LOCUS       BGC0000876              9389 bp    DNA     linear   BCT 15-APR-2005
DEFINITION  Streptomyces tendae nikkomycin biosynthetic gene cluster (nikP1,
            nikP2, nikQ, nikR, nikS, nikT, nikU, nikV genes), strain Tue901.
ACCESSION   BGC0000876
VERSION     BGC0000876
KEYWORDS    .
SOURCE      Streptomyces tendae
  ORGANISM  Streptomyces tendae
            Bacteria; Actinobacteria; Streptomycetales; Streptomycetaceae;
            Streptomyces.
COMMENT     ##antiSMASH-Data-START##
            Version      :: 6.2.0-924c3663(changed)
            Run date     :: 2022-11-07 20:55:13
            NOTE: This is a single region extracted from a larger record!
            Orig. start  :: 0
            Orig. end    :: 9389
            ##antiSMASH-Data-END##
FEATURES             Location/Qualifiers
     source          1..9389
                     /db_xref="taxon:1932"
                     /mol_type="genomic DNA"
                     /organism="Streptomyces tendae"
                     /strain="Tue901"
     protocluster    1..9389
                     /aStool="rule-based-clusters"
                     /category="NRPS"
                     /contig_edge="True"
                     /core_location="[71:2105]"
                     /cutoff="0"
                     /detection_rule="cds((PP-binding or NAD_binding_4) and
                     (AMP-binding or A-OX))"
                     /neighbourhood="20000"
                     /product="NRPS-like"
                     /protocluster_number="1"
                     /tool="antismash"
     proto_core      72..2105
                     /aStool="rule-based-clusters"
                     /tool="antismash"
                     /cutoff="0"
                     /detection_rule="cds((PP-binding or NAD_binding_4) and
                     (AMP-binding or A-OX))"
                     /neighbourhood="20000"
                     /product="NRPS-like"
                     /protocluster_number="1"
     cand_cluster    1..9389
                     /SMILES="NC([*])C(=O)O"
                     /candidate_cluster_number="1"
                     /contig_edge="True"
                     /detection_rules="cds((PP-binding or NAD_binding_4) and
                     (AMP-binding or A-OX))"
                     /kind="single"
                     /product="NRPS-like"
                     /protoclusters="1"
                     /tool="antismash"
     subregion       1..9389
                     /aStool="externally annotated by: MIBiG"
                     /contig_edge="True"
                     /label="BGC0000876"
                     /subregion_number="1"
                     /tool="antismash"
     region          1..9389
                     /candidate_cluster_numbers="1"
                     /contig_edge="True"
                     /product="NRPS-like"
                     /region_number="1"
                     /rules="cds((PP-binding or NAD_binding_4) and (AMP-binding
                     or A-OX))"
                     /subregion_numbers="1"
                     /tool="antismash"
     regulatory      58..61
                     /citation=[2]
                     /gene="nikP1"
                     /regulatory_class="ribosome_binding_site"
     gene            58..2105
                     /gene="nikP1"
     CDS             72..2105
                     /NRPS_PKS="Domain: AMP-binding (77-488). E-value: 4.8e-108.
                     Score: 353.2. Matches aSDomain:
                     nrpspksdomains_nikP1_AMP-binding.1"
                     /NRPS_PKS="Domain: PCP (596-665). E-value: 1.4e-23. Score:
                     74.7. Matches aSDomain: nrpspksdomains_nikP1_PCP.1"
                     /citation=[2]
                     /codon_start=1
                     /db_xref="GOA:Q9F2E7"
                     /db_xref="HSSP:O30409"
                     /db_xref="InterPro:IPR000873"
                     /db_xref="InterPro:IPR005153"
                     /db_xref="InterPro:IPR006163"
                     /db_xref="InterPro:IPR009081"
                     /db_xref="InterPro:IPR010071"
                     /db_xref="UniProtKB/TrEMBL:Q9F2E7"
                     /function="non-ribosomal peptide synthase"
                     /gene="nikP1"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     NRPS-like: PP-binding"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     NRPS-like: AMP-binding"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1009:mbtH-like protein (Score: 71.1; E-value:
                     8.2e-22)"
                     /gene_kind="biosynthetic"
                     /product="NikP1 protein"
                     /protein_id="CAC11137.1"
                     /sec_met_domain="AMP-binding (E-value: 2.3e-120, bitscore:
                     390.9, seeds: 400, tool: rule-based-clusters)"
                     /sec_met_domain="PP-binding (E-value: 2.1e-18, bitscore:
