LOCUS       BGC0000940              7328 bp    DNA     linear   CON 06-FEB-2015
DEFINITION  Streptomyces coelicolor A3(2) complete genome.
ACCESSION   BGC0000940
VERSION     BGC0000940
KEYWORDS    .
SOURCE      Streptomyces coelicolor A3(2)
  ORGANISM  Streptomyces coelicolor A3(2)
            Bacteria; Actinobacteria; Streptomycetales; Streptomycetaceae;
            Streptomyces; Streptomyces albidoflavus group.
COMMENT     ##antiSMASH-Data-START##
            Version      :: False
            Run date     :: 2022-11-07 21:07:32
            NOTE: This is a single region extracted from a larger record!
            Orig. start  :: 3033354
            Orig. end    :: 3040682
            ##antiSMASH-Data-END##
FEATURES             Location/Qualifiers
     gene            1..1050
                     /gene="SCO2780"
                     /gene_synonym="SCC105.11"
     CDS             1..1050
                     /codon_start=1
                     /db_xref="InterPro:IPR002491"
                     /db_xref="PDB:2X4L"
                     /db_xref="UniProtKB/TrEMBL:Q9L074"
                     /gene="SCO2780"
                     /gene_functions="transport (smcogs) SMCOG1033:iron compound
                     ABC transporter, periplasmic (Score: 90; E-value: 2.2e-27)"
                     /gene_kind="transport"
                     /gene_synonym="SCC105.11"
                     /note="SCC105.11, possible secreted protein, len: 349 aa;
                     similar to TR:CAB53324 (EMBL:AL109974) Streptomyces
                     coelicolor putative iron-siderophore binding lipoprotein
                     SCF34.13c, 350 aa; fasta scores: opt: 288 z-score: 297.2
                     E(): 4.1e-09; 28.3% identity in 332 aa overlap. Contains
                     possible N-terminal region signal peptide sequence"
                     /product="Ferric-siderophore lipoprotein receptor"
                     /protein_id="CAB87217.1"
                     /transl_table=11
                     /translation="MSHASATHPTRRGILAAGGALGLGAVLAACGDGDGKSDGAGDGSG
                     GAAKSGPWSFKDDRGTTVKLDKVPANIVAFTGVAAALFDYGVEVKGVFGPTTTKDGKPD
                     VQAGDLDVDKVTVLGNEWGKLNVEKYASLAPEVLITTTFDTAGTLWSVPEESKDKVAKL
                     APSVAISVFDRQLTQPLQRMWELAESLGADMKAKKVTDAKAAFDKAAARLRAAAKAKPE
                     IRVLAGSASPDLFYVSGTNLSVDLEYFKALGVNFVEPSEDAKKATGGWFESLSWENVDK
                     YPADVIIMDDRASTIQPADITEGTWKQLPAVKAGQVIARSPEPILSYDKCTPLLDNLAE
                     AIENAKKVG"
     subregion       1..7328
                     /aStool="mibig"
                     /contig_edge="False"
                     /label="Other"
                     /subregion_number="1"
                     /tool="antismash"
     region          1..7328
                     /contig_edge="False"
                     /product="unknown"
                     /region_number="1"
                     /subregion_numbers="1"
                     /tool="antismash"
     regulatory      1067..1070
