LOCUS       BGC0000887             30991 bp    DNA     linear   BCT 14-JUL-2016
DEFINITION  Anabaena circinalis AWQC131C toxin biosynthesis gene cluster,
            complete sequence.
ACCESSION   BGC0000887
VERSION     BGC0000887
KEYWORDS    .
SOURCE      Dolichospermum circinale AWQC131C
  ORGANISM  Dolichospermum circinale AWQC131C
            Bacteria; Cyanobacteria; Nostocales; Aphanizomenonaceae;
            Dolichospermum; Dolichospermum circinale.
COMMENT     ##antiSMASH-Data-START##
            Version      :: 6.2.0-924c3663(changed)
            Run date     :: 2022-11-07 20:57:18
            ##antiSMASH-Data-END##
FEATURES             Location/Qualifiers
     source          1..30991
                     /db_xref="taxon:398007"
                     /mol_type="genomic DNA"
                     /organism="Dolichospermum circinale AWQC131C"
                     /strain="AWQC131C"
     misc_feature    1..30991
                     /note="toxin biosynthesis gene cluster"
     subregion       1..30991
                     /aStool="externally annotated by: MIBiG"
                     /contig_edge="True"
                     /label="BGC0000887"
                     /subregion_number="1"
                     /tool="antismash"
     region          1..30991
                     /candidate_cluster_numbers="1"
                     /contig_edge="True"
                     /product="crocagin"
                     /region_number="1"
                     /rules="(PhyH and Carbam_trans_N)"
                     /subregion_numbers="1"
                     /tool="antismash"
     gene            complement(1817..2794)
                     /gene="sxtB"
     CDS             complement(1817..2794)
                     /codon_start=1
                     /gene="sxtB"
                     /product="cytidine deaminase"
                     /protein_id="ABI75122.1"
                     /transl_table=11
                     /translation="MTHVRLEQAIAQVPLSIQSELRTILSQHAVIDSSVVTSWLDRLGI
                     DIGTLMIQLLPVATAYARVPISQFYVGAIALGKPKSNNQVDSGTLYFGADMEFVGQALS
                     FSVHAEQSATINAWLHGETGLQALATNEAPCGYCRQFLYEMATVNQDFVILLKSNKTQI
                     EQTYTSNKLPYFLPEAFGPPNLGLTSGLMETVFHGLETCSTDDTDDVVLAALSAANQSY
                     APYTKNFAGVALKDSHGNIFTGRYAENAAYHSSMSPMESALTYMNMNRYPQSLFDICDA
                     VLVEAETTISQMSVTESFLSSIAPKVDLRYAPATLSSNKLGPTH"
     gene            complement(2800..6504)
                     /gene="sxtA"
     CDS             complement(2800..6504)
                     /NRPS_PKS="Domain: GNAT (509-648). E-value: 4.2e-50. Score:
                     161.1. Matches aSDomain: nrpspksdomains_sxtA_GNAT.1"
                     /NRPS_PKS="Domain: PKS_PP (731-813). E-value: 9.7e-14.
                     Score: 43.4. Matches aSDomain:
                     nrpspksdomains_sxtA_PKS_PP.1"
                     /NRPS_PKS="Domain: Aminotran_1_2 (866-1223). E-value:
                     1.9e-33. Score: 107.9. Matches aSDomain:
                     nrpspksdomains_sxtA_Aminotran_1_2.1"
                     /codon_start=1
                     /gene="sxtA"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1109:8-amino-7-oxononanoate synthase (Score: 276.4;
                     E-value: 5.7e-84)"
                     /gene_kind="biosynthetic-additional"
                     /product="polyketide synthase-related protein"
                     /protein_id="ABI75123.1"
                     /transl_table=11
                     /translation="MLQKINRYTHGFVAIPVILACREKGFFELLAHESPLSLEQMVKHL
                     GANTGHFQVALRMLESLHWLSRNEQLKYSLTSEAAIHNQIPEDVLELYHLPIESYLQGK
                     QEKLLGRWIDRSCQLWNLDNPLIADFLDGLLLIPLLLTLHKHNLLAESEEKPLFSSLSR
                     TVQEELGNLFFRLGWADLKPGRLTLTELGQFMGGRALNTAVVASYTPMLSRIHDVLFGD
                     CLSVFKTDNSGHESHIDRTLNVIGSGFQHQKYFADLEESILSVFNQLPLEEQPKYIADM
                     GCGDGTLLKRVWETIQFKSARGKAIKEYPLRLIGVDYNEASLTATTYTLGDLPHLVLQG
                     DIGNPEQMVLSLKAHGIHDPENILHIRSFLDHDRPFIPPQKRNEVKERAHLPYQAVCVD
                     GQGELIPPHVMVQSLVEHLERWSRVVTKHGLMILEVHCLEPKVVYQFLDKSENLHFDAF
                     QGFSQQYLVEADVFLRSAAEVGLFPKLELSKRYPKTFPLTRITLNYFEKRPYKIRNAYL
                     SDLPALVNLEVQCWSEHLQASANEIRRRLELNPQGNLVLITEDQIIGAVYSQTITSTEV
                     LENVKYEQVPSLHTPQGSVIQLLALNILPEFQARGLGNELRDFMLYYCTLKGGIESVVG
                     VTRCRNYVNYSQMPMTEYLKLHNEQRQLLDPIVGFHVSGGAEIRGIIANYRPEDAENFG
                     MGILIEYNLRDSALHPLGDRQALYTNSAVSSSVPTLPATSATKENKTVAALVKECVLKV
                     MGSQREAAYAPEQKLLDMGLDSLDLSELQTLLEKRLGVNLSGTFFFQNNTPTAIITYFQ
                     NQVVQEKQSDLASPVDLANEINTLENVVNQQKIPQVTRVVTEQQGRKVLIDGHWVIDFA
                     SCNYLGLDLHPKVKEAIPPALEKWGVHPSWTRLVASPVIYEELEEELSKLLGVPDVLVF
                     PSVTLLQIGVLPLLTGSNGVILGDIAAHRCIYEACCLAQQKGSQFIQYRHNDLNDLAEK
                     LAKYPLEQVKIIVIDGVYSMSADFPDLPAYVRLAKEYNAFIYMDDAHGFGILGENPSSD
                     MPYGYKGNGMVNYFDLQFAEDNIIYVAGLSKAYSSYAAFLTCGDRQIKTNFRNAWTAIF
                     SGPSPVASLASALAGLQVNRQEGEQLRKQIYHLTRKLVTQARAIGFEVDNYGYVPIVSV
                     LVGDAQHMIDVCRLLWEYGILITPAIFPIVPLNKSALRFSITAANTEEEIDQAIKALEA
                     VWVLLQKEK"
     aSDomain        complement(2836..3906)
                     /aSDomain="Aminotran_1_2"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_sxtA_Aminotran_1_2.1"
                     /evalue="1.90E-33"
                     /label="sxtA_Aminotran_1_2.1"
                     /locus_tag="sxtA"
                     /protein_end="1223"
                     /protein_start="866"
                     /score="107.9"
                     /tool="antismash"
                     /translation="VIDFASCNYLGLDLHPKVKEAIPPALEKWGVHPSWTRLVASPVIY
                     EELEEELSKLLGVPDVLVFPSVTLLQIGVLPLLTGSNGVILGDIAAHRCIYEACCLAQQ
                     KGSQFIQYRHNDLNDLAEKLAKYPLEQVKIIVIDGVYSMSADFPDLPAYVRLAKEYNAF
                     IYMDDAHGFGILGENPSSDMPYGYKGNGMVNYFDLQFAEDNIIYVAGLSKAYSSYAAFL
                     TCGDRQIKTNFRNAWTAIFSGPSPVASLASALAGLQVNRQEGEQLRKQIYHLTRKLVTQ
                     ARAIGFEVDNYGYVPIVSVLVGDAQHMIDVCRLLWEYGILITPAIFPIVPLNKSALRFS
                     ITAANTEEEIDQAIKAL"
     aSModule        2836..4977
                     /domains="nrpspksdomains_sxtA_GNAT.1"
                     /domains="nrpspksdomains_sxtA_PKS_PP.1"
                     /domains="nrpspksdomains_sxtA_Aminotran_1_2.1"
                     /incomplete
                     /locus_tags="sxtA"
                     /tool="antismash"
                     /type="pks"
     aSDomain        complement(4066..4311)
                     /aSDomain="PKS_PP"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_sxtA_PKS_PP.1"
                     /evalue="9.70E-14"
                     /label="sxtA_PKS_PP.1"
                     /locus_tag="sxtA"
                     /protein_end="813"
                     /protein_start="731"
                     /score="43.4"
                     /tool="antismash"
                     /translation="ATSATKENKTVAALVKECVLKVMGSQREAAYAPEQKLLDMGLDSL
                     DLSELQTLLEKRLGVNLSGTFFFQNNTPTAIITYFQN"
     aSDomain        complement(4561..4977)
                     /aSDomain="GNAT"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_sxtA_GNAT.1"
                     /evalue="4.20E-50"
                     /label="sxtA_GNAT.1"
                     /locus_tag="sxtA"
                     /protein_end="648"
                     /protein_start="509"
                     /score="161.1"
                     /tool="antismash"
                     /translation="YKIRNAYLSDLPALVNLEVQCWSEHLQASANEIRRRLELNPQGNL
                     VLITEDQIIGAVYSQTITSTEVLENVKYEQVPSLHTPQGSVIQLLALNILPEFQARGLG
                     NELRDFMLYYCTLKGGIESVVGVTRCRNYVNYSQM"
     gene            complement(6750..7226)
                     /gene="sxtE"
     CDS             complement(6750..7226)
                     /codon_start=1
                     /gene="sxtE"
                     /note="chaperone-like protein"
                     /product="chaperone-like protein"
                     /protein_id="ABI75124.1"
                     /transl_table=11
                     /translation="MLVSERDNCTSCIIPVIILKYNCQLIGYLIPVITYIYIMLKAFKH
                     FFMGSLAFVFAFGIFLTTGVGIAKADYLVQGGKITNVQNTSSNGDNYAISISEGVGPCA