                     55.9, seeds: 164, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MVNPIHDDNGACLVLVNSENRHALWADGPDVPPGWRVAHRAAGRR
                     ECLEYIGAHWPDIRPARLPDTGKDAGACLHDLFAAQVARTPGAPALIWRDHEISYRQLD
                     DDSSKLAAYLRLRGVGPGAFVGLCVERSPQMITALLGVLKTGAAYVPLDPEYPVERLRY
                     VLSDTGARLLLTQEPLRPLFPDHDGEILCLDQHRQDIDALAAAPAPDSPVPLPSDTAYV
                     IHTSGSTGRPKGVLVTHRSLANHSSAVNRYFAFAPGDRVLQCRPLSFDAAAEEIFPPLL
                     HGAALVLGSDPLRQTFRALTQQVIDTGTTFLSVPTAFWHSWVAEEDCLLRLATESALRT
                     MIVAGEKAARQALLTWKKRVGEDIRWFNVYGPTEGTITTTVHEPGADWETGEYGSVPIG
                     RPIDNVRTYVLDDALRPVPAGEPGELFIGGAGVAVGYLNAPQTTAERFLPDPFSGVPGS
                     RLYRTGDLVRADADGCLEFLGRRDHQVKLRGYRIEPGEIEAVLTEHEDVRACVALVTDD
                     GPDSALVCFVTAGGRAAPPAAELIAHLRGRLPWYMIPTAVHVLDAFPLTPNGKIDRAAL
                     LALEPDDDGEAVHIAPRTPEEAVLADIWEDILGRRGISVDADFFQVGGHSLLAASLIAR
                     IRARFDVAMTARVLFESPTIAGLAEAVTRATGDGAAARAGRS"
     aSDomain        303..1535
                     /aSDomain="AMP-binding"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_nikP1_AMP-binding.1"
                     /evalue="4.80E-108"
                     /label="nikP1_AMP-binding.1"
                     /locus_tag="nikP1"
                     /protein_end="488"
                     /protein_start="77"
                     /score="353.2"
                     /specificity="consensus: X"
                     /tool="antismash"
                     /translation="FAAQVARTPGAPALIWRDHEISYRQLDDDSSKLAAYLRLRGVGPG
                     AFVGLCVERSPQMITALLGVLKTGAAYVPLDPEYPVERLRYVLSDTGARLLLTQEPLRP
                     LFPDHDGEILCLDQHRQDIDALAAAPAPDSPVPLPSDTAYVIHTSGSTGRPKGVLVTHR
                     SLANHSSAVNRYFAFAPGDRVLQCRPLSFDAAAEEIFPPLLHGAALVLGSDPLRQTFRA
                     LTQQVIDTGTTFLSVPTAFWHSWVAEEDCLLRLATESALRTMIVAGEKAARQALLTWKK
                     RVGEDIRWFNVYGPTEGTITTTVHEPGADWETGEYGSVPIGRPIDNVRTYVLDDALRPV
                     PAGEPGELFIGGAGVAVGYLNAPQTTAERFLPDPFSGVPGSRLYRTGDLVRADADGCLE
                     FLGRRDHQVKLR"
     aSModule        303..2066
                     /complete
                     /domains="nrpspksdomains_nikP1_AMP-binding.1"
                     /domains="nrpspksdomains_nikP1_PCP.1"
                     /locus_tags="nikP1"
                     /monomer_pairings="X -> X"
                     /starter_module
                     /tool="antismash"
                     /type="nrps"
     CDS_motif       489..530
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_nikP1_0001"
                     /evalue="6.10E-06"
                     /label="NRPS-A_a2"
                     /locus_tag="nikP1"
                     /protein_end="153"
                     /protein_start="139"
                     /score="19.3"
                     /tool="antismash"
                     /translation="LGVLKTGAAYVPLD"
     CDS_motif       729..788
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_nikP1_0002"
                     /evalue="4.00E-10"
                     /label="NRPS-A_a3"
                     /locus_tag="nikP1"
                     /protein_end="239"
                     /protein_start="219"
                     /score="31.6"
                     /tool="antismash"
                     /translation="AYVIHTSGSTGRPKGVLVTH"
     CDS_motif       1323..1412
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_nikP1_0003"
                     /evalue="1.20E-13"
                     /label="NRPS-A_a6"
                     /locus_tag="nikP1"
                     /protein_end="447"
                     /protein_start="417"
                     /score="43.2"
                     /tool="antismash"
                     /translation="PAGEPGELFIGGAGVAVGYLNAPQTTAERF"
     CDS_motif       1500..1565
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_nikP1_0004"
                     /evalue="1.40E-12"
                     /label="NRPS-A_a8"
                     /locus_tag="nikP1"
                     /protein_end="498"
                     /protein_start="476"
                     /score="39.4"
                     /tool="antismash"
                     /translation="FLGRRDHQVKLRGYRIEPGEIE"
     aSDomain        1860..2066
                     /aSDomain="PCP"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_nikP1_PCP.1"
                     /evalue="1.40E-23"
                     /label="nikP1_PCP.1"
                     /locus_tag="nikP1"
                     /protein_end="665"
                     /protein_start="596"
                     /score="74.7"
                     /tool="antismash"
                     /translation="EAVLADIWEDILGRRGISVDADFFQVGGHSLLAASLIARIRARFD
                     VAMTARVLFESPTIAGLAEAVTRA"
     gene            2112..2933
                     /gene="nikP2"
     CDS             2112..2933
                     /NRPS_PKS="Domain: Thioesterase (28-255). E-value: 8.3e-46.