                     /regulatory_class="ribosome_binding_site"
     gene            1278..2123
                     /gene="SCO2781"
                     /gene_synonym="desF"
                     /gene_synonym="SCC105.12"
     CDS             1278..2123
                     /codon_start=1
                     /db_xref="GOA:Q9L073"
                     /db_xref="InterPro:IPR007037"
                     /db_xref="InterPro:IPR013113"
                     /db_xref="InterPro:IPR017927"
                     /db_xref="InterPro:IPR017938"
                     /db_xref="UniProtKB/TrEMBL:Q9L073"
                     /gene="SCO2781"
                     /gene_functions="other (smcogs) SMCOG1200:vibriobactin
                     utilization protein ViuB (Score: 242.1; E-value: 9.3e-74)"
                     /gene_kind="other"
                     /gene_synonym="desF"
                     /gene_synonym="SCC105.12"
                     /note="SCC105.12, hypothetical protein, len: 281 aa;
                     similar to TR:CAB56689 (EMBL:AL121596) Streptomyces
                     coelicolor hypothetical 28.7 kD protein, 259 aa; fasta
                     scores: opt: 261 z-score: 302.6 E(): 2e-09; 34.9% identity
                     in 255 aa overlap"
                     /product="Ferric-siderophore hydrolase"
                     /protein_id="CAB87218.1"
                     /transl_table=11
                     /translation="MRVPDPAPPAGSKRHPPSPALARVTFAGPDLRAFRSDGLDQSLSL
                     FLPHPGQAEPAVPVELGEGWWQGWRELPEDVRAVMRSYTLRSLRRDTDGHTAEIDVDFV
                     LHGLEPDSGIQAGPAARWAADAAPGDRVLLLGPAVADNRAIRFRPPEDTDLVVIWGDET
                     AVPAACAIVEALPAGTRARVWLQVPHAEDVQDLRTAADAEITWLVGDAADGPEATLATL
                     RAAQLPPAEHPYVWIAGESGCVKRLRRHFVGERGVDRRRVTFVGYWRRGLTEEQLREQG
                     "
     regulatory      2274..2279
                     /regulatory_class="ribosome_binding_site"
     gene            2287..3729
                     /gene="SCO2782"
                     /gene_synonym="desA"
                     /gene_synonym="SCC105.13"
     CDS             2287..3729
                     /NRPS_PKS="Domain: Aminotran_5 (141-265). E-value: 6.1e-09.
                     Score: 27.0. Matches aSDomain:
                     nrpspksdomains_SCO2782_Aminotran_5.1"
                     /codon_start=1
                     /db_xref="GOA:Q9L072"
                     /db_xref="InterPro:IPR002129"
                     /db_xref="InterPro:IPR010977"
                     /db_xref="InterPro:IPR015421"
                     /db_xref="InterPro:IPR015422"
                     /db_xref="InterPro:IPR015424"
                     /db_xref="UniProtKB/TrEMBL:Q9L072"
                     /gene="SCO2782"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1180:Decarboxylase, pyridoxal-dependent (Score: 381.1;
                     E-value: 1.2e-115)"
                     /gene_kind="biosynthetic-additional"
                     /gene_synonym="desA"
                     /gene_synonym="SCC105.13"