                     DRVIILPVSAVLNRDIHTRGYKAALTALSNGFLVDIYDYTGSSCSNGGQVTITK"
     gene            complement(7741..8499)
                     /gene="sxtD"
     CDS             complement(7741..8499)
                     /codon_start=1
                     /gene="sxtD"
                     /product="sterole desaturase"
                     /protein_id="ABI75125.1"
                     /transl_table=11
                     /translation="MIDTILILLRDWTVILITGMIFWLWEIRYPLHEIKYKANFFKELG
                     WAGISLVFRIIYAYVSVVIIKLLTFLFMGESATFAGLMYVPLWLRIITAYILQDFTDYT
                     LHRIMHSNQFLWLTHKWHHSTKQSWWLSGNKDSFTGGLLYTVTSLWFPLMDIPSEIMSV
                     VALHQVIHNNWIHLNVKWHSWLGILEWIYVTPRVHALHHIDTKGRNLSGMFTFTDRLFG
                     TYVFPENFDLEKHKNRLDDKSVTVKTIVGV"
     protocluster    8030..30991
                     /aStool="rule-based-clusters"
                     /category="RiPP"
                     /contig_edge="True"
                     /core_location="[18029:27354]"
                     /cutoff="10000"
                     /detection_rule="(PhyH and Carbam_trans_N)"
                     /neighbourhood="10000"
                     /product="crocagin"
                     /protocluster_number="1"
                     /tool="antismash"
     proto_core      18030..27354
                     /aStool="rule-based-clusters"
                     /tool="antismash"
                     /cutoff="10000"
                     /detection_rule="(PhyH and Carbam_trans_N)"
                     /neighbourhood="10000"
                     /product="crocagin"
                     /protocluster_number="1"
     cand_cluster    8030..30991
                     /candidate_cluster_number="1"
                     /contig_edge="True"
                     /detection_rules="(PhyH and Carbam_trans_N)"
                     /kind="single"
                     /product="crocagin"
                     /protoclusters="1"
                     /tool="antismash"
     gene            8576..10024
                     /gene="sxtP"
     CDS             8576..10024
                     /codon_start=1
                     /gene="sxtP"
                     /product="putative saxitoxin-binding protein"
                     /protein_id="ABI75126.1"
                     /transl_table=11
                     /translation="MKRLSSLVLAALLFVSTFLCITTVALADTTNDYLKNEKLSGQFSV
                     SVKLDAGVRFTNRTNQSLPETFTNLGKWAASNDTVNLIYNTTETNTITFPLHKSLTFVA
                     NETIGTNNDNSDGIIVKSFVPGSYATATNFPVGIDADFVATGDFNGDSKLDLAVTNWAN
                     NNVSILLGNGNGSFSAATNFPVGTNPVSVVTGDVNHDSKLDLAVANFTSNNVSILLGNG
                     NGSFGTATNFPVGTNPYSVAIGDVNGDSELDLAFTNWVSNKVSVLLGNGNGSFGAATNF
                     PVGTYSISVAIGDVNGDSNLDLAVTNWVNNKVSVLLGNGNGSFGAATNFSVGTNPISVV
                     IADVNGDSKLDLAVANTSSHNVSVLLGNGHGSFSAATNFPVGTNPYSVAIGDLNGDSKL
                     DLTVTNYSSNNVSVLLGNGNGSFGAATNFPVGTNPESTAIGDFNGDSKLDLAVTNSGNN
                     NVSVLLNNCFKNTYLNLARAKNFV"
     CDS             10049..10825
                     /codon_start=1
                     /note="ORF7"
                     /product="Unknown"
                     /protein_id="ABI75127.1"
                     /transl_table=11
                     /translation="MVIKNLCPDGFTPIWNKSQMESVLVEECLPAWVRTNYSTFVETIR
                     DPAFPCFWGTIGEQKGMIRYLIASSLTEPSVVEHTLEGVYNYINEVNENELLQHENADL
                     LTLVIFFPPEPTVLTVEEYSRQAFAFLNALHSLDAVSCPCHWSADPQSPNWSYSLGGCA
                     LFVSVSTPANQKRRSRHLGSGMTFVITPVEVLLRKHGGENSSIFRRVREYDGISPHPNL
                     LIMPGSSKVGNELTVQVLPDDNDSEISFDFQYKFKD"
     gene            10836..11639
                     /gene="sxtR"
     CDS             10836..11639
                     /codon_start=1
                     /gene="sxtR"
                     /product="acyl-CoA N-acyltransferase"
                     /protein_id="ABI75128.1"
                     /transl_table=11
                     /translation="MTIQLIQRNLEYSFVTPNETSDFVQKTINVFEQAYPKFLIHDVWA
                     DPDSLALFEIYPEFQFGLVEATTQRMIAQGNCIPLAWESRFDELPEEGCDWALAKWLED
                     REQNRQPNALCVVSISILPEYQGKNLSQYLIGYMKELAQSHGLSSLIMAARPSLKYLYP
                     LTPIERYITWRDKNGLLFDSWLRANVKQGAKIAGICFKSTTIRDTIAGWENRVGMRFPE
                     TGDYIISNGLVPLKIDYPNNMGIYIEPNVWLYYDIHFSIGFKLFS"
     CDS             14474..15361
                     /codon_start=1
                     /note="ORF10"
                     /product="transposase"
                     /protein_id="ABI75129.1"
                     /transl_table=11
                     /translation="MELEQLFCAIDDFCLDFEAKLNSELISSQSQKRKRKSHLCLSEVM
                     TIIVHFHQSRYRNFQDYYQKSILKNYQKYFPSLVSYNRFVELMPDALLPLICYLNTRKG
                     QCSGISFIDSMGIPICHNKRAKRNKVFRGLSGWGKSSVDWYFGFKLHLIINEQGELLAF
                     QVTPGNIDDRKPVPTLAQNLWGRLFGDKGYISKSLFQELLENDVKLITPFKKNMNNKLV
                     ELWEKLMLRKRALIETVNDQLQNISQVVHSRHRSISNFMVNIISGLIAYTWQDKKPSLK
                     LDKHEVTSLPALLI"
     CDS             complement(15960..16916)
                     /codon_start=1
                     /gene_functions="transport (smcogs) SMCOG1166:transporter,
                     EamA family (Score: 84.8; E-value: 1.1e-25)"
                     /gene_kind="transport"
                     /note="ORF11"
                     /product="permease"
                     /protein_id="ABI75130.1"
                     /transl_table=11
                     /translation="MVNQDLTELQNSLDKVEMTTSAPENNRYILGVLLIILATLVYSSI
                     LPITKGLITNISKEVLMAVRFTMAAVVFTPFLRNLNIPLVRDGAIMGLLSFGMYVSATS
                     GLETFSANRGAFTLGISVIFVMLFDLLLGKRIAPRAIVGATLAFSGIGVMFWGSGESLN
                     GAGWLLLCALLNSAYLIAIQQFVQRHPTVQLVAVGLWVPAVAGLLWAAPELTGHFEAIV
                     GSLNVNLGSLIYLVVVDTIVFTWLEMIGQHWIPATEVAILQTIEPLMAAIISFWLLGET
                     FETHDFIGAGMVLGAMILVVTRPKVDESSSPVLMPTE"
     CDS             17125..17751
                     /codon_start=1
                     /note="ORF12"
                     /product="hypothetical protein"
                     /protein_id="ABI75131.1"
                     /transl_table=11
                     /translation="MLQLPITTSEEKSNIMINLEQFRQEMEDWIINVVSIPNPLTGNFL
                     PCPYAKAAWLNNRVSLRWFHGFELPELLMEQIKTWNDDFEMVLFGCDSQNLDAQTLEKY
                     ITEANYVLLEYDLVALASHPDKQYVGDDPNNVNNVNNVIITHPKYVLASVQSLSQLQKA
                     SDELFRLGYFQYWSEEKLAGMKARSELLEKVSFNQRKNSRRIIPT"
     gene            18030..18755
                     /gene="sxtS"
     CDS             18030..18755
                     /codon_start=1
                     /gene="sxtS"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     crocagin: PhyH"
                     /gene_kind="biosynthetic"
                     /product="phytanoyl-CoA dioxygenase"
                     /protein_id="ABI75132.1"
                     /sec_met_domain="PhyH (E-value: 1.3e-12, bitscore: 39.0,
                     seeds: 39, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MLTVEQKQAYVNDGYFTLEETVPKALVEEIRHEVELITEQKRGGV
                     LPGDYEWWSDYTIPDPIKYQKIIQRLLELPTVIESVQALIGSDISLLISDLAIIRAGTG
                     YIAWHQDHGYVVEVLNKLASKSTKELNDDDLQLLVPVANQATVFITIHLQNTDNAMGAL
                     RVIPSSHRWEHSLDPSSDNSLDTEICLPLPGGAAMFYTPTLWHTAAANTSTTNYWTLTL
                     IFTKNNIEPLLADALKGRI"
     gene            18851..19870
                     /gene="sxtT"
     CDS             18851..19870
                     /codon_start=1
                     /gene="sxtT"
                     /product="phenylpropionate dioxygenase"
                     /protein_id="ABI75133.1"
                     /transl_table=11
                     /translation="MTNADQILINDWYVVAKVEDCKPGSITTASLLGVKLVLWRSHEQN
                     SPIQVWQDHCPHRGVALSMGEIVNNTLVCAYHGWRYNEAGKCVQIPAHPDMIPPASAIA
                     KTYHCQERYGLVWVCLGNPVNDIPEFPEWDDPNYHKTYTKSYLIQASAFRVMDNSLDVS
                     HFPFIHDGWLGDRNYTKVENFEVKLDKDGLTMGKYQFQTSRIVSDIEDDSWVNWLRLSH
                     PLCQYCVSESPEMRIVDLMTITPIDEDKSILQMLITWKCLRMLDSKTLESKLLTEYDET
                     IEQDIRILHAQQPARLPLLPPKQINTQWLLQEIHVPSDKCTVAYRRWLKELGVTYGVC"
     gene            20019..20768
                     /gene="sxtU"
     CDS             20019..20768
                     /NRPS_PKS="Domain: PKS_KR (8-172). E-value: 1.3e-14. Score:
                     46.4. Matches aSDomain: nrpspksdomains_sxtU_PKS_KR.1"
                     /codon_start=1
                     /gene="sxtU"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) adh_short"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1001:short-chain dehydrogenase/reductase SDR (Score:
                     221; E-value: 3e-67)"
                     /gene_kind="biosynthetic-additional"
                     /product="short-chain alcohol dehydrogenase"
                     /protein_id="ABI75134.1"
                     /sec_met_domain="adh_short (E-value: 2.1e-37, bitscore:
                     119.4, seeds: 230, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MAGKLDGKVAIITGASSGIGAATAFALAAEGAKVAIAARRAECLD
                     VLAKQIAASGGQALSIVTDITNEAQVNNLVQKTNGELGHVDILVNNAGIGVFGTIDTGN
                     PADWRRAFDVNVLGVLYAIHAVLPLLKAQKSGHIVNISSVDGRIAQAGAGVYSATKSGV
                     NALSEALRQEVYKDNIRVTIIEPGLVDTPFIDLISDPIIKQLSEEQRQTITPLQSEDIA
                     RAIIYAVTQPDHVNVNEILIRPTTEGN"
     aSDomain        20043..20534
                     /aSDomain="PKS_KR"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_sxtU_PKS_KR.1"
                     /evalue="1.30E-14"
                     /label="sxtU_PKS_KR.1"
                     /locus_tag="sxtU"
                     /protein_end="172"
                     /protein_start="8"
                     /score="46.4"
                     /specificity="KR activity: inactive"
                     /specificity="KR stereochemistry: C2"
                     /tool="antismash"
                     /translation="VAIITGASSGIGAATAFALAAEGAKVAIAARRAECLDVLAKQIAA
                     SGGQALSIVTDITNEAQVNNLVQKTNGELGHVDILVNNAGIGVFGTIDTGNPADWRRAF
                     DVNVLGVLYAIHAVLPLLKAQKSGHIVNISSVDGRIAQAGAGVYSATKSGVNALSEALR
                     Q"
     CDS_motif       20049..20126
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_sxtU_0001"
                     /evalue="1.40E-03"
                     /label="PKSI-KR_m1"
                     /locus_tag="sxtU"
                     /protein_end="36"
                     /protein_start="10"
                     /score="11.3"
                     /tool="antismash"
                     /translation="IITGASSGIGAATAFALAAEGAKVAI"
     gene            20821..21690
                     /gene="sxtN"
     CDS             20821..21690
                     /codon_start=1
                     /gene="sxtN"
                     /product="sulfotransferase"
                     /protein_id="ABI75135.1"
                     /transl_table=11
                     /translation="MNAVDAGNSKKNENKHIAMWACPRSRSTVIARAFENLDGCIVYDE
                     PLFAPSVFMTTYTTINSRTLEEENLKQLLQQNNFEPDIKKVIEKITGNLPDGKLFSFQK
                     MITGDYRSEFGIDWVKKLTNFFLIRHPQDIILSFDIAEKKTGITELFTQQMIGMKTLYQ
                     VFQQIELITGQIPLVIHSDDIIKNPPSALEWLCKNLELAFDKRMLTWKANLEDSNQLLY
                     KQLFANSEFSSSEAWFETLRSSQTFLPYEKKEKNLPDRLIPLLDESIPYYEKLLQHCHS
                     FEWSEHRV"
     gene            21809..22942
                     /gene="sxtG"
     CDS             21809..22942
                     /codon_start=1
                     /gene="sxtG"
                     /product="amidinotransferase"
                     /protein_id="ABI75136.1"
                     /transl_table=11
                     /translation="MTNQNNQELENNSPIAKQPCPVNSYNEWDALEEVIVGSVEGAMLP
                     ALEPINKWTFPLEELASAQKVLSERGGIPYPPEMIALAHKELNEFIHILEAEGVKVRRV
                     NPVDFSGSFSTPAWQVGSGFCAANPRDVFLVIGNEIIEAPMADRNRYFETWAYRKLLKE
                     YFQAGVKWTAAPKPQLLDAQYNLNFQFPQTGKPSRFVVTEFEPTFDAADFVRCGRDIFG
                     QKSHVTNSLGIEWLQRHLEDEYRIHIIESHCPEALHIDTTLMPLAPGKILVNPEFVDVN
                     KLPKILKSWDILVAPYPNHIPQNQLRLVSEWAGLNVLMLDEERVIVEKNQEPMIKALKD
                     WGFKPIVCSFESYYPFLGSFHCATLDVRRRGTLQSYF"
     gene            23005..24024
                     /gene="sxtH"
     CDS             23005..24024
                     /codon_start=1
                     /gene="sxtH"
                     /product="phenylpropionate dioxygenase"
                     /protein_id="ABI75137.1"
                     /transl_table=11
                     /translation="MTNADQILINNWYVVANGEDCKPGSITTASLLGVKLVLWRSDEPN
                     SPIQVWQDHCPHRGVALSMGEIVNNTLVCAYHGWRYNEAGKCVQIPAHPDMIPPASAIA
                     KTYHCQERYGLVWVCLGNPVNDIPEFPEWDDPNYHKTYTKSYLIQASAFRVMDNFIDVS
                     HFPFVHDGGLGNRHHAQVEDLEVKVDKDGITMGNLQLQMPRLNSSIKYDLWTLWQRVIH
                     PLCQYYIAESSEIRTADLMLVTPIDEDNSLVRMLITWNSPEILDFKTLESKLLAEFDQT
                     IEEDIRILHSQQPARLPLLPPKQINTQWLPQEIHVPSDKCTVAYRRWLKELNVTYGVC"
     gene            24071..25528
                     /gene="sxtM"
     CDS             24071..25528
                     /codon_start=1
                     /gene="sxtM"
                     /gene_functions="transport (smcogs) SMCOG1086:MATE efflux
                     family protein (Score: 252.9; E-value: 8.4e-77)"
                     /gene_kind="transport"
                     /product="sodium-driven multidrug and toxic compound
                     extrusion protein"
                     /protein_id="ABI75138.1"
                     /transl_table=11
                     /translation="MTNPQIRLAEITSKGYKSELISEARVSLQLAIPLVVVEICETSIN
                     TVDVVMMGLLGTQVLAGGALGAITFLALFFTCSSMFLVGGAQAAEAFGANKIDQVSRIA
                     SGQIWLAVALSLPAMLLLWHTDTILLLLGQEESNVLVTKTYLHSIVWGFPAALGIKILR
                     GIASAVNLTRLITVTMVLGLLLNAPANYVLMFGKFGLPQLGLAGIGWASTLVFWVSFIA
                     GVILLIFSPKVRDYQLFRYMRQFDKQTFVKIFQTGWPMGFLLGAESVVLNVNAWLAGYV
                     GTATLAAHEIAAQTAAMAMVIPLGVGNVAVTRVAQTLGEKKPLGARRAASIGITIGAIF
                     ASAAALIFWLLPYQIAGIYLNINNPENIEAVKTATSFLALSGLFQIFYSIQIITVGALI
                     GLQDTFVPLLMNLVGWGLGLAGSYFMAIILGWGGIGIWLGMVLSPLLSGVILMVRFYQM
                     IAYKIANSNNGEESQIIPDEKVLKCIS"
     gene            25516..27354
                     /gene="sxtI"
     CDS             25516..27354
                     /codon_start=1
                     /gene="sxtI"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     crocagin: Carbam_trans_N"
                     /gene_kind="biosynthetic"
                     /product="NodU/CmcH-related carbamoyltransferase"
                     /protein_id="ABI75139.1"
                     /sec_met_domain="Carbam_trans_N (E-value: 1.3e-125,
                     bitscore: 409.9, seeds: 4, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MHILGISAYYHHSAAAMVVDGEIVAAAQEERFSRRKHDASFPIGA
                     IAYCLKQAGIKLQHIDQIVFYDKPLVKFERLLETYLAHAPKGFSSFITAMPIWLKEKLY
                     LKTILKKELALLEECKTSQLPPLLFTSHHQAHAASAFFPSPFERAAVLCLDGVGEWATT
                     SVWMGLGHQLTPQWEIHFPHSIGLLYSAFTYYTGFKVNSGEYKLMGLAPYGKPKYVDQI
                     LNHLLDLKEDGTFRLNIDYFNYTVGLTMTNHKFHNLFGEPPRKPEGKITQREMDLASSI
                     QKVTEEVVLRLAKTVKKELGAEYLCLAGGVALNCVANGRILRESDFKDIWIQPAAGDAG
                     GAVGAALAIWHEYHEKPRTPTSGDRMKGSYLGPSFSEAEILEYLNSANIPYQRLADSEL
                     MPRLAEILQQGNVVGWFSGRMEFGPRALGSRSIIGDSRSPKMQSVMNLKIKYRESFRPF
                     APSVLAERVSDYFDLDRPSPYMLLVAPIKENLHIPMTQEQQQLFGIEKLNVPRSQIPAV
                     THVDYSARIQTVHKETNPRYYELIRHFEARTGCAVLVNTSFNVRGEPIVCTPEDAYRCF
                     MRTEMDYLVMENFLLVKSEQPQGNSDESWQQEFELD"
     gene            27397..27801
                     /gene="sxtJ"
     CDS             27397..27801
                     /codon_start=1
                     /gene="sxtJ"
                     /note="hypothetical protein"
                     /product="hypothetical protein"
                     /protein_id="ABI75140.1"
                     /transl_table=11
                     /translation="MEQIKELNQKGLREFGLIGGSIVAVLFGFLLPFIRHHSLSVIPWV
                     IAVILWIWAIIAPATLNFVYKNWMRIGLVLGWIQTRIILGVLFYIMITPIGLMKRLLNQ
                     APMMRSLDPDLPTYRQLSKLRTTESMEKPF"
     gene            27801..27965
                     /gene="sxtK"
     CDS             27801..27965
                     /codon_start=1
                     /gene="sxtK"
                     /note="hypothetical protein"
                     /product="hypothetical protein"
                     /protein_id="ABI75141.1"
                     /transl_table=11