                     Score: 149.1. Matches aSDomain:
                     nrpspksdomains_nikP2_Thioesterase.1"
                     /citation=[2]
                     /codon_start=1
                     /db_xref="GOA:Q9F2E6"
                     /db_xref="InterPro:IPR001031"
                     /db_xref="InterPro:IPR012223"
                     /db_xref="UniProtKB/TrEMBL:Q9F2E6"
                     /function="similar to thioesterase II"
                     /gene="nikP2"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Abhydrolase_6"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1004:thioesterase (Score: 231.7; E-value: 1.1e-70)"
                     /gene_kind="biosynthetic-additional"
                     /product="NikP2 protein"
                     /protein_id="CAC11138.1"
                     /sec_met_domain="Abhydrolase_6 (E-value: 8.5e-12, bitscore:
                     35.2, seeds: 455, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MAPRQAAATRPDSPWLRTFGPPRPAAPARLVCFPHAGGAASYFRD
                     WGGRDLAGAEVWAVQYPGRENRIREGFPPDLHTLADQVTGELRGLLDRPAVFFGHSMGA
                     VVGYEVLRRLTADGRGGAVLHLVVSGCGAPQRVRPFAGQEGAHLLDDDRLVALLKELGS
                     GNAGLLDDPDMRSVFLPAVRDDYRIVQSYVPRAGGPLLRTDVTAFVGRQDEAVGVGDAG
                     AWAGATLGRFTLRTFPGGHFYLGEHPDHVLHALREVLLSATTIDTGRADES"
     aSDomain        2196..2876
                     /aSDomain="Thioesterase"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_nikP2_Thioesterase.1"
                     /evalue="8.30E-46"
                     /label="nikP2_Thioesterase.1"
                     /locus_tag="nikP2"
                     /protein_end="255"
                     /protein_start="28"
                     /score="149.1"
                     /tool="antismash"
                     /translation="RLVCFPHAGGAASYFRDWGGRDLAGAEVWAVQYPGRENRIREGFP
                     PDLHTLADQVTGELRGLLDRPAVFFGHSMGAVVGYEVLRRLTADGRGGAVLHLVVSGCG
                     APQRVRPFAGQEGAHLLDDDRLVALLKELGSGNAGLLDDPDMRSVFLPAVRDDYRIVQS
                     YVPRAGGPLLRTDVTAFVGRQDEAVGVGDAGAWAGATLGRFTLRTFPGGHFYLGEHPDH
                     VLHAL"
     CDS_motif       2388..2453
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_nikP2_0001"
                     /evalue="3.20E-05"
                     /label="NRPS-te1"
                     /locus_tag="nikP2"
                     /protein_end="114"
                     /protein_start="92"
                     /score="16.5"
                     /tool="antismash"
                     /translation="RPAVFFGHSMGAVVGYEVLRRL"
     gene            2923..4113
                     /gene="nikQ"
     CDS             2923..4113
                     /citation=[1]
                     /codon_start=1
                     /db_xref="GOA:Q9L465"
                     /db_xref="HSSP:P33006"
                     /db_xref="InterPro:IPR001128"
                     /db_xref="InterPro:IPR002397"
                     /db_xref="UniProtKB/TrEMBL:Q9L465"
                     /function="cytochrome P450"
                     /gene="nikQ"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) p450"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1007:cytochrome P450 (Score: 397.8; E-value:
                     8.5e-121)"
                     /gene_kind="biosynthetic-additional"
                     /product="NikQ protein"
                     /protein_id="CAC11139.1"
                     /sec_met_domain="p450 (E-value: 3e-28, bitscore: 87.7,
                     seeds: 50, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MRVDLSDPLLYRDSDPEPVWSRLRAEHPVYRNERANGEHFWAVMT
                     HGLCTDMLTDPRVFSSQNGMRLDSDPQVLAAAAGKMLNITDPPRHDKIRKVVSSAFTPR
                     MVSRLEATMRETAAKAIDEALAAGECEFTRVAQKLPVSVICDMLGVAPADWDFMVERTR
                     FAWSSTALDEAEEARKVRAHTEILLHFQDLAAERRREPKDDLMSALVCGEIDGAPLTDQ
                     EILYNCDALVSGGNETTRHATVGGLLALIDNPDQWHRLRDEPALMPSAIQEIVRYTSPV
                     MHALRTATEDVEFGGERISAGDHVVAWLPSANRDEKVFDDPDRFDIEREPNRHLGFIQG
                     NHYCIGSSLAKLELTVMFEELLARVEVAELAGQVRRLRSNLLWGFDSLPVKFVPRA"
     gene            4127..4807
