gacagcgtgg gcaaagagac atggacgcac tcgctgcgca
    21301 gtgtccggca cggcggcacg gtggtggtcg ccggtgcgac gacgggagac gtcccgcccg
    21361 cccggctgca ccgcgtctac ttccaccaga tcaacgtcgt gggctccttc agcggcaccc
    21421 gcgaggagta ccggcgcctg gtgacgctga tgcgcaccac cggtatcagg ccgctggtgg
    21481 acgatgtgct gccggtccag gaggcgcgcg cggcactgaa gcggctcgcc gacggcgacg
    21541 tacgaggcaa cctcgtcctc acctggtccg aggacgaccg ggaagcccac tgcgaggcga
    21601 ctcggcggat gtccgtctgg atcccctgac ggcccaggac ccgcgcggag cgcacatgca
    21661 gaccatgttc cagaaagggt gatgacagtg atccctgaca ggtggcgggc gaggagcgcg
    21721 atcgatctcg tgcgcgaggc aggggacggc gccgacctgc cgccgtgtga cagcaggttc
    21781 cactacgttc cgccgtggcg gtccgaagct ctggaaacac tggccgagaa ggtggtgccc
    21841 gccgtcgccg gcatcgcggc gcggtacgcg gccgccggcc ggccggacga cctgatcacg
    21901 gcggacgaga cggcgacact ggtcggcgcg tgtgcatacg tacggctgcg cggcgacggt
    21961 gacggctgca ccctcgcctt cggcggcctg ccctcggaac tgaccgggca cgcgcagcat
    22021 gaccggatga ccgtccgcgc ggccctggag tgcgtcggct ggttcgacgc gaaccagcgc
    22081 ctcctcaccg ccaccggcat cacaccgggg cggcccggtg gaacggcggc tgccgacggc
    22141 gcgctctacg gaccggagct ggcacgccgc tacgacccgg cgcggcaggt gaccgagcag
    22201 ttcaacgacg tgctgcgggg attcgccaag gagttcctcg ggatgcgccg cgtcctggaa
    22261 ctgggcaccg gcaccggtcg agtggcacgt aacatcgccc ctttcgccgg ctcctacgtg
    22321 gggatcgagg cctcccgcgc gatgatcgac gccggacgcc gggacggctt ggacgtacgg
    22381 cagggggaca tgatggcgat gccgttcgag acggggtcgg tcgacgtggt cgtcgagcac
    22441 gagagtgtcg acttctgcac ggagccgctg ctggccgcca ccgagatcga acgggtactg
    22501 gccctgggcg ggcagttcta ccggatcgag ctggagaccg tgccggccgc cggcatcacc
    22561 cgactccagg acgagatcac cgcgcggctg gcgaaactct ccggcggagt cttcccctac
    22621 tggaccaagg gacagcgccg gcgcctgcac agccggctga cgggccgcgg cttcgcacac
    22681 cgcaggatcc ggctcgcgcg gtggcacgag acgcggaccc tgcgcaactg gctccagggc
    22741 ctggtcaacg cgagctatcc gtcgttctcg ggcgtcgacg aagagacggc gtcgtccacc
    22801 tgtgtggaac tggcccgcgc ggcgtcgatg ggggacctcg acacgaagtg gccgggagaa
    22861 gccggcgtgg tggtgcatca gtacgaggcc gtcgagtggt gctgcgccgc acaccgcccc
    22921 cggccgacca cgtgaccagg acggagaagc ccttgctggt gtggatcaac ggtcccttcg
    22981 gggccggcaa gtcgaccgtc accgacgagc tgtcacgggc cgccggcgag gtcatcgtct
    23041 tcgatcccga agaagtcggc ttccacctgc gcacatgggt tccgttgccg gcatcggggg
    23101 acttccagga cctcgcgtgc tggcgcgatg tcgtcgggca gacgtgtgcg gcgttcgccc
    23161 ggcactaccc gtcccgtctt ctcctcgtgc cgatgaccgt ggtgaacgac gactaccggc
    23221 aggagatctt cgacatcatc cgcaagagca cggaccaggt cctgcacgtc tggctgtccg
    23281 tcacccggca gacgctcgcc gaccgcatca cccaccaggt catctggccg gacgaccccg
    23341 agcgggacgc cgaggtacgg gcctggcgac tcgcgcagat cgacggcgcg atgaccgccg
    23401 agagccgact cggcgcggac accgtcgtcc tgcccaccga cgacacgcgt cctcggcaac
    23461 tggcggaacg gatcctcgcc gaagccgcgc ggcgcaccgg aaaggcctga catccgtcag