                     /translation="MLKDTLDFLKDIGGFIKEQKNYLLIPLIVTLVSLGALIVFAQSSA
                     IAPFIYTLF"
     gene            27976..29256
                     /gene="sxtL"
     CDS             27976..29256
                     /codon_start=1
                     /gene="sxtL"
                     /product="GDSL-lipase"
                     /protein_id="ABI75142.1"
                     /transl_table=11
                     /translation="MSNLKGWVKTALIGSLIFCGLIFGVVFIEIGLRIAGIEHVAFHTI
                     NEHRGWVGRPHVSGWYQTEGEAYVQMNSDGFRDQEHTKVKPENTFRIALLGDSFVESLQ
                     VPLDKGFAAVIERELSSCTALAGRKVEVINFGVTGYGTDQELITLREKVWDYSPDMVVL
                     NFYTGNDISDNSHAISQKLYAGEQALLKPFFLLKDGDLVVDTSFISTDTYRSKLTWWGK
                     AYIKIKDHLRILQVANIIQDSLKNLNRVLSPQAIEEPLFSTGRHDQNSSWIDNNIYKPP
                     TDPEWQQAWQVTEKLISLMHDEVIAKKADFVVVTFGGPFQRDPSARQKEMQAFGVTDWF
                     YSENRITALGEGEGFSVLNLSPTLLDYTEQNNTCLYGFEDTLGCVGHWNASGHQLAGKM
                     IASGLCQQEGQKAAPMARLYPSGNFVR"
     gene            29274..29843
                     /gene="sxtO"
     CDS             29274..29843
                     /codon_start=1
                     /gene="sxtO"
                     /product="adenylylsulfate kinase"
                     /protein_id="ABI75143.1"
                     /transl_table=11
                     /translation="MNVKQQGAVLWFTGLSGAGKTTIASRVVQKLQKQNYSTELLDGDT
                     VRTFLSQGLGFSKQDRDINVRRIGFVANLLSRNGIIALVAAISPYHEIRDELKQTSNNF
                     IEIYVKAPLEVCESRDVKGLYAKARAGEIQSFTGISDSYEEPTNPDIICQTDRFTIEQC
                     VNQVLQYLLDFGLLTGDKVVEDEMCQ"
     CDS             complement(30059..>30991)
                     /codon_start=1
                     /note="ORF25"
                     /product="SMF protein"
                     /protein_id="ABI75144.1"
                     /transl_table=11
                     /translation="RRNPEQLLTQHQQINPHFWTPADPEYPQLLREIRTPPPLLYYRGE
                     IDLQENSGQKPLVGIVGTRQPTEYGIKWTRQISTALAKNGFTVVSGMAEGIDTESHSAT
                     LKAGGRTIAVMGTGVDVIYPHKNRDLYQQILKSGIVISEYPAKTPPNRTHFPRRNRIIA
                     GLSRAVLVMEAPLKSGALITATYANEFNRDVYALPGKIDDQPSQGCLKLISQGAGLINH
                     ELNELLIMLGAIPQIDIETETPLVKSPPIPNLAPELQQIINILAVDALSFDFIIQKTGM
                     NAAIVSSSLLQLELMGLVTQLPGMRYQKC"
ORIGIN
        1 aagatacgct gcaaagcctc cctgctacta attctgactt aacgccgggg gtatttttat
       61 tagacttaga taatggtgct tatgtagata ttaatggtaa taggagtttt ccggccgcta
      121 gtacaattaa aatcccgatt ttgatggctt ttttccagga tgtagatgcg ggtaaaatcc
      181 gtttagatga aatattaact ctggaaaagg aaatgattgt cggtggttca ggaaatatac
      241 aatatcaagc tccaggcagc aagtacacgg ctcttgatct ggcgacaaaa atgattacaa
      301 ttagcgataa caccgcgaca aatatgctaa ttgctaaatt ggggggacaa gaggctttaa
      361 atgggcgttt tcgcagttgg ggactaacaa caacgatgat tcgtagtcct ctcccagatt
      421 tacaagggac taataccacc agtccgcgag aattggggaa tttaatctct atggtcaatc
      481 aaggtaatgt ggtgactatg cgatcgcgtg attcaatgct taatattatg aaccgtacgg
      541 aaagagataa tcttttacct gctggtttag gaaaaggcgc aaatgcgtat cacaaaactg
      601 gtgatattgg tacaatgtta gcagatgcgg gattgattga tgtgccgacg ggtaagcgtt
      661 atattgcggc tattatggta caacgtccaa ataatgatcc tcgtgctgca aaattaatta
      721 gttctatttc cagttctgct tatcaatact tcagcaaagc tacagtacaa cctagtaatt
      781 ttactaataa tcagcctaat caacctattc ctaattatca agtaccgatt ccacctattc
      841 aacctattca acctgttcaa cctgttcagc cttttattca agcaccgatg atcaatccaa
      901 acgtaccgaa tggaatggtt aataatgtgc ctatgggtac ttatcaagcc ccgatgatca
      961 ccccccaata ttatccacaa caataaataa ttcaaaattt aaagcggtgc aaaaaatgtg
     1021 gctttgttgt tagagaacag cgttcaggct atcaattcag atggagaata tatcatgaat
     1081 ttgagggggc gacaagcaag gtgaaaccaa tataagtaaa gggttttagg tgatagaccc
     1141 tctgaaaaaa gttggtactt attgagaatg ggatacagtt attaagcagg tgtttatggg
     1201 gttaaaagaa atacagaaaa ttgaacctat gggtctacaa aaatatctcg ttcgtgtcaa
     1261 agaatatgga cgcattgaaa gacggtatag cagcttttac attcagtaga ctgaaaactt
     1321 ttgaaagttg acgaaaaaat agggatttta gccgtcgttt tggaggctag cgaactgctt
     1381 gcagcagcgc ttcgctatcg cttgcctcct gcctttttcg ataatttgaa gttaaatacc
     1441 taaaattaag acctcatttt catttctaga cgttcagcaa cgggcattaa ttgacgtatc
     1501 agatcgaagt ttcctacgtt ctttctcatc caatctaata agaatttttc tccttcattg
     1561 agcttaccgt catcatcaat aaaaaccatc tgttcgcacc aatctacaaa tccggaatta
     1621 gtcatctcat agactaaaat gagaggagga aagtgtgcga atcccatggt ttcaatgact
     1681 tccatgcaaa tcagtttaaa tacttgttcg tttgtcaact cagtagacat aatgagcctt
     1741 ctcttaatca gttctgtctt tgatcatacc acagaataat aactcttggg cttgaacgta
     1801 cattattcag tttctgtcaa tgtgtaggtc ctaacttatt actggagaga gttgcagggg
     1861 cgtacctcag atcaaccttg ggggcgatag aagaaaggaa ggattcagtg acagacattt
     1921 gactaatggt agtttccgct tccactaaaa cagcatcaca aatgtcgaat agtgattgag
     1981 gatatctatt catattcatg taggtcagag cagattccat cggagacatg gatgaatgat
     2041 aagcagcgtt ttcagcgtac cgacctgtaa atatattccc atgggaatct tttaacgcta
     2101 cccctgcaaa atttttcgta tagggagcat aactttgatt ggcggctgat agagcagcaa
     2161 gcacaacatc atcggtatca tcggtagaac aagtctccag accatgaaat actgtttcca
     2221 ttaatccact cgtaagtcca agatttggtg gtccaaaggc ctcaggtaga aaatatggga
     2281 gtttatttga agtataagtt tgctctattt gtgtcttgtt ggactttaag agaataacaa
     2341 aatcctgatt tacagttgcc atctcgtata aaaactgtcg gcaatatcca catggtgctt
     2401 cattggttgc taaagcttgc aaacccgtct ctccgtgcaa ccacgcattg atggttgcgg
     2461 actgttctgc atgaactgag aaactaagtg cctgccctac aaattccata tcggcaccaa
     2521 aataaagagt tccagaatcc acctgattat tggattttgg tttaccaaga gcgatcgccc
     2581 ctacataaaa ctgcgatatt ggtaccctag cataggccgt ggctactggt agtaactgaa
     2641 tcattaacgt accaatatca ataccaagtc gatcaagcca agaggtgaca acacttgagt
     2701 caattacagc atgttgggac agaattgtcc ttaactctga ttgaatggaa agtggaacct
     2761 gagcaatcgc ctgttctaat cttacatggg tcatttgggt tatttctcct tttgtagcaa
     2821 aacccaaacg gcttcgagag ctttaattgc ttggtctatc tcctcttcgg tattggcagc
     2881 tgtaatcgaa aaccttaaag cacttttatt taaaggtacg atcgggaaaa tagccggagt
     2941 aatcaaaata ccatattccc aaagaagtcg acagacatca atcatatgtt gagcatctcc
     3001 cactaacacg ctgacgatgg gaacgtaacc ataattatcc acttcaaatc caatggctct
     3061 tgcttgtgta accagtttgc gagtcaagtg ataaatttgt tttcttaact gctccccttc
     3121 ctgacgattc acctgtagtc cagctaaggc acttgccaaa ctcgcaacag gagaaggtcc
     3181 agaaaatata gcagtccaag cgttgcggaa gttggttttg atctggcgat cgccacaagt
     3241 caagaatgct gcataggaag aataggcttt ggacaaaccg gcgacataga tgatattatc
     3301 ctctgcaaac tgcaggtcaa agtaattcac catcccgttt cctttatacc cgtaaggcat
     3361 atcgctgctg ggattttcgc ccaaaatgcc aaaaccatgt gcatcatcca tgtaaatgaa
     3421 agcattgtac tcttttgcca gacgcacgta agctggcaga tcgggaaaat ctgccgacat
     3481 ggaatacacg ccatcaatga caataatctt tacttgctca agcggatatt ttgctagctt
     3541 ttcggctaaa tcgttcaaat cgttatgtcg atattggatg aactgggatc ctttttgctg
     3601 cgccagacag cacgcttcat aaatacaacg atgtgcagct atgtcaccca aaatgacacc
     3661 attactccca gttaatagcg gtaacactcc tatctgaagc agcgttacag atggaaatac
     3721 taaaacatca ggtacgccta aaagtttgga caattcttct tctaactctt catagattac
     3781 cggggaagca acaagccgag tccagcttgg atgtacgccc catttttcca aagccggtgg
     3841 aatcgcttcc ttaacttttg gatgcaagtc aagacctaaa tagttgcaag aagcaaagtc
     3901 tattacccaa tgtccgtcaa ttagtacctt gcgaccttgt tgttctgtga cgactcttgt
     3961 gacttgagga attttttgtt ggttaactac gttttctaga gtgttgattt cgttggctaa
     4021 gtcaacaggt gaggctagat cagattgttt ctcttgtact acttggtttt ggaaataagt
     4081 aatgatggca gttggagtgt tattttggaa aaagaacgtc ccagagagat tcacccctaa
     4141 acgtttctct agcagcgttt gcagttctga taaatctaaa gaatctaatc ccatatccag
     4201 cagtttttgt tctggagcgt aagctgcttc ccgttgggaa cccatcactt ttaaaacgca
     4261 ttctttgacc agagcggcta cagttttgtt ttccttagtt gcagatgttg ctggcaaagt
     4321 tggtactgat gaactaactg ctgagttggt atacagcgct tggcgatcgc caagggggtg
     4381 caaagcacta tcgcgcaggt tatattcaat caaaataccc atgccgaaat tctctgcatc
     4441 ttctggacgg taattagcaa taattcccct aatttcggct cctcccgaca catggaaccc
     4501 cacaatcgga tctagaagct gccgttgctc gttgtgtagc ttcaaatact ccgtcatcgg
     4561 catttgggaa taattgacat aattgcgaca gcgagttaca cccaccacgc tctcaatgcc
     4621 gcctttcagg gtacagtagt agagcataaa gtcccgcaat tcatttccca acccccgcgc
     4681 ctgaaactca ggcagaatat ttagtgcgag tagttgaata actgaccctt ggggagtatg