                     /note="SCC105.13, probable pyridoxal-dependent
                     decarboxylase, len: 480 aa; similar to SW:RHSB_RHIME
                     (EMBL:AF110737) Rhizobium meliloti L-2,4-diaminobutyrate
                     decarboxylase (EC 4.1.1.-) RhsB, 495 aa; fasta scores: opt:
                     1111 z-score: 1326.2 E(): 0; 41.9% identity in 458 aa
                     overlap. Contains Pfam match to entry PF00282
                     pyridoxal_deC, Pyridoxal-dependent decarboxylase conserved
                     domain"
                     /product="putative pyridoxal-dependent decarboxylase"
                     /protein_id="CAB87219.1"
                     /transl_table=11
                     /translation="MRSHLLNDTTAEQYRRSVTEGVERVAAKLATTDRPFTGVTVDALS
                     PRIDAIDLDEPLHDTAAVLDELEDVYLRDAVYFHHPRYLAHLNCPVVIPALLGEAVLSA
                     VNSSLDTWDQSAGGTLIERKLIDWTCARIGLGPAADGVFTSGGTQSNLQALLLAREEAK
                     AEDFADLRIFASEASHFSVRKSAKLLGLGPDAVVSIPVDRDKRMQTVALARELERCARD
                     GLVPMAVVATGGTTDFGSIDPLPEIAGLCEQYGVWMHVDAAYGCGLLASLKYRDRITGI
                     ERADSVTVDYHKSFFQPVSSSAVLVRDAATLRHATYHAEYLNPRRMVQERIPNQVDKSL
                     QTTRRFDALKLWMTLRVMGADGIGVLFDEVCDLAAEGWKLLAADPRFDVVVQPSLSTLV
                     FRHIPADVTDPAEIDRANLYARKALFASGDAVVAGTKVAGRHYLKFTLLNPETTPADIA
                     AVLDLIAGHAEQYLGDSLDRAS"
     misc_feature    2701..3495
                     /gene="SCO2782"
                     /gene_synonym="desA"
                     /gene_synonym="SCC105.13"
                     /note="Pfam match to entry PF00282 pyridoxal_deC,
                     Pyridoxal-dependent decarboxylase conserved domain, score
                     157.60, E-value 4.6e-45"
     aSDomain        2710..3081
                     /aSDomain="Aminotran_5"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_SCO2782_Aminotran_5.1"
                     /evalue="6.10E-09"
                     /label="SCO2782_Aminotran_5.1"
                     /locus_tag="SCO2782"
                     /protein_end="265"
                     /protein_start="141"
                     /score="27.0"
                     /tool="antismash"
                     /translation="VFTSGGTQSNLQALLLAREEAKAEDFADLRIFASEASHFSVRKSA
                     KLLGLGPDAVVSIPVDRDKRMQTVALARELERCARDGLVPMAVVATGGTTDFGSIDPLP
                     EIAGLCEQYGVWMHVDAAYG"
     gene            3752..4993
                     /gene="SCO2783"
                     /gene_synonym="desB"
                     /gene_synonym="SCC105.14"
     CDS             3752..4993
                     /codon_start=1
                     /db_xref="GOA:Q9L071"
                     /db_xref="InterPro:IPR025700"
                     /db_xref="UniProtKB/TrEMBL:Q9L071"
                     /gene="SCO2783"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1080:lysine/ornithine N-monooxygenase (Score: 419.6;
                     E-value: 2.1e-127)"
                     /gene_kind="biosynthetic-additional"