    23521 gcgctccgcg ccggcgccgc acgcgtgcgg cgtcttctcg aagacgaacc tcaccaggga
    23581 gttgctgaag atggccgtgt ggaaagacat cgaattcctg gaccggttga tcgtcgccgc
    23641 gggcggagac gaacgaggcc tcgtggagat cacgaagaac ctcccgctgg acgaactcac
    23701 ctcggtcctg gtcgacgaga tcgtgttccg ggcgaacacc aacgccgccg gctcggcgtt
    23761 ccgccgggaa gaggcccagg tgccggaaat cggcaccgtg ctcctcgggg tgcatcacga
    23821 cggcctcacg caggagcggg cgctcggcgt acgggccgac ggcacggtcg agcagaccac
    23881 cgggacgagg ggcgacatcg ccctgcgcct cgactacgac ttgcacgacc tcatccgggt
    23941 gctgttcggg ccgacgcgcc tcaggccggc cggtacctac tcctcggcct tcctcccggc
    24001 caccgcaggc catcagcgga tgcccccgct cgaaaccgtc taccagggca tggaggtcgc
    24061 gggaaccgtg ctgtccgggc tgtcccagca ccaccccgac ctcagcgaac tggccagacg
    24121 ctaccggacc gacaagtggg gcgggctgca ctggttcacg gggctgtacg agcgccacct
    24181 gcgggagttc cgggaactgc cggtgcggat cctggagatc ggcatcggcg gctacggcaa
    24241 cgccacgctc ggtggcgagt cactgcgcat gtggaaacgc tacttcccgc gtggtctcgt
    24301 cttcggcgtc gacatcttcg acaagtccgc ggtcgacgag cagcggatca ccaccctgcg
    24361 cgcggaccag aacgacccgc aggccctcat cgaggtcgag gagaagtacg gccccttcga
    24421 cctcgtcatc gacgacggca gccatgtgaa cggccacgtc cgcacctcgc tcgagacgct
    24481 cttccccaga ctgcgtgccg gaggcctcta cgtgatcgag gacctctgga cgtcgtactg
    24541 ccccggttac ggcggtcagg accgggttcc cgtggaccgg acgacctcgg tggggatgct
    24601 caaggacatc gtggagggca tccagtacga ggagcagccc cggccgcccg gccggccgcc
    24661 ggcccatctg gagcggaacg tggtcggcgc acacgtctat cacaacctcg cgttcctgga
    24721 aaagggcgtc aacgccgagg gaggggtccc gtcgtgggtg ccccgccatc cgaggtactg
    24781 acgcccggta tctcccctga caccatcgac cccagggaac tcccatgaca accgctggac
    24841 ccgcgaccgc ccacgacaac gccgcggacg cctacctcga cctgctgaaa cgctgcctga
    24901 cccgatacga cggccatcag atcttcctgg gcccgccgct ggcgaagccc cgcacgatgg
    24961 agcagatcga gcggggccgg ttcgcacacc aggacgccga caccatggtc ggctggccgc
    25021 gcctggacaa cgtccgccac tgcgtggaga ccgtgctccg ggaacaggtc ccgggcgacc
    25081 tgctcgaagc gggcgtgtgg cggggcggtt gctgcgtcta catgcgcggc atcctcaaag
    25141 cccgggctgt cgacgaccgc acggtgtggg tggccgactc gttcgcgggg ttccccgagc
    25201 cggacatcga ccggtacccg gacgactccg tctacgacag ccccgtcgcg cgggagatcc
    25261 tcgacggctt cggatacccg atcgccatca gcctggacga ggtgaagtcc cggttcaggt
    25321 cctacgggct gctggacagc caggtccgct tcctcgccgg gtacttcgcg gacacactgc
    25381 cgcaggcccc cgtggagcgg ctggccgttc tgcggctgga cggcgacatg taccagtcga
    25441 cactggagtc gctggagcac ctgtacccga agctgtccgc cgggggctac tgcatcatcg
    25501 acgactactc gctggagggc tgtcgcaagg ccgtcgagca cttccgcgag gcgcacggga
    25561 taggggagcc gatcgagaag atcgactgga cgggcgtctt ctggcgcagg acgtccgcat
    25621 gacgggagcg ctgcgaggcc cgcgtgcaga ggcgtcttcg gtggacagca ccgtcgcccg
    25681 ggtgatctcg gcggcaggct gcagggacga ggagatcacg tcggtcatcg aatccgcggg
    25741 acccgagagg gtcgccggaa tcctggtgga cgagatcgtg tgcagagcgg acctgccgcc