     4741 taacgacggc acttgctcat attttacatt ctctaatacc tcagtgctgg tgattgtttg
     4801 ggaataaacc gcaccaataa tttgatcttc tgtaatcagc actaaattcc cctgtgggtt
     4861 tagctcaagt cttcgccgaa tttcattagc agatgcctgt aaatgttctg accaacactg
     4921 gacctccaag ttaactaagg caggcaaatc tgacaaatag gcattacgaa ttttgtaagg
     4981 tcttttctca aagtaattaa gcgtaatgcg agttaaagga aacgttttcg ggtatctttt
     5041 agaaagctct aattttggaa atagacctac ttctgcagca gacctgagaa aaacatcggc
     5101 ttcgacaaga tactgctgag aaaatccctg aaacgcatcg aaatgtaagt tttcgctttt
     5161 gtctaaaaac tgatagacta cctttggttc taaacaatgg acttccaaaa tcattaaacc
     5221 gtgcttagtg accactcgag accatcgttc taagtgttct accaaactct gcaccataac
     5281 atgaggagga ataagctctc cttgaccatc gacacagact gcttggtaag gtaagtgagc
     5341 acgctctttc acttcgttcc ttttctgggg aggaataaag ggacgatcat ggtcgaggaa
     5401 ggaacggatg tgcaggatat tttcgggatc atgaatacca tgagccttta aagaaagcac
     5461 catttgttcc gggttcccaa tatctccctg caaaactaaa tggggaaggt caccaagggt
     5521 atatgtggta gctgttaaag aagcttcgtt ataatccaca cctataagac gcaagggata
     5581 ctctttgatc gcttttcccc tagcagattt gaactgaatg gtttcccaga ctcgtttcag
     5641 gagagttcca tcgccacacc ccatatcagc aatgtatttg ggctgttctt ccaatggtaa
     5701 ctgattgaat actgagagga tactttcttc taaatcggca aaatatttct ggtgttgaaa
     5761 tccactcccg atcacgttga gggtacgatc aatgtggctt tcgtgaccag aattatctgt
     5821 tttaaatact gaaagacaat cgccaaacag tacatcatga atgcgagaca acataggggt
     5881 gtaagaagca actacggcgg tattcaaggc tcgccccccc ataaattgac cgagctctgt
     5941 tagagtcaga cgacctggtt taaggtcagc ccaaccaagg cggaaaaata agttgcccaa
     6001 ttcttcttgc actgttctgc ttaatgagga gaacaagggt ttctcttccg actctgcaag
     6061 caagttgtgt ttgtggagtg tcagcaggag tgggatcagc agtagtccat ctaaaaaatc
     6121 tgctattaag ggattatcca gattccacag ttggcaagaa cgatcaatcc atcttcccag
     6181 caacttttct tgttttcctt gtaaataaga ctcaattggt aggtggtaca actcgagaac
     6241 gtcttctgga atttggttgt gaatcgctgc ttctgaggtc agagaatatt taagttgctc
     6301 atttcgggaa agccaatgta aagattcgag catcctcaaa gcaacttgga aatgtccggt
     6361 attagctccc agatgcttga ccatttgctc taaggagaga ggactttcat gggctagtag
     6421 ctcgaaaaaa cctttttctc gacaagcgag gatcactgga atcgcaacaa atccgtgggt
     6481 atagcggtta atcttttgta acattgttag agggtcaaag ttctaatcta ctattttttg
     6541 atatttagta cacttacgca ccagtgtaat agttaatatt tcagacaggt ctgatgataa
     6601 ttttcattgg cgtacataat taattattta cggcttatgt gaattaaatg cggaaaccct
     6661 tgtaataccg ttgatgattc tggaattatc gttctagaga actctggaaa ccctaataaa
     6721 accacaatat ttttaactca cataaggcgt tatttggtaa tagttacttg gccaccattg
     6781 ctgcaagaag agccagtata gtcgtaaata tctactaaaa agccattgga taatgcagtt
     6841 aatgcagctt tataaccacg tgtatgaatg tctctattta gtactgctga aacaggtaag
     6901 atgatcactc tatctgcaca aggaccaact ccctcactga tactaatagc ataattatcg
     6961 ccgttagaag aagtattttg aacattggta atctttccac cttgaactaa atagtcagct
     7021 ttggcaatgc caactccggt agttaagaaa ataccaaatg cgaagacgaa tgctagtgat
     7081 cccataaaga aatgcttgaa agctttcaac atgatgtaaa tatacgttat gaccggaatt
     7141 aagtaaccga ttaattgaca gttatatttt aatataataa caggaattat gcaactggta
     7201 caattatctc tttcggacac aagcattaca attaatacag agttagctcg atcatgatac
     7261 tgctcctgct agaactttaa tactgaggct gtggtttgag tggttaatac tggtggtgta
     7321 gcgatcgcat ccttcaccca atcccgtctc acccaaagcc tttctgagcc gcctgtggct
     7381 tggtaataaa tctgacttgg ataacctgag ttcgatataa ataatcatcc tgaaaactaa
     7441 ttatatctcc tgaaactctt tccagtcaac acttgtaagt tattctctta catcgaactc
     7501 aggttggatc ggtttcggga tagtctatgc gaatatgttc gctgcgtgtt tctgtgcgat
     7561 gcaaagcact aaagatgccc atcgtgctac agctacaaga gcagccgccc gacgagaaaa
     7621 ttccatatcg cgcacagtat cttgtttcgg gtttccttgt acttgcagcc acagcatttc
     7681 taatttggcg agggctatcc ctgatatttt ggtctaaact ccagatggaa ctcatgtcta
     7741 ttaaacaccc acaattgtct ttaccgttac tgatttatca tccaatctat ttttatgttt
     7801 ttccagatca aagttttctg gaaatacgta cgttccaaat aatcggtcag tgaaagtaaa
     7861 cataccactt aaatttcttc cttttgtatc aatatgatgc aaagcatgaa cacggggcgt
     7921 gacataaatc cattccaata ttcctaacca ggagtgccat ttcacattga ggtgtatcca
     7981 attattatga atcacttgat gcagtgccac tacggacata atttctgagg gaatgtccat
     8041 caatggaaac cataaggatg taacagtgta taagagtccg ccagtaaagc tatctttgtt
     8101 tccgcttagc caccacgatt gctttgttga atgatgccat ttgtgggtca accaaagaaa
     8161 ttgattacta tgcattatcc tgtgtaatgt atagtcagtg aagtcctgca atatatatgc
     8221 tgtgatgatc ctcagccaga gaggcacata cattagtcct gcaaaagttg ctgactctcc
     8281 cataaataga aaagtcaata gttttatgat taccacagaa acgtatgcat agataattct
     8341 aaagacgagt gatattcctg cccatcccaa ttccttaaag aaattagctt tgtatttaat
     8401 ctcatgtaaa ggatagcgaa tttcccaaag ccagaatatc atacccgtaa ttaaaattac
     8461 agtccaatct cttaatagga ttaatattgt atctatcatt ttgtatctat cattggtaac
     8521 cttagtgtat actagtcaag tatactctta ttaacaaatt tccacaagac aactcatgaa
     8581 aaggctcagt tcgttagttc tagcagcact cttgtttgtc agcacattcc tatgtataac
     8641 cactgttgca ttagcagata caactaacga ttatctgaag aatgaaaagc tttctgggca
     8701 atttagtgtt tcggttaagt tggatgcagg agtgagattt accaatagga ctaatcaatc
     8761 gctacctgag acgttcacaa atcttgggaa atgggctgct agtaatgaca ctgtcaacct
     8821 catttataat actacagaga caaacacaat tacttttcct ctgcataaaa gtttaacttt
     8881 tgttgcgaat gaaactatcg gcacaaacaa cgacaactcg gatggtatta tcgtcaagtc
     8941 ctttgttcca gggtcttatg ccactgctac taacttcccg gtcggtattg atgctgactt
     9001 tgtagctact ggggatttca atggcgacag taagctcgac ctggctgtta caaattgggc
     9061 caataataac gtctcgatat tactgggaaa tggtaatggc tcttttagtg cagcgactaa
     9121 cttcccggtg ggtactaatc ccgtctctgt agtgactggg gatgtgaatc atgatagcaa
     9181 gcttgatctg gctgttgcaa attttactag caataacgtc tcgatattac tgggaaatgg
     9241 taatggctct tttggtacag cgactaactt tccagttggt actaaccctt actctgtagc
     9301 gattggggat gtgaatggcg acagtgagct tgacctagct tttacaaatt gggtcagcaa
     9361 taaggtctcg gtattactgg gaaatggtaa tggctccttt ggtgcagcaa ctaacttccc
     9421 ggtcggaact tattccatct ctgtagcgat tggggatgtg aatggcgaca gtaaccttga
     9481 cctagctgtg acaaattggg tcaacaataa ggtctcagta ttactgggaa atggtaatgg
     9541 ctcttttggt gcagcgacta acttctccgt cggtactaat cccatctctg tagtaattgc
     9601 ggatgtgaat ggcgacagta agcttgacct agctgttgca aatactagca gccataacgt
     9661 ctcagtccta ctgggaaatg gtcatggctc ctttagtgcg gcaactaact tcccggtagg
     9721 tactaatccc tactctgtag cgattgggga tctgaatggc gacagtaagc ttgacctgac
     9781 tgtgacaaat tatagtagca ataacgtctc agtcttactg ggaaatggta atggctcctt
     9841 tggtgcggca actaacttcc cagtaggtac taatcccgaa tcaacagcaa ttggggattt
     9901 caacggcgac agcaagctcg acctggctgt gacaaattct ggcaacaata acgtttcagt
     9961 cttgttgaat aactgcttca aaaatactta cctaaactta gccagagcta agaattttgt
    10021 ataaataagc tcactcttaa actcagctat ggtaatcaag aatttatgtc ctgacggatt
    10081 tacaccaatc tggaacaaaa gccagatgga atccgttctt gtagaggagt gtcttcctgc
    10141 ctgggtacgc actaactact caacatttgt tgaaacaatc cgcgatcctg ccttcccctg
    10201 cttctgggga actatcgggg aacagaaggg aatgattcga tacctaattg cctcatcttt
    10261 aaccgagcca agcgtggttg agcataccct tgagggtgtc tacaactata ttaatgaagt
    10321 taacgaaaat gaattgcttc agcacgagaa tgctgatctt ctgacacttg ttatcttttt
    10381 cccacctgaa ccaacggttc tcacagtaga ggaatattca cgtcaggcat ttgcattttt
    10441 aaatgcgttg catagccttg atgcggtatc ttgtccctgt cattggtctg ccgatccgca
    10501 gtctcctaac tggtcttatt ctctaggagg gtgtgcctta tttgttagtg tttccactcc
    10561 agcaaatcaa aagcggcgat cgcgccacct cggatcggga atgacttttg tcatcacacc
    10621 agttgaagtt ctcttgagaa aacacggtgg cgagaattcg agcatttttc gccgcgtccg
    10681 cgagtacgac ggcatttcac ctcaccctaa cttattaatt atgcctggga gtagcaaagt
    10741 cggtaacgaa ctaacagtgc aagtgcttcc ggatgataac gatagcgaga tctcatttga
    10801 ctttcagtat aaatttaagg attaggcaac aatcaatgac catccaactt atacaacgca
    10861 atttagagta tagctttgta accccaaacg aaacttctga ttttgtgcaa aagacaataa
    10921 atgtcttcga gcaagcatac ccaaaatttt taatacatga tgtttgggca gatccagatt
    10981 ccttagctct atttgaaatt tatccagaat tccagtttgg cttagtagaa gctactacac
    11041 agcgtatgat agcgcaagga aactgtatcc ctttagcatg ggaaagccgt tttgatgagt
    11101 tgccggagga aggttgtgac tgggctttgg ccaagtggct cgaagaccga gaacagaacc
    11161 gccagcctaa tgcgttatgt gtagtatcga tttcaatcct accggagtat caaggcaaaa
    11221 acttaagcca gtatctgatt ggatacatga aagaacttgc ccaatcccat ggtcttagtt