                     /gene_synonym="desB"
                     /gene_synonym="SCC105.14"
                     /note="SCC105.14, probable monooxygenase, len: 413 aa;
                     similar to SW:RHSE_RHIME (EMBL:AF110737) Rhizobium meliloti
                     rhizobactin siderophore biosynthesis protein RhsE (EC
                     1.-.-.-), 454 aa; fasta scores: opt: 616 z-score: 727.2
                     E(): 0; 42.3% identity in 430 aa overlap and to
                     SW:IUCD_ECOLI (EMBL:M18968) Escherichia coli L-lysine
                     6-monooxygenase (EC 1.13.12.10) IucD, 425 aa; fasta scores:
                     opt: 802 z-score: 946.5 E(): 0; 31.6% identity in 414 aa
                     overlap"
                     /product="putative monooxygenase"
                     /protein_id="CAB87220.1"
                     /transl_table=11
                     /translation="MGIGLGPFNLGLACLTEPVAELNGVFLESKPDFEWHAGMFLDGAH
                     LQTPFMSDLVTLADPTSPYSFLNYLKEQGRLYSFYIRENFYPLRVEYDDYCRWAARKLS
                     SVRFSTTVTEVTYDEREELYAVATTSGDTYRARRLVLGTGTPPHIPDACRGLAGDFLHN
                     SRYVRHRAELVKKKSITLVGSGQSAAEIYQDLLSEIDVHGYGLNWVTRSPRFFPLEYTK
                     LTLEMTSPEYVDYYHALPEDTRYRLTAEQKGLFKGIDGDLINEIFDLLYQKRLGGPVPT
                     RLLTNSALTSARYADGTYTLGFRQEEQGTDFEIETEGLVLATGYRYTEPEFLKPVRDRL
                     RYDSRGNFDIGRNYAVDVTGGGVFLQNAGVHAHSVTSPDLGMGAYRNSCIVRELLGREY
                     YPVEQSIAFQEFAV"
     regulatory      4977..4981
                     /gene="SCO2783"
                     /gene_synonym="desB"
                     /gene_synonym="SCC105.14"
                     /regulatory_class="ribosome_binding_site"
     gene            4990..5544
                     /gene="SCO2784"
                     /gene_synonym="desC"
                     /gene_synonym="SCC105.15"
     CDS             4990..5544
                     /codon_start=1
                     /db_xref="InterPro:IPR016181"
                     /db_xref="InterPro:IPR019432"
                     /db_xref="UniProtKB/TrEMBL:Q9L070"
                     /gene="SCO2784"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1203:putative siderophore biosynthesis protein (Score:
                     135.3; E-value: 6.2e-41)"
                     /gene_kind="biosynthetic-additional"
                     /gene_synonym="desC"
                     /gene_synonym="SCC105.15"
                     /note="SCC105.15, probable aceytltranferase, len: 184 aa;
                     similar to SW:RHSD_RHIME (EMBL:AF110737) Rhizobium meliloti
                     rhizobactin siderophore biosynthesis protein RhsD, 196 aa;
                     fasta scores: opt: 257 z-score: 326.7 E(): 9.2e-11; 33.7%
                     identity in 172 aa overlap and to TR:AAD46626
                     (EMBL:AF162771) Pseudomonas aeruginosa aminoglycoside
                     6'-N-acetyltransferase Aac, 193 aa; fasta scores: opt: 175
                     z-score: 226.3 E(): 3.6e-05; 28.2% identity in 174 aa