                     /gene="nikR"
     CDS             4127..4807
                     /citation=[1]
                     /codon_start=1
                     /db_xref="GOA:Q9L464"
                     /db_xref="HSSP:Q26998"
                     /db_xref="InterPro:IPR000836"
                     /db_xref="UniProtKB/TrEMBL:Q9L464"
                     /function="4-formyl-4-imidazolin-2-one
                     phosphoribosyltransferase"
                     /gene="nikR"
                     /product="NikR protein"
                     /protein_id="CAC11140.1"
                     /transl_table=11
                     /translation="MTAPTAPSTDTYLGTNVRLLPQTDQLRALHTAIRDRDASHEDFVR
                     YSRRIIRLLIEAGMDLLPFEPHEVRTPTGAAYQGLRFASGLCGVTVVRAGESMEGELRD
                     VCPGIRIGKILIQRDETTKEARLYYTSLPADIARRHVLLLDPVMATGGTALAALRVLTD
                     LGVPEENIVFVNFITVPEGITAFCGQYPRVRIVTSAIEERLTEDAWMLPGIGDFGDRYF
                     GTDD"
     gene            4876..6150
                     /gene="nikS"
     CDS             4876..6150
                     /citation=[2]
                     /codon_start=1
                     /db_xref="GOA:Q9F2E5"
                     /db_xref="InterPro:IPR003135"
                     /db_xref="InterPro:IPR011761"
                     /db_xref="UniProtKB/TrEMBL:Q9F2E5"
                     /function="protein P4, nikkomycin biosynthesis protein,
                     putative carboxylase"
                     /gene="nikS"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) ATP-grasp"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) ATP-grasp_3"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1063:argininosuccinate lyase/adenylosuccinate lyase
                     (Score: 97.5; E-value: 1.5e-29)"
                     /gene_kind="biosynthetic-additional"
                     /product="NikS protein"
                     /protein_id="CAC11141.1"
                     /sec_met_domain="ATP-grasp (E-value: 5.4e-10, bitscore:
                     28.2, seeds: 20, tool: rule-based-clusters)"
                     /sec_met_domain="ATP-grasp_3 (E-value: 1e-08, bitscore:
                     24.5, seeds: 15, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MKAEQGPFLLLNTKKIVSRLHEWFPDAARELVVVTTKADIPSADI
                     SAYARRFLHLEVVPNLWELSDDELLALARRFGVRRILSLGEREVLRAARIRAELGLPGQ
                     SLASATAYRDKHVMKSTLAAAGIDVAPMRKFRTNDDLAEFAWKVGFPVVVKELDSGASN
                     GTVVLMDEEDLRALPERATAAPRLAEAWVEGDFYHVNGLMKDGEVVLAVPSRNLYSDWF
                     SVAYDAPTMTGMMPDDHPLSERLRSTARQVVAALPAVPDLCAFHLELFHTADDRVVVCE
                     IACRAGAALVSDVHEAVLGVNFHGASLLGQAGRGDQVEIRPTGERLGFVWFPPAKGVLR
                     ALPDTCPLPGTVSYRPCGDIGRRYGSSSGLGRPIAEMVFRLTEPDTGAELRRIEEWWDD
                     NVVWEHRTNAVPDRWKTPRRKPADA"
     gene            6178..7500
                     /gene="nikT"
     CDS             6178..7500
                     /NRPS_PKS="Domain: PP-binding (3-69). E-value: 2.5e-14.
                     Score: 45.5. Matches aSDomain:
                     nrpspksdomains_nikT_PP-binding.1"
                     /NRPS_PKS="Domain: Aminotran_1_2 (118-432). E-value:
                     8.5e-52. Score: 168.2. Matches aSDomain:
                     nrpspksdomains_nikT_Aminotran_1_2.1"
                     /citation=[2]
                     /codon_start=1
                     /db_xref="GOA:Q9F2E4"
                     /db_xref="HSSP:Q5SL79"
                     /db_xref="InterPro:IPR001917"
                     /db_xref="InterPro:IPR003231"
                     /db_xref="InterPro:IPR004839"
                     /db_xref="InterPro:IPR006163"
                     /db_xref="InterPro:IPR009081"
                     /db_xref="UniProtKB/TrEMBL:Q9F2E4"
                     /function="4-hydroxy-2-oxo-4-(2'-pyridyl)-isovaleric acid
                     aminotransferase"
                     /gene="nikT"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) PP-binding"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1019:aminotransferase (Score: 167.3; E-value:
                     8.8e-51)"
                     /gene_kind="biosynthetic-additional"