    11281 cgctgatcat ggctgcacgt ccaagcctga aatatcttta cccacttaca cccatagagc
    11341 gttatattac atggcgggat aaaaatggtc ttctatttga ctcttggtta cgagctaatg
    11401 tcaaacaggg ggctaaaatt gcaggcatct gttttaaatc cacgacaatt cgcgatacta
    11461 ttgctggttg ggaaaataga gtcggaatgc gttttccaga aacgggtgac tatattattt
    11521 caaacggctt agtacctctc aaaattgact atcccaacaa tatgggaata tacatcgagc
    11581 ctaatgtctg gttatactac gacatacatt tctcaatagg cttcaaactc ttttcataat
    11641 agaattccag tttttcaagc cgtaacaaaa taagacctct tgcaaaagtt ttttgtggta
    11701 taataaaggg ttattcatac tttggttttt tgagaaagtc tgggtctttc tttccttgtg
    11761 gtagggaatt ggcatgctga tataatttta tatataaagg caagcttttt gttccatcat
    11821 ataaatgact tgttaccaga actattccgt tgtcagtttt gccaagttct cctatgtact
    11881 gtctcacaca cgtgacgtaa aattcccact ttttctgtgt cctttttcat caacaattaa
    11941 agaaaatcct gtcgatatcg cgaataaatt tttccttttt acaaaaatgg gatgctccca
    12001 tttaattgcg cttttatccc tcctctgaac ggttacgatc aaactcggtg ttctgaccat
    12061 tcaaaactat gacaatgctg taagagtttt tcatagtagg gaatagattc atctagtagc
    12121 ggtattagcc gatctggtaa atttttctcc ttcttttcat aggggagaaa tgtttgggac
    12181 gatcttaaag tttcaaacca ggcttctgaa ctgctaaact cagaattagc aaataattgt
    12241 ttatacaata attgattgga atcttctaga tttgctttcc atgtcagcat ccttttatcc
    12301 cacattccgc accctgaact gtcacagatc aaaaaagcag agctagtagt acataataac
    12361 taacgataaa ttaaagagaa ataagcttaa tgagaatata tatcattaaa atgagggtga
    12421 tgtgagaaag taaagtttcc taaagatgcc gaaagaaaaa gaaaattcaa gatgattaaa
    12481 aaatttatta ttcagaaagc aagaaatgag agaatcataa tagacaagta gaggaaactg
    12541 ttgtgaaatt aaaaccccaa gaaatagaaa ttcagaacat agaccatcta gggatagtag
    12601 caggaatcat agattcaatc ggaatagtag aaataataaa tgaattaata ggagtcgaaa
    12661 aagacgaaaa agtaaatgca ggtcaagtag taaaagccat gataataaac gggttaggat
    12721 ttgtctccaa accgttatat atgtttccta aatattttga aacaatcgct tgtgaacatc
    12781 taataggaac aggagtaaaa ccagaatatc tcaacgacga caaactaggc agagtcatgg
    12841 ataaactatt tatcaaagga ttagatacaa tattttttat catcgcctta aaagccgccc
    12901 aaaaatttgg ggtatcacta tcaacatcac atctagactc atcatcaatg cacctacatg
    12961 ggcagtataa cactagctta ccagaagtaa tatttgagag tcaagaaata ggaaataacc
    13021 aagaattaga agaaatagca gtaaaatcac caaaagaaat aaccatcact tacggaaatg
    13081 gtgagtgcag ggcgttttat tattgctacg aacgtttgag attcaaagga actaagtaat
    13141 gattctatgc taagtgaata taaagctcaa caatcatgtg aacgggggtt tgcttttctc
    13201 aaagacccat tattttttgc cgacagtatt ttcctcaaaa gtcctgaaag aatagagtct
    13261 ctgggaatga ttatgggttt atgtttacta gtttatactt tggcgcaacg tcaaattaga
    13321 aatgctctct tcaattctaa atcaacaatt aaaaatcaat taggtaaagc aacagaccgc
    13381 cctactttgc gctggatttt tcaatgcttt cagtgtattc atttggttat actcaatcag
    13441 gaagaacata tttctaattg gaataaggac agagatttta tcttgagtct tttaccagat
    13501 gattgtttac gttactatca attagtcacc taattattat ctctatcaat ttaatttctc
    13561 ttgtaaagat gagctaattt ctttgattta tagctctatt ttactatgtc tataatttcg
    13621 ttttttactt taattgatta ggctaactta tgatttgtct tttgaatctc ttattttatt
    13681 tatttgttgt cctctccagg tggtgtgcat tcttattgtt ttttattgag aataggtttt
    13741 gatgacgttt ttggcgattt actgtttctc aaatgccttt tttcacttta tatgtttgtt
    13801 ttcatgctcc ctttaatttt ttctctacgt aatttacccc agtgacagtt tggggtgcgg
    13861 aatgtgggtt ttatcaaatg caagctctaa gtttttacac aggcattcca aagcagaagg
    13921 agggttttta attatatcat ctgagtgaat aactaaaggt atttgtcctg taataagttc
    13981 aatctgttgg aaaacttgat aaagtgtttt catcccaatc atttgttgtg tgaatagttc
    14041 tgtgatacct gtctctttct ccgctatatc gaaagacaaa ataatatctt gaggatgcct
    14101 tattaaaaag aagttagtta gcttttttac ccaatctatt ccaaattcag atctatagtc
    14161 acctgttatc attttttgaa atgagaataa ttttccgtcc ggtaaatttc cagttatttt
    14221 ttctataact ttcttgatgt cacctgagtt cgatgtaaga gaataactta caagtgttga
    14281 ctggaaagag tttcaggatt aaataaattt ttagggattg tcaataattg cgagttattg
    14341 acaattattg aaaaataggc aatataaact gtaaattttt tttaaaaacc attaaataac
    14401 attactaatt atactcaaaa ttacaccaaa gatttaagaa taaagtagtt gtttgagcaa
    14461 ggaaaaatgg acaatggaat tagaacaatt attttgtgca atagatgatt tctgtttgga
    14521 ttttgaagca aaattgaact cagaactaat ttcgagccag tcacaaaaaa gaaaaagaaa
    14581 aagtcactta tgtttaagtg aagtcatgac tattattgtt cattttcacc aatcaagata
    14641 tcgtaatttt caggactact atcaaaaaag cattttaaaa aactaccaga aatattttcc
    14701 atctttagtg agttataatc gctttgttga attaatgcct gatgctttac tgcctttaat
    14761 ttgttatctt aatactcgca aaggtcaatg tagtggtatc tcttttattg atagtatggg
    14821 tattcctatt tgtcataata aaagagcaaa aagaaataaa gtttttcggg gtttatctgg
    14881 ctggggtaag agttctgtag attggtactt tggatttaaa cttcatttaa ttattaatga
    14941 gcaaggggaa ttattagctt ttcaagtcac tcctggaaat attgatgacc ggaaaccagt
    15001 tcctacttta gcacaaaatt tatggggaag actttttgga gataaaggat atatttctaa
    15061 aagtttattt caggaactat tggagaatga tgtgaagtta attactcctt ttaagaagaa
    15121 tatgaataat aaattagttg aattgtggga aaaacttatg ttaagaaaaa gggctttaat
    15181 cgaaactgtc aatgaccaac tccaaaatat ttcccaagtt gttcattctc gtcatcgtag
    15241 tatttctaac tttatggtta atattatttc gggtttaatt gcttatactt ggcaagataa
    15301 aaaaccttct ttaaagttag ataaacatga agtaacttct ctaccagctt tattaattta
    15361 attattttta tacaattaaa ttgtgaatcc aaaattgaat attttggatt gttttctctt
    15421 gtttatttat tgtcaataat cattgctaat tgagaaaagt ctgatataat tagttttcag
    15481 gatgattatt tatatcgaac tcaggtgatg tccggttcaa aattattttg ctgcaataat
    15541 tgctttaagt tttcttcttc taatgtacga ctgttaatag tcgtgtaagt tgtcataaag
    15601 acagatggag cgaatagagg ctcatcataa acaatacacc catctaaatt ctcaaaagca
    15661 cgagcaatga cagtagaacg acttctagga caagcccaca tagctatatg tttgttttca
    15721 ttttggatta gattagaatg tgactgaaat ctaaagaata ggataatggt ttgactgtgt
    15781 caagtctata ttaggataat ggtttgactg tgtcaagtct atatgacgag gtaataatta
    15841 tggataatgc tctcccatta ttcaaatagc cgtagtttat gctctgtatc taattcgcta
    15901 ttgttttttc tgccacgtcc ctaacctaga tgcgacgata ttcacccata atgccactgt
    15961 cactctgttg gcatcaagac aggtgaacta ctttcatcaa ccttggggcg ggttacaacc
    16021 aaaatcattg cccctaacac catgccagcg ccaataaaat cgtgagtttc aaatgtctcc
    16081 cccaatagcc aaaacgagat aattgccgcc atcaatggct cgatagtttg taggattgct
    16141 acttcagtag ctggaatcca gtgttgtcct atcatttcta accaggtaaa tacaatagta
    16201 tcaactacca ctagatagat gagactacca agattgacat tgagactgcc aacaatcgcc
    16261 tcaaaatgac cagtcaattc gggagcagcc cacaacaaac ctgcgactgc tggcacccat
    16321 aatccaactg caactagttg cacagttgga tgacgttgta cgaactgctg aattgctatt
    16381 aagtaagctg agtttaacag ggcgcaaagg agcagccaac ctgcgccgtt aagagactct
    16441 ccactccccc aaaacattac cccaattccg ctgaaggcca gtgttgctcc tactatggct
    16501 ctgggagcta tgcgcttgcc caacagcaga tcaaacagca tcacaaagat cacgcttatt
    16561 cccaaggtga atgcccctcg gttggcagag aatgtctcca gtccagaagt ggcgctaaca
    16621 tacataccaa aagacaacag tcccatgatt gccccatcac gtactagggg gatattcaga
    16681 ttacgaagga atggggtaaa aaccacagca gccattgtaa agcgaactgc cattagcact
    16741 tctttagaga tgttagtgat taaaccttta gtaattggca agattgagct atagactaga
    16801 gttgccagaa taatcaacag cacacccaaa atatatcggt tattttctgg ggcagatgtt
    16861 gtcatctcaa ccttatccaa gctattttgg agttctgtta aatcttggtt taccatctca
    16921 acttaaaatt tccttaggtc tgggcgtagt gctataatga aatctttggc tgtacggtat
    16981 atcgctaata acgcgaataa tgtgagtcat gtaattgtaa ctcataaatc ccttgaattg
    17041 caaggaaata aaacagatgc ttacatctga ataaaaacca agcaatgttt tatacagaaa
    17101 ttacatagca caccgcagct gccaatgctt caactaccaa ttactacaag cgaggaaaaa
    17161 tcaaatatta tgataaatct cgaacaattt cgccaagaga tggaggattg gattatcaat
    17221 gttgtcagca ttcccaatcc tctaacagga aattttctac cctgtcctta cgccaaggca
    17281 gcttggttga ataaccgtgt tagtcttcgt tggtttcatg gatttgaact gccagagctt
    17341 ctaatggaac agataaaaac atggaatgat gactttgaga tggtgctttt tggctgcgac
    17401 tctcaaaacc tagatgcaca gacgttggaa aagtacatta cagaggcgaa ttatgtatta
    17461 ctagaatacg atttggtagc tttagcatcg catccagaca aacagtatgt cggtgatgac
    17521 ccgaataacg tgaataacgt gaataacgta atcataactc accccaagta cgtcttagca
    17581 tcagtacagt cattaagcca gttacaaaag gctagtgatg aattatttag attgggatat
    17641 tttcagtatt ggtctgaaga aaaattagct ggaatgaagg cgcggagcga gcttctcgag
    17701 aaagtttctt ttaaccagag aaagaacagc cgcaggataa ttcctaccta gagcttgctg
    17761 aataacagta aaagcattac caaataaggg tttcaagctt ttttaaccta aagggatgtc
    17821 agattctgaa ctaccctaac tcaaaatact tgcacttttg ggaaacttgg ccaaaaaatt