                     overlap"
                     /product="Acyl CoA acyl transferase"
                     /protein_id="CAB87221.1"
                     /transl_table=11
                     /translation="MSRLSTTTPVGALTLRPVDPLTDAVLLHGWLTHPKSAFWMMQDAR
                     LVDVERAYMELAADEHQQAHLGLHDGVPAFLTERYDPAHRELVGLYEPEPGDVGMHFLV
                     APTDRPVHGFTRAVITTVMTELFADPATRRVVVEPDVTNTAVHALNAAVGFVPEREIQK
                     PEKKALLSFCTREQFAKAVSA"
     gene            5541..7328
                     /gene="SCO2785"
                     /gene_synonym="desD"
                     /gene_synonym="SCC105.16"
     CDS             5541..7328
                     /codon_start=1
                     /db_xref="GOA:Q9L069"
                     /db_xref="InterPro:IPR007310"
                     /db_xref="InterPro:IPR022770"
                     /db_xref="UniProtKB/TrEMBL:Q9L069"
                     /gene="SCO2785"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     siderophore: IucA_IucC"
                     /gene_kind="biosynthetic"
                     /gene_synonym="desD"
                     /gene_synonym="SCC105.16"
                     /note="SCC105.16, len: 595 aa; type C NRPS-independent
                     siderophore synthetase; catalyzes ATP- and
                     magnesium-dependent condensation of three molecules of
                     N-hydroxy-N-succinylcadaverine to form desferrioxamine G1
                     and desferrioxamine E and two molecules of
                     N-hydroxy-N-succinylcadaverine with one molecule of
                     N-acetyl-N-hydroxycadaverine to form desferrioxamine B"
                     /product="ATP-dependent siderophore synthetase (IucA-IucC
                     family)"
                     /protein_id="CAB87222.1"
                     /sec_met_domain="IucA_IucC (E-value: 4.1e-81, bitscore:
                     260.8, seeds: 168, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MSLADAVAHLTPERWEEANRLLVRKALAEFTHERLLTPEREPDDG
                     GGQTYVVRSDDGQTAYRFTATVRALDHWQVDAASVTRHRDGAELPLAALDFFIELKQTL
                     GLSDEILPVYLEEISSTLSGTCYKLTKPQLSSAELARSGDFQAVETGMTEGHPCFVANN
                     GRLGFGIHEYLSYAPETASPVRLVWLAAHRSRAAFTAGVGIEYESFVRDELGAATVDRF
                     HGVLRGRGLDPADYLLIPVHPWQWWNKLTVTFAAEVARGHLVCLGEGDDEYLAQQSIRT
                     FFNASHPGKHYVKTALSVLNMGFMRGLSAAYMEATPAINDWLARLIEGDPVLKETGLSI
                     IRERAAVGYRHLEYEQATDRYSPYRKMLAALWRESPVPSIREGETLATMASLVHQDHEG
                     ASFAGALIERSGLTPTEWLRHYLRAYYVPLLHSFYAYDLVYMPHGENVILVLADGVVRR
                     AVYKDIAEEIAVMDPDAVLPPEVSRIAVDVPDDKKLLSIFTDVFDCFFRFLAANLAEEG
                     IVTEDAFWRTVAEVTREYQESVPELADKFERYDMFAPEFALSCLNRLQLRDNRQMVDLA
                     DPSGALQLVGTLKNPLAGR"
ORIGIN
        1 atgtcccacg ccagcgctac ccacccgacc cgccgtggaa tcctcgccgc cggcggcgcc
       61 ctcggcctcg gcgccgtgct cgcggcctgc ggcgacggcg acggcaagag cgatggggcg
      121 ggcgacgggt cgggcggcgc cgccaagtcc ggcccctggt ccttcaagga cgaccgcggc