                     /product="NikT protein"
                     /protein_id="CAC11142.1"
                     /sec_met_domain="PP-binding (E-value: 3.6e-15, bitscore:
                     45.5, seeds: 164, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MYELLKTIMIEELEVEAGQVSPDASREDAGLDSLATFELSLALSQ
                     RLGVTIADEDLFGLRTLADIAEFLEKRTAGLPGSPGTSGSPAADQAEGREHAGLTRLLG
                     TGDGVHPGGPAPAHQLARNENPFQPPASVLDAITRAAAEANRYPDPACEALRAALARHY
                     GLFPDRVAVGAGSITLLQALLTVTAGPGAAVAYSWPSFDGYEVLADLAGFRTVRVPLAE
                     DGHDLDALAAAVDEHTRLVLLCNPNNPTGTASGEADLLRFLDAVPRTCLVVLDEAYCEY
                     ARDPGLGARLLTSWPNLIVARTFSKAYGLAGMRVGYLLAEPGLISRVHRMVMPLSVSDV
                     AQAAAVASLAAEKELLGRVRETAAERDRVRAALLALGFDVPPSEANFLWLPLGARAEEF
                     AAACASAGVAVRPYPGDGVRVTTGTAEDNDAFLAAAEMNRP"
     aSDomain        6187..6384
                     /aSDomain="PP-binding"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_nikT_PP-binding.1"
                     /evalue="2.50E-14"
                     /label="nikT_PP-binding.1"
                     /locus_tag="nikT"
                     /protein_end="69"
                     /protein_start="3"
                     /score="45.5"
                     /tool="antismash"
                     /translation="LLKTIMIEELEVEAGQVSPDASREDAGLDSLATFELSLALSQRLG
                     VTIADEDLFGLRTLADIAEFL"
     aSModule        6187..7473
                     /domains="nrpspksdomains_nikT_PP-binding.1"
                     /domains="nrpspksdomains_nikT_Aminotran_1_2.1"
                     /incomplete
                     /locus_tags="nikT"
                     /tool="antismash"
                     /type="unknown"
     aSDomain        6532..7473
                     /aSDomain="Aminotran_1_2"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_nikT_Aminotran_1_2.1"
                     /evalue="8.50E-52"
                     /label="nikT_Aminotran_1_2.1"
                     /locus_tag="nikT"
                     /protein_end="432"
                     /protein_start="118"
                     /score="168.2"
                     /tool="antismash"
                     /translation="QLARNENPFQPPASVLDAITRAAAEANRYPDPACEALRAALARHY
                     GLFPDRVAVGAGSITLLQALLTVTAGPGAAVAYSWPSFDGYEVLADLAGFRTVRVPLAE
                     DGHDLDALAAAVDEHTRLVLLCNPNNPTGTASGEADLLRFLDAVPRTCLVVLDEAYCEY
                     ARDPGLGARLLTSWPNLIVARTFSKAYGLAGMRVGYLLAEPGLISRVHRMVMPLSVSDV
                     AQAAAVASLAAEKELLGRVRETAAERDRVRAALLALGFDVPPSEANFLWLPLGARAEEF
                     AAACASAGVAVRPYPGDGVRVTTGTAEDNDAFL"
     gene            7497..7964
                     /gene="nikU"
     CDS             7497..7964
                     /citation=[2]
                     /codon_start=1
                     /db_xref="GOA:Q9F2E3"
                     /db_xref="InterPro:IPR006158"
                     /db_xref="UniProtKB/TrEMBL:Q9F2E3"
                     /function="similar to glutamate mutase component S"
                     /gene="nikU"
                     /product="NikU protein"
                     /protein_id="CAC11143.1"
                     /transl_table=11
                     /translation="MNSASRGNGRTFVVTSVSSDSHMWNLVFLQLLLEENGGKVINLGA
                     CTPDELVMSECLRIRPDALVISTVNGHGHIDGLRLIRKIRGHAVLASMKVVIGGKLGVH
                     GSRQAGSRAELVANGFDAVFEADADLDRFLDCLSLGTPAPQRVASTEIWST"
     gene            7964..9235
                     /gene="nikV"
     CDS             7964..9235
                     /citation=[2]
                     /codon_start=1
                     /db_xref="GOA:Q9F2E2"
                     /db_xref="InterPro:IPR006396"
                     /db_xref="UniProtKB/TrEMBL:Q9F2E2"
                     /function="similar to gluatamate mutase chain E"
                     /gene="nikV"
                     /product="NikV protein"
                     /protein_id="CAC11144.1"
                     /transl_table=11
                     /translation="MAPPTGPGRFTRFVRRASSEGKLVVQPRMGFGTVEQMRAGLDAVR
                     IVDAATVGTITVDSYTRVNDHASALLALEKGADLNGFPLVAHGAAATRELLAGIAGDDF