    17881 agctcggatt tcccccctgc ccctgcttct ttgaaagctc accaaaaact tttcagcaag
    17941 ccctacttac ctgatggttg cagcagtatt aaacttaatt atggcgagac gatccactaa
    18001 atcctttaaa ttgcgaggaa ataaaagaga tgcttacagt cgaacaaaaa caagcttacg
    18061 taaatgatgg ttatttcacg ctagaagaaa ctgtaccaaa agcgttagtt gaagaaatac
    18121 ggcatgaagt agaacttatt actgaacaaa aacgtggagg agtattgccg ggtgactatg
    18181 aatggtggtc tgattatact atccctgatc caattaagta tcaaaagata attcagaggc
    18241 ttttagagct tcctactgtg atagaatcag tgcaagctct aattggctct gatatttccc
    18301 tattgattag cgatctagca ataattcgtg cgggtacagg atacattgct tggcatcaag
    18361 atcatggata tgtagttgaa gtattgaaca aacttgcatc caagtcaaca aaagagttga
    18421 atgacgatga tcttcagttg ttggttccag tagccaatca agctacggta ttcataacta
    18481 tacacttaca gaataccgat aatgctatgg gtgcattaag agttatacca agtagccacc
    18541 gatgggaaca ctcattagat ccgtcttctg ataattcact agatacagaa atatgtcttc
    18601 cacttcctgg aggagcagca atgttttata caccaactct atggcacacc gcagctgcca
    18661 atacttcaac taccaattac tggacactaa ctctgatttt tacaaaaaac aacatcgaac
    18721 cgctgttggc ggatgctttg aaagggagaa tctagtgatc gcaggttcaa ttataaacta
    18781 aaataatgtc aaaaataatg ttaaattttc tgacttacgc tttgctggcg ggtaaaacta
    18841 ggagacaatt atgacaaatg ccgaccaaat cttaatcaac gactggtacg tagtcgcaaa
    18901 ggtagaagat tgtaaaccag gaagtatcac cacagctagt ttgttgggag ttaagttggt
    18961 actatggcgc agtcatgaac agaattcacc catacaggtg tggcaagacc actgtcccca
    19021 ccgaggtgtg gctctgtcta tgggagaaat agtgaataat actttggttt gtgcgtatca
    19081 cggatggaga tacaatgaag caggtaaatg cgtacagatc ccggctcacc ctgacatgat
    19141 acccccagca agtgcgattg ccaagaccta tcattgccag gaacgctacg gcttagtgtg
    19201 ggtctgttta gggaaccctg tgaatgatat acctgagttc cccgaatggg acgatccgaa
    19261 ttatcacaaa acttatacta agtcttactt gattcaagct agtgcgtttc gtgtgatgga
    19321 taattcctta gatgtatctc attttccttt tatccatgac ggttggttag gcgatcgcaa
    19381 ttatacaaaa gttgaaaact ttgaggtgaa actagacaaa gatggcctga ctatgggtaa
    19441 gtatcaattc cagacatcaa ggattgtcag cgatatcgaa gatgactcat gggttaattg
    19501 gttgaggctt agtcatcctt tatgtcaata ctgcgtttca gaatcccctg aaatgcggat
    19561 tgtggatttg atgaccatca caccgattga tgaagacaag agcatattgc agatgttgat
    19621 aacatggaag tgccttagaa tgttggactc taaaaccttg gagtcaaagc tactaaccga
    19681 atatgacgaa acaatagaac aagatattcg gattctacat gcccaacagc cagcgcgttt
    19741 accactgtta ccgccaaagc agataaacac gcaatggttg ttacaggaaa tccatgtgcc
    19801 atcagataaa tgcacagttg cctatcgtcg atggctaaag gaactaggcg taacttatgg
    19861 tgtttgttaa cctcagttgt atggcacgaa gaaaacccat agtgtttatt ttgtaggcac
    19921 ttttagcttt tgtatataaa aattaccaaa aaacaaaatc aagtacaaaa ggcaattatt
    19981 acatatccca tgagcaaaac gaaaataagg agtgactgat ggcaggtaaa ttagatggaa
    20041 aagtagctat tattactgga gcttcgtctg gtattggagc ggctacagcc ttcgccttgg
    20101 ctgcggaggg ggcaaaagtc gcaatcgcgg caagacgtgc tgaatgtttg gatgtactag
    20161 caaaacagat cgcagccagt ggcggtcagg cgttatctat tgttacagat attacaaatg
    20221 aagctcaggt aaataactta gtccaaaaga ccaatggaga acttggacat gtggatattc
    20281 tggtgaataa cgcaggaatt ggtgtatttg gtacaattga tactgggaat cccgcagact
    20341 ggagacgagc attcgatgtg aatgttctag gagttttata tgctatccac gcagttttac
    20401 ctcttctcaa agcccaaaaa tccgggcata tagtcaatat atcttctgtc gatggcagga
    20461 tagcgcaagc tggggctgga gtttatagtg ctacaaaatc gggtgtcaat gctctttcag
    20521 aagcattacg ccaagaagtg tataaagaca acattcgcgt taccatcatt gaaccaggtt
    20581 tagttgatac accatttatt gacttaattt ctgaccccat catcaaacag cttagtgaag
    20641 aacaacgtca gacaataaca cctttacaaa gtgaggatat tgccagagct ataatctatg
    20701 cagtgacaca acccgatcat gtgaatgtga atgaaatttt gattcgacca actacagaag
    20761 gtaattagag atgtttctaa aatatgatac aattaattgt cccaattatc gtttcctaat
    20821 atgaatgccg ttgatgctgg aaattccaaa aaaaatgaaa acaaacatat agctatgtgg
    20881 gcttgtccta gaagtcgttc gactgtcatt gctcgtgctt ttgagaattt agatgggtgt
    20941 attgtttatg atgagcctct attcgctcca tctgtcttta tgacaactta cacgactatt
    21001 aacagtcgta cattagaaga agaaaactta aagcaattat tgcagcaaaa taattttgaa
    21061 ccggacatca agaaagttat agaaaaaata actggaaatt taccggacgg aaaattattc
    21121 tcatttcaaa aaatgataac aggtgactat agatctgaat ttggaataga ttgggtaaaa
    21181 aagctaacta acttcttttt aataaggcat cctcaagata ttattttgtc tttcgatata
    21241 gcggagaaaa agacaggtat cacagaacta ttcacacaac aaatgattgg gatgaaaaca
    21301 ctttatcaag ttttccaaca gattgaactt attacaggac aaataccttt agttattcac
    21361 tcagatgata taattaaaaa ccctccttct gctttggaat ggctgtgtaa aaacttagag
    21421 cttgcatttg ataaaaggat gctgacatgg aaagcaaatc tagaagattc caatcaatta
    21481 ttgtataaac aattatttgc taattctgag tttagcagtt cagaagcctg gtttgaaact
    21541 ttaagatcgt cccaaacatt tctcccctat gaaaagaagg agaaaaattt accagatcgg
    21601 ctaataccgc tactagatga atctattccc tactatgaaa aactcttaca gcattgtcat
    21661 agttttgaat ggtcagaaca ccgagtttga tcataaccgt tcagacaggg aataaaaacg
    21721 caattaggga gatatgaaca ataaaatatc cagccgtgta aactccagtg aataatgata
    21781 ttctgtttat caattaggaa aacaacttat gaccaatcaa aataaccaag aattagagaa
    21841 caattcacca atcgccaagc agccatgtcc tgtcaattct tataatgagt gggacgcact
    21901 tgaggaagtc attgttggca gtgttgaagg tgcaatgtta cctgccctag aaccaatcaa
    21961 caaatggaca ttccctcttg aagaattggc atctgcccaa aaggtactct ctgagagggg
    22021 aggaattccc tatccaccag agatgattgc attagcacac aaagaactaa atgaatttat
    22081 tcacattctt gaagcagaag gagtcaaagt tcgtcgagtc aaccctgtag atttctctgg
    22141 ctccttctcc acaccagctt ggcaagtagg aagtggtttt tgtgccgcca atcctcgtga
    22201 tgtttttttg gtgattggca atgagattat tgaagcacca atggcagatc gcaaccgcta
    22261 ttttgaaact tgggcgtatc gaaagctgct caaggaatat tttcaggcag gggttaagtg
    22321 gactgcggca ccgaagccac aattattgga cgcacagtat aacttaaatt tccagtttcc
    22381 tcaaacaggg aagccgtcgc gctttgtcgt tacagagttt gaaccaactt ttgatgcagc
    22441 agattttgtg cgctgcggac gggatatttt tggtcaaaaa agtcatgtca ctaatagttt
    22501 gggtatagag tggttacaac gccacctgga agacgaatac cgcattcaca ttattgaatc
    22561 gcattgtcca gaagcactgc acattgatac caccttaatg cctcttgctc ccggcaaaat
    22621 actagttaac ccagaatttg tagatgttaa taaattgcca aaaatcctga aaagctggga
    22681 cattttggtt gcaccttacc ccaaccatat cccccagaac cagctgagat tagtcagtga
    22741 atgggcaggg ttgaatgtac tgatgttaga tgaagagcga gtcattgtag aaaaaaacca
    22801 ggagccgatg atcaaagcac tcaaagattg gggatttaag cctattgtgt gttcgtttga
    22861 aagctattat ccctttttag gctcatttca ctgtgcaacg ttagatgttc gccgacgcgg
    22921 aactcttcaa tcttattttt aatatttatt tctattatcc tttcaccagg gtgataaaag
    22981 taataaaact actaggagac aattatgaca aatgccgacc aaatcttaat caacaactgg
    23041 tacgtagtcg ccaacggaga agattgtaaa ccaggaagta tcaccacagc tagtttgttg
    23101 ggagttaaat tggtactatg gcgcagtgat gaacctaatt cacccataca ggtgtggcaa
    23161 gaccactgtc cccaccgagg tgtggctctg tctatgggag aaatagtgaa taatactttg
    23221 gtttgtgcgt atcacggatg gagatacaat gaagcaggta aatgcgtaca gatcccggct
    23281 caccctgaca tgataccccc agcaagtgcg attgccaaga cctatcattg ccaggaacgc
    23341 tacggcttag tgtgggtctg tttagggaac cctgtgaatg atatacctga gttccccgaa
    23401 tgggacgatc cgaattatca caagacttat actaagtctt acttgattca agctagtgcg
    23461 tttcgtgtga tggataattt catagatgta tctcattttc cttttgtcca cgatggcggg
    23521 ttaggcaatc gccaccacgc acaagttgaa gaccttgagg tgaaagtaga caaagatggt
    23581 attactatgg gtaaccttca actccagatg ccaaggttga acagcagtat caaatatgac
    23641 ttatggactc tttggcaaag ggttattcac cctttatgtc aatactacat tgcggaatcc
    23701 tctgaaattc ggactgcgga tttgatgctg gtaacaccga ttgatgaaga caacagcttg
    23761 gtgcggatgt tgatcacgtg gaacagccct gaaattttgg actttaaaac attggagtca
    23821 aagctactag ccgaatttga ccaaacaata gaagaagata ttcggatcct acattcccaa
    23881 caaccagcgc gtttaccact gttaccgcca aagcagataa acacgcaatg gttgccacag
    23941 gaaatccatg tgccatcaga taaatgcaca gttgcctatc gtagatggtt aaaagaacta
    24001 aatgtaactt atggtgtttg ttaacttcag ttgcattgag tgcattaaat agacgcagga
    24061 tatttaagat atgacaaatc cccaaataag attggcagaa ataacatcaa aaggatataa
    24121 gtcagagctt atatcagaag cacgagtcag cctacaattg gcaattccct tagtcgttgt
    24181 cgaaatatgc gaaacgagta ttaatacagt ggatgtagtc atgatgggtt tacttggtac
    24241 acaagttttg gccggtggtg ctttgggtgc gatcactttt ttggctttat tctttacctg
    24301 ctctagtatg tttttagtag gaggagcaca agcagccgag gcttttgggg caaacaaaat
    24361 agatcaagtt agtcgtattg catctggaca aatatggcta gcagttgcgt tgtctttacc