      181 acgaccgtga agctggacaa ggtgccggcg aacatcgtcg ccttcacggg tgtcgccgcc
      241 gccctcttcg actacggcgt cgaggtcaag ggcgtcttcg gcccgaccac caccaaggac
      301 ggcaagcccg acgtgcaggc cggcgacctc gacgtcgaca aggtcaccgt gctcggcaac
      361 gagtggggca agctcaacgt cgagaagtac gcctccctcg ccccggaggt gctcatcacc
      421 acgacgttcg acaccgcggg caccctgtgg tccgtcccgg aggagtcgaa ggacaaggtc
      481 gccaagctcg ccccgagcgt cgcgatctcg gtcttcgacc gccagctcac ccagccgctc
      541 cagcgcatgt gggagctggc ggagtcgctc ggcgcggaca tgaaggccaa gaaggtcacc
      601 gacgccaagg ccgccttcga caaggccgcc gcccggctgc gcgccgccgc caaggccaag
      661 ccggagatcc gggtgctggc cggttccgcg agccccgacc tgttctacgt ctccggcacc
      721 aacctctcgg tggacctgga gtacttcaag gccctcggcg tgaacttcgt cgagccctcc
      781 gaggacgcca agaaggcgac cggcggctgg ttcgagtccc tgagctggga gaacgtcgac
      841 aagtacccgg ccgacgtcat catcatggac gaccgcgcct cgaccatcca gcccgccgac
      901 atcaccgagg gcacctggaa gcagctcccc gcggtcaagg ccggacaggt catcgcccgc
      961 tcccccgagc cgatcctgtc ctacgacaag tgcacgccgc tcctcgacaa cctggccgag
     1021 gcgatcgaga acgccaagaa ggtcggctga cccgcccccc tcccccggag cccctcatga
     1081 ggacggccgt cgccgccccg ttccgtttct tcgccctcca ggtcgtacgg acgaggcggt
     1141 tggggggtgt cgattggatc aggccggctc cggccaacgg tgcttcgctg ccgacccgag
     1201 cggggtccgg tgcgtgcagc tgcacggcgg aggagggcga cagggcggag ccccggcaac
     1261 cgacgacaac gccgcagatg cgcgtgccag accccgcgcc cccggcagga tccaaacgac
     1321 accccccaag cccggccctg gcccgggtca ccttcgcggg gcccgacctg cgcgccttcc
     1381 gctccgacgg cctcgaccag tcgctgtcgc tgttcctgcc gcacccgggg caggcggagc
     1441 ccgcggtccc ggtggagctg ggcgagggct ggtggcaggg ctggcgggaa ctgccggagg
     1501 acgtacgggc ggtgatgcgc tcgtacacgc tgcggtcact gcgccgcgac accgacgggc
     1561 acaccgccga gatcgacgtc gacttcgtcc tgcacggcct cgaaccggac tcggggatcc
     1621 aggccggtcc cgccgcccgc tgggccgccg acgccgcccc cggcgaccgc gtgctgctgc
     1681 tcggcccggc ggtcgccgac aaccgggcga tccgcttccg gccgcccgag gacaccgacc
     1741 tggtggtgat ctggggtgac gagacagccg tacccgccgc ctgcgccatc gtggaggcac
     1801 tgccggccgg cacccgcgcg cgggtctggc ttcaggtgcc gcacgccgag gacgtgcagg
     1861 acctccggac ggccgcggac gccgagatca cctggctggt cggggacgcc gccgacgggc
     1921 ccgaggcgac cctcgccacc ctccgcgccg cccaactgcc gcccgccgaa cacccctacg
     1981 tctggatcgc gggcgagtcc ggctgcgtga agcggctgcg gcggcacttc gtgggcgagc
     2041 gcggcgtcga ccgacggcgc gtcaccttcg tcggctactg gcgccggggc ctgacggagg
     2101 aacaactccg cgagcagggc tgaggaccgc acccgcccca cccggccgca cggagggcgt
     2161 gagtgacagc ggtcacccac aggcacgcgt ttgatcgact taacttaggt taggctcacc
     2221 taagtcgtag cgagggctcc ggccctcccc acccctctcg gaccgtcccc accggaggac
     2281 ccccccatgc gctcgcacct gctcaacgac accaccgcgg agcagtaccg ccgttccgtg
     2341 accgaaggag tcgagcgggt ggccgccaaa ctcgccacca ccgaccgccc gttcaccggc
     2401 gtcacggtcg acgccctctc cccccgcatc gacgcgatcg acctcgacga gccgctgcac
     2461 gacaccgccg cggtcctcga cgagctggag gacgtctacc tccgcgacgc cgtctacttc
     2521 caccaccccc gctacctcgc ccacctcaac tgcccggtcg tcataccggc gctgctcggt