                     PVQVRHGSALPGALFEGLVAAGIDATEGGPVSYCLPYSRVPLAQAVDAWAECCEMLAGT
                     SEPVHLESFGGCMLGQLCPPSLLISLSILEGLFFREHGLRDISVSYAQQTNQQQDLEAI
                     HALRALAKEWLGDTDWHAVLYTYMGVYPRTRQGAYRLLEESARLAARSGTERLIVKTAV
                     EASRIPSITENVDALERAARAAEREAVAEPAGIPDSGIYEEAQAIITHTLTLGSDVGKA
                     LVRAFALGHLDIPFCLHQDNANRCRARHRRPWPAHLGRPRRWPIPRARALPGNRQRLTA
                     RGLLEMLSYNERRYDHPPRTSHPR"
ORIGIN
        1 ccttggggct tcccccgcta caacgccagt gcgcacgccg cacattcagc atccgaaggg
       61 gactgcgatc cgtggtcaac ccgattcatg acgacaacgg tgcctgcctg gtcctggtga
      121 acagcgagaa ccggcacgct ctgtgggccg acggccccga cgtaccaccg ggctggcgcg
      181 tcgcgcaccg ggcggccggc cgccgggagt gcctggagta catcggcgcc cactggccgg
      241 acatccggcc cgccagactc ccggacaccg ggaaggacgc gggcgcctgc ctgcacgacc
      301 tgttcgccgc ccaggtcgcg cgcacccccg gggcgccggc cctgatctgg cgggaccatg
      361 agatctcgta ccgtcaactc gacgacgact ccagcaagtt ggccgcatac ctgcggctgc
      421 gcggcgtggg gcccggcgcg ttcgtgggcc tgtgcgtcga gcggtcgccg cagatgatca
      481 cggccctgct cggcgtcctg aagaccggcg ccgcctacgt gcccctcgac cccgagtacc
      541 cggtcgagcg gctgcggtac gtcctgtccg acacgggagc acgcctgctc ctgacccagg
      601 agccgctgag gccgctcttc cccgaccacg acggcgagat cctctgcctc gaccagcacc
      661 ggcaggacat cgacgcgctg gccgccgcgc ccgcaccgga cagccccgtc ccgctgccgt
      721 cggacaccgc ctacgtcatc cacacctccg gctccacggg ccgccccaag ggcgtcctgg
      781 tgacgcaccg ctccctggcg aaccacagct ctgccgtgaa ccggtacttc gccttcgccc
      841 ccggcgaccg cgtcctgcag tgcaggccgc tgagcttcga cgccgctgcc gaggagatct
      901 tcccgccgct cctgcacggc gcggccctcg tcctcggcag cgaccccctg cgccagacgt
      961 tccgggccct gacccagcag gtcatcgaca ccggcacgac cttcctgagc gtgcccacgg
     1021 ccttctggca cagctgggtc gcggaggagg actgcctgct gcggctggcc acggagtccg
     1081 cgctgcgcac gatgatcgtg gccggtgaga aggcggcccg tcaggccctg ctgacctgga
     1141 agaaacgggt cggcgaggac atccgctggt tcaacgtcta cggccccacc gagggcacca
     1201 tcaccacgac ggtccacgag ccgggcgccg actgggagac cggcgagtac ggctccgtcc
     1261 cgatcggccg ccccatcgac aacgtccgca cgtacgtcct cgacgacgcc ctgcggccgg
     1321 tcccggcggg agagccgggc gagctgttca tcggcggggc gggcgtggcc gtcggctacc
     1381 tgaacgcgcc gcagaccacc gccgagcggt tcctgcccga ccccttctcc ggcgtgcccg
     1441 gcagccggct ctaccgcacc ggggacctgg tgcgcgcgga cgccgacggc tgcctggagt
     1501 tcctcggccg ccgggaccac caggtgaaac tgcgcggtta ccgcatcgag cccggcgaga
     1561 tcgaggccgt gctcaccgag cacgaggacg tccgggcgtg cgtcgccctg gtgaccgacg
     1621 acggccccga cagtgccctc gtgtgcttcg tgaccgcggg tgggcgggcc gcgccgccgg
     1681 ccgccgaact gatcgcccac ctgcgcggcc ggctgccctg gtacatgatc ccgacggccg
     1741 tccacgtcct ggacgccttc cccctgaccc ccaacgggaa gatcgaccgg gccgccctgc
     1801 tcgccctcga acccgacgac gacggcgaag ccgtccacat cgcgccgcgc acccccgagg
     1861 aagcggtcct ggccgacatc tgggaggaca tcctcggccg ccgcggcatc agcgtcgacg
     1921 ccgacttctt ccaggtgggc ggccactccc tgctcgccgc gagcctcatc gcccgcatcc
     1981 gcgcccggtt cgacgtcgcc atgacggccc gcgtgctgtt cgagtccccg accatcgccg
     2041 ggctcgccga agccgtcacc cgggcgaccg gcgacggcgc ggcggcccgc gccggacgga
     2101 gctgaccggc ggtggcaccg cgacaggccg ccgccacgcg cccggacagc ccctggctgc
     2161 gcaccttcgg cccgccgagg cctgcggccc cggcccggct cgtgtgcttc ccgcacgccg
     2221 ggggcgcggc cagctacttc cgggactggg gcggccgtga cctcgccggg gccgaggtgt
     2281 gggccgtcca gtacccgggc cgcgagaacc ggatccggga ggggttcccg cccgacctgc
     2341 acaccctcgc cgaccaggtc accggggagc tgcgcggact cctcgaccgg cccgccgtct
     2401 tcttcgggca cagcatgggc gccgtcgtcg gctacgaggt cctgcgccgc ctcacggccg
     2461 acggccgggg cggcgccgta ctccacctcg tggtctcggg gtgcggcgcc ccccagcggg
     2521 tgcgcccctt cgccggacag gaaggtgccc acctcctgga cgacgaccgg ctcgtggcgc
     2581 tcctcaagga gctgggctcg ggcaacgccg gcctgctcga cgacccggac atgcgctcgg
     2641 tcttcctgcc ggcggtccgc gacgactacc gcatcgtcca gtcctacgtc ccgcgcgccg
     2701 gcggcccgct cctgcggacc gacgtcaccg cgttcgtggg ccgccaggac gaggcggtcg
     2761 gcgtcggcga cgcgggcgcc tgggccggcg cgaccctggg ccgcttcacg ctccgcacct
     2821 tccccggcgg ccacttctac ctgggagaac acccggacca cgtcctgcac gccctgcgcg