    24421 cgcaatgctt ctgctttggc ataccgatac tatcttgctg ctattaggtc aagaagaaag
    24481 caatgtttta gtgacaaaaa cctatttaca ctcaattgtg tggggctttc ctgctgcact
    24541 tggtattaag atcttaagag gcattgcctc tgctgtcaac ctcacccgat tgataactgt
    24601 cactatggta ctagggctgc tcttaaatgc ccctgccaat tatgtcttaa tgttcggtaa
    24661 atttggtctt cctcaacttg gtttagctgg aataggctgg gcaagtactc tggttttttg
    24721 ggttagtttt atagcgggag ttatcttgct gattttctcc ccaaaagtta gagattatca
    24781 acttttccgc tatatgcgtc agtttgataa acagacgttt gtcaaaattt ttcaaactgg
    24841 atggcctatg ggttttctat tgggagcgga atcagtagta ttgaacgtca acgcttggct
    24901 agcagggtat gtaggaacag caacattagc agcccatgag attgcagccc aaacagcagc
    24961 gatggcgatg gtaataccac tcggagtcgg caatgttgct gtcacgagag tagctcagac
    25021 cctgggagaa aaaaaaccgt tgggtgcaag aagggcagca tcaattggga ttacgattgg
    25081 tgccattttt gccagtgctg cggcactcat tttctggttg cttccatatc aaattgcggg
    25141 aatttattta aatataaaca atccagagaa tatcgaagca gttaagacag caacttcttt
    25201 tctcgctttg tcgggattat tccaaatttt ttacagtatt caaataatta ctgttggggc
    25261 tttgataggg ttgcaagata cgttcgtgcc gttgttaatg aacttagtag gctggggtct
    25321 tgggttggca ggaagctatt tcatggcaat cattttaggt tggggaggta tcggtatctg
    25381 gttaggtatg gttttgagtc cactcctatc tggagtcatc ttaatggttc gtttttatca
    25441 aatgattgcc tataagattg ccaatagtaa taacggggaa gagagtcaaa ttatacccga
    25501 cgaaaaggtg ttgaaatgca tatcttagga atttcagctt actaccacca tagcgctgcc
    25561 gctatggtgg ttgatggcga aatcgttgcc gcagcccagg aagaacgttt ttcaagacga
    25621 aagcacgatg ctagttttcc tattggagcg atcgcttact gtctaaaaca agcaggaatc
    25681 aagttacaac atatcgatca aattgttttt tacgacaagc cattagtcaa gtttgagcga
    25741 ttgttggaaa cctatttagc ccatgcgcca aaaggattta gctcgtttat cacagccatg
    25801 cccatctggc taaaagaaaa gctttaccta aaaacaatcc taaaaaaaga attggcactc
    25861 ttggaggagt gcaaaacttc tcaattgccg cctctattat ttacctcaca tcatcaagcc
    25921 catgcggctt ctgctttttt tcccagtcct tttgagcgtg ctgccgtttt gtgcttagat
    25981 ggtgtaggag agtgggcaac cacctccgtt tggatgggat tggggcatca actcacaccc
    26041 caatgggaaa ttcattttcc ccactccatc gggttgcttt attcagcctt tacctactac
    26101 accggattca aagttaactc aggtgagtat aaacttatgg gtttagctcc ctacggcaaa
    26161 cccaaatatg tagaccaaat tctcaaccat ctgttggatc tcaaagaaga tggcactttt
    26221 cgtttgaaca tagactactt caactacacg gttggtttaa ccatgaccaa tcataagttt
    26281 cataatttgt ttggggaacc accacgcaaa ccagaaggaa aaatcaccca aagagaaatg
    26341 gatctggcca gttccatcca gaaggtgact gaagaagtgg tactgcgttt ggctaaaact
    26401 gtcaaaaaag aactgggtgc agagtatcta tgtttagcag gtggtgtcgc cctcaattgc
    26461 gtagccaacg gacgaattct gcgagaaagt gacttcaaag atatttggat tcaacccgca
    26521 gccggagatg caggtggtgc agtcggagca gcattagcga tttggcatga ataccatgaa
    26581 aaaccccgta ctccaacatc aggcgatcgc atgaagggtt cttatcttgg acctagcttt
    26641 agcgaagctg agattctcga gtatctcaat tctgctaata taccttacca gcgactcgct
    26701 gatagcgaac ttatgcctcg cctcgcagaa attttacaac agggaaatgt tgttggctgg
    26761 ttttctggac gaatggagtt tggtccgcgt gctttgggga gtcgttcgat tattggcgat
    26821 tcacggagtc ccaaaatgca atcggtcatg aacctgaaaa ttaaatatcg tgagtccttc
    26881 cgtccgtttg ctccttcagt cttggctgag cgggtctccg actacttcga tcttgatcgt
    26941 cctagtcctt atatgctact ggtagcacca atcaaggaga atctgcacat tcccatgaca
    27001 caagagcaac aacagttatt tggaatcgag aagctgaatg ttcctcgttc ccaaattcct
    27061 gcggtcactc atgttgatta ctcagctcgt attcagacag ttcacaagga aaccaatcct
    27121 cgttactatg agttaattcg tcattttgag gcacgaactg gttgtgctgt cttagtcaat
    27181 acttcgttca atgtacgcgg cgaaccaatt gtttgtactc ccgaagatgc ttatcgatgc
    27241 tttatgagaa ctgaaatgga ctatttggtt atggagaatt tcttgttggt caaatctgaa
    27301 cagccacagg gaaatagtga tgagtcgtgg caacaagaat tcgagttaga ttaactcagg
    27361 agttaatatt tcccacaaaa aaagtagtaa ataaagatgg aacagataaa ggaacttaac
    27421 caaaaaggat tgcgtgaatt tggactgatc ggcggttcca tagtggcagt tttatttggc
    27481 tttttactac catttatacg gcatcattcc ttgtcagtta tcccttgggt tattgcagta
    27541 attctctgga tttgggcaat aatcgcaccc gcaactttaa attttgttta caaaaactgg
    27601 atgaggattg gacttgtttt aggttggata caaacacgaa ttattttagg ggttttattt
    27661 tatataatga ttaccccaat aggattgatg aagcggctgt tgaatcaagc tccaatgatg
    27721 cgaagcttag atccagattt gcccacttat cgccaattga gcaagttaag aactacagaa
    27781 agtatggaga aaccattcta atgctaaaag acactttaga ttttcttaaa gacattggcg
    27841 gatttattaa agaacaaaaa aactacttgt tgattcccct gatcgtcacc ctggtatcct
    27901 tgggggcgct aattgtcttc gctcaatctt ctgcgatcgc gccgttcatt tacactcttt
    27961 tttaaaaatt gccatatgag taacttgaag ggttgggtaa agacagcatt aatcggaagt
    28021 ttgattttct gcgggctaat ctttggagta gtattcattg aaattggctt acgtattgct
    28081 ggtatcgaac acgtagcatt ccataccatc aatgaacaca gaggttgggt agggcgacct
    28141 catgtttccg gttggtatca aaccgaaggt gaagcttacg tccagatgaa tagtgatgga
    28201 ttccgagacc aagaacacac taaggtcaaa ccagaaaata ccttcaggat agcgctgttg
    28261 ggagattcct ttgtagagag tttgcaagtg ccgttggata aaggttttgc ggcagttata
    28321 gaacgagaat taagtagttg tacagctttg gctggacgaa aggtggaagt gattaatttc
    28381 ggggttactg gttatggaac agaccaagaa ctaattaccc tacgggagaa agtttgggac
    28441 tattcacctg atatggtagt gctgaatttt tatactggca acgacattag tgataactcc
    28501 catgctatca gtcagaaact ctatgctggt gaacaagctt tactaaaacc gttttttcta
    28561 ttaaaagacg gtgatctggt tgttgatact tcgtttatca gtacagatac ttatcgctca
    28621 aagctgacat ggtggggcaa agcttatatc aaaataaaag accacttgcg gattttacag
    28681 gttgcgaaca tcatacaaga ttctcttaaa aaccttaata gagtgctttc tcctcaagca
    28741 atagaggagc cgttatttag cactggaaga cacgatcaaa attcgagctg gattgataat
    28801 aatatctaca aaccacctac tgaccctgaa tggcaacagg catggcaagt cacagagaaa
    28861 ctgattagct taatgcacga tgaggtgatt gcgaagaaag cagattttgt agttgttacc
    28921 tttggcggtc catttcaacg cgatccttca gcgcgtcaaa aagaaatgca agcatttggt
    28981 gtgactgatt ggttttattc tgagaaccga attacagctt tgggtgaggg tgagggcttt
    29041 agtgtactta atctcagccc gactttgctg gactataccg aacagaacaa tacttgccta
    29101 tacgggtttg aggatactct tggctgtgta gggcattgga atgcttcggg gcatcagttg
    29161 gcaggaaaaa tgattgcgtc tgggctttgt caacaagaag ggcagaaagc agccccgatg
    29221 gctagattgt acccaagcgg gaattttgta cgctaagaaa aactcaaatt caaatgaacg
    29281 tgaaacaaca aggtgcagtg ctatggttta cagggctaag tggggctggt aaaacaacta
    29341 ttgcttctag agtagtgcaa aaactccaaa agcagaatta ttccacagaa ttgttagacg
    29401 gtgatacagt ccgcactttt ctttcacaag gattaggatt cagcaagcaa gaccgagaca
    29461 taaatgttcg ccgtattggc tttgttgcta atttgctgag tcggaatggt atcatagcac
    29521 tcgttgctgc tatcagccct tatcatgaaa ttcgagatga attgaaacag acatctaaca
    29581 attttattga aatctatgtt aaagctccct tagaagtttg cgaatcccgt gatgttaaag
    29641 gactttatgc taaagccaga gcaggagaaa tccagagttt tactggcatt tctgactctt
    29701 atgaagaacc aacaaatcca gatattatct gtcaaactga tagatttact attgagcagt
    29761 gtgttaacca agtgcttcaa tatttactgg actttggact cttaactggt gacaaggtgg
    29821 ttgaagatga gatgtgccaa taattttaga aaataaggag gtataggtgt agccattaag
    29881 atgaggacat aaaccataat gaccagactt gatagccgag caaaagtggt gaaagcagcc
    29941 tcctaagtaa cctggctaca gctataaaaa aataggggca aagaagcccc gaaaacctta
    30001 acgggtgaca agatagctaa acaacttgtc acccgttaag gactttccga gagtcatttc
    30061 aacatttttg atatcgcatt cccggaagtt gggtaactaa acccataagt tctaactgta
    30121 ataaagaact ggatactatt gcagcattca tacctgtttt ttgaataata aaatcaaaag
    30181 ataaagcatc aacagctaaa atatttatta tctgttgtaa ttccggtgct aagttaggta
    30241 taggaggaga tttaactaaa ggtgtttctg tttctatatc tatttgggga attgctccca
    30301 acatgattaa taattcatta agttcatgat taattaaacc cgcaccttga ctaattaatt
    30361 ttaaacaacc ttgtgatggt tgatcatcaa tttttcccgg taacgcataa acatctcgat
    30421 taaattcatt agcataggta gctgtaatta aagcaccaga ttttagcggc gcttccataa
    30481 ctaataccgc acgactcaaa ccagcaataa ttcgatttcg acggggaaaa tgggtgcggt
    30541 tcggtggcgt ttttgcggga tattcactaa ttactatccc agatttcaaa atctgttgat
    30601 ataaatctcg atttttatgg ggataaataa catctacacc tgttcccata actgctattg
    30661 ttcttcctcc agctttcaat gttgctgaat gactttcggt gtctattccc tcggccatac
    30721 cagaaacaac ggtaaaacca ttttttgcta atgcggtact aatttgacga gtccatttaa
    30781 ttccgtattc tgtgggttga cgagttccca caattcctac caggggtttt tgtcctgaat
    30841 tttcctgtaa atcaatttca cctcgataat acaacagtgg gggtggagta cgaatttctc
    30901 gcaatagttg gggatattct gggtctgctg gtgtccaaaa atgggggttt atttgttggt
    30961 gttgggtaag tagttgttca gggtttctcc g
//