     2581 gaagcggtcc tgtccgccgt caactcctcc ctggacacct gggaccagtc ggccggcggc
     2641 acgctcatcg agcggaagct gatcgactgg acctgcgccc gcatcggcct cggcccggcg
     2701 gccgacggcg tgttcacctc cggcggcacc cagtccaacc tccaggcgct gctcctcgcc
     2761 cgcgaggagg cgaaggccga ggacttcgcc gacctgcgga tcttcgcctc cgaggccagc
     2821 cacttcagcg tcaggaagtc cgcgaaactg ctcggcctcg gccccgacgc cgtcgtgtcg
     2881 atcccggtcg accgcgacaa gcggatgcag accgtcgccc tcgcccgcga gctggagcgc
     2941 tgcgcgcggg acggcctggt ccccatggcc gtcgtcgcca ccggcggcac caccgacttc
     3001 ggctcgatcg acccgctgcc ggagatcgcc gggctgtgcg agcagtacgg cgtgtggatg
     3061 cacgtcgacg cggcctacgg ctgcgggctg ctcgcctccc tgaagtaccg ggaccgcatc
     3121 accggcatcg agcgggccga ctcggtcacc gtggactacc acaagtcctt cttccagccg
     3181 gtgagttcgt cggccgtgct ggtccgggac gcggccaccc tgcgccacgc cacctaccac
     3241 gcggagtacc tcaacccgcg ccgcatggtg caggaacgta tccccaacca ggtggacaag
     3301 tccctccaga ccacccgccg cttcgacgcg ctcaagctgt ggatgacgct gcgcgtgatg
     3361 ggcgccgacg gcatcggcgt cctcttcgac gaggtgtgcg acctggccgc cgagggctgg
     3421 aaactgctcg ccgccgaccc gcgcttcgac gtcgtggtcc agccgtcgct gtccacgctg
     3481 gtcttccgcc acatcccggc ggacgtcacc gatcccgccg agatcgaccg cgccaacctg
     3541 tacgcccgca aggccctgtt cgcgtccggc gacgccgtgg tcgcgggcac caaggtcgcc
     3601 ggtcgccact acctgaagtt caccctgctc aaccccgaga cgaccccggc cgacatcgcc
     3661 gccgtcctcg acctgatcgc cggccacgcc gagcagtacc tgggagactc ccttgaccgc
     3721 gcttcctgaa gccagcgccc cgtacgactt cgtgggcatc ggcctcggcc ccttcaacct
     3781 cggcctcgcc tgcctcaccg agcccgtcgc cgagctgaac ggcgtcttcc tggagtccaa
     3841 gccggacttc gagtggcacg ccgggatgtt cctggacggc gcccacctcc agaccccgtt
     3901 catgtcggac ctggtgacgc tcgccgaccc gacctcgccg tactccttcc tcaactacct
     3961 gaaggagcag ggccggctgt actccttcta catccgggag aacttctacc cgctgcgggt
     4021 cgagtacgac gactactgcc gctgggccgc gcgcaagctg agcagcgtcc gcttctccac
     4081 cacggtcacc gaggtcacgt acgacgagcg cgaggagctg tacgccgtcg ccaccacgtc
     4141 cggcgacacc taccgcgccc gccgcctcgt cctcggcacc ggcaccccgc cgcacatccc
     4201 ggacgcctgc cggggcctgg ccggcgactt cctccacaac tcccggtacg tgcggcaccg
     4261 ggcggagctg gtgaagaaga agtcgatcac gctggtcggc agcggccagt ccgccgccga
     4321 gatctaccag gacctgctga gcgagatcga cgtccacggc tacgggctga actgggtgac
     4381 ccgctccccg cggttcttcc cgctcgaata caccaagctc accctggaga tgacgtcccc
     4441 ggagtacgtg gactactacc acgcgctgcc cgaggacacc cgctaccgcc tcacggccga
     4501 gcagaagggc ctgttcaagg gcatcgacgg cgacctgatc aacgagatct tcgacctgct
     4561 ctaccagaaa cggctcggcg gccccgtccc cacccgcctg ctcaccaact cggcgctgac
     4621 cagcgcccgg tatgcggacg gcacctacac gctcgggttc cgccaggagg agcagggcac
     4681 ggacttcgag atcgagaccg agggcctggt cctcgccacc ggctaccggt acaccgagcc
     4741 ggagttcctc aagcccgtcc gggaccggct gcgctacgac tcccgcggca acttcgacat
     4801 cggccgcaac tacgccgtcg acgtcacggg aggcggcgtg ttcctccaga acgcgggggt
     4861 ccacgcgcac agcgtcacca gccccgacct gggcatgggc gcctaccgca acagctgcat
     4921 cgtccgggag ctgctcggac gcgagtacta cccggtcgag cagtcgatcg cgttccagga