     2881 aggtcctcct ttccgccacc acgatcgaca ccgggagagc cgatgagagt tgacctgtcc
     2941 gacccgctct tgtaccggga ctccgacccc gaaccggtct ggtcgcggct gcgcgccgaa
     3001 caccccgtct accgcaacga gcgggccaac ggggagcact tctgggcggt gatgacccac
     3061 ggcctgtgca ccgacatgct gaccgacccc cgcgtgttca gctcccagaa cgggatgcgc
     3121 ctcgactccg acccgcaggt cctcgccgcc gcggccggca agatgctcaa catcaccgac
     3181 ccgccccggc acgacaagat ccgcaaggtc gtcagctcgg cgttcacccc gcgcatggtg
     3241 agccggctgg aggccaccat gcgcgagacg gccgccaaag ccatcgacga ggcgctggcc
     3301 gcgggggagt gcgagttcac gcgcgtcgcc cagaaactgc cggtctcggt catctgcgac
     3361 atgctcggcg tcgcacccgc cgactgggac ttcatggtcg agcgcacccg cttcgcctgg
     3421 agctccaccg ccctcgacga ggcggaggag gcgcgcaagg tccgggccca caccgagatc
     3481 ctgctccact tccaggacct cgccgcggag cgcaggcggg agccgaagga cgacctcatg
     3541 agcgccctgg tgtgcggcga gatcgacggc gccccgctga ccgaccagga gatcctctac
     3601 aactgcgacg ccctggtctc cggcggcaac gagacgaccc ggcacgccac cgtcggcggg
     3661 ctgctcgccc tcatcgacaa cccggatcag tggcaccggc tgcgcgacga gcccgccctc
     3721 atgccctcgg cgatccagga gatcgtgcgc tacacctcgc ctgtcatgca cgcgctgcgc
     3781 accgcgaccg aggacgtcga gttcggcggg gagcggatca gcgccgggga ccacgtcgtc
     3841 gcctggctgc cctcggccaa ccgcgacgag aaggtcttcg acgaccccga ccgcttcgac
     3901 atcgagcgcg aacccaaccg ccacctgggc ttcatccagg gcaaccacta ctgcatcggc
     3961 tcctcgctcg ccaagctcga actcacggtg atgttcgagg aactcctggc gcgggtcgag
     4021 gtcgccgaac tcgccggcca ggtccgccgc ctgcgctcga acctgctgtg ggggttcgac
     4081 tcgcttcccg tgaaattcgt cccgagggcc tgaggagagc tgccccatga ccgcgcccac
     4141 cgccccctcg accgacacat acctcggcac caatgtccgt ctgctgcccc agaccgacca
     4201 gctgcgcgcc ctgcacaccg cgatccgcga ccgggacgcc agccacgagg acttcgtccg
     4261 ctactcgcgc cggatcatcc gcctgctgat cgaggcgggc atggacctgc tgcccttcga
     4321 gccgcacgag gtccgcaccc cgaccggcgc cgcctaccag gggctgcgct tcgcctccgg
     4381 gctgtgcggg gtcaccgtgg tgcgcgccgg ggagagcatg gagggcgaac tgcgggacgt
     4441 ctgcccgggg atcaggatcg ggaagatcct catccagcgg gacgagacga ccaaagaggc
     4501 ccgcctctac tacacctccc tgcccgccga catcgcccgg cggcacgtgc tgctcctcga
     4561 cccggtcatg gcgaccggcg ggaccgcgct ggcggcgctg cgcgtgctga cagacctcgg
     4621 cgtgcccgag gagaacatcg tcttcgtcaa cttcatcacc gtccccgagg gcatcaccgc
     4681 cttctgcggg cagtacccgc gggtgcggat cgtgacctcc gccatcgagg agcggctgac
     4741 cgaggacgcg tggatgctgc ccggcatcgg ggacttcggg gaccgctact tcggcacgga
     4801 cgactgaggt gtgcgcggcc ggcttccccg gccggcctgg aagaccgtga aacgacgact
     4861 gaccgaagga tgcacatgaa ggccgaacag gggccgtttc tgctgctgaa caccaagaag
     4921 atcgtctcgc gcctgcacga gtggttcccc gacgcggcgc gggagctggt cgtggtgacc
     4981 acgaaagcgg acatcccctc cgccgacatc tccgcgtacg cacgacgctt cctccacctg
     5041 gaggtggtgc ccaacctctg ggagctgtcg gacgacgaac tcctggccct cgcccggcgg
     5101 ttcggcgtac gccggatcct gtcgctcggc gagcgcgagg tgctgcgcgc ggcacgcata
     5161 cgggccgaac tcggcctgcc cggccagagc ctcgcctcgg ccacggcgta ccgggacaag
     5221 cacgtcatga agtcgaccct ggcggcggcg ggcatcgacg tcgcccccat gcgcaagttc
     5281 cggaccaacg acgacctcgc cgagttcgcg tggaaggtcg gcttcccggt cgtcgtcaag
     5341 gaactcgact ccggcgcgtc gaacggcacg gtggtcctga tggacgagga ggacctgcgc
     5401 gccctcccgg agcgtgccac cgcggcgccc cggctggccg aagcctgggt cgagggcgac
     5461 ttctaccacg tcaacggcct catgaaggac ggcgaggtgg tgctcgcggt gccctcccgc
     5521 aacctgtact ccgactggtt ctcggtcgcc tacgacgccc cgaccatgac ggggatgatg
     5581 cccgacgacc accccctgtc cgagcggctg cgcagtaccg cgcggcaggt cgtggccgcg
     5641 cttcccgccg tacccgacct gtgcgccttc cacctcgaac tgttccacac cgccgacgac
     5701 cgcgtggtcg tctgcgagat cgcctgccgt gcgggcgcgg ccctcgtcag cgacgtccac
     5761 gaagcggtgc tgggcgtgaa cttccacggc gcgagcctgc tcggccaggc cggacgcggt
     5821 gaccaggtcg agatccggcc gaccggcgaa cggctcggct tcgtctggtt cccgccggcc
     5881 aagggagtgc tgcgcgcgct gcccgacacg tgcccgctgc cggggacggt gagctaccgg
     5941 ccctgcggcg acatcggacg ccgctacggc agttcctccg gactcggccg gcccatcgcc
     6001 gagatggtct tccggctcac cgagccggac accggggcgg agctgcggcg gatcgaggag
     6061 tggtgggacg acaacgtcgt ctgggagcac cggaccaacg cggtgcccga ccgctggaag