    25801 cgtcgaactc ggcgagggag tcgtcgtgca gttgctcttc ggacacggga ccaggaccat
    25861 ctcccatctc gtgcaggcag gacccgccgg tgtcacgtac gagccgggtg gtgcggagag
    25921 tccgcacgcc cggatcgagc aggacctgtg tgaggcggtg cgcgctgtct tcgggccgca
    25981 cggcgatcgc gcggcggcga ccagacggct ggagctgcgg ggatcagaca cgccgcaggc
    26041 ttacgtgctg ccaccgacgg cgttctgggt ggcccaacgg ctgctcgcca ccatggacga
    26101 ccgcgacgag atcgggctga ccgaactggc cagccggtac ggctcggaca aatgggggat
    26161 ccaccggtac acacagcact accagcacca cttcgcgccg ctgcgcgatc gaccgctgac
    26221 cgtcctggag atcggtgtcg ggggcctcag cggcggcacc accggctacc gtgcccccga
    26281 caagggcggc ggttccctgc ggatgtggaa gcgctacttc ccgcgcgccc tggtctacgg
    26341 catcgacatc gccgacaagc gggcgctgtc ggagcagcgg atcaccgtac tgcgcgccga
    26401 ccagtcgaac gccgacgaac tgcacgaggt ggtcgagcag acgggccccc tggacatcgt
    26461 gatcgacgac gggagccatc gcagcgagca cgtcctgacg tccttcacca cgttgtttcc
    26521 gcacctgaga gacggcggcc tgtatgtgat cgaggacctg cagacctcct actggccgcg
    26581 gttcggcggg aacagcgatg tgttcgacag cccgacgacg agtgtcgggt tcctgaagtc
    26641 cctggtggac gccctgcact acgaggagat cctcgactcc ggcgggcggg cgcccggcgc
    26701 gtacgaccgg ctcgtcaagg ggctgcactt ctaccacaac atcgggttcg tcgagaaagg
    26761 cctgaacgcg gagggcggcg gcccctcctg gctcaggcat ccgccccgcc gccggggcga
    26821 ccggggaccg gccggtgacc gttcatcctc tcaaccgcct tcgcacggac cgaggtgagc
    26881 catgcgcgtg ctcttcacga cgtcgcccgg gctggggcac atgttcccgg tggtctcgct
    26941 cgcctgggcg ctgcgcgcgg ccggacacga gatccttctc gccacggccg gccgggccga
    27001 gagccatgtc cgggccatgg ccgaggccgg cctgccggtg gtggaggtgc tgagtgtcga
    27061 gcggacgacc agagccttcg ccttcgggat cagcgcctgg ctgaagcagg agggcaaggg
    27121 catcgccggg aggccggact ggccccggcg ggtgggcagg gagctggcgc gtggcggggg
    27181 cgggctggag accgtcgccc ccatgtacgg ccccctctcc atggccatga gcgacgaggt
    27241 ggtggccgtc gccgagcaat ggcggccgga cctgctcgtc cacaccccca tggagggagc
    27301 aggaccgctg gccgcggcca ggctcggcgt gcccgctgtg gagcatccct tcgggttcag
    27361 ccgcaatgac aagatcgccc ccgtgctgcg ggagtcgatg gaccgggcct accgtgcgca
    27421 cggcgtggcc gggctgcccg agcggagaat cgccctgtcc gtcactcccg cgagcatggc
    27481 gggcgaagcg accacggcct ggccgatgcg ctacgtaccg ttcaacggcg gcggggtcct
    27541 ggccgactgg ttgcgggtgc ggccggaccg tccccgggtg gcactcactc tcgggtccga
    27601 ggtggtgcag tggcacagcg agctcggccc gctgtcctgg gtcaccgagg tggccgccaa
    27661 cgtggacgcg gagttcgtgc tcgccgtcgg cggcgacatc gacccggctc agctcggcga
    27721 gctgccggag aacgtgcggc cggccggata cgtcccgctc aatcagctgt tgccgacctg
    27781 cacggcggtc atccatcacg gcgggtccgg cagtacgatg gctgcgctgg acgccggaat
    27841 cccgcaactg gtgctgccac agagcgcgga ccagttcatc aacgcgaatg cggtcgtcgg
    27901 gcggggatgc ggcttggcga cggaggacaa ggtggacctc gaactgatcg tccgtctgct
    27961 caccgacccg cggccggccg aggccgcggc gcaggtgcgg gccgagctgc acggtatgcc
    28021 ctcgcctgcc gaggtggtgc ccaggctggc cgaactggcg aggagggcct ag
//