     4981 gttcgccgta tgagccgctt gagcaccacc acccccgtcg gggcactgac cctgcgcccc
     5041 gtcgacccgc tgacggacgc cgtactgctg cacggctggc tcacccaccc caagtccgcg
     5101 ttctggatga tgcaggacgc ccggctggtg gacgtcgagc gggcctacat ggagctggcc
     5161 gccgacgagc accagcaggc ccacctcggc ctgcacgacg gggtcccggc cttcctgacg
     5221 gagcgctacg accccgccca ccgcgaactg gtcgggctgt acgagcccga gccgggcgac
     5281 gtcggcatgc acttcctggt cgcgcccacc gaccggcccg tgcacggctt cacccgcgcc
     5341 gtgatcacca ccgtgatgac ggagctgttc gccgacccgg cgacccggcg ggtcgtcgtc
     5401 gaaccggacg tcaccaacac cgccgtgcac gccctgaacg cagccgtcgg attcgtgccc
     5461 gagcgcgaga tccagaagcc ggagaagaag gccttgctga gcttctgcac ccgcgagcag
     5521 ttcgcgaagg cggtgtccgc atgagcctcg ccgacgccgt cgcccacctg acccccgaac
     5581 gctgggagga ggccaaccgc ctcctggtcc gcaaggcgct ggccgagttc acccacgagc
     5641 ggctgctgac ccccgagcgg gagccggacg acgggggcgg gcagacgtac gtcgtccgca
     5701 gcgacgacgg ccagaccgcg taccgcttca ccgccaccgt ccgcgccctg gaccactggc
     5761 aggtggacgc cgcctccgtc acccgccacc gcgacggcgc ggaactcccg ctcgccgcgc
     5821 tggacttctt catcgagctg aagcagaccc tgggcctgag cgacgagatc ctcccggtct
     5881 acctggagga gatctcctcc accctctccg gcacctgcta caaactgacc aagccgcagc
     5941 tcagctccgc cgagctggcc cggagcggag acttccaggc cgtcgagacg ggcatgaccg
     6001 agggccaccc gtgcttcgtc gccaacaacg ggcgcctcgg cttcggcatc cacgagtacc
     6061 tgtcgtacgc ccccgagacc gcgagcccgg tccggctggt gtggctggcc gcgcaccgct
     6121 cgcgggcggc gttcacggcg ggcgtgggca tcgagtacga gtccttcgtc cgggacgagc
     6181 tgggcgcggc caccgtcgac cgcttccacg gcgtgctgcg cgggcgcggc ctggacccgg
     6241 ccgactacct gctcatcccg gtccacccct ggcagtggtg gaacaagctc accgtcacct
     6301 tcgccgccga ggtcgcccgc gggcacctgg tgtgcctggg cgagggcgac gacgagtacc
     6361 tggcccagca gtccatccgc accttcttca acgcctcgca ccccgggaag cactacgtga
     6421 agactgccct gtccgtcctc aacatgggct tcatgcgcgg tctgtcggcg gcgtacatgg
     6481 aggccactcc ggccatcaac gactggctcg cccggctgat cgagggcgac ccggtgctga
     6541 aggagacggg gctgagcatc atccgggagc gggcggccgt cggctaccgg cacctggagt
     6601 acgagcaggc caccgaccgc tactcgccct accgcaagat gctggcggcg ctgtggcggg
     6661 agagcccggt gccgtccatc cgggagggcg agacgctcgc caccatggcc tccctggtcc
     6721 accaggacca cgagggcgcc tccttcgcgg gcgcgctgat cgagcggtcc ggactcacgc
     6781 ccaccgagtg gctgcggcac tacctgcggg cctactacgt cccgctgctg cacagcttct
     6841 acgcctacga cctggtgtac atgccgcacg gcgagaacgt gatcctggtg ctggcggacg
     6901 gggtggtgcg gcgggcggtc tacaaggaca tcgccgagga gatcgcggtg atggacccgg
     6961 acgcggtgct gccgccggag gtctcccgca tcgcggtgga cgtgccggac gacaagaagc
     7021 tcctgtcgat cttcacggac gtcttcgact gcttcttccg cttcctggcc gcgaacctgg
     7081 cggaggaggg gatcgtcacg gaggacgcct tctggcggac ggtcgcggag gtcacccggg
     7141 agtaccagga gtcggtgccg gagctggccg acaagttcga gcggtacgac atgttcgcgc
     7201 ccgagttcgc cctgtcctgc ctcaaccggc tccagctgcg cgacaaccgg cagatggtgg
     7261 acctggccga cccgtccggc gcgctccagc tcgtcggcac cctgaagaac cccctggcag
     7321 gccggtag
//