     6121 acgccccgaa ggaagccggc cgacgcgtag cggcccggca atcggaccgg aggacccgtg
     6181 tacgaactgc tgaagacgat catgatcgag gagctggagg tggaggccgg ccaggtgtcc
     6241 ccggacgcga gccgcgagga cgccggcctg gactccctcg ccaccttcga actctccctg
     6301 gcgctcagcc agcgcctcgg cgtcaccatc gccgacgagg acctgttcgg actcaggacg
     6361 ctggcggaca tcgccgagtt cctggagaag cgcaccgccg gcctgccggg ctccccggga
     6421 acatccggat ctccggcggc ggaccaggcc gagggccgcg agcacgccgg gctcacccgg
     6481 ctgctcggca ccggggacgg cgtccacccc ggcgggcccg cccccgccca ccaactcgcc
     6541 cgcaacgaaa acccgttcca gcccccagcg tccgtgctgg acgcgatcac ccgcgccgcc
     6601 gccgaggcca accggtaccc ggacccggcc tgcgaagcgc tgcgcgccgc gctcgcccgg
     6661 cactacggcc tcttcccgga ccgcgtcgcg gtgggcgccg gatcgatcac gctcctccag
     6721 gcactgctca cggtgaccgc cggaccggga gcagccgtcg cctactcgtg gccgtccttc
     6781 gacggctacg aggtgctcgc ggacctcgcc ggattccgca cggtacgggt cccgctggcc
     6841 gaggacgggc acgacctcga cgccctggcc gcggcggtcg acgagcacac ccgcctggtg
     6901 ctgctctgca accccaacaa ccccaccggc accgcgtcgg gcgaggccga cctcctgcgg
     6961 ttcctcgacg ccgtgccgcg cacgtgcctg gtcgtgctcg acgaggcgta ctgcgaatac
     7021 gcgcgcgacc ccggcctcgg cgcccgcctc ctcacctcgt ggccgaacct gatcgtcgcc
     7081 cgcaccttct ccaaggcgta cggcctcgcc ggcatgcgcg tcggctatct gctcgcggaa
     7141 cccggcctga tctcccgcgt ccaccgcatg gtcatgccgt tgagcgtcag tgacgtcgcc
     7201 caggccgccg ccgtcgcgtc gctggcggcg gagaaggagc tcctcggccg cgtccgggaa
     7261 acggccgccg aacgggaccg cgtccgcgcc gcgctgctcg ccctgggatt cgacgtgccg
     7321 ccctcggagg cgaacttcct ctggctcccg ctcggcgccc gcgccgagga gttcgccgcc
     7381 gcgtgcgcgt cggccggagt cgccgtacgg ccctacccgg gtgacggcgt gcgcgtgacg
     7441 acaggaaccg cggaggacaa cgacgcgttc ctggcagcgg ccgagatgaa ccgcccgtga
     7501 attccgcttc ccgtggaaac ggcaggacat tcgtcgtgac cagcgtgtcg tcggattccc
     7561 acatgtggaa cctcgttttc ctccagttgc tgctcgagga gaacggcggg aaggtgatca
     7621 acctcggcgc gtgcactccg gacgaactgg tcatgtccga atgcctcaga atccggccgg
     7681 acgccttggt catcagcacg gtcaacggac acggccacat cgacggccta cggctgatca
     7741 gaaagattcg cgggcatgcg gtgctcgctt ccatgaaagt cgtcatcggc gggaagctcg
     7801 gcgtccacgg ttcccggcag gcgggatccc gggcggaact ggtggcgaac ggcttcgacg
     7861 cggtgttcga ggcggacgcc gatctcgacc ggttcctcga ctgcctcagc ctgggcacgc
     7921 ccgcgccgca acgcgtcgcc tccacggaaa tctggagcac ctgatggcac ctcccaccgg
     7981 ccccggacgc ttcacccggt tcgtccggcg ggcgtcgagc gaagggaaac tggtcgtcca
     8041 gccgcgcatg gggttcggca cggtcgagca gatgcgcgcg ggactcgacg cggtcaggat
     8101 cgtcgacgcg gccacggtgg gcaccatcac cgtcgacagc tacacgcggg tgaacgatca
     8161 cgcctcggcc cttctcgctc tggagaaggg cgcggacctc aacgggttcc cgctggtggc
     8221 ccacggcgcg gcggccaccc gcgagctgct cgccggaatc gcgggcgacg acttcccggt
     8281 gcaggtgagg cacggctcgg cgttgcccgg cgcattgttc gagggactgg tggcggccgg
     8341 catcgacgcc accgaaggcg gccctgtctc ctactgcctg ccgtatagcc gcgtccctct
     8401 ggcgcaagcc gtcgacgcct gggcggaatg ctgcgagatg ctcgcgggaa ccagcgaacc
     8461 ggtgcatctg gagagtttcg gcggctgtat gctgggacag ttgtgcccgc cgagcctgtt
     8521 gatctccctg agcattctgg aaggcttgtt cttccgcgaa cacggactgc gggacatttc
     8581 cgtcagctac gcccagcaga cgaatcagca acaggacctc gaggcgatcc acgccctgcg
     8641 cgccctggcg aaggaatggc tcggagacac cgactggcac gccgtcctgt acacctacat
     8701 gggcgtttat ccccgcaccc ggcagggggc gtacaggctc ctcgaggaga gtgcgaggct
     8761 cgccgccaga tccgggaccg agcggttgat cgtcaagacc gcggtggagg ccagcagaat
     8821 cccgtcgatc acggagaacg tcgacgccct ggaacgcgcc gcgagggcgg ccgagcggga
     8881 ggcggtggcc gaaccggccg gaatcccgga ctccgggatc tacgaggagg cccaggcgat
     8941 catcacgcac acgctgaccc tcggcagtga tgtcggaaag gcgctcgtcc gcgcgttcgc
     9001 cctcggacac ctcgacatcc cgttctgcct gcaccaggac aacgcgaacc gctgccgggc
     9061 ccggcatcga cgaccgtggc cggctcacct gggccgaccc cgcaggtggc cgattccccg
     9121 ggcgcgcgct ctgcccggga accggcagcg gctcaccgcc cggggcctcc tcgagatgct
     9181 cagttacaac gaacggcgct acgaccaccc gccccggacc agccaccctc gttgacgggc
     9241 cgcacgacga ggaagatcac gaactagtgc gtctcaccca ggacgaccgg gcccacaccg
     9301 gactccagga agcgacggcc ctttcaccgc actcggcgat cggagcggcc aggaccgcac
     9361 ccaccggtcg ccggccttcc cggccaagg
//
